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pavA

Victor ID 3089
Gene Name pavA
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4442613
NCBI Protein GI 116516285
Locus Tag SPD_0854
Protein Accession YP_816336.1
Other Database IDs UniProtKB-ID: Q04KW2_STRP2
UniRef100: UniRef100_Q04KW2
UniRef90: UniRef90_B1IBC6
UniRef50: UniRef50_B1IBC6
UniParc: UPI0000E532C6
EMBL: CP000410
EMBL-CDS: ABJ54581.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000019204.
EnsemblGenome_TRS: EBSTRT00000019204
EnsemblGenome_PRO: EBSTRP00000018444
GenomeReviews: CP000410_GR
KEGG: spd:SPD_0854
eggNOG: COG1293
HOGENOM: HBG635182
OMA: TIIMVGR
ProtClustDB: CLSK877142
Taxonomy ID 373153
Gene Starting Position 868726
Gene Ending Position 870381
Gene Strand (Orientation) -
Protein Name adherence and virulence protein A
DNA Sequence 
>gi|116515308:868726-870381 Streptococcus pneumoniae D39, complete genome
ATCAGGATTTTTTCATGGATGCAATTTTTTTGGAGTCTGGTGTGACGCGGAGGGTCTTTTGTCCTGTGTA
AGTGACAAAGCCGGGTTTTCCACCAGTTGGTTTATTGAGTTTTTTGACTTCAATCATATCTACCTGCACC
AGATTCGACAGGCGCCCTTGAGAGAAGTAGGCAGCTAACTCTGCTGCGTCTGTCTTGACTGCATCAGATG
GGTCAAGATTTCCTGAGATGACAACATGGCTTCCAGGAATGTCCTTAGCATGGAACCAAAGTTCCTCCTT
GCGGGCCATTTTAAAGGTCAATTCCTCATTTTGAAGATTGTTTCGTCCGACATAGATGATGGTTTTGCCA
TCGCTTGCTAGATATTGTTCTAGTTTTTTGCGTTTCTGGATTTTCTCCCGTTGTCTTCTGCGGATAAAAC
CTGTTTGAATCAATTCTTCACGGATTTCAGCGATTTCTTCCAGTCCAGCTTGGTTGAGGACGGTTTCTAC
ACTTTCCAGATAGAGAATAGTGGCTTTGGTTTCTTCAATCAAATCAGTCAAGTATTTGACAGCTTCTTTG
AGTTTCTGATACCGTTTAAAATAGCGTTGGGCATTCTGGTTGGGAGTCAGAGCCTTATCAAGCGCAATCA
TGATAGGTTGGTTGGTATAGTAGTTGTCTAGGATAACCTGGTCTTGGTCGTTAGGCACTTGGTGGAGGAA
GGTTGTCAGCAATTCTCCTTTTTGACGAAATTCTTCAGCGTTGTCTGTCGCCAGTAACTCTTTTTCCTGT
TTTTTGAGTTTGTGTCGGTTTTTCTGAAGTTCATTTTCAACACGACGAATCAGTTCACTGGCCTGTTGTT
TGACGCGGTCGCGCTCAGCCTTATTCTTATAGTAGGTGTCCAACAAATCAGAAAGATTTGCAAAAGGCTC
TCCCGCCTGATTTGCAAAAGGAACTGGACTGAAGGAAGTCTCAGTCAAGCATGGCTTGGTTTCTTGATTG
AAAAAATTTCGGAAAGCGGAAAGTTTTTCACTAACCAGTATCCTTTCCAATTCATTTGCCGTATCGCGTC
CCAGACCTTGAAAGAGGCTTTGAAGATTTTTTGCTGTTAGTTCTTGGGTTTGCAGGATTTCAAAGAGCTT
TTCATCCTTGATAGTAAAAGGATTGAGAGATTCTGTACTTGGCGGAGCGATATAGGTCGATCCTGGAAGT
AAGGTGCGGTAGCTATTTTGTGAAAAACCGACGTGTTTGATAACTTCGAGGATTTTATGACTGCTTTTAT
CGACCAGTAGAATATTACTGTGTTTCCCCATAATTTCGATAATCAAGGTAGCCTGGATATGGTCTCCAAT
CTCGTTTTTATTGGAAACTGTCATTTCCACAATACGGTCATTTTCCACTTGCTCAATCGACTCAATCAGG
GCCCCCTGCAAATACTTTCTCAAAACCATGATAAAGGTAGAAGGTTGAGCTGGATTTTCAAAAGTCGTTT
GGGTCAGCTGAATGCGTCCAAAAACTGGATGGGCAGAAAGGAGCAGGCGATGGCTTTGGCGATTGCTGCG
GATTTGCAAGACCAACTCTTGTTCAAAAGGCTGATTGATTTTCTGGATGCGACCATTCACTAATTCGCTT
CGCAATTCCTCAACTATGTGGTGTAAAAAAAATCCGTCAAATGACA
Protein Sequence 
>gi|116516285|ref|YP_816336.1| adherence and virulence protein A [Streptococcus pneumoniae D39] MSFDGFFLHHIVEELRSELVNGRIQKINQPFEQELVLQIRSNRQSHRLLLSAHPVFGRIQLTQTTFENPAQPSTFIMVLRKYLQGALIESIEQVENDRIVEMTVSNKNEIGDHIQATLIIEIMGKHSNILLVDKSSHKILEVIKHVGFSQNSYRTLLPGSTYIAPPSTESLNPFTIKDEKLFEILQTQELTAKNLQSLFQGLGRDTANELERILVSEKLSAFRNFFNQETKPCLTETSFSPVPFANQAGEPFANLSDLLDTYYKNKAERDRVKQQASELIRRVENELQKNRHKLKKQEKELLATDNAEEFRQKGELLTTFLHQVPNDQDQVILDNYYTNQPIMIALDKALTPNQNAQRYFKRYQKLKEAVKYLTDLIEETKATILYLESVETVLNQAGLEEIAEIREELIQTGFIRRRQREKIQKRKKLEQYLASDGKTIIYVGRNNLQNEELTFKMARKEELWFHAKDIPGSHVVISGNLDPSDAVKTDAAELAAYFSQGRLSNLVQVDMIEVKKLNKPTGGKPGFVTYTGQKTLRVTPDSKKIASMKKS
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pavA mutant is attenuated in mice (Holmes et al., 2001).
COG COG1293K, under K: Transcription
References
Holmes et al., 2001: Holmes AR, McNab R, Millsap KW, Rohde M, Hammerschmidt S, Mawdsley JL, Jenkinson HF. The pavA gene of Streptococcus pneumoniae encodes a fibronectin-binding protein that is essential for virulence. Molecular microbiology. 2001; 41(6); 1395-1408. [PubMed: 11580843].