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ciaR from Streptococcus pneumoniae R6

Victor ID 3120
Gene Name ciaR from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 934251
NCBI Protein GI 15902751
Locus Tag spr0707
Protein Accession NP_358301.1
Other Database IDs UniProtKB-ID: CIAR_STRR6
UniRef100: UniRef100_P0A4H8
UniRef90: UniRef90_P0A4H8
UniRef50: UniRef50_P0A4H8
UniParc: UPI0000127989
EMBL: X77249
EMBL: AE007317
EMBL-CDS: CAA54465.1
EMBL-CDS: AAK99511.1
RefSeq_NT: NC_003098.1
EnsemblGenome: EBSTRG00000015388
EnsemblGenome_TRS: EBSTRT00000015388
EnsemblGenome_PRO: EBSTRP00000014784
GenomeReviews: AE007317_GR
KEGG: spr:spr0707
eggNOG: COG0745
HOGENOM: HBG753323
ProtClustDB: CLSK876907
BioCyc: SPNE171101:SPR0707-MONOMER
Taxonomy ID 171101
Gene Starting Position 707225
Gene Ending Position 707965
Gene Strand (Orientation) +
Protein Name Response regulator, transcriptional regulatory protein
DNA Sequence 
>gi|15902044:707225-707965 Streptococcus pneumoniae R6, complete genome
AATGCAGAGAGTTGAGTTTTTTTTAAGGCAAATTTGGTATAATAGTTTTAATAAGGAGGAGTTTCTCATG
ATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTG
CGGATGTTATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGAT
TTTGCTGGATTTGATGTTGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATT
ACGACACCAGTTCTGATTATGACTGCCAAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAG
CGGATGATTATCTGACCAAACCTTTCTACCTAGAAGAACTTAAAATGCGGATTCAGGCCCTTCTCAAACG
TTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGGTTAATTTATCAACCAATACCGTT
AAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTATTTCCTTCAAAATC
AAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGATTTC
GGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAA
ACCTTGCGTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTA
Protein Sequence 
>gi|15902751|ref|NP_358301.1| DNA-binding response regulator CiaR [Streptococcus pneumoniae R6] MQRVEFFLRQIWYNSFNKEEFLMIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVYFLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ciaR mutant is attenuated in mice (Ibrahim et al., 2004).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Ibrahim et al., 2004: Ibrahim YM, Kerr AR, McCluskey J, Mitchell TJ. Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. Journal of bacteriology. 2004; 186(16); 5258-5266. [PubMed: 15292127].