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SP_2176

Victor ID 3346
Gene Name SP_2176
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 931927
NCBI Protein GI 15901986
Locus Tag SP_2176
Protein Accession NP_346590.1
Other Database IDs UniProtKB-ID: DLTA_STRPN
UniRef100: UniRef100_Q04HZ7
UniRef90: UniRef90_Q04HZ7
UniRef50: UniRef50_Q04HZ7
UniParc: UPI0000051B5B
EMBL: AE005672
EMBL-CDS: AAK76230.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000025776
EnsemblGenome_TRS: EBSTRT00000025776
EnsemblGenome_PRO: EBSTRP00000024868
GenomeReviews: AE005672_GR
KEGG: spn:SP_2176
TIGR: SP_2176
HOGENOM: HBG320748
OMA: MIATIEN
ProtClustDB: PRK04813
BioCyc: SPNE170187-1:SP_2176-MONOMER
Taxonomy ID 170187
Gene Starting Position 2093184
Gene Ending Position 2094734
Gene Strand (Orientation) -
Protein Name D-alanine--D-alanyl carrier protein ligase
DNA Sequence 
>gi|194172857:2093184-2094734 Streptococcus pneumoniae TIGR4 chromosome, complete genome
ATCATCTCTTATTCACCTCGTTAATCAATCCTTTGATGTCAATCTTTCCATTTGGAGTTAGTGGCAAACT
GTCTCGGTAAAGGAATTTAGATGGCATCATATAGGACATCATGATGTCTGTCAGGTCTTCCTTGATGGCC
TTGGTAATATCGATATCTCGCTCAAACTGCTCACGAACACCGTCTTTTAAGATGACATAAGCCAATAGAT
TTTGTACCTTGTGGTCCTTGTTATAGCGCGGTACTGCGACAGCAGATTCGATAAAGCGAGACTTGTTGAG
GTTTTGAGAGACATCTTCTAACTCAATGCGGTAACCGTTAAACTTAATCTGGAAGTCCATGCGTCCGCCG
TAGAGAAGCAAGCCCTCATCTGTCATGGTTCCCACATCGCCTGTGTGATAGGCTGGCAGATCTTCAAACT
CAAAGAAGGCTTCTGCTGTTTTTTCAGGATTGTTCATATAACCTTTTGAAACAGCTGGCCCAGAAACAAT
GATTTCTCCCTGCTCACCATTTGGCAGTTTATTTCCTTCCTCGTCAATGATAAAGGTTGGAGAATCAGCC
TTGGTATAGCCGATTGGTAGGCGTTTGAGAGTCGCTAACATCTCGTCTGTCACGGCAACTGCTGACAGAG
CTACTGTCGCTTCTGTTGGGCCGTAAGCATTGATGATACGGGCATTTGGGAAACGCTCGCGCAGTTTTTG
AGCTGTTTTGACCGTCAATTCTTCACCATCAAAGTAGAAATGCGTGATTCCAGGCATTTTCTCACTGTTG
AAGTATTCAGACAACATGGCCATATCTGCAAAGGATGGTGTTGATGTCCAGATAGCGATTGGCAATGAAA
AGATAGCCGCAAAGAGTTGCTTAAAGTCCTGAGTGATGACTGAAGGAAGAGTGAAAAGCGTACCACCAAG
TGCCAAGGTCGGTGCCCAATACATGACAGACAAGTCAAAAGAATAAGGTGGCTGTGCCAGCATTTGCGGA
CGACTCGGTGTCGCAAATTCCTTATCCGTAATCATCCAGTTTGTAAAGCTGAGGAGATTATCATGTGAAA
TCTGCACTCCCTTAGGCTTACCAGTCGTACCAGAAGTAAAGATAATGTAGTAATTATCATCTCCCTTGAC
TGGATGCGTGATTTCATAGTTATTCCCTTGGGCAAAGGCTTCTTGAACCTGAGCTAGATTTATCATTGGT
GTAGAAACCTGCTCCAAGGGAAAGGCTGAAATGGCAATAATCAAGCTTGGCTCTGCTACTTCTAAAATAG
CTGAAACTCGCTCCAAGGCCGAATGGCTATCAATTGGAATGTAGGCATGACCTGACTTAGTCAGCGCTAC
AAAGGTTGCCAACATTTCATATTCTTGGCCACCAAAAACAACCACAGGAGACTTCTCAGGCAAGCCTAGT
TGGTCAATGACTGCAGCCAAACTATCCGAATCAGCCTTTAAATCGCCATAAGTGTGTTCCTGCCCCAAAA
CATTATAGACAGGATAGCTAGGCTGTGTCTGAGCAAAATGCTCAATGGTTTCAATCATATCTGCTATTGG
TTTATTTGACA
Protein Sequence 
>gi|15901986|ref|NP_346590.1| D-alanine--poly(phosphoribitol) ligase subunit 1 [Streptococcus pneumoniae TIGR4] MSNKPIADMIETIEHFAQTQPSYPVYNVLGQEHTYGDLKADSDSLAAVIDQLGLPEKSPVVVFGGQEYEMLATFVALTKSGHAYIPIDSHSALERVSAILEVAEPSLIIAISAFPLEQVSTPMINLAQVQEAFAQGNNYEITHPVKGDDNYYIIFTSGTTGKPKGVQISHDNLLSFTNWMITDKEFATPSRPQMLAQPPYSFDLSVMYWAPTLALGGTLFTLPSVITQDFKQLFAAIFSLPIAIWTSTPSFADMAMLSEYFNSEKMPGITHFYFDGEELTVKTAQKLRERFPNARIINAYGPTEATVALSAVAVTDEMLATLKRLPIGYTKADSPTFIIDEEGNKLPNGEQGEIIVSGPAVSKGYMNNPEKTAEAFFEFEDLPAYHTGDVGTMTDEGLLLYGGRMDFQIKFNGYRIELEDVSQNLNKSRFIESAVAVPRYNKDHKVQNLLAYVILKDGVREQFERDIDITKAIKEDLTDIMMSYMMPSKFLYRDSLPLTPNGKIDIKGLINEVNKR
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_2176 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG1020Q, under Q: Secondary metabolites biosynthesis, transport and catabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].