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spxB from Streptococcus pneumoniae R6

Victor ID 3117
Gene Name spxB from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 934181
NCBI Protein GI 15902686
Locus Tag spr0642
Protein Accession NP_358236.1
Other Database IDs UniProtKB-ID: Q8DQJ4_STRR6
UniRef100: UniRef100_Q8DQJ4
UniRef90: UniRef90_Q54970
UniRef50: UniRef50_Q54970
UniParc: UPI00000E34BC
EMBL: AE007317
EMBL-CDS: AAK99446.1
RefSeq_NT: NC_003098.1
HSSP: P37063
EnsemblGenome: EBSTRG00000016052.
EnsemblGenome_TRS: EBSTRT00000016052
EnsemblGenome_PRO: EBSTRP00000015448
GenomeReviews: AE007317_GR
KEGG: spr:spr0642
eggNOG: COG0028
HOGENOM: HBG323037
OMA: KHRERSL
ProtClustDB: CLSK883986
BioCyc: SPNE171101:SPR0642-MONOMER
Taxonomy ID 171101
Gene Starting Position 649444
Gene Ending Position 651219
Gene Strand (Orientation) +
Protein Name Pyruvate oxidase
DNA Sequence 
>gi|15902044:649444-651219 Streptococcus pneumoniae R6, complete genome
TATGACTCAAGGGAAAATTACTGCATCTGCAGCAATGCTTAACGTATTGAAAACATGGGGCGTAGATACA
ATCTACGGTATCCCATCAGGAACACTCAGCTCATTGATGGACGCTTTGGCTGAAGACAAAGATATCCGCT
TCTTACAAGTTCGCCACGAAGAGACAGGTGCTCTTGCAGCGGTTATGCAAGCTAAATTCGGCGGCTCAAT
CGGGGTTGCAGTTGGTTCAGGTGGTCCAGGTGCGACTCACTTGATTAACGGTGTTTACGATGCAGCTATG
GATGACACTCCATTCCTAGCGATCCTTGGATCACGTCCAGTTAACGAATTGAACATGGATGCTTTCCAAG
AGCTTAACCAAAACCCAATGTACAACGGTATCGCTGTTTACAACAAACGTGTAGCTTACGCTGAGCAATT
GCCAAAAGTAATTGACGAAGCCTGCCGTGCTGCAATTTCTAAAAAAGGTCCAGCTGTTGTTGAAATTCCA
GTAAACTTCGGTTTCCAAGAAATCGACGAAAACTCATACTACGGTTCAGGTTCATACGAACGCTCATTCA
TCGCTCCTGCTTTGAACGAAGTTGAAATCGACAAAGCTGTTGAAATCTTGAACAATGCTGAACGCCCAGT
TATCTATGCTGGATTTGGTGGTGTTAAAGCTGGTGAAGTGATTACTGAATTGTCACGTAAAATCAAAGCA
CCAATCATCACAACTGGTAAAAACTTTGAAGCTTTCGAATGGAACTATGAAGGTTTGACAGGTTCTGCTT
ACCGTGTTGGTTGGAAACCAGCCAACGAAGTGGTCTTTGAAGCAGACACAGTTCTTTTCCTTGGTTCAAA
CTTCGCATTTGCTGAAGTTTACGAAGCATTCAAGAACACTGAAAAATTCATACAAGTCGATATCGACCCT
TACAAACTTGGTAAACGTCATGCCCTTGACGCTTCAATCCTTGGTGATGCTGGTCAAGCAGCTAAAGCTA
TCCTTGACAAAGTAAACCCAGTTGAATCAACTCCATGGTGGCGTGCAAACGTTAAGAACAACCAAAACTG
GCGTGATTACATGAACAAACTCGAAGGTAAAACTGAGGGTGAATTGCAATTGTATCAAGTTTACAATGCA
ATCAACAAACATGCTGATCAAGACGCTATCTACTCAATCGACGTAGGTAACACTACTCAAACATCTACTC
GTCACCTTCACATGACACCTAAGAATATGTGGCGTACATCTCCGCTCTTTGCGACAATGGGTATTGCCCT
TCCTGGTGGTATCGCTGCTAAGAAAGACAATCCAGATCGCCAAGTATGGAACATCATGGGTGATGGAGCA
TTCAACATGTGCTACCCAGACGTTATCACAAACGTTCAATACGACCTTCCAGTTATCAACCTTGTCTTCT
CAAATGCTGAGTACGGCTTCATCAAGAACAAATACGAAGATACAAACAAACACTTGTTTGGTGTAGACTT
CACAAACGCTGACTACGCTAAAATTGCGGAAGCTCAAGGAGCTGTTGGATTCACAGTTGACCGTATCGAA
GACATCGATGCAGTTGTTGCAGAAGCTGTTAAATTGAACAAAGAAGGTAAAACTGTTGTCATCGATGCTC
GCATCACTCAACACCGTCCACTTCCAGTAGAAGTACTTGAATTGGATCCAAAACTTCACTCAGAAGAAGC
TATCAAAGCCTTCAAGGAAAAATACGAAGCAGAAGAACTCGTACCATTCCGTCTCTTCTTGGAAGAAGAA
GGATTGCAATCACGCGCAATTAAATA
Protein Sequence 
>gi|15902686|ref|NP_358236.1| pyruvate oxidase [Streptococcus pneumoniae R6] MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDDTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFAFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits (Spellerberg et al., 1996).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Spellerberg et al., 1996: Spellerberg B, Cundell DR, Sandros J, Pearce BJ, Idanpaan-Heikkila I, Rosenow C, Masure HR. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular microbiology. 1996; 19(4); 803-813. [PubMed: 8820650].