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Found 413 gene(s). Export as Excel file, text file

Victors ID Gene Name Sequence Strain (Species/Organism) NCBI Gene ID NCBI Nucleotide GI NCBI Protein GI Locus Tag Genbank Accession Protein Accession Protein Name Molecule Role Molecule Role Annotation PMID
iga from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216375 182684113 SPCG_1143 YP_001835860.1 immunoglobulin A1 protease Virulence factor MUTATION: iga mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
regR from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216376 182683304 SPCG_0334 YP_001835051.1 sugar binding transcriptional regulator RegR Virulence factor MUTATION: regR mutant is attenuated in mice [Ref6773:Chapuy-Regaud et al., 2003]. 12704136
spxB from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216487 182683649 SPCG_0679 YP_001835396.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
nox from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216649 182684428 SPCG_1458 YP_001836175.1 NADH oxidase Virulence factor MUTATION: nox mutant is attenuated in mice [Ref6775:Yu et al., 2001]. 11158360
ccpA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216676 182684935 SPCG_1964 YP_001836682.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
lytC from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6216707 182684529 SPCG_1559 YP_001836276.1 lysozyme Virulence factor MUTATION: lytC mutant have reduced colonization of rat nasopharynx compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
luxS from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217141 182683313 SPCG_0343 YP_001835060.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
ply from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217360 182684868 SPCG_1898 YP_001836615.1 pneumolysin Virulence factor MUTATION: ply mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
zmpB from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217389 182683590 SPCG_0620 YP_001835337.1 zinc metalloprotease ZmpB, putative Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
pspC from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217403 182685128 SPCG_2158 YP_001836875.1 choline binding protein A Virulence factor MUTATION: pspC mutant is has reduced ability to colonize nasopharynx of mice compared to the wild type [Ref6780:Ogunniyi et al., 2007]. 17261599
cbpG from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217428 182683357 SPCG_0387 YP_001835104.1 choline binding protein G Virulence factor MUTATION: cbpG has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
cbpD from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217546 182685138 SPCG_2168 YP_001836885.1 choline binding protein D Virulence factor MUTATION: cbpD has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
nanA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217600 182684635 SPCG_1665 YP_001836382.1 sialidase A precursor (neuraminidase A) Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
sodA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217646 182683685 SPCG_0715 YP_001835432.1 superoxide dismutase, manganese-dependent Virulence factor MUTATION: sodA mutant is attenuated in mice [Ref6782:Yesilkaya et al., 2000]. 10768978
pspA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217682 182683090 SPCG_0120 YP_001834837.1 pneumococcal surface protein A Virulence factor MUTATION: pspA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
pgdA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217943 182684437 SPCG_1467 YP_001836184.1 peptidoglycan N-acetylglucosamine deacetylase A Virulence factor MUTATION: pgdA mutant is attenuated in mice [Ref6783:Vollmer and Tomasz, 2002]. 12438406
lytA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6217991 182684882 SPCG_1911 YP_001836629.1 autolysin Virulence factor MUTATION: lytA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
ciaR from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6218247 182683717 SPCG_0747 YP_001835464.1 DNA-binding response regulator CiaR Virulence factor MUTATION: ciaR mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
lytB from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6218274 182683911 SPCG_0941 YP_001835658.1 endo-beta-N-acetylglucosaminidase Virulence factor MUTATION: lytB has reduced colonization of nasopharynx of rats compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
glnA from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6218347 182683450 SPCG_0480 YP_001835197.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
codY from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6218441 182684537 SPCG_1567 YP_001836284.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
mutX from Streptococcus pneumoniae CGSP14 Streptococcus pneumoniae CGSP14 6218513 182684099 SPCG_1129 YP_001835846.1 mutator MutT protein Virulence factor MUTATION: mutX mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
clpP from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6028624 169832484 SPH_0848 YP_001694209.1 Clp protease Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
spxB from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6028647 169832534 SPH_0817 YP_001694187.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
codY from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6028818 169832460 SPH_1697 YP_001694987.1 GTP-sensing transcriptional pleiotropic repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
zmpB from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6028839 169833025 SPH_0759 YP_001694137.1 zinc metalloprotease ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
luxS from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6029035 169833604 SPH_0450 YP_001693860.1 S-ribosylhomocysteinase LuxS Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
glnA from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6029135 169832640 SPH_0611 YP_001694002.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
ccpA from Streptococcus pneumoniae Hungary19A-6 Streptococcus pneumoniae Hungary19A-6 6029776 169833371 SPH_2142 YP_001695354.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
cbpA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441159 116515359 SPD_2017 YP_817402.1 choline binding protein A Virulence factor MUTATION: cbpA mutant is attenuated in rat pups [Ref6788:Rosenow et al., 1997]. 9364908
ciaR from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441190 116515465 SPD_0701 YP_816195.1 DNA-binding response regulator CiaR Virulence factor MUTATION: ciaR mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
mutX from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441251 116515668 SPD_1031 YP_816505.1 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) Virulence factor MUTATION: mutX mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
bacA Streptococcus pneumoniae 4441316 116515636 SPD_0417 YP_815925.1 undecaprenyl pyrophosphate phosphatase Virulence factor MUTATION: a bacA mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
pspA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441373 116515876 SPD_0126 YP_815641.1 pneumococcal surface protein A Virulence factor MUTATION: pspA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
regR from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441432 116515692 SPD_0301 YP_815818.1 sugar binding transcriptional regulator RegR Virulence factor MUTATION: regR mutant is attenuated in mice [Ref6773:Chapuy-Regaud et al., 2003]. 12704136
luxS from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441459 116516199 SPD_0309 YP_815826.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
clpP from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441476 116516216 SPD_0650 YP_816144.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
cbpE from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441485 116516225 SPD_0821 YP_816304.1 choline binding protein E Virulence factor MUTATION: cbpE has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
lytC from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441545 116515853 SPD_1403 YP_816863.1 1,4-beta-N-acetylmuramidase, putative Virulence factor MUTATION: lytC mutant have reduced colonization of rat nasopharynx compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
pgdA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441553 116515788 SPD_1309 YP_816775.1 peptidoglycan GlcNAc deacetylase Virulence factor MUTATION: pgdA mutant is attenuated in mice [Ref6783:Vollmer and Tomasz, 2002]. 12438406
purN Streptococcus pneumoniae D39 4441567 116515802 SPD_0055 YP_815495.1 phosphoribosylglycinamide formyltransferase Virulence factor MUTATION: a purN mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
ply from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441611 116515376 SPD_1726 YP_817150.1 pneumolysin Virulence factor MUTATION: ply mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
spxB from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441644 116516119 SPD_0636 YP_816132.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
zmpB from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441680 116515780 SPD_0577 YP_816076.1 zinc metalloprotease ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
ccpA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441881 116517109 SPD_1797 YP_817219.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
lytB from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4441884 116517112 SPD_0853 YP_816335.1 endo-beta-N-acetylglucosaminidase precursor, putative Virulence factor MUTATION: lytB has reduced colonization of nasopharynx of rats compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
pepC Streptococcus pneumoniae D39 4442061 116516913 SPD_0261 YP_815779.1 aminopeptidase C Virulence factor MUTATION: a pepC mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
lytA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442230 116516777 SPD_1737 YP_817160.1 autolysin/N-acetylmuramoyl-L-alanine amidase Virulence factor MUTATION: lytA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
psaC from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442282 116516771 SPD_1462 YP_816918.1 manganese ABC transporter, permease protein, putative Virulence factor MUTATION: psaC mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
