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spxB from Streptococcus pneumoniae Hungary19A-6

Victor ID 3056
Gene Name spxB from Streptococcus pneumoniae Hungary19A-6
Sequence Strain (Species/Organism) Streptococcus pneumoniae Hungary19A-6
NCBI Gene ID 6028647
NCBI Protein GI 169832534
Locus Tag SPH_0817
Protein Accession YP_001694187.1
Other Database IDs UniProtKB-ID: B1IAQ2_STRPI
UniRef100: UniRef100_Q54970
UniRef90: UniRef90_Q54970
UniRef50: UniRef50_Q54970
UniParc: UPI000005156C
EMBL: CP000936
EMBL-CDS: ACA35648.1
RefSeq_NT: NC_010380.1
EnsemblGenome: EBSTRG00000024447.
EnsemblGenome_TRS: EBSTRT00000024447
EnsemblGenome_PRO: EBSTRP00000023613
GenomeReviews: CP000936_GR
KEGG: spv:SPH_0817
HOGENOM: HBG323037
OMA: KHRERSL
ProtClustDB: CLSK883986
BioCyc: SPNE487214:SPH_0817-MONOMER
Taxonomy ID 487214
Gene Starting Position 762997
Gene Ending Position 764772
Gene Strand (Orientation) +
Protein Name pyruvate oxidase
DNA Sequence 
>gi|169832377:762997-764772 Streptococcus pneumoniae Hungary19A-6, complete genome
TATGACTCAAGGGAAAATTACTGCATCTGCAGCAATGCTTAACGTATTGAAAACATGGGGCGTAGATACA
ATCTACGGTATCCCATCAGGAACACTCAGCTCATTGATGGACGCTTTGGCTGAAGACAAAGATATCCGCT
TCTTACAAGTTCGCCACGAAGAGACAGGTGCTCTTGCAGCGGTTATGCAAGCTAAATTCGGCGGCTCAAT
CGGGGTTGCAGTTGGTTCAGGTGGTCCAGGTGCGACTCACTTGATTAACGGTGTTTACGATGCAGCTATG
GATAACACTCCATTCCTAGCGATCCTTGGATCACGTCCAGTTAACGAATTGAACATGGATGCTTTCCAAG
AGCTTAACCAAAACCCAATGTACAACGGTATCGCTGTTTACAACAAACGTGTAGCTTACGCTGAGCAATT
GCCAAAAGTAATTGACGAAGCCTGCCGTGCTGCAGTTTCTAAAAAAGGTCCAGCTGTTGTTGAAATTCCA
GTAAACTTCGGTTTCCAAGAAATCGACGAAAACTCATACTACGGTTCAGGTTCATACGAACGCTCATTCA
TCGCTCCTGCTTTGAACGAAGTTGAAATCGACAAAGCTGTTGAAATCTTGAACAATGCTGAACGCCCAGT
TATCTATGCTGGATTTGGTGGTGTTAAAGCTGGTGAAGTGATTACTGAATTGTCACGTAAAATCAAAGCA
CCAATCATCACAACTGGTAAAAACTTTGAAGCTTTCGAATGGAACTATGAAGGTTTGACAGGTTCTGCTT
ACCGTGTTGGTTGGAAACCAGCCAACGAAGTGGTCTTTGAAGCAGACACAGTTCTTTTCCTTGGTTCAAA
CTTCCCATTTGCTGAAGTTTACGAAGCATTCAAGAACACTGAAAAATTCATCCAAGTCGATATCGACCCT
TACAAACTTGGTAAACGTCATGCCCTTGACGCTTCAATCCTