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codY from Streptococcus pneumoniae Hungary19A-6

Victor ID 3057
Gene Name codY from Streptococcus pneumoniae Hungary19A-6
Sequence Strain (Species/Organism) Streptococcus pneumoniae Hungary19A-6
NCBI Gene ID 6028818
NCBI Protein GI 169832460
Locus Tag SPH_1697
Protein Accession YP_001694987.1
Other Database IDs UniProtKB-ID: CODY_STRPI
UniRef100: UniRef100_C1C8H3
UniRef90: UniRef90_Q04JG7
UniRef50: UniRef50_A2RCV3
UniParc: UPI000152B52E
EMBL: CP000936
EMBL-CDS: ACA35574.1
RefSeq_NT: NC_010380.1
EnsemblGenome: EBSTRG00000023146
EnsemblGenome_TRS: EBSTRT00000023146
EnsemblGenome_PRO: EBSTRP00000022312
GenomeReviews: CP000936_GR
KEGG: spv:SPH_1697
HOGENOM: HBG304760
OMA: HIFEELD
ProtClustDB: PRK04158
BioCyc: SPNE487214:SPH_1697-MONOMER
Taxonomy ID 487214
Gene Starting Position 1564249
Gene Ending Position 1565037
Gene Strand (Orientation) -
Protein Name GTP-sensing transcriptional pleiotropic repressor CodY
DNA Sequence 
>gi|169832377:1564249-1565037 Streptococcus pneumoniae Hungary19A-6, complete genome
ATTAGTAATCTCTTTTCTTCACTTCTTCAAAAATATCTGAAATCAAGACCTTAAGATAGGTTCCCTTCAT
TCCAAGTGAGCGACTTTCAATAATCCCCGCAGACTCAAGTTTACGAAGAGCATTGACAATCACAGAGCGA
GTGATTCCGATACGATCTGCAATCACTGACGCAGTCAACTTCCCTTCATTTCCATTTAATTCCCCTAAAA
TTGCTGAAACAGCACGGAGTTCGGAGTAAGAAAGGGTATTGACCGCCATGGTGACAGCAGTACGACGACG
AATATTTTTCTCATCTTCTTCACGTTGGAAGTTAAGAAGCTGAATCCCAACAACGGTACTGGCAATCTCA
ACAAGAACCAAGTCCTCATCTTCGAATTTTTTATCATTACGCCAAATAATCAAAGAACCAAGGCGAATCC
CCGATACATGAATCGGTGCAATAGTCGTCAAGCCATCTGGAAAATCATCTCTACTCTCAACAGGGAAAAT
ACTCATATCATGCTCAACAGGCAAGTTTGCTTCTGTTTCGTAAATCATATTAGCCCCTTGAACGTAGTCA
TCTGGGAAAATCTTAGTTTGGAAGAATTGCTCTACGCGATCTGTATTTGTTTTATAACGCATAAAATAGC
CAAGCAGACGTCCCTTACTATTGATAATGCAGGCATTGCAATGAATAATATCCGCTAACTGACGCGTAAT
AGCGTTGTAAGGGAGCTCATCCTGCAACTGCTCCTCTGAGCGTTTCAAAATTGATGTAATTTTTCTAGTT
TTTTCTAATAAATGTGCCA
Protein Sequence 
>gi|169832460|ref|YP_001694987.1| transcriptional repressor CodY [Streptococcus pneumoniae Hungary19A-6] MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro (Hendriksen et al., 2008).
COG COG4465K, under K: Transcription
References
Hendriksen et al., 2008: Hendriksen WT, Bootsma HJ, Estevão S, Hoogenboezem T, de Jong A, de Groot R, Kuipers OP, Hermans PW. CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. Journal of bacteriology. 2008; 190(2); 590-601. [PubMed: 18024519].