nanA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442379 116517141 SPD_1504 YP_816960.1 sialidase A precursor Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
purB Streptococcus pneumoniae D39 4442401 116516623 SPD_0062 YP_815510.1 adenylosuccinate lyase Virulence factor MUTATION: a purB mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
codY from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442404 116515749 SPD_1412 YP_816871.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
cbpD from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442443 116516664 SPD_2028 YP_817413.1 choline binding protein D Virulence factor MUTATION: cbpD has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
nox from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442449 116516669 SPD_1298 YP_816764.1 NADH oxidase Virulence factor MUTATION: nox mutant is attenuated in mice [Ref6775:Yu et al., 2001]. 11158360
aga Streptococcus pneumoniae 4442466 116515396 SPD_1678 YP_817127.1 alpha-galactosidase AgaN Virulence factor MUTATION: an aga mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
potD from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442604 116516276 SPD_1218 YP_816685.1 spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein Virulence factor MUTATION: potD mutant is attenuated in pulmonary and systemic models of infection in mice [Ref6791:Ware et al., 2006]. 16368990
pavA Streptococcus pneumoniae D39 4442613 116516285 SPD_0854 YP_816336.1 adherence and virulence protein A Virulence factor MUTATION: pavA mutant is attenuated in mice [Ref6792:Holmes et al., 2001]. 11580843
glnA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442684 116516090 SPD_0448 YP_815956.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
sodA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442721 116515547 SPD_0667 YP_816161.1 superoxide dismutase, manganese-dependent Virulence factor MUTATION: sodA mutant is attenuated in mice [Ref6782:Yesilkaya et al., 2000]. 10768978
psaB from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442774 116515895 SPD_1461 YP_816917.1 manganese ABC transporter, ATP-binding protein Virulence factor MUTATION: psaB mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
pbp1A Streptococcus pneumoniae D39 4442813 116516330 SPD_0336 YP_815850.1 penicillin-binding protein 1A Virulence factor MUTATION: a pbp1A mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
iga from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442828 116516343 SPD_1018 YP_816492.1 immunoglobulin A1 protease precursor Virulence factor MUTATION: iga mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
srtA from Streptococcus pneumoniae D39 Streptococcus pneumoniae D39 4442999 116515518 SPD_1076 YP_816547.1 sortase Virulence factor MUTATION: The srtA mutant colonized the nasopharynx of chinchillas at a significantly lower level than the wild type [Ref6793:Chen et al., 2005]. 16246506
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 932849 15902667 spr0623 NP_358217.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
pspA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 932894 15902165 spr0121 NP_357715.1 Surface protein pspA precursor Virulence factor MUTATION: pspA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 932908 15902668 spr0624 NP_358218.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
psaA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933003 15903537 spr1494 NP_359087.1 ABC transporter substrate-binding protein - manganese transport. Virulence factor MUTATION: psaA mutant is attenuated in mice [Ref6795:Berry and Paton, 1996]. 8945574
mutX from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933037 15903098 spr1054 NP_358648.1 8-oxodGTP nucleoside triphosphatase Virulence factor MUTATION: mutX mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
lytC from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933163 15903474 spr1431 NP_359024.1 1,4-beta-N-acetylmuramidase Virulence factor MUTATION: lytC mutant have reduced colonization of rat nasopharynx compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
zmpB from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933274 15902625 spr0581 NP_358175.1 Zinc metalloprotease Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
ccpA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933352 15903681 spr1639 NP_359231.1 Catabolite control protein Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933482 15902576 spr0532 NP_358126.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933485 15902577 spr0533 NP_358127.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
pspC from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933487 15904036 spr1995 NP_359586.1 Choline binding protein A Virulence factor MUTATION: pspC mutant had reduced ability to colonize the nasopharynx of mice [Ref6780:Ogunniyi et al., 2007]. 17261599
ccpA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933600 15903855 spr1813 NP_359405.1 Catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
lytA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933669 15903796 spr1754 NP_359346.1 Autolysin (N-acetylmuramoyl-L-alanine amidase) Virulence factor MUTATION: lytA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
ply from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933687 15903781 spr1739 NP_359331.1 Pneumolysin (sulfhydryl-activated toxin that lyses cholesterol containing membranes) Virulence factor MUTATION: ply mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
psaC from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933751 15903536 spr1493 NP_359086.1 ABC transporter membrane-spanning permease - manganese transport Virulence factor MUTATION: psaC mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
psaB from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933772 15903535 spr1492 NP_359085.1 ABC transporter ATP-binding protein - manganese transport Virulence factor MUTATION: psaB mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
nanA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933902 15903579 spr1536 NP_359129.1 Sialidase A precursor (neuraminidase A) Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
iga from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933909 15903086 spr1042 NP_358636.1 Immunoglobulin A1 protease Virulence factor MUTATION: iga mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
codY from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933916 15903482 spr1439 NP_359032.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
srtA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 933969 15903141 spr1098 NP_358691.1 Sortase Virulence factor MUTATION: The srtA mutant colonized the nasopharynx of chinchillas at a significantly lower level than the wild type [Ref6793:Chen et al., 2005]. 16246506
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934028 15903163 spr1120 NP_358713.1 ABC transporter membrane spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
spxB from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934181 15902686 spr0642 NP_358236.1 Pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
clpP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934194 15902700 spr0656 NP_358250.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
sodA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934215 15902718 spr0674 NP_358268.1 Manganese co-factored superoxide dismutase Virulence factor MUTATION: sodA mutant is attenuated in mice [Ref6782:Yesilkaya et al., 2000]. 10768978
ciaR from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934251 15902751 spr0707 NP_358301.1 Response regulator, transcriptional regulatory protein Virulence factor MUTATION: ciaR mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934267 15902771 spr0727 NP_358321.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
lytB from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934406 15902911 spr0867 NP_358461.1 Endo-beta-N-acetylglucosaminidase Virulence factor MUTATION: lytB has reduced colonization of nasopharynx of rats compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
potD from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934459 15903286 spr1243 NP_358836.1 ABC transporter substrate-binding protein - spermidine/putrescine transport Virulence factor MUTATION: potD mutant is attenuated in pulmonary and systemic models of infection in mice [Ref6791:Ware et al., 2006]. 16368990
nox from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934540 15903366 spr1323 NP_358916.1 NADH oxidase Virulence factor MUTATION: nox mutant is attenuated in mice [Ref6775:Yu et al., 2001]. 11158360
pgdA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934547 15903376 spr1333 NP_358926.1 Peptidoglycan GlcNAc deacetylase Virulence factor MUTATION: pgdA mutant is attenuated in mice [Ref6783:Vollmer and Tomasz, 2002]. 12438406
glnP from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934570 15903398 spr1355 NP_358948.1 ABC transporter membrane-spanning permease - glutamine transport Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
regR from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934722 15902342 spr0298 NP_357892.1 Transcription regulator, member of GalR family Virulence factor MUTATION: regR mutant is attenuated in mice [Ref6773:Chapuy-Regaud et al., 2003]. 12704136
luxS from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934756 15902352 spr0308 NP_357902.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
glnA from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934783 15902488 spr0444 NP_358038.1 Glutamine synthetase type 1 Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
cbpG from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934834 15902394 spr0350 NP_357944.1 Choline binding protein G Virulence factor MUTATION: cbpG has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
cbpD from Streptococcus pneumoniae R6 Streptococcus pneumoniae R6 934859 15904047 spr2006 NP_359597.1 Choline binding protein D Virulence factor MUTATION: cbpD has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
