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spxB from Streptococcus pneumoniae P1031

Victor ID 3926
Gene Name spxB from Streptococcus pneumoniae P1031
Sequence Strain (Species/Organism) Streptococcus pneumoniae P1031
NCBI Gene ID 7681180
NCBI Protein GI 225856408
Locus Tag SPP_0741
Protein Accession YP_002737919.1
Other Database IDs UniProtKB-ID: C1CJI1_STRZP
UniRef100: UniRef100_Q54970
UniRef90: UniRef90_Q54970
UniRef50: UniRef50_Q54970
UniParc: UPI000005156C
EMBL: CP000920
EMBL-CDS: ACO21470.1
RefSeq_NT: NC_012467.1
EnsemblGenome: EBSTRG00000081558.
EnsemblGenome_TRS: EBSTRT00000080971
EnsemblGenome_PRO: EBSTRP00000075086
GenomeReviews: CP000920_GR
KEGG: spp:SPP_0741
OMA: KHRERSL
ProtClustDB: CLSK883986
BioCyc: SPNE1313-1:SPP_0741-MONOMER
Taxonomy ID 488223
Gene Starting Position 677448
Gene Ending Position 679223
Gene Strand (Orientation) +
Protein Name pyruvate oxidase
DNA Sequence 
>gi|225855735:677448-679223 Streptococcus pneumoniae P1031, complete genome
TATGACTCAAGGGAAAATTACTGCATCTGCAGCAATGCTTAACGTATTGAAAACATGGGGCGTAGATACA
ATCTACGGTATCCCATCAGGAACACTCAGCTCATTGATGGATGCTTTGGCTGAAGACAAAGATATCCGTT
TCTTACAAGTTCGCCACGAAGAGACAGGTGCTCTTGCAGCGGTTATGCAAGCTAAATTCGGCGGCTCAAT
CGGGGTTGCAGTTGGTTCAGGTGGTCCAGGTGCGACTCACTTGATTAACGGTGTTTACGATGCAGCTATG
GATAACACTCCATTCCTAGCGATCCTTGGATCACGTCCAGTTAACGAATTGAACATGGATGCTTTCCAAG
AGCTTAACCAAAACCCAATGTACAACGGTATCGCTGTTTACAACAAACGTGTAGCTTACGCTGAGCAATT
GCCAAAAGTAATTGACGAAGCCTGCCGTGCTGCAGTTTCTAAAAAAGGTCCAGCTGTTGTTGAAATTCCA
GTAAACTTCGGTTTCCAAGAAATCGATGAAAACTCATACTACGGTTCAGGTTCATACGAACGCTCATTCA
TCGCTCCTGCTTTGAACGAAGTTGAAATCGACAAAGCTGTTGAAATCTTGAACAATGCTGAACGCCCAGT
TATCTATGCTGGATTTGGTGGTGTTAAAGCTGGTGAAGTGATTACTGAATTGTCACGTAAAATCAAAGCA
CCAATCATCACAACTGGTAAAAACTTTGAAGCTTTCGAATGGAACTATGAAGGTTTGACAGGTTCTGCTT
ACCGTGTTGGTTGGAAACCAGCCAACGAAGTGGTCTTTGAAGCAGACACAGTTCTTTTCCTTGGTTCAAA
CTTCCCATTCGCTGAAGTTTACGAAGCATTCAAGAACACTGAAAAATTCATCCAAGTCGATATCGACCCT
TACAAACTTGGTAAACGTCATGCCCTTGACGCTTCAATCCTTGGTGATGCTGGTCAAGCAGCTAAAGCTA
TCCTTGACAAAGTAAACCCAGTTGAATCAACTCCATGGTGGCGTGCAAACGTTAAGAACAATCAAAACTG
GCGTGATTACATGAACAAACTCGAAGGTAAAACTGAGGGTGAATTGCAATTGTATCAAGTTTACAATGCA
ATCAACAAACATGCTGATCAAGACGCTATCTACTCAATCGACGTAGGTAACACTACTCAAACATCTACTC
GTCACCTTCACATGACACCTAAGAACATGTGGCGTACATCTCCACTCTTTGCGACAATGGGTATTGCCCT
TCCTGGTGGTATCGCTGCTAAGAAAGACAATCCAGATCGCCAAGTATGGAACATCATGGGTGACGGAGCA
TTCAACATGTGCTACCCAGACGTTATCACAAACGTTCAATACGACCTTCCAGTTATCAACCTTGTCTTCT
CAAATGCTGAGTACGGCTTCATCAAGAACAAATACGAAGATACAAACAAACACTTGTTTGGTGTAGACTT
CACAAACGCTGACTACGCTAAAATTGCGGAAGCTCAAGGAGCTGTTGGATTCACAGTTGACCGTATCGAA
GACATCGATGCAGTTGTTGCAGAAGCTGTTAAATTGAACAAAGAAGGTAAAACTGTTGTCATCGATGCTC
GCATCACTCAACACCGTCCACTTCCAGTAGAAGTACTTGAATTGGATCCAAAACTTCACTCAGAAGAAGC
TATCAAAGCCTTCAAGGAAAAATACGAAGCAGAAGAACTCGTACCATTCCGTCTCTTCTTGGAAGAAGAA
GGATTGCAATCACGCGCAATTAAATA
Protein Sequence 
>gi|225856408|ref|YP_002737919.1| pyruvate oxidase [Streptococcus pneumoniae P1031] MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAVSKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits (Spellerberg et al., 1996).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Spellerberg et al., 1996: Spellerberg B, Cundell DR, Sandros J, Pearce BJ, Idanpaan-Heikkila I, Rosenow C, Masure HR. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular microbiology. 1996; 19(4); 803-813. [PubMed: 8820650].