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SP_1645

Victor ID 3281
Gene Name SP_1645
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 931192
NCBI Protein GI 15901481
Locus Tag SP_1645
Protein Accession NP_346085.1
Other Database IDs UniProtKB-ID: Q97PH2_STRPN
UniRef100: UniRef100_B2IRP9
UniRef90: UniRef90_B2IRP9
UniRef50: UniRef50_Q54089
UniParc: UPI000005191D
EMBL: AE005672
EMBL-CDS: AAK75725.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026001.
EnsemblGenome_TRS: EBSTRT00000026001
EnsemblGenome_PRO: EBSTRP00000025093
GenomeReviews: AE005672_GR
KEGG: spn:SP_1645
TIGR: SP_1645
HOGENOM: HBG594146
OMA: ARTAIRH
ProtClustDB: CLSK876689
BioCyc: SPNE170187-1:SP_1645-MONOMER
Taxonomy ID 170187
Gene Starting Position 1541750
Gene Ending Position 1543972
Gene Strand (Orientation) -
Protein Name GTP pyrophosphokinase
DNA Sequence 
>gi|194172857:1541750-1543972 Streptococcus pneumoniae TIGR4 chromosome, complete genome
ACTAGCCGTTGGTCCGTTTGACAGAGTAAACTTCTGGCACACTCTTAATTTTATCGACAACCGTGGTCAG
TGTAGAGAGGTTGGCAATACCGAAGGACACATGGATATTAGCAAACTTCATATCCTTGGTTGGTTGGGCA
TTGACCGTTGAAATATTCTTGGTTGTATTTGAAAGAACTTGCAGTACATCGTTCAACAGTCCTGTACGGT
TGAGACCGTAGATATCGATATGGGCCATATACTCCTTATTTGAGCTAGGGTACTGGTCTTCCCATTCCAC
ATCAAGGAGACGTTGCTCGTAGTTTTCTTGGGCACGCAGGTTCATACAGTCCACACGGTGAATAGCCACA
CCACGACCCTTGGTAATGTAGCCAACAATATCGTCACCAGGCACGGGGTTACAACACTTAGCAATCCGCA
CTAGGAGACCAGAAGCACCTTCAATAACCACTCCCCCCTCATGCTTGACCTTGAGGGTTTCTTTATTTTC
AACCTTGACCTCGCCACCTTTGACAAGCTCCTCTGCCTCAGCTTTGGCCTTGGCACGCTCTTCCTCACGG
CGTTCCTTTTCAGTCAGACGGTTAAAGACGGTAATCGCACCGATTTCCCCAAAACCAATGGCCGCAAAGA
GGGAGTCTTCTGTCTTGTAACTGGTCTTTTGCAGAACTTGATCCATGTGGCGCTTGTCCATAAATTTATT
TGCCACATAGCCATTTTCTTGGAACTGAGCCATCAGCATCTCACGACCCTTGTTGACAGACAATTCCTTA
TCTTGGTTTTTAAAGAACTGGCGAATCTTATTGCGCGCCTTGCTAGTCTTGACCATATTGAGCCAGTCAC
GGCTAGGTCCAAAGGAGTTCGGGTTGGCGATAATTTCAACCTGATCCCCTGTCTTTAACTTGGTTGTCAG
TGGAACCATGCGGCCATTGACCTTGGCACCAGTTGCTTTTTCACCGACCTTGGTATGGATTTCGTAGGCA
AAATCAATCGGTCCTGAATCTTTGGGAAGGGAACGGACAGCTCCATCTGGGGTAAAAACGTAAATCTCCT
CAGCCAAATAGTTTTCCTTAACAGAGTCCACAAATTCCTTAGCATCATCAGCCTGGTCTTGGAGCTCCAT
CATCTCCTTGATCCAGTTCATTCCAATAGCTGATTCCTTGCTGTTAACTTGCCCCTTTATACCTTTCTTA
TAAGCCCAGTGAGCCGCAACCCCGTACTCAGCCACCTCGTGCATTTCCTTGGTTCGAATCTGGAATTCAA
TCGGCCCTTTTGGTCCATAAACAGTCGTATGGATAGACTGATAACCATTGGCCTTGCGGTTGGCGATATA
GTCTTTGAAGCGACCTGGCATCGGTTTCCAAAATTCATGCACGTAACCAAGCATGGCATAAACATCACTT
TGGGTATCTAAAATACAACGAATAGCAATCAGATCATAGATTTCCTCAAACCGTTTTCTCTTGTCCTGCA
TTTTGCGGAAAATTGAGTAAATATGCTTGGGACGACCATAAATCTTCCCTTTCAAGTGACGTTCTGTCGT
ATACTCCTCTAATTTTGTGACTACCTCATCCACCAAGGCCTCACGCTCCCTGCGCTTTTCCTTCATCATA
TGGGTAATCTTGTAAAACTCCGTTGGATTGAGATAACGGAAAGACAAGTCTTCTAATTCCCATTTGACAC
TGGAAATCCCCAAACGATGGGCAAGCGGGGCATAGATTTCCATGGTTTCTTTGGAAATACGCTCCTGCTT
GTCTTTTCGAAGATGTTTCAGGGTCCGCATATTGTGCAAGCGGTCAGACAGTTTGACCAAAATAACGCGG
ATGTCCTCAGACATGGCCATGAGCATCTTGCGATGATTTTCCGCTAATTGCTCCTCGATCGATTTGTACT
CGACCTTGCCAAGCTTGGTAACTCCGTCAACAATCATCCGCACATCAGGACCAAACTCTCTTTCCAAATC
GTCCAAAGTCGCATCTGTATCTTCCACCACATCATGCAAGAATCCACAAGCTACTGTTACAGCATCCAGC
TTTAGCTTAGCTAAAATACCTGCCACTTGGATAGGGTGAATGATATAAGGCTCGCCTGATTTGCGATATT
GACCACTGTGGCATTCAACAGCATAGACCAAGGCCTTATGGACAAAATGAACATCCTCTTCCGTTAAATA
TTCTTTGGTTAAAGCGACAACTTCTTCGCCTGTTAAATTCACTTCTTTCGGCA
Protein Sequence 
>gi|15901481|ref|NP_346085.1| GTP pyrophosphokinase [Streptococcus pneumoniae TIGR4] MPKEVNLTGEEVVALTKEYLTEEDVHFVHKALVYAVECHSGQYRKSGEPYIIHPIQVAGILAKLKLDAVTVACGFLHDVVEDTDATLDDLEREFGPDVRMIVDGVTKLGKVEYKSIEEQLAENHRKMLMAMSEDIRVILVKLSDRLHNMRTLKHLRKDKQERISKETMEIYAPLAHRLGISSVKWELEDLSFRYLNPTEFYKITHMMKEKRREREALVDEVVTKLEEYTTERHLKGKIYGRPKHIYSIFRKMQDKRKRFEEIYDLIAIRCILDTQSDVYAMLGYVHEFWKPMPGRFKDYIANRKANGYQSIHTTVYGPKGPIEFQIRTKEMHEVAEYGVAAHWAYKKGIKGQVNSKESAIGMNWIKEMMELQDQADDAKEFVDSVKENYLAEEIYVFTPDGAVRSLPKDSGPIDFAYEIHTKVGEKATGAKVNGRMVPLTTKLKTGDQVEIIANPNSFGPSRDWLNMVKTSKARNKIRQFFKNQDKELSVNKGREMLMAQFQENGYVANKFMDKRHMDQVLQKTSYKTEDSLFAAIGFGEIGAITVFNRLTEKERREEERAKAKAEAEELVKGGEVKVENKETLKVKHEGGVVIEGASGLLVRIAKCCNPVPGDDIVGYITKGRGVAIHRVDCMNLRAQENYEQRLLDVEWEDQYPSSNKEYMAHIDIYGLNRTGLLNDVLQVLSNTTKNISTVNAQPTKDMKFANIHVSFGIANLSTLTTVVDKIKSVPEVYSVKRTNG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_1645 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0317TK, under T: Signal transduction mechanisms; K: Transcription
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].