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Brucella Genomes
Genome Analysis
Protein Domains
Host-Brucella interaction
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Gene Query
Virulence Factors
Interaction Network
Brucella as a Hazard
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Welcome to the Brucella Bioinformatics Portal (BBP)!

Brucella is a Gram-negative, facultative intracellular coccobacillus which causes zoonotic brucellosis in humans and a variety of animal species. Brucellosis is one of the most common zoonotic diseases worldwide. Brucellosis is also re-emerging zoonosis. As described by Pappas et al, "human brucellosis remains the commonest zoonotic disease worldwide with more than 500,000 new cases annually".

The Brucellae are taxonomically placed in the alpha-2 subdivision of the class Proteobacteria. Traditionally there are six species of Brucella based on the preferential host specificity: B. melitensis (goats), B. abortus (cattle), B. suis (swine), B. canis (dogs), B. ovis (sheep) and B. neotomae (desert mice); two new species B. cetaceae (cetacean) and B. pinnipediae (seal) were described by Cloeckaert et al. [Microbes Infect (2001) 3, 729-738]. The first four species are pathogenic to humans in decreasing order of severity making brucellosis a zoonotic disease. These Brucella species have been identified as priority agents amenable for use in biological warfare and bio-terrorism and listed as NIAID category B priority pathogens. Complete genome sequences of 25 Brucella strains are now available. A Brucella genome usually has two circular chromosomes of approximately 2.1 MB and 1.2 MB and has a GC content of approximately 57%. There are approximately 3,200 - 3,400 ORFs in each genome. The DNA sequences among different Brucella spp. share greater than 90% homology. The Brucella taxonomy is available here from the NCBI Taxonomy database, and is also overseen by the Brucella Taxonomy subommittee.

This BBP website is dedicated to becoming a bioinformatics resource portal for the Brucella research community to facilitate Brucella reearch. BBP has long been developed by Dr. He and used as a model for the overall PHIDIAS development. BBP includes a list of programs for analysis of Brucella and host-Brucella interactions. Please use the left side navigation bar to identify and access specific a BBP program. Please feel free to contact us with any questions you might have. Thank you.

BBP publication:

Zuoshuang Xiang, Wenjie Zheng and Yongqun He. BBP: Brucella genome annotation with literature mining and curation. BMC Bioinformatics. 2006 Jul 16;7(1):347. PMID: 16842628.

Listed are the news related to Brucella research and development. Please submit your news to us and we will have it posted here. Thank you.

  • 9/12/2018: Brucellosis 2018 - 71st Annual Brucellosis Research Conference information released by Ms. Sue Hagius:
    • Time: Saturday, December 1, 2018 at 8:00 am to Sunday, December 2, at 5pm. 
    • Venue: Chicago Marriott, Downtown Magnificent Mile, Chicago, Illinois
    • Hotel reservation: Make your Chicago Marriott, Downtown Magnificent Mile hotel reservations prior to November 11, 2018, to receive the discounted CRWAD rate ($189 plus tax/fees for single or double occupancy)
    • Registration: On-site registration for the meeting will begin at 7:00 a.m., Saturday, Dec 1, 2018, in front of the meeting room. The registration fee will be $200 for PIs/guests and $150 for students/post docs (US$), payable by cash or check (no credit cards). Online registration is being arranged through RegOnline which includes an additional service fee.
    • Presentation and Abstract Submission: Friday, October 19, 2018 (indicate if you prefer an oral presentation or a poster). Please send to
    • Check out three files: (1) Sue's email; (2) Brucellosis 2018 conference announcement; (2) Brucellosis 2018 abstract example.

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