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SP_0648

Victor ID 3218
Gene Name SP_0648
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930597
NCBI Protein GI 15900551
Locus Tag SP_0648
Protein Accession NP_345155.1
Other Database IDs UniProtKB-ID: Q9KGU0_STRPN
UniRef100: UniRef100_Q9KGU0
UniRef90: UniRef90_B1IAI8
UniRef50: UniRef50_C1CD16
UniParc: UPI0000051518
EMBL: AF282987
EMBL: AE005672
EMBL-CDS: AAF97242.1
EMBL-CDS: AAK74795.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026154.
EnsemblGenome_TRS: EBSTRT00000026154
EnsemblGenome_PRO: EBSTRP00000025246
GenomeReviews: AE005672_GR
KEGG: spn:SP_0648
TIGR: SP_0648
HOGENOM: HBG697187
OMA: MIEDRKV
ProtClustDB: CLSK883971
BioCyc: SPNE170187-1:SP_0648-MONOMER
Taxonomy ID 170187
Gene Starting Position 615441
Gene Ending Position 622142
Gene Strand (Orientation) +
Protein Name beta-galactosidase
DNA Sequence 
>gi|194172857:615441-622142 Streptococcus pneumoniae TIGR4 chromosome, complete genome
TATGGGGAAAGGCCATTGGAATCGGAAAAGAGTTTATAGCATTCGTAAGTTTGCTGTGGGAGCTTGCTCA
GTAATGATTGGGACTTGTGCAGTTTTATTAGGAGGAAATATAGCTGGAGAATCTGTAGTTTATGCGGATG
AAACACTTATTACTCATACTGCTGAGAAACCTAAAGAGGAAAAAATGATAGTAGAAGAAAAGGCTGATAA
AGCTTTGGAAACTAAAAATATAGTTGAAAGGACAGAACAAAGTGAACCTAGTTCAACTGAGGCTATTGCA
TCTGAGAAGAAAGAAGATGAAGCCGTAACTCCAAAAGAGGAAAAAGTGTCTGCTAAACCGGAAGAAAAAG
CTCCAAGGATAGAATCACAAGCTTCAAATCAAGAAAAACCGCTCAAGGAAGATGCTAAAGCTGTAACAAA
TGAAGAAGTGAATCAAATGATTGAAGACAGGAAAGTGGATTTTAATCAAAATTGGTACTTTAAACTCAAT
GCAAATTCTAAGGAAGCCATTAAACCTGATGCAGACGTATCTACGTGGAAAAAATTAGATTTACCGTATG
ACTGGAGTATCTTTAACGATTTCGATCATGAATCTCCTGCACAAAATGAAGGTGGACAGCTCAACGGTGG
GGAAGCTTGGTATCGCAAGACTTTCAAACTAGATGAAAAAGACCTCAAGAAAAATGTTCGCCTTACTTTT
GATGGCGTCTACATGGATTCTCAAGTTTATGTCAATGGTCAGTTAGTGGGGCATTATCCAAATGGTTATA
ACCAGTTCTCATATGATATCACCAAATACCTTCAAAAAGATGGTCGTGAGAATGTGATTGCTGTCCATGC
AGTCAACAAACAGCCAAGTAGCCGTTGGTATTCAGGAAGTGGTATCTATCGTGATGTGACTTTACAAGTG
ACAGATAAGGTGCATGTTGAGAAAAATGGGACAACTATTTTAACACCAAAACTTGAAGAACAACAACATG
GCAAGGTTGAAACTCATGTGACCAGCAAAATCGTCAATACGGACGACAAAGACCATGAACTTGTAGCCGA
