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PCD-base: PHI-induced Programmed Cell Death (PCD)

PCD-base is a web-based programmed cell death (PCD) database as an integrated part of PHIDIAS for data integration, curation, analysis, and modeling of PCD data, with a focus on PHI-induced PCD.

PCD Gene Search:

Search Field	Search Parameter
Protein Group	All 7TM receptors, their ligands and ligand synthases Adhesion, Anchoring, Transcytosis, Anti-Adhesion Molecules, NKRs and Related Proteins Antibacterial peptides Bcl-2 family Calpain and associated proteins Caspase Regulators and Other CARD/DED/Pyrin-N/BIR proteins Caspases (C14) and Related Cysteine Proteases Complement and Related Proteins CTGF family, ECM-associated Cullin proteins Death Domain (DD) containing proteins E3-related proteins, RING proteins and their-related proteins Enzymes of Lipid and Inohsitol Metabolism and their Regulators F box/SOCS box - SCF related proteins Forkhead Family HECT proteins Ig-related Proteins IL/FGF/IFN/GH familes IL/FGF/IFN/GH Receptors and Binding Factors IL8 Family Chemokines and Their Receptors Inducible Proteins for Immunity JAK Kinases related to apoptosis, NF-kB activation and JNK pathway Ligands of membrane-located receptor kinase Metalloproteinasess midkine/pleiotrophin NF-kB, Apoptosis and JNK Regulators NOTCH Other apoptosis regulators Other factors Other ILs Other proteins Other Transcription Coactivators or Corepressors Other Transcriptional Apoptosis Regulators Post-transcriptional Regulators and RNA binding proteins Protein Phosphatases Proteins induced during apoptosis Reelin/Disabled Regulators of Engulfment and Endocytosis Saccharide Transferases Sara family Skp1 proteins SMAD STAT TGF beta family TGFR family and TGF-associated proteins TLRs, related protein and non-lectin/Ig type pathgen recognizing proteins TNF and TNFR Families Transcription factors for apoptosis, NF-kB/I-kB/NF-AT USPs proteins Viral Apoptotic Inhibitors Wnt pathway and related
Gene Name
Protein Name
Other keywords

Pathogen-induced PCD pathways:

Salmonella-induced PCD pathway

Bacillus anthracis-induced PCD

Useful Links:

• The International Cell Death Society
• Celldeath.de
• The Apoptosis Database (Ref: Docter, et al., 2003)
• The CASBAH: a searchable database of caspase substrates (Ref: Lüthi and Martin, 2007)
• Casbase: The Caspases Database
• Roch Apoptosis and Cell Proliferation Source
• STKE: Mitochondrial Pathway of Apoptosis: Caspases
• BioChemWeb.org apoptosis
• List of Apoptosis Regulators (by Naohiro Inohara, University of Michigan)
• Gene Ontology (GO) Browsers:
  • MGI GO Browser: Programmed cell death
  • AmiGo GO Brower: Programmed cell death, apoptosis, necrosis, and autophagy
• KEGG Apoptosis Pathway Source: human apoptosis, and mouse apoptosis
• Reactome pathways: human apoptosis, and mouse apoptosis (inferred)