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codY from Streptococcus pneumoniae P1031

Victor ID 3927
Gene Name codY from Streptococcus pneumoniae P1031
Sequence Strain (Species/Organism) Streptococcus pneumoniae P1031
NCBI Gene ID 7681757
NCBI Protein GI 225857208
Locus Tag SPP_1606
Protein Accession YP_002738719.1
Other Database IDs UniProtKB-ID: CODY_STRZP
UniRef100: UniRef100_C1C8H3
UniRef90: UniRef90_Q04JG7
UniRef50: UniRef50_A2RCV3
UniParc: UPI000152B52E
EMBL: CP000920
EMBL-CDS: ACO21476.1
RefSeq_NT: NC_012467.1
EnsemblGenome: EBSTRG00000080667
EnsemblGenome_TRS: EBSTRT00000081409
EnsemblGenome_PRO: EBSTRP00000075056
GenomeReviews: CP000920_GR
KEGG: spp:SPP_1606
OMA: HIFEELD
ProtClustDB: PRK04158
BioCyc: SPNE1313-1:SPP_1606-MONOMER
Taxonomy ID 488223
Gene Starting Position 1485366
Gene Ending Position 1486154
Gene Strand (Orientation) -
Protein Name GTP-sensing transcriptional pleiotropic repressor CodY
DNA Sequence 
>gi|225855735:1485366-1486154 Streptococcus pneumoniae P1031, complete genome
ATTAGTAATCTCTTTTCTTCACTTCTTCAAAAATATCTGAAATCAAGACCTTAAGATAGGTTCCCTTCAT
TCCAAGTGAGCGACTTTCAATAATCCCCGCAGACTCAAGTTTACGAAGAGCATTGACAATCACAGAGCGA
GTGATTCCGATACGATCTGCAATCACTGACGCAGTCAACTTCCCTTCATTTCCATTTAATTCCCCTAAAA
TTGCTGAAACAGCACGGAGTTCGGAGTAAGAAAGGGTATTGACCGCCATGGTGACAGCAGTACGACGACG
AATATTTTTCTCATCTTCTTCACGTTGGAAGTTAAGAAGCTGAATCCCAACAACGGTACTGGCAATCTCA
ACAAGAACCAAGTCCTCATCTTCGAATTTTTTATCATTACGCCAAATAATCAAAGAACCAAGGCGAATCC
CCGATACATGAATCGGTGCAATAGTCGTCAAGCCATCTGGAAAATCATCTCTACTCTCAACAGGGAAAAT
ACTCATATCATGCTCAACAGGTAAGTTTGCTTCTGTTTCGTAAATCATATTAGCCCCTTGAACGTAGTCA
TCTGGGAAAATCTTAGTTTGGAAGAATTGCTCTACGCGATCTGTATTTGTTTTATAACGCATAAAATAGC
CAAGCAGACGTCCCTTACTATTGATAATGCAGGCATTGCAATGAATAATATCCGCTAACTGACGCGTAAT
AGCGTTGTAAGGAAGCTCATCCTGCAACTGCTCCTCTGAGCGTTTCAAAATTGATGTAATTTTTCTAGTT
TTTTCTAATAAATGTGCCA
Protein Sequence 
>gi|225857208|ref|YP_002738719.1| transcriptional repressor CodY [Streptococcus pneumoniae P1031] MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro (Hendriksen et al., 2008).
COG COG4465K, under K: Transcription
References
Hendriksen et al., 2008: Hendriksen WT, Bootsma HJ, Estevão S, Hoogenboezem T, de Jong A, de Groot R, Kuipers OP, Hermans PW. CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. Journal of bacteriology. 2008; 190(2); 590-601. [PubMed: 18024519].