radA Streptococcus pneumoniae TIGR4 929770 0 SP_0023 - pseudo Virulence factor MUTATION: radA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1976 Streptococcus pneumoniae TIGR4 929784 15901799 SP_1976 NP_346403.1 pyruvate formate-lyase-activating enzyme Virulence factor MUTATION: SP_1976 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2239 Streptococcus pneumoniae TIGR4 929800 15902042 SP_2239 NP_346646.1 serine protease Virulence factor MUTATION: SP_2239 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0049 Streptococcus pneumoniae TIGR4 929801 15899994 SP_0049 NP_344598.1 vanZ protein, putative Virulence factor MUTATION: SP_0049 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
purH Streptococcus pneumoniae TIGR4 929804 15899995 SP_0050 NP_344599.1 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase Virulence factor MUTATION: purH mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0057 Streptococcus pneumoniae TIGR4 929812 15900002 SP_0057 NP_344606.1 beta-N-acetylhexosaminidase Virulence factor MUTATION: SP_0057 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0063 Streptococcus pneumoniae TIGR4 929823 15900008 SP_0063 NP_344612.1 PTS system, IID component Virulence factor MUTATION: SP_0063 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2231 Streptococcus pneumoniae TIGR4 929826 15902035 SP_2231 NP_346639.1 ABC transporter, permease protein, putative Virulence factor MUTATION: SP_2231 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0071 Streptococcus pneumoniae TIGR4 929838 15900016 SP_0071 NP_344620.1 immunoglobulin A1 protease Virulence factor MUTATION: SP_0071 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0078 Streptococcus pneumoniae TIGR4 929848 15900023 SP_0078 AE005672 NP_344627 Trk family potassium uptake protein Virulence factor MUTATION: SP_0078 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2210 Streptococcus pneumoniae TIGR4 929865 15902017 SP_2210 NP_346621.1 cysteine synthase Virulence factor MUTATION: SP_2210 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0092 Streptococcus pneumoniae TIGR4 929866 15900035 SP_0092 NP_344639.1 ABC transporter, substrate-binding protein Virulence factor MUTATION: SP_0092 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0095 Streptococcus pneumoniae TIGR4 929869 15900038 SP_0095 NP_344642.1 hypothetical protein Virulence factor MUTATION: SP_0095 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0100 Streptococcus pneumoniae TIGR4 929875 15900043 SP_0100 NP_344647.1 hypothetical protein Virulence factor MUTATION: SP_0100 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0102 Streptococcus pneumoniae TIGR4 929877 15900045 SP_0102 NP_344649.1 glycosyl transferase Virulence factor MUTATION: SP_0102 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0110 Streptococcus pneumoniae TIGR4 929888 15900053 SP_0110 NP_344657.1 hypothetical protein Virulence factor MUTATION: SP_0110 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0117 Streptococcus pneumoniae TIGR4 929896 15900059 SP_0117 NP_344663.1 pneumococcal surface protein A Virulence factor MUTATION: pspA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0121 Streptococcus pneumoniae TIGR4 929900 15900063 SP_0121 NP_344667.1 metallo-beta-lactamase superfamily protein Virulence factor MUTATION: SP_0121 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0128 Streptococcus pneumoniae TIGR4 929911 15900070 SP_0128 NP_344674.1 ribosomal-protein-alanine acetyltransferase, putative Virulence factor MUTATION: SP_0128 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0136 Streptococcus pneumoniae TIGR4 929922 15900075 SP_0136 NP_344679.1 glycosyl transferase, family 2 Virulence factor MUTATION: SP_0136 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0141 Streptococcus pneumoniae TIGR4 929928 15900079 SP_0141 NP_344683.1 transcriptional regulator Virulence factor MUTATION: SP_0141 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0145 Streptococcus pneumoniae TIGR4 929933 15900083 SP_0145 NP_344687.1 hypothetical protein Virulence factor MUTATION: SP_0145 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0146 Streptococcus pneumoniae TIGR4 929934 15900084 SP_0146 NP_344688.1 hypothetical protein Virulence factor MUTATION: SP_0146 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0150 Streptococcus pneumoniae TIGR4 929938 15900088 SP_0150 NP_344692.1 hypothetical protein Virulence factor MUTATION: SP_0150 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0156 Streptococcus pneumoniae TIGR4 929947 15900094 SP_0156 NP_344698.1 DNA-binding response regulator Virulence factor MUTATION: SP_0156 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0157 Streptococcus pneumoniae TIGR4 929948 15900095 SP_0157 NP_344699.1 hypothetical protein Virulence factor MUTATION: SP_0157 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0160 Streptococcus pneumoniae TIGR4 929951 15900098 SP_0160 NP_344702.1 hypothetical protein Virulence factor MUTATION: SP_0160 mutation is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1964 Streptococcus pneumoniae TIGR4 929957 15901787 SP_1964 NP_346391.1 DNA-entry nuclease Virulence factor MUTATION: SP_1964 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0177 Streptococcus pneumoniae TIGR4 929969 15900114 SP_0177 NP_344718.1 riboflavin synthase subunit alpha Virulence factor MUTATION: SP_0177 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0198 Streptococcus pneumoniae TIGR4 929993 15900134 SP_0198 NP_344738.1 hypothetical protein Virulence factor MUTATION: SP_0198 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0199 Streptococcus pneumoniae TIGR4 929994 15900135 SP_0199 NP_344739.1 cardiolipin synthetase Virulence factor MUTATION: SP_0199 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0240 Streptococcus pneumoniae TIGR4 930040 15900176 SP_0240 NP_344780.1 phosphoglycerate mutase family protein Virulence factor MUTATION: SP_0240 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0242 Streptococcus pneumoniae TIGR4 930043 15900177 SP_0242 NP_344781.1 ABC transporter, ATP-binding protein Virulence factor MUTATION: SP_0242 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0246 Streptococcus pneumoniae TIGR4 930048 15900181 SP_0246 NP_344785.1 transcriptional regulator, DeoR family Virulence factor MUTATION: SP_0246 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0247 Streptococcus pneumoniae TIGR4 930049 15900182 SP_0247 NP_344786.1 transcriptional regulator Virulence factor MUTATION: SP_0247 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0251 Streptococcus pneumoniae TIGR4 930053 15900186 SP_0251 NP_344790.1 formate acetyltransferase, putative Virulence factor MUTATION: SP_0251 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
gldA Streptococcus pneumoniae TIGR4 930055 15900188 SP_0253 NP_344792.1 glycerol dehydrogenase Virulence factor MUTATION: gldA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
leuS Streptococcus pneumoniae TIGR4 930056 15900189 SP_0254 NP_344793.1 leucyl-tRNA synthetase Virulence factor MUTATION: leuS mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0265 Streptococcus pneumoniae TIGR4 930071 15900199 SP_0265 NP_344803.1 glycosyl hydrolase, family 1 Virulence factor MUTATION: SP_0625 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0267 Streptococcus pneumoniae TIGR4 930074 15900201 SP_0267 NP_344805.1 oxidoreductase, putative Virulence factor MUTATION: SP_0267 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0268 Streptococcus pneumoniae TIGR4 930075 15900202 SP_0268 NP_344806.1 alkaline amylopullulanase, putative Virulence factor MUTATION: SP_0268 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
polC Streptococcus pneumoniae TIGR4 930082 15900208 SP_0274 NP_344812.1 DNA polymerase III PolC Virulence factor MUTATION: polC mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0298 Streptococcus pneumoniae TIGR4 930110 15900232 SP_0298 NP_344836.1 hypothetical protein Virulence factor MUTATION: SP_0298 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0306 Streptococcus pneumoniae TIGR4 930119 15900239 SP_0306 NP_344843.1 transcriptional regulator, putative Virulence factor MUTATION: SP_0306 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0312 SStreptococcus pneumoniae TIGR4 930125 15900245 SP_0312 NP_344849.1 glycosyl hydrolase, family 31 Virulence factor MUTATION: SP_0312 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0314 Streptococcus pneumoniae TIGR4 930127 15900247 SP_0314 NP_344851.1 hyaluronidase Virulence factor MUTATION: SP_0314 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0320 Streptococcus pneumoniae TIGR4 930133 15900252 SP_0320 NP_344856.1 gluconate 5-dehydrogenase Virulence factor MUTATION: SP_0320 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0332 Streptococcus pneumoniae TIGR4 930147 15900263 SP_0332 NP_344867.1 hypothetical protein Virulence factor MUTATION: SP_0332 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0338 Streptococcus pneumoniae TIGR4 930156 15900269 SP_0338 NP_344873.1 ATP-dependent Clp protease, ATP-binding subunit, putative Virulence factor MUTATION: SP_0338 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2175 Streptococcus pneumoniae TIGR4 930192 15901985 SP_2175 NP_346589.1 dltB protein Virulence factor MUTATION: dltB mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2170 Streptococcus pneumoniae TIGR4 930196 15901980 SP_2170 NP_346584.1 zinc ABC transporter, permease protein Virulence factor MUTATION: SP_2170 mutant is attenuated [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2164 Streptococcus pneumoniae TIGR4 930201 15901974 SP_2164 NP_346578.1 PTS system, IIA component Virulence factor MUTATION: SP_2164 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2162 Streptococcus pneumoniae TIGR4 930202 15901972 SP_2162 NP_346576.1 PTS system, IIC component Virulence factor MUTATION: SP_2162 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2145 Streptococcus pneumoniae TIGR4 930213 15901958 SP_2145 NP_346562.1 antigen, cell wall surface anchor family Virulence factor MUTATION: SP_2145 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2143 Streptococcus pneumoniae TIGR4 930214 15901956 SP_2143 NP_346560.1 hypothetical protein Virulence factor MUTATION: SP_2143 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2128 Streptococcus pneumoniae TIGR4 930222 15901942 SP_2128 NP_346546.1 transketolase, N-terminal subunit Virulence factor MUTATION: SP_2128 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2108 Streptococcus pneumoniae TIGR4 930238 15901923 SP_2108 NP_346527.1 maltose/maltodextrin ABC transporter, maltose/maltodextrin-binding protein Virulence factor MUTATION: SP_2108 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2101 Streptococcus pneumoniae TIGR4 930243 15901916 SP_2101 NP_346520.1 cation-transporting ATPase, EI-E2 family Virulence factor MUTATION: SP_2101 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2098 Streptococcus pneumoniae TIGR4 930245 15901913 SP_2098 NP_346517.1 membrane protein Virulence factor MUTATION: SP_2098 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2095 Streptococcus pneumoniae TIGR4 930248 15901910 SP_2095 NP_346514.1 5-formyltetrahydrofolate cyclo-ligase family protein Virulence factor MUTATION: SP_2095 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2076 Streptococcus pneumoniae TIGR4 930262 0 SP_2076 - pseudo Virulence factor MUTATION: SP_2076 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1952 Streptococcus pneumoniae TIGR4 930283 15901776 SP_1952 NP_346380.1 hypothetical protein Virulence factor MUTATION: SP_1952 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002] 12207705
SP_0377 Streptococcus pneumoniae TIGR4 930291 15900300 SP_0377 NP_344904.1 choline binding protein C Virulence factor MUTATION: cbpC mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0385 Streptococcus pneumoniae TIGR4 930301 15900308 SP_0385 NP_344912.1 hypothetical protein Virulence factor MUTATION: SP_0385 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0396 Streptococcus pneumoniae TIGR4 930330 15900316 SP_0396 NP_344920.1 PTS system, mannitol-specific IIA component Virulence factor MUTATION: SP_0396 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0445 Streptococcus pneumoniae TIGR4 930383 15900362 SP_0445 NP_344966.1 acetolactate synthase catalytic subunit Virulence factor MUTATION: SP_0445 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0454 Streptococcus pneumoniae TIGR4 930392 15900371 SP_0454 NP_344975.1 hypothetical protein Virulence factor MUTATION: SP_0454 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0461 Streptococcus pneumoniae TIGR4 930399 15900377 SP_0461 NP_344981.1 transcriptional regulator, putative Virulence factor MUTATION: SP_0461 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0468 Streptococcus pneumoniae TIGR4 930406 15900384 SP_0468 NP_344988.1 sortase, putative Virulence factor MUTATION: SP_0468 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0474 Streptococcus pneumoniae TIGR4 930412 15900389 SP_0474 NP_344993.1 PTS system, cellobiose-specific IIC component Virulence factor MUTATION: SP_0474 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0478 Streptococcus pneumoniae TIGR4 930416 15900393 SP_0478 NP_344997.1 PTS system, lactose-specific IIBC components Virulence factor MUTATION: SP_0478 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0479 Streptococcus pneumoniae TIGR4 930417 15900394 SP_0479 NP_344998.1 potassium uptake protein, Trk family Virulence factor MUTATION: SP_0479 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0492 Streptococcus pneumoniae TIGR4 930429 15900406 SP_0492 NP_345010.1 hypothetical protein Virulence factor MUTATION: SP_0492 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0494 Streptococcus pneumoniae TIGR4 930432 15900408 SP_0494 NP_345012.1 CTP synthase Virulence factor MUTATION: SP_0494 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0498 Streptococcus pneumoniae TIGR4 930436 15900412 SP_0498 NP_345016.1 endo-beta-N-acetylglucosaminidase, putative Virulence factor MUTATION: SP_0498 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0510 Streptococcus pneumoniae TIGR4 930448 15900424 SP_0510 NP_345028.1 type I restriction-modification system, R subunit Virulence factor MUTATION: SP_0510 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
blpA Streptococcus pneumoniae 930470 0 SP_0530 - pseudo Virulence factor MUTATION: blpA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0571 Streptococcus pneumoniae TIGR4 930515 15900482 SP_0571 NP_345086.1 cell filamentation protein Fic-related protein Virulence factor MUTATION: SP_0571 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0586 Streptococcus pneumoniae TIGR4 930532 15900495 SP_0586 NP_345099.1 5,10-methylenetetrahydrofolate reductase, putative Virulence factor MUTATION: SP_0586 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0595 Streptococcus pneumoniae TIGR4 930541 15900504 SP_0595 NP_345108.1 hypothetical protein Virulence factor MUTATION: SP_0595 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0600 Streptococcus pneumoniae TIGR4 930547 15900508 SP_0600 NP_345112.1 ABC transporter, ATP-binding protein Vexp2 Virulence factor MUTATION: vexp2 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0614 Streptococcus pneumoniae TIGR4 930563 15900522 SP_0614 NP_345126.1 tributyrin esterase Virulence factor MUTATION: SP_0614 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0622 Streptococcus pneumoniae TIGR4 930571 15900530 SP_0622 NP_345134.1 nitroreductase family protein Virulence factor MUTATION: SP_0622 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0633 Streptococcus pneumoniae TIGR4 930582 15900539 SP_0633 NP_345143.1 hypothetical protein Virulence factor MUTATION: SP_0633 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0641 Streptococcus pneumoniae TIGR4 930590 15900547 SP_0641 NP_345151.1 serine protease, subtilase family Virulence factor MUTATION: SP_0641 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0645 Streptococcus pneumoniae TIGR4 930594 15900548 SP_0645 NP_345152.1 PTS system IIA component, putative Virulence factor MUTATION: SP_0645 mutation is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0648 Streptococcus pneumoniae TIGR4 930597 15900551 SP_0648 NP_345155.1 beta-galactosidase Virulence factor MUTATION: SP_0648 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0655 Streptococcus pneumoniae TIGR4 930604 118090028 SP_0655 NP_345160.2 sodium/hydrogen exchanger family protein Virulence factor MUTATION: SP_0655 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0661 Streptococcus pneumoniae TIGR4 930610 15900562 SP_0661 NP_345166.1 DNA-binding response regulator Virulence factor MUTATION: SP_0661 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0663 Streptococcus pneumoniae TIGR4 930612 15900564 SP_0663 NP_345168.1 hypothetical protein Virulence factor MUTATION: SP_0663 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0664 Streptococcus pneumoniae TIGR4 930613 15900565 SP_0664 NP_345169.1 zinc metalloprotease ZmpB, putative Virulence factor MUTATION: SP_0664 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0665 Streptococcus pneumoniae TIGR4 930614 15900566 SP_0665 NP_345170.1 chorismate binding enzyme Virulence factor MUTATION: SP_0665 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0686 Streptococcus pneumoniae TIGR4 930636 15900587 SP_0686 NP_345191.1 hypothetical protein Virulence factor MUTATION: SP_0686 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0690 Streptococcus pneumoniae TIGR4 930640 15900591 SP_0690 NP_345195.1 cell division protein DivIB Virulence factor MUTATION: SP_0690 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0719 Streptococcus pneumoniae TIGR4 930669 15900616 SP_0719 NP_345220.1 hypothetical protein Virulence factor MUTATION: SP_0719 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0720 Streptococcus pneumoniae TIGR4 930670 15900617 SP_0720 NP_345221.1 ABC transporter, ATP-binding protein Virulence factor MUTATION: SP_0720 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0726 Streptococcus pneumoniae TIGR4 930676 15900623 SP_0726 NP_345227.1 phosphomethylpyrimidine kinase Virulence factor MUTATION: SP_0736 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0728 Streptococcus pneumoniae TIGR4 930678 15900625 SP_0728 NP_345229.1 hypothetical protein Virulence factor MUTATION: SP_0728 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0729 Streptococcus pneumoniae TIGR4 930679 15900626 SP_0729 NP_345230.1 cation-transporting ATPase, E1-E2 family Virulence factor MUTATION: SP_0729 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
clpP from Streptococcus pneumoniae TIGR4 Streptococcus pneumoniae TIGR4 930696 15900641 SP_0746 NP_345245.1 ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
SP_0766 Streptococcus pneumoniae TIGR4 930716 15900660 SP_0766 NP_345264.1 superoxide dismutase, manganese-dependent Virulence factor MUTATION: SP_0766 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0767 Streptococcus pneumoniae TIGR4 930717 15900661 SP_0767 NP_345265.1 hypothetical protein Virulence factor MUTATION: SP_0767 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0774 Streptococcus pneumoniae TIGR4 930724 15900668 SP_0774 NP_345272.1 hypothetical protein Virulence factor MUTATION: SP_0774 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0785 Streptococcus pneumoniae TIGR4 930735 15900678 SP_0785 NP_345282.1 hypothetical protein Virulence factor MUTATION: SP_0785 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0789 Streptococcus pneumoniae TIGR4 930739 15900682 SP_0789 NP_345286.1 hypothetical protein Virulence factor MUTATION: SP_0789 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0797 Streptococcus pneumoniae TIGR4 930747 15900690 SP_0797 NP_345294.1 aminopeptidase N Virulence factor MUTATION: SP_0797 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0807 Streptococcus pneumoniae TIGR4 930757 15900700 SP_0807 NP_345304.1 septation ring formation regulator EzrA Virulence factor MUTATION: SP_0807 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0829 Streptococcus pneumoniae TIGR4 930779 15900716 SP_0829 NP_345320.1 phosphopentomutase Virulence factor MUTATION: SP_0829 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0842 Streptococcus pneumoniae TIGR4 930792 15900729 SP_0842 NP_345333.1 pyrimidine-nucleoside phosphorylase Virulence factor MUTATION: SP_0842 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0856 Streptococcus pneumoniae TIGR4 930806 15900741 SP_0856 NP_345345.1 branched-chain amino acid aminotransferase Virulence factor MUTATION: SP_0856 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0877 Streptococcus pneumoniae TIGR4 930830 15900760 SP_0877 NP_345364.1 PTS system, fructose specific IIABC components Virulence factor MUTATION: SP_0877 mutant is attenuated [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0886 Streptococcus pneumoniae TIGR4 930839 15900769 SP_0886 NP_345373.1 type I restriction-modification system, M subunit, putative Virulence factor MUTATION: SP_0886 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0887 Streptococcus pneumoniae TIGR4 930840 15900770 SP_0887 NP_345374.1 type I restriction-modification system, S subunit, putative Virulence factor MUTATION: SP_0887 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0892 Streptococcus pneumoniae TIGR4 930845 15900775 SP_0892 NP_345379.1 type I restriction-modification system, R subunit, putative Virulence factor MUTATION: SP_0892 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0916 Streptococcus pneumoniae TIGR4 930869 15900796 SP_0916 NP_345400.1 lysine decarboxylase Virulence factor MUTATION: SP_0916 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0927 Streptococcus pneumoniae TIGR4 930880 15900807 SP_0927 NP_345411.1 transcriptional regulator, LysR family Virulence factor MUTATION: SP_0927 is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0939 Streptococcus pneumoniae TIGR4 930892 15900819 SP_0939 NP_345423.1 hypothetical protein Virulence factor MUTATION: SP_0939 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0943 Streptococcus pneumoniae TIGR4 930896 15900822 SP_0943 NP_345426.1 tRNA (uracil-5-)-methyltransferase Gid Virulence factor MUTATION: gid mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1889 Streptococcus pneumoniae TIGR4 930933 15901716 SP_1889 NP_346320.1 oligopeptide ABC transporter, permease protein AmiD Virulence factor MUTATION: AmiD mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1898 Streptococcus pneumoniae TIGR4 930935 15901725 SP_1898 NP_346329.1 alpha-galactosidase Virulence factor MUTATION: SP_1898 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1896 Streptococcus pneumoniae TIGR4 930937 15901723 SP_1896 NP_346327.1 sugar ABC transporter, permease protein Virulence factor MUTATION: SP_1896 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1890 Streptococcus pneumoniae TIGR4 930941 15901717 SP_1890 NP_346321.1 oligopeptide ABC transporter, permease protein AmiC Virulence factor MUTATION: AmiC mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1891 Streptococcus pneumoniae TIGR4 930943 15901718 SP_1891 NP_346322.1 oligopeptide ABC transporter, oligopeptide-binding protein AmiA Virulence factor MUTATION: AmiA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1879 Streptococcus pneumoniae TIGR4 930953 15901707 SP_1879 NP_346311.1 hypothetical protein Virulence factor MUTATION: SP_1879 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1869 Streptococcus pneumoniae TIGR4 930959 15901697 SP_1869 NP_346301.1 iron-compound ABC transporter, permease protein Virulence factor MUTATION: SP_1869 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1861 Streptococcus pneumoniae TIGR4 930972 15901689 SP_1861 NP_346293.1 choline transporter Virulence factor MUTATION: SP_1861 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1859 Streptococcus pneumoniae TIGR4 930975 15901687 SP_1859 NP_346291.1 transporter, putative Virulence factor MUTATION: SP_1859 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1856 Streptococcus pneumoniae TIGR4 930978 15901684 SP_1856 NP_346288.1 transcriptional regulator, MerR family Virulence factor MUTATION: SP_1856 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1855 Streptococcus pneumoniae TIGR4 930979 15901683 SP_1855 NP_346287.1 alcohol dehydrogenase, zinc-containing Virulence factor MUTATION: SP_1855 mutation is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1854 Streptococcus pneumoniae TIGR4 930980 15901682 SP_1854 NP_346286.1 galactose operon repressor Virulence factor MUTATION: SP_1854 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1847 Streptococcus pneumoniae TIGR4 930985 15901675 SP_1847 NP_346279.1 xanthine phosphoribosyltransferase Virulence factor MUTATION: SP_1847 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1830 Streptococcus pneumoniae TIGR4 931005 15901659 SP_1830 NP_346263.1 phosphate transport system regulatory protein PhoU, putative Virulence factor MUTATION: SP_1830 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1817 Streptococcus pneumoniae TIGR4 931018 15901646 SP_1817 NP_346250.1 anthranilate synthase component I Virulence factor MUTATION: SP_1817 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1800 Streptococcus pneumoniae TIGR4 931019 15901629 SP_1800 NP_346233.1 transcriptional activator, putative Virulence factor MUTATION: SP_1800 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1816 Streptococcus pneumoniae TIGR4 931020 15901645 SP_1816 NP_346249.1 anthranilate synthase component II Virulence factor MUTATION: SP_1816 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
trpD Streptococcus pneumoniae TIGR4 931021 15901644 SP_1815 NP_346248.1 anthranilate phosphoribosyltransferase Virulence factor MUTATION: trpD mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1793 Streptococcus pneumoniae TIGR4 931039 15901622 SP_1793 NP_346226.1 hypothetical protein Virulence factor MUTATION: SP_1793 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1770 Streptococcus pneumoniae TIGR4 931052 15901600 SP_1770 NP_346204.1 glycosyl transferase, family 8 Virulence factor MUTATION: SP_1770 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1780 Streptococcus pneumoniae TIGR4 931054 15901609 SP_1780 NP_346213.1 oligoendopeptidase F, putative Virulence factor MUTATION: SP_1780 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1771 Streptococcus pneumoniae TIGR4 931055 15901601 SP_1771 NP_346205.1 glycosyl transferase, family 2/glycosyl transferase family 8 Virulence factor MUTATION: SP_1771 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1779 Streptococcus pneumoniae TIGR4 931057 15901608 SP_1779 NP_346212.1 hypothetical protein Virulence factor MUTATION: SP_1779 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1772 Streptococcus pneumoniae TIGR4 931060 15901602 SP_1772 NP_346206.1 cell wall surface anchor family protein Virulence factor MUTATION: SP_1772 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1760 Streptococcus pneumoniae TIGR4 931073 15901591 SP_1760 NP_346195.1 hypothetical protein Virulence factor MUTATION: SP_1760 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1717 Streptococcus pneumoniae TIGR4 931115 15901551 SP_1717 NP_346155.1 ABC transporter, ATP-binding protein Virulence factor MUTATION: SP_1717 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1715 Streptococcus pneumoniae TIGR4 931117 15901549 SP_1715 NP_346153.1 ABC transporter, ATP-binding protein Virulence factor MUTATION: SP_1715 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1706 Streptococcus pneumoniae TIGR4 931126 15901540 SP_1706 NP_346144.1 hypothetical protein Virulence factor MUTATION: Sp_1706 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1652 Streptococcus pneumoniae TIGR4 931175 15901487 SP_1652 NP_346091.1 hypothetical protein Virulence factor MUTATION: SP_1652 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1654 Streptococcus pneumoniae TIGR4 931185 15901489 SP_1654 NP_346093.1 hypothetical protein Virulence factor MUTATION: SP_1654 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1646 Streptococcus pneumoniae TIGR4 931191 15901482 SP_1646 NP_346086.1 metallo-beta-lactamase superfamily protein Virulence factor MUTATION: SP_1646 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1645 Streptococcus pneumoniae TIGR4 931192 15901481 SP_1645 NP_346085.1 GTP pyrophosphokinase Virulence factor MUTATION: SP_1645 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1636 Streptococcus pneumoniae TIGR4 931205 15901472 SP_1636 NP_346076.1 Rrf2 family protein Virulence factor MUTATION: SP_1636 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1633 Streptococcus pneumoniae TIGR4 931206 15901469 SP_1633 NP_346073.1 DNA-binding response regulator Virulence factor MUTATION: SP_1633 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1591 Streptococcus pneumoniae TIGR4 931254 15901433 SP_1591 NP_346037.1 proline dipeptidase Virulence factor MUTATION: SP_1591 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1580 Streptococcus pneumoniae TIGR4 931258 15901422 SP_1580 NP_346026.1 sugar ABC transporter, ATP-binding protein Virulence factor MUTATION: SP_1580 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
lytC from Streptococcus pneumoniae TIGR4 Streptococcus pneumoniae TIGR4 931265 118090031 SP_1573 YP_873931.1 lysozyme Virulence factor MUTATION: lytC mutant have reduced colonization of rat nasopharynx compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
SP_0966 Streptococcus pneumoniae TIGR4 931286 15900843 SP_0966 NP_345447.1 adherence and virulence protein A Virulence factor MUTATION: SP_0966 mutant is attenuated [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1544 Streptococcus pneumoniae TIGR4 931296 15901387 SP_1544 NP_345991.1 aspartate aminotransferase Virulence factor MUTATION: SP_1544 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1538 Streptococcus pneumoniae TIGR4 931302 15901382 SP_1538 NP_345986.1 Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type Virulence factor MUTATION: SP_1538 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1529 Streptococcus pneumoniae TIGR4 931308 15901374 SP_1529 NP_345978.1 polysaccharide biosynthesis protein, putative Virulence factor MUTATION: SP_1529 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1518 Streptococcus pneumoniae TIGR4 931319 15901364 SP_1518 NP_345968.1 hypothetical protein Virulence factor MUTATION: SP_1518 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1483 Streptococcus pneumoniae TIGR4 931359 15901333 SP_1483 NP_345937.1 ATP-dependent RNA helicase, DEAD/DEAH box family Virulence factor MUTATION: SP_1483 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1433 Streptococcus pneumoniae TIGR4 931406 15901285 SP_1433 NP_345889.1 transcriptional regulator, AraC family Virulence factor MUTATION: SP_1433 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1434 Streptococcus pneumoniae TIGR4 931407 15901286 SP_1434 NP_345890.1 ABC transporter, ATP-binding/permease protein Virulence factor MUTATION: SP_1434 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1431 Streptococcus pneumoniae TIGR4 931411 15901283 SP_1431 NP_345887.1 type II DNA modification methyltransferase, putative Virulence factor MUTATION: SP_1431 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1400 Streptococcus pneumoniae TIGR4 931432 15901254 SP_1400 NP_345858.1 phosphate ABC transporter, phosphate-binding protein, putative Virulence factor MUTATION: SP_1400 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1399 Streptococcus pneumoniae TIGR4 931438 15901253 SP_1399 NP_345857.1 phosphate ABC transporter, permease protein, putative Virulence factor MUTATION: SP_1339 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1398 Streptococcus pneumoniae TIGR4 931439 15901252 SP_1398 NP_345856.1 phosphate ABC transporter, permease protein, putative Virulence factor MUTATION: SP_1398 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1396 Streptococcus pneumoniae TIGR4 931441 15901250 SP_1396 NP_345854.1 phosphate ABC transporter, ATP-binding protein, putative Virulence factor MUTATION: SP_1396 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1378 Streptococcus pneumoniae TIGR4 931450 15901232 SP_1378 NP_345836.1 hypothetical protein Virulence factor MUTATION: SP_1378 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1382 Streptococcus pneumoniae TIGR4 931456 15901236 SP_1382 NP_345840.1 cytoplasmic alpha-amylase Virulence factor MUTATION: SP_1382 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
aroD Streptococcus pneumoniae 931457 15901231 SP_1377 NP_345835.1 3-dehydroquinate dehydratase Virulence factor MUTATION: aroD mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0978 Streptococcus pneumoniae TIGR4 931491 15900855 SP_0978 NP_345459.1 competence protein CoiA Virulence factor MUTATION: CoiA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_0979 Streptococcus pneumoniae TIGR4 931492 15900856 SP_0979 NP_345460.1 oligoendopeptidase F Virulence factor MUTATION: SP_0979 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1001 Streptococcus pneumoniae TIGR4 931514 15900874 SP_1001 NP_345478.1 amino acid permease family protein Virulence factor MUTATION: SP_1001 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1003 Streptococcus pneumoniae TIGR4 931516 15900876 SP_1003 NP_345480.1 hypothetical protein Virulence factor MUTATION: SP_1003 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1018 Streptococcus pneumoniae TIGR4 931532 15900889 SP_1018 NP_345493.1 thymidine kinase Virulence factor MUTATION: SP_1018 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1023 Streptococcus pneumoniae TIGR4 931537 15900894 SP_1023 NP_345498.1 acetyltransferase, GNAT family Virulence factor MUTATION: SP_1023 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1029 Streptococcus pneumoniae TIGR4 931543 15900900 SP_1029 NP_345504.1 RNA methyltransferase, TrmA family Virulence factor MUTATION: SP_1029 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1032 Streptococcus pneumoniae TIGR4 931546 15900903 SP_1032 NP_345507.1 iron-compound ABC transporter, iron compound-binding protein Virulence factor MUTATION: SP_1032 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1040 Streptococcus pneumoniae TIGR4 931554 15900911 SP_1040 NP_345515.1 site-specific recombinase, resolvase family Virulence factor MUTATION: SP_1040 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1043 Streptococcus pneumoniae TIGR4 931557 15900914 SP_1043 NP_345518.1 hypothetical protein Virulence factor MUTATION: Sp_1043 (phgA) mutant is attenuated in mice [Ref6797:Brown et al., 2004]. 15271918
SP_1045 Streptococcus pneumoniae TIGR4 931559 15900916 SP_1045 NP_345520.1 conserved hypothetical protein TIGR00147 Virulence factor MUTATION: SP_1045 (phgC) mutant is attenuated in mice [Ref6797:Brown et al., 2004]. 15271918
SP_1089 Streptococcus pneumoniae TIGR4 931603 15900957 SP_1089 NP_345561.1 glutamine amidotransferase, class I Virulence factor MUTATION: SP_1089 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1111 Streptococcus pneumoniae TIGR4 931625 15900978 SP_1111 NP_345582.1 hypothetical protein Virulence factor MUTATION: SP_1111 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1112 Streptococcus pneumoniae TIGR4 931626 15900979 SP_1112 NP_345583.1 degV family protein Virulence factor MUTATION: SP_1112 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1115 Streptococcus pneumoniae TIGR4 931629 15900982 SP_1115 NP_345586.1 transcriptional regulator MutR, putative Virulence factor MUTATION: SP_1115 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1118 Streptococcus pneumoniae TIGR4 931632 15900985 SP_1118 NP_345589.1 pullulanase, putative Virulence factor MUTATION: SP_1118 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1121 Streptococcus pneumoniae TIGR4 931635 15900988 SP_1121 NP_345592.1 glycogen branching enzyme Virulence factor MUTATION: SP_1121 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1127 Streptococcus pneumoniae TIGR4 931641 15900993 SP_1127 NP_345597.1 hypothetical protein Virulence factor MUTATION: SP_1127 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1143 Streptococcus pneumoniae TIGR4 931657 15901009 SP_1143 NP_345613.1 hypothetical protein Virulence factor MUTATION: SP_1143 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1153 Streptococcus pneumoniae TIGR4 931667 15901018 SP_1153 NP_345622.1 hypothetical protein Virulence factor MUTATION: SP_1153 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1154 Streptococcus pneumoniae TIGR4 931668 15901019 SP_1154 NP_345623.1 immunoglobulin A1 protease Virulence factor MUTATION: SP_1154 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
rnhB Streptococcus pneumoniae TIGR4 931670 15901021 SP_1156 NP_345625.1 ribonuclease HII Virulence factor MUTATION: rnhB mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1174 Streptococcus pneumoniae TIGR4 931688 15901039 SP_1174 NP_345643.1 hypothetical protein Virulence factor MUTATION: SP_1174 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1175 Streptococcus pneumoniae TIGR4 931689 15901040 SP_1175 NP_345644.1 hypothetical protein Virulence factor MUTATION: SP_1175 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1193 Streptococcus pneumoniae TIGR4 931707 15901058 SP_1193 NP_345662.1 galactose-6-phosphate isomerase subunit LacA Virulence factor MUTATION: LacA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1202 Streptococcus pneumoniae TIGR4 931716 15901065 SP_1202 NP_345669.1 DNA repair protein RecN Virulence factor MUTATION: RecN mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1278 Streptococcus pneumoniae TIGR4 931792 15901138 SP_1278 NP_345742.1 pyrimidine regulatory protein PyrR Virulence factor MUTATION: SP_1278 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1281 Streptococcus pneumoniae TIGR4 931795 15901141 SP_1281 NP_345745.1 hypothetical protein Virulence factor MUTATION: SP_1281 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
gidB Streptococcus pneumoniae TIGR4 931799 15901145 SP_1285 NP_345749.1 glucose-inhibited division protein B Virulence factor MUTATION: gidB mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1286 Streptococcus pneumoniae TIGR4 931800 15901146 SP_1286 NP_345750.1 uracil permease Virulence factor MUTATION: SP_1286 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1292 Streptococcus pneumoniae TIGR4 931806 15901152 SP_1292 NP_345756.1 SAP domain protein Virulence factor MUTATION: SP_1292 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1321 Streptococcus pneumoniae TIGR4 931837 15901175 SP_1321 NP_345779.1 V-type ATP synthase subunit K Virulence factor MUTATION: SP_1321 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1328 Streptococcus pneumoniae TIGR4 931845 15901182 SP_1328 NP_345786.1 sodium:solute symporter family protein Virulence factor MUTATION: SP_1328 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1343 Streptococcus pneumoniae TIGR4 931860 15901197 SP_1343 NP_345801.1 prolyl oligopeptidase family protein Virulence factor MUTATION: SP_1343 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1344 Streptococcus pneumoniae TIGR4 931861 15901198 SP_1344 NP_345802.1 hypothetical protein Virulence factor MUTATION: SP_1344 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1941 Streptococcus pneumoniae TIGR4 931883 15901765 SP_1941 NP_346369.1 competence damage-inducible protein A Virulence factor MUTATION: SP_1941 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1970 Streptococcus pneumoniae TIGR4 931885 15901793 SP_1970 NP_346397.1 asparagine synthetase AsnA Virulence factor MUTATION: SP_1970 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1998 Streptococcus pneumoniae TIGR4 931895 15901821 SP_1998 NP_346425.1 L-asparaginase, putative Virulence factor MUTATION: SP_1988 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2201 Streptococcus pneumoniae TIGR4 931907 15902008 SP_2201 NP_346612.1 choline binding protein D Virulence factor MUTATION: cbpD mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2236 Streptococcus pneumoniae TIGR4 931908 15902039 SP_2236 NP_346643.1 putative sensor histidine kinase ComD Virulence factor MUTATION: SP_2236 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1923 Streptococcus pneumoniae TIGR4 931915 15901747 SP_1923 NP_346351.1 pneumolysin Virulence factor MUTATION: pneumolysin mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1956 Streptococcus pneumoniae TIGR4 931916 15901779 SP_1956 NP_346383.1 hypothetical protein Virulence factor MUTATION:SP_1956 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2190 Streptococcus pneumoniae TIGR4 931921 15901997 SP_2190 NP_346601.1 choline binding protein A Virulence factor MUTATION: SP_2190 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2176 Streptococcus pneumoniae TIGR4 931927 15901986 SP_2176 NP_346590.1 D-alanine--D-alanyl carrier protein ligase Virulence factor MUTATION: SP_2176 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2182 Streptococcus pneumoniae TIGR4 931928 15901989 SP_2182 NP_346593.1 hypothetical protein Virulence factor MUTATION: SP_2182 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2167 Streptococcus pneumoniae TIGR4 931931 15901977 SP_2167 NP_346581.1 L-fuculose kinase fucK, putative Virulence factor MUTATION: fucK mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2159 Streptococcus pneumoniae TIGR4 931935 15901969 SP_2159 NP_346573.1 fucolectin-related protein Virulence factor MUTATION: SP_2159 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2146 Streptococcus pneumoniae TIGR4 931940 15901959 SP_2146 NP_346563.1 hypothetical protein Virulence factor MUTATION: SP_2146 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2142 Streptococcus pneumoniae TIGR4 931944 15901955 SP_2142 NP_346559.1 ROK family protein Virulence factor MUTATION: SP_2142 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2136 Streptococcus pneumoniae TIGR4 931946 15901950 SP_2136 NP_346554.1 choline binding protein PcpA Virulence factor MUTATION: PcpA mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2131 Streptococcus pneumoniae TIGR4 931948 15901945 SP_2131 NP_346549.1 transcriptional regulator, BglG family Virulence factor MUTATION: SP_2131 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2105 Streptococcus pneumoniae TIGR4 931957 15901920 SP_2105 NP_346524.1 hypothetical protein Virulence factor MUTATION: SP_2105 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2086 Streptococcus pneumoniae TIGR4 931966 15901902 SP_2086 NP_346506.1 phosphate ABC transporter, permease protein Virulence factor MUTATION: SP_2086 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2060 Streptococcus pneumoniae TIGR4 931978 15901880 SP_2060 NP_346484.1 pyrrolidone-carboxylate peptidase Virulence factor MUTATION: SP_2060 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2052 Streptococcus pneumoniae TIGR4 931979 15901872 SP_2052 NP_346476.1 competence protein CglB Virulence factor MUTATION: CglB mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_1939 Streptococcus pneumoniae TIGR4 931984 15901763 SP_1939 NP_346367.1 MATE efflux family protein DinF Virulence factor MUTATION: SP_1939 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2002 Streptococcus pneumoniae TIGR4 931986 15901825 SP_2002 NP_346429.1 hypothetical protein Virulence factor MUTATION: SP_2002 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2017 Streptococcus pneumoniae TIGR4 932016 15901840 SP_2017 NP_346444.1 membrane protein Virulence factor MUTATION: SP_2017 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2022 Streptococcus pneumoniae TIGR4 932024 15901843 SP_2022 NP_346447.1 PTS system, IIC component Virulence factor MUTATION: SP_2022 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
SP_2039 Streptococcus pneumoniae TIGR4 932042 15901860 SP_2039 NP_346464.1 hypothetical protein Virulence factor MUTATION: SP_2039 mutant is attenuated in mice [Ref6796:Hava and Camilli, 2002]. 12207705
cbpD from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6478692 194398386 SPG_2147 YP_002038797.1 choline binding protein D Virulence factor MUTATION: cbpD has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
piaA Streptococcus pneumoniae G54 6478755 194398219 SPG_0956 YP_002037666.1 iron ABC transporter, iron-binding protein Virulence factor MUTATION: piaA piuB double mutant is attenuated in systemic infection of mice [Ref6813:Brown et al., 2002]. 12117949
psaB from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6478858 194396962 SPG_1558 YP_002038263.1 manganese ABC transporter, ATP-binding protein Virulence factor MUTATION: psaB mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
glnA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6478869 194396896 SPG_0458 YP_002037173.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
igA Streptococcus pneumoniae G54 6478876 194398492 SPG_1053 YP_002037763.1 immunoglobulin A1 protease Virulence factor MUTATION: iga mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
cpsC Streptococcus pneumoniae G54 6478888 194396683 SPG_0316 YP_002037031.1 capsular polysaccharide biosynthesis protein wzh Virulence factor MUTATION: cpsC mutant is avirulent in mice [Ref6814:Morona et al., 2004]. 15122528
sodA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6478940 194397985 SPG_0697 YP_002037412.1 superoxide dismutase, manganese-dependent Virulence factor MUTATION: sodA mutant is attenuated in mice [Ref6782:Yesilkaya et al., 2000]. 10768978
cbpE from S treptococcus pneumoniae G54 S treptococcus pneumoniae G54 6478968 194397033 SPG_0856 YP_002037567.1 choline binding protein E Virulence factor MUTATION: cbpE has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
codY from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6478994 194397588 SPG_1509 YP_002038214.1 transcriptional repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
lytB from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479000 194398062 SPG_0889 YP_002037600.1 endo-beta-N-acetylglucosaminidase Virulence factor MUTATION: lytB has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
zmpB from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479105 194397255 SPG_0605 YP_002037320.1 zinc metalloprotease ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
cbpG from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479228 194397667 SPG_0356 YP_002037071.1 choline binding protein G Virulence factor MUTATION: cbpG has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
purL Streptococcus pneumoniae G54 6479310 194397931 SPG_0051 YP_002036766.1 phosphoribosylformylglycinamide synthetase Virulence factor MUTATION: a purL mutant was attenuated in a murine model [Ref6789:Lau et al., 2001] 11359563
spxB from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479320 194397524 SPG_0663 YP_002037378.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
pgdA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479325 194397649 SPG_1406 YP_002038113.1 peptidoglycan GlcNAc deacetylase (pgdA) Virulence factor MUTATION: pgdA mutant is attenuated in mice [Ref6783:Vollmer and Tomasz, 2002]. 12438406
cpsB Streptococcus pneumoniae G54 6479425 194398654 SPG_0315 YP_002037030.1 tyrosine-protein phosphatase wzh Virulence factor MUTATION: cpsB mutant is avirulent in mice [Ref6814:Morona et al., 2004]. 15122528
zmpC Streptococcus pneumoniae G54 6479482 194396933 SPG_0074 YP_002036789.1 zinc metalloprotease ZmpC Virulence factor MUTATION: zmpC mutant is attenuated in mice [Ref6815:Oggioni et al., 2003]. 12864860
ciaR from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479630 194398608 SPG_0728 YP_002037443.1 CiaR response regulator TCS05 Virulence factor MUTATION: ciaR mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
ply from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479683 194397945 SPG_1836 YP_002038518.1 pneumolysin Virulence factor MUTATION: ply mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
nanA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479746 194397355 SPG_1600 YP_002038305.1 neuraminidase A Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
ritR Streptococcus pneumoniae G54 6479772 194396773 SPG_0342 YP_002037057.1 RitR response regulator Virulence factor MUTATION: ritR mutant is attenuated in lung infection model of mice [Ref6816:Ulijasz et al., 2004]. 15547286
glnP from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6479830 194398103 SPG_1131 YP_002037841.1 ABC transporter, amino acid-binding protein/permease protein Virulence factor MUTATION: glnP mutant is attenuated in mice [Ref6794:Hendriksen et al., 2008]. 18174343
mutX from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480061 194397879 SPG_1068 YP_002037778.1 mutator mutT protein Virulence factor MUTATION: mutX is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
luxS from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480079 194398223 SPG_0309 YP_002037024.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
pspC from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480115 194398341 SPG_2135 YP_002038785.1 surface protein PspC Virulence factor MUTATION: pspC mutant has reduced ability to colonize the nasopharynx of mice compared to t he wild type [Ref6780:Ogunniyi et al., 2007]. 17261599
pspA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480167 194396737 SPG_0121 YP_002036836.1 pneumococcal surface protein A Virulence factor MUTATION: pspA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
regR from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480263 194397639 SPG_0298 YP_002037013.1 sugar binding transcriptional regulator RegR Virulence factor MUTATION: regR mutant is attenuated in mice [Ref6773:Chapuy-Regaud et al., 2003]. 12704136
lytA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480363 194397555 SPG_1847 YP_002038529.1 autolysin Virulence factor MUTATION: lytA mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
potD from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480374 194398708 SPG_1325 YP_002038032.1 spermidine/putrescine ABC transporter, spermidine/putrescine-binding protein Virulence factor MUTATION: potD mutant is attenuated in pulmonary and systemic models of infection in mice [Ref6791:Ware et al., 2006]. 16368990
lytC from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480618 194397706 SPG_1499 YP_002038205.1 endo-beta-N-acetylglucosaminidase Virulence factor MUTATION: lytC mutant have reduced colonization of rat nasopharynx compared to wild type [Ref6777:Gosink et al., 2000]. 10992472
psaA from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480660 194398710 SPG_1560 YP_002038265.1 manganese ABC transporter substrate-binding lipoprotein Virulence factor MUTATION: psaA mutant is attenuated in mice [Ref6795:Berry and Paton, 1996]. 8945574
psaC from Streptococcus pneumoniae G54 Streptococcus pneumoniae G54 6480715 194398501 SPG_1559 YP_002038264.1 manganese ABC transporter, permease protein Virulence factor MUTATION: psaC mutant is attenuated in mice [Ref6790:Marra et al., 2002]. 11988523
mutX from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327429 221231880 SPN23F_10710 YP_002511032.1 mutator MutX protein (7,8-dihydro-8-oxoguanine-triphosphatase) Virulence factor MUTATION: mutX mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
lytB from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327431 221231728 SPN23F_08900 YP_002510880.1 putative endo-beta-N-acetylglucosaminidase Virulence factor MUTATION: lytB has reduced colonization of nasopharynx of rats compared to the wild type [Ref6777:Gosink et al., 2000]. 10992472
cbpG from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327530 221231260 SPN23F_03640 YP_002510412.1 choline binding protein G Virulence factor MUTATION: cbpG has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
srtA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327675 221231914 SPN23F_11150 YP_002511066.1 sortase SrtA Virulence factor MUTATION: The srtA mutant colonized the nasopharynx of chinchillas at a significantly lower level than the wild type [Ref6793:Chen et al., 2005]. 16246506
nanA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327738 221232004 SPN23F_12210 YP_002511156.1 probable N-acetylneuraminate lyase Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
ciaR from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7327765 221231598 SPN23F_07270 YP_002510750.1 response regulator protein Virulence factor MUTATION: ciaR mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
zmpB from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328238 221231480 SPN23F_05990 YP_002510632.1 putative zinc metalloproteinase ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
spxB from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328274 221231532 SPN23F_06550 YP_002510684.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
sodA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328296 221231560 SPN23F_06880 YP_002510712.1 superoxide dismutase Virulence factor MUTATION: sodA mutant is attenuated in mice [Ref6782:Yesilkaya et al., 2000]. 10768978
ply from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328330 221232655 SPN23F_19470 YP_002511809.1 pneumolysin (thiol-activated cytolysin) Virulence factor MUTATION: ply mutant is attenuated in mice [Ref6779:Berry and Paton, 2000]. 10603379
cbpA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328513 221232892 SPN23F_22240 YP_002512046.1 choline-binding surface protein A Virulence factor MUTATION: cbpA mutant is attenuated in rat pups [Ref6788:Rosenow et al., 1997]. 9364908
glnA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328606 221231340 SPN23F_04560 YP_002510492.1 putative glutamine synthetase Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
htrA Streptococcus pneumoniae ATCC 700669 7328624 221232937 SPN23F_22720 YP_002512091.1 serine protease Virulence factor MUTATION: htrA mutant is attenuated in mice [Ref6784:Ibrahim et al., 2004]. 15292127
ccpA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328668 221232723 SPN23F_20200 YP_002511877.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
pclA Streptococcus pneumoniae ATCC 700669 7328731 221232257 SPN23F_15100 YP_002511410.1 putative NADPH-dependent FMN reductase Virulence factor MUTATION: pclA mutant was defective in adherence and invasion of host cells in vitro [Ref6823:Paterson et al., 2008]. 18557785
codY from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328802 221232343 SPN23F_16000 YP_002511496.1 GTP-sensing transcriptional pleiotropic repressor Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
cbpE from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7328890 221231701 SPN23F_08530 YP_002510853.1 choline binding protein E Virulence factor MUTATION: cbpE has reduced colonization of nasopharynx of rats and reduced adherence to human epithelial cells [Ref6777:Gosink et al., 2000]. 10992472
potD from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329269 221232126 SPN23F_13500 YP_002511279.1 spermidine/putrescine extracellular binding protein Virulence factor MUTATION: potD mutant is attenuated in pulmonary and systemic models of infection in mice [Ref6791:Ware et al., 2006]. 16368990
nox from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329323 221232194 SPN23F_14330 YP_002511347.1 NADH oxidase Virulence factor MUTATION: nox mutant is attenuated in mice [Ref6775:Yu et al., 2001]. 11158360
clpP from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329421 221231543 SPN23F_06700 YP_002510695.1 putative ATP-dependent Clp protease proteolytic subunit Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
luxS from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329460 221231219 SPN23F_03130 YP_002510371.1 S-ribosylhomocysteinase Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
cbpD from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329486 221232902 SPN23F_22340 YP_002512056.1 choline binding protein D Virulence factor MUTATION: cbpD has reduced colonization of nasopharynx of rats compared to the wild type [Ref6824:Foehrenbach, 1975]. 1099247
nanA from Streptococcus pneumoniae ATCC 700669 Streptococcus pneumoniae ATCC 700669 7329489 221232428 SPN23F_16920 YP_002511581.1 sialidase A (neuraminidase A) Virulence factor MUTATION: nanA mutant is attenuated in mice [Ref6781:Polissi et al., 1998]. 9826334
psrP Streptococcus pneumoniae ATCC 700669 7329552 221232510 SPN23F_17820 YP_002511663.1 cell wall surface anchored protein Virulence factor MUTATION: psrP mutants failed to bind to A549 and LA-4 lung cells, yet adhered normally to human nasopharyngeal epithelial cells and to cells from human and rodent capillary endothelial cell lines. psrP mutants were also unable to persist in the lungs of mice [Ref6825:Rose et al., 2008]. 18507531
ccpA from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7685361 225861818 SPT_1980 YP_002743327.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
luxS from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7685557 225860378 SPT_0389 YP_002741887.1 S-ribosylhomocysteinase LuxS Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
codY from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7686158 225861415 SPT_1523 YP_002742924.1 GTP-sensing transcriptional pleiotropic repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
zmpB from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7686335 225860655 SPT_0688 YP_002742164.1 zinc metalloprotease ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
glnA from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7686610 225860520 SPT_0539 YP_002742029.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
clpP from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7686613 225860721 SPT_0761 YP_002742230.1 Clp protease Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
spxB from Streptococcus pneumoniae Taiwan19F-14 Streptococcus pneumoniae Taiwan19F-14 7687021 225860708 SPT_0746 YP_002742217.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
spxB from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7683145 225858545 SP70585_0777 YP_002740055.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
ccpA from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7683357 225859756 SP70585_2072 YP_002741266.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
codY from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7683683 225859339 SP70585_1624 YP_002740849.1 GTP-sensing transcriptional pleiotropic repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
luxS from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7684294 225858194 SP70585_0404 YP_002739704.1 S-ribosylhomocysteinase LuxS Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
glnA from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7684741 225858342 SP70585_0562 YP_002739852.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
zmpB from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7684951 225858492 SP70585_0723 YP_002740002.1 zinc metalloprotease ZmpB Virulence factor MUTATION: zmpB mutant is attenuated in mice [Ref6772:Chiavolini et al., 2003]. 12841855
clpP from Streptococcus pneumoniae 70585 Streptococcus pneumoniae 70585 7685058 225858557 SP70585_0792 YP_002740067.1 Clp protease Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
luxS from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7680711 225856082 SPP_0375 YP_002737593.1 S-ribosylhomocysteinase LuxS Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
spxB from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7681180 225856408 SPP_0741 YP_002737919.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
codY from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7681757 225857208 SPP_1606 YP_002738719.1 GTP-sensing transcriptional pleiotropic repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
ccpA from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7682073 225857574 SPP_2023 YP_002739085.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
glnA from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7682623 225856221 SPP_0524 YP_002737732.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
clpP from Streptococcus pneumoniae P1031 Streptococcus pneumoniae P1031 7682798 225856422 SPP_0757 YP_002737933.1 Clp protease Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
luxS from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7678909 225853922 SPJ_0332 YP_002735434.1 S-ribosylhomocysteinase LuxS Virulence factor MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice [Ref6778:Joyce et al., 2004]. 15102809
glnA from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7679297 225854055 SPJ_0471 YP_002735567.1 glutamine synthetase, type I Virulence factor MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells [Ref6785:Kloosterman et al., 2006]. 16787930
codY from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7679394 225855025 SPJ_1490 YP_002736537.1 GTP-sensing transcriptional pleiotropic repressor CodY Virulence factor MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro [Ref6786:Hendriksen et al., 2008]. 18024519
ccpA from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7679761 225855490 SPJ_1993 YP_002737002.1 catabolite control protein A Virulence factor MUTATION: ccpA mutant is attenuated in mice [Ref6776:Iyer et al., 2005]. 16321938
spxB from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7680032 225854241 SPJ_0670 YP_002735753.1 pyruvate oxidase Virulence factor MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits [Ref6774:Spellerberg et al., 1996]. 8820650
clpP from Streptococcus pneumoniae JJA Streptococcus pneumoniae JJA 7680127 225854255 SPJ_0685 YP_002735767.1 Clp protease Virulence factor MUTATION: clpP mutant is attenuated in mice [Ref6787:Ibrahim et al., 2005]. 15664911
Type 38 Polysaccharide Capsule Streptococcus pneumoniae Virulence factor MUTATION: an isogenic capsule mutant was attenuated in rabbit model of endophthalmitis [Ref7306:Sanders et al., 2010]. 21051708