ATATCAAATCGTTGAACGAGGTGGTCATGCTGTAACAGGCTTAGTTCGTACAGCGAGTCGTACCTTAAAA
GCACATGAATCAACAAGCCTAGATGCGATTTTAGAAGTTGAAAGACCAAAACTCTGGACTGTTTTAAATG
ACAAACCTGCCTTGTACGAATTGATTACGCGTGTTTACCGTGACGGTCAATTGGTTGATGCTAAGAAGGA
TTTGTTTGGTTACCGTTACTATCACTGGACTCCAAATGAAGGTTTCTCTTTGAATGGTGAACGTATTAAA
TTCCATGGAGTATCCTTGCACCACGACCATGGGGCGCTTGGAGCAGAAGAAAACTATAAAGCAGAATATC
GCCGTCTCAAACAAATGAAGGAGATGGGAGTTAACTCCATCCGTACAACCCACAACCCTGCTAGTGAGCA
AACCTTGCAAATCGCAGCAGAACTAGGTTTACTCGTTCAGGAAGAGGCCTTTGATACGTGGTATGGTGGC
AAGAAACCTTATGACTATGGACGTTTCTTTGAAAAAGATGCCACTCACCCAGAAGCTCGAAAAGGTGAAA
AATGGTCTGATTTTGACCTACGTACCATGGTCGAAAGAGGCAAAAACAACCCTGCTATCTTCATGTGGTC
AATTGGTAATGAAATAGGTGAAGCTAATGGTGATGCCCACTCTTTAGCAACTGTTAAACGTTTGGTTAAG
GTTATCAAGGATGTTGATAAGACTCGCTATGTTACCATGGGAGCAGATAAATTCCGTTTCGGTAATGGTA
GCGGAGGGCATGAGAAAATTGCTGATGAACTCGATGCTGTTGGATTTAACTATTCTGAAGATAATTACAA
AGCCCTTAGAGCTAAGCATCCAAAATGGTTGATTTATGGATCAGAAACATCTTCAGCTACCCGTACACGT
GGAAGTTACTATCGCCCTGAACGTGAATTGAAACATAGCAATGGACCTGAGCGTAATTATGAACAGTCAG
ATTATGGAAATGATCGTGTGGGTTGGGGGAAAACAGCAACCGCTTCATGGACTTTTGACCGTGACAACGC
TGGCTATGCTGGACAGTTTATCTGGACAGGTACGGACTATATTGGTGAACCTACACCATGGCACAACCAA
AATCAAACTCCTGTTAAGAGCTCTTACTTTGGTATCGTAGATACAGCCGGCATTCCAAAACATGACTTCT
ATCTCTACCAAAGCCAATGGGTTTCTGTTAAGAAGAAACCGATGGTACACCTTCTTCCTCACTGGAACTG
GGAAAACAAAGAATTAGCATCCAAAGTAGCTGACTCAGAAGGTAAGATTCCAGTTCGTGCTTATTCGAAT
GCTTCTAGTGTAGAATTGTTCTTGAATGGAAAATCTCTTGGTCTTAAGACTTTCAATAAAAAACAAACCA
GCGATGGGCGGACTTACCAAGAAGGTGCAAATGCTAATGAACTTTATCTTGAATGGAAAGTTGCCTATCA
ACCAGGTACCTTGGAAGCAATTGCTCGTGATGAATCTGGCAAGGAAATTGCTCGAGATAAGATTACGACT
GCTGGTAAGCCAGCGGCAGTTCGTCTTATTAAGGAAGACCATGCGATTGCAGCAGATGGAAAAGACTTGA
CTTACATCTACTATGAAATTGTTGACAGCCAGGGGAATGTGGTTCCAACTGCTAATAATCTGGTTCGCTT
CCAATTGCATGGCCAAGGTCAACTGGTCGGTGTAGATAACGGAGAACAAGCCAGCCGTGAACGCTATAAG
GCGCAAGCAGATGGTTCTTGGATTCGTAAAGCATTTAATGGTAAAGGTGTTGCCATTGTCAAATCAACTG
AACAAGCAGGGAAATTCACCCTGACTGCCCACTCTGATCTCTTGAAATCGAACCAAGTCACTGTCTTTAC
TGGTAAGAAAGAAGGACAAGAGAAGACTGTTTTGGGGACAGAAGTGCCAAAAGTACAGACCATTATTGGA
GAGGCACCTGAAATGCCTACCACTGTTCCGTTTGTATACAGTGATGGTAGCCGTGCAGAACGTCCTGTAA
CCTGGTCTTCAGTAGATGTGAGCAAGCCTGGTATTGTAACGGTGAAAGGTATGGCTGACGGACGAGAAGT
AGAAGCTCGTGTAGAAGTGATTGCTCTTAAATCAGAGCTACCAGTTGTGAAACGTATTGCTCCAAATACT
GACTTGAATTCTGTAGACAAATCTGTTTCCTATGTTTTGATTGATGGAAGTGTTGAAGAGTATGAAGTGG
ACAAGTGGGAGATTGCCGAAGAAGATAAAGCTAAGTTAGCAATTCCAGGTTCTCGTATTCAAGCGACCGG
TTATTTAGAAGGTCAACCAATTCATGCAACCCTTGTGGTAGAAGAAGGCAATCCTGCGGCACCTGCAGTA
CCAACTGTAACGGTTGGTGGTGAGGCAGTAACAGGTCTTACTAGTCAAAAACCAATGCAATACCGCACTC
TTGCTTATGGAGCTAAGTTGCCAGAAGTCACAGCAAGTGCTAAAAATGCAGCTGTTACAGTTCTTCAAGC
AAGCGCAGCAAACGGCATGCGTGCGAGCATCTTTATTCAGCCTAAAGATGGTGGCCCTCTTCAAACCTAT
GCAATTCAATTCCTTGAAGAAGCGCCAAAAATTGCTCACTTGAGCTTGCAAGTGGAAAAAGCTGACAGTC
TCAAAGAAGACCAAACTGTCAAATTGTCGGTTCGAGCTCACTATCAAGATGGAACGCAAGCTGTATTACC
AGCTGATAAAGTAACCTTCTCTACAAGTGGTGAAGGGGAAGTCGCAATTCGTAAAGGAATGCTTGAGTTG
CATAAGCCAGGAGCAGTCACTCTGAACGCTGAATATGAGGGAGCTAAAGACCAAGTTGAACTCACTATCC
AAGCCAATACTGAGAAGAAGATTGCGCAATCCATCCGTCCTGTAAATGTAGTGACAGATTTGCATCAGGA
ACCAAGTCTTCCAGCAACAGTAACAGTTGAGTATGACAAAGGTTTCCCTAAAACTCATAAAGTCACTTGG
CAAGCTATTCCGAAAGAAAAACTAGACTCCTATCAAACATTTGAAGTACTAGGTAAAGTTGAAGGAATTG
ACCTTGAAGCGCGTGCAAAAGTCTCTGTAGAAGGTATCGTTTCAGTTGAAGAAGTCAGTGTGACAACTCC
AATCGCAGAAGCACCACAATTACCAGAAAGTGTTCGGACATATGATTCAAATGGTCACGTTTCATCAGCT
AAGGTTGCATGGGATGCGATTCGTCCAGAGCAATACGCTAAGGAAGGTGTCTTTACAGTTAATGGTCGCT
TAGAAGGTACGCAATTAACAACTAAACTTCATGTTCGCGTATCTGCTCAAACTGAGCAAGGTGCAAACAT
TTCTGACCAATGGACCGGTTCAGAATTGCCACTTGCCTTTGCTTCAGACTCAAATCCAAGCGACCCAGTT
TCAAATGTTAATGACAAGCTCATTTCCTACAATAACCAACCAGCCAATCGTTGGACAAACTGGAATCGTA
CTAATCCAGAAGCTTCAGTCGGTGTTCTGTTTGGAGATTCAGGTATCTTGAGCAAACGCTCCGTTGATAA
TCTAAGTGTCGGATTCCATGAAGACCATGGAGTTGGTGTACCGAAGTCTTATGTGATTGAGTATTATGTT
GGTAAGACTGTCCCAACAGCTCCTAAAAACCCTAGTTTTGTTGGTAATGAGGACCATGTCTTTAATGATT
CTGCCAACTGGAAACCAGTTACTAATCTAAAAGCCCCTGCTCAACTCAAGGCTGGAGAAATGAACCACTT
TAGCTTTGATAAAGTTGAAACCTATGCTGTTCGTATTCGCATGGTTAAAGCAGATAACAAGCGTGGAACG
TCTATCACAGAGGTACAAATCTTTGCGAAACAAGTTGCGGCAGCCAAGCAAGGACAAACAAGAATCCAAG
TTGACGGCAAAGACTTAGCAAACTTCAACCCTGATTTGACAGACTACTACCTTGAGTCTGTAGATGGAAA
AGTTCCGGCAGTCACAGCAAGTGTTAGCAACAATGGTCTCGCTACCGTCGTTCCAAGCGTTCGTGAAGGT
GAGCCAGTTCGTGTCATCGCGAAAGCTGAAAATGGCGACATCTTAGGAGAATACCGTCTGCACTTCACTA
AGGATAAGAGCTTACTTTCTCATAAACCAGTTGCTGCGGTTAAACAAGCTCGCTTGCTACAAGTAGGTCA
AGCACTTGAATTGCCGACTAAGGTTCCAGTTTACTTCACAGGTAAAGACGGCTACGAAACAAAAGACCTG
ACAGTTGAATGGGAAGAAGTTCCAGCGGAAAATCTGACAAAAGCAGGTCAATTTACTGTTCGAGGCCGTG
TCCTTGGTAGTAACCTTGTTGCTGAGATCACTGTACGAGTGACAGACAAACTTGGTGAGACTCTTTCAGA
TAACCCTAACTATGATGAAAACAGTAACCAGGCCTTTGCTTCAGCAACCAATGATATTGACAAAAACTCT
CATGACCGCGTTGACTATCTCAATGACGGAGATCATTCAGAAAATCGTCGTTGGACAAACTGGTCACCAA
CACCATCTTCTAATCCAGAAGTATCAGCGGGTGTGATTTTCCGTGAAAATGGTAAGATTGTAGAACGGAC
TGTTACACAAGGAAAAGTTCAGTTCTTTGCAGATAGTGGTACGGATGCACCATCTAAACTCGTTTTAGAA
CGCTATGTCGGTCCAGAGTTTGAAGTGCCAACCTACTATTCAAACTACCAAGCCTACGACGCAGACCATC
CATTCAACAATCCAGAAAATTGGGAAGCTGTTCCTTATCGTGCGGATAAAGACATTGCAGCTGGTGATGA
AATCAACGTAACATTTAAAGCTATCAAAGCCAAAGCTATGAGATGGCGTATGGAGCGTAAAGCAGATAAG
AGCGGTGTTGCGATGATTGAGATGACCTTCCTTGCACCAAGTGAATTGCCTCAAGAAAGCACTCAATCAA
AGATTCTTGTAGATGGAAAAGAACTTGCTGATTTCGCTGAAAATCGTCAAGACTATCAAATTACCTATAA
AGGTCAACGGCCAAAAGTCTCAGTTGAAGAAAACAATCAAGTAGCTTCAACTGTGGTAGATAGTGGAGAA
GATAGCTTTCCAGTACTTGTTCGCCTCGTTTCAGAAAGTGGAAAACAAGTCAAGGAATACCGTATCCACT
TGACTAAGGAAAAACCAGTTTCTGAGAAGACAGTTGCTGCTGTACAAGAAGATCTTCCAAAAATCGAATT
TGTTGAAAAAGATTTGGCATACAAGACAGTTGAGAAAAAAGATTCAACACTGTATCTAGGTGAAACTCGT
GTAGAACAAGAAGGAAAAGTTGGAAAAGAACGTATCTTTACAGCGATTAATCCTGATGGAAGTAAGGAAG
AAAAACTCCGTGAAGTGGTAGAAGTTCCGACAGACCGCATCGTCTTGGTTGGAACCAAACCAGTAGCTCA
AGAAGCTAAAAAACCACAAGTGTCAGAAAAAGCAGATACAAAACCAATTGATTCAAGTGAAGCTAGTCAA
ACTAATAAAGCCCAGTTACCAAGTACAGGTAGTGCGGCAAGCCAAGCAGCAGTAGCAGCAGGTTTAACTC
TTCTAGGTTTGAGTGCAGGATTAGTAGTTACTAAAGGTAAAAAAGAAGACTA
Protein Sequence 
>gi|15900551|ref|NP_345155.1| beta-galactosidase [Streptococcus pneumoniae TIGR4] MGKGHWNRKRVYSIRKFAVGACSVMIGTCAVLLGGNIAGESVVYADETLITHTAEKPKEEKMIVEEKADKALETKNIVERTEQSEPSSTEAIASEKKEDEAVTPKEEKVSAKPEEKAPRIESQASNQEKPLKEDAKAVTNEEVNQMIEDRKVDFNQNWYFKLNANSKEAIKPDADVSTWKKLDLPYDWSIFNDFDHESPAQNEGGQLNGGEAWYRKTFKLDEKDLKKNVRLTFDGVYMDSQVYVNGQLVGHYPNGYNQFSYDITKYLQKDGRENVIAVHAVNKQPSSRWYSGSGIYRDVTLQVTDKVHVEKNGTTILTPKLEEQQHGKVETHVTSKIVNTDDKDHELVAEYQIVERGGHAVTGLVRTASRTLKAHESTSLDAILEVERPKLWTVLNDKPALYELITRVYRDGQLVDAKKDLFGYRYYHWTPNEGFSLNGERIKFHGVSLHHDHGALGAEENYKAEYRRLKQMKEMGVNSIRTTHNPASEQTLQIAAELGLLVQEEAFDTWYGGKKPYDYGRFFEKDATHPEARKGEKWSDFDLRTMVERGKNNPAIFMWSIGNEIGEANGDAHSLATVKRLVKVIKDVDKTRYVTMGADKFRFGNGSGGHEKIADELDAVGFNYSEDNYKALRAKHPKWLIYGSETSSATRTRGSYYRPERELKHSNGPERNYEQSDYGNDRVGWGKTATASWTFDRDNAGYAGQFIWTGTDYIGEPTPWHNQNQTPVKSSYFGIVDTAGIPKHDFYLYQSQWVSVKKKPMVHLLPHWNWENKELASKVADSEGKIPVRAYSNASSVELFLNGKSLGLKTFNKKQTSDGRTYQEGANANELYLEWKVAYQPGTLEAIARDESGKEIARDKITTAGKPAAVRLIKEDHAIAADGKDLTYIYYEIVDSQGNVVPTANNLVRFQLHGQGQLVGVDNGEQASRERYKAQADGSWIRKAFNGKGVAIVKSTEQAGKFTLTAHSDLLKSNQVTVFTGKKEGQEKTVLGTEVPKVQTIIGEAPEMPTTVPFVYSDGSRAERPVTWSSVDVSKPGIVTVKGMADGREVEARVEVIALKSELPVVKRIAPNTDLNSVDKSVSYVLIDGSVEEYEVDKWEIAEEDKAKLAIPGSRIQATGYLEGQPIHATLVVEEGNPAAPAVPTVTVGGEAVTGLTSQKPMQYRTLAYGAKLPEVTASAKNAAVTVLQASAANGMRASIFIQPKDGGPLQTYAIQFLEEAPKIAHLSLQVEKADSLKEDQTVKLSVRAHYQDGTQAVLPADKVTFSTSGEGEVAIRKGMLELHKPGAVTLNAEYEGAKDQVELTIQANTEKKIAQSIRPVNVVTDLHQEPSLPATVTVEYDKGFPKTHKVTWQAIPKEKLDSYQTFEVLGKVEGIDLEARAKVSVEGIVSVEEVSVTTPIAEAPQLPESVRTYDSNGHVSSAKVAWDAIRPEQYAKEGVFTVNGRLEGTQLTTKLHVRVSAQTEQGANISDQWTGSELPLAFASDSNPSDPVSNVNDKLISYNNQPANRWTNWNRTNPEASVGVLFGDSGILSKRSVDNLSVGFHEDHGVGVPKSYVIEYYVGKTVPTAPKNPSFVGNEDHVFNDSANWKPVTNLKAPAQLKAGEMNHFSFDKVETYAVRIRMVKADNKRGTSITEVQIFAKQVAAAKQGQTRIQVDGKDLANFNPDLTDYYLESVDGKVPAVTASVSNNGLATVVPSVREGEPVRVIAKAENGDILGEYRLHFTKDKSLLSHKPVAAVKQARLLQVGQALELPTKVPVYFTGKDGYETKDLTVEWEEVPAENLTKAGQFTVRGRVLGSNLVAEITVRVTDKLGETLSDNPNYDENSNQAFASATNDIDKNSHDRVDYLNDGDHSENRRWTNWSPTPSSNPEVSAGVIFRENGKIVERTVTQGKVQFFADSGTDAPSKLVLERYVGPEFEVPTYYSNYQAYDADHPFNNPENWEAVPYRADKDIAAGDEINVTFKAIKAKAMRWRMERKADKSGVAMIEMTFLAPSELPQESTQSKILVDGKELADFAENRQDYQITYKGQRPKVSVEENNQVASTVVDSGEDSFPVLVRLVSESGKQVKEYRIHLTKEKPVSEKTVAAVQEDLPKIEFVEKDLAYKTVEKKDSTLYLGETRVEQEGKVGKERIFTAINPDGSKEEKLREVVEVPTDRIVLVGTKPVAQEAKKPQVSEKADTKPIDSSEASQTNKAQLPSTGSAASQAAVAAGLTLLGLSAGLVVTKGKKED
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0648 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG3250G, under G: Carbohydrate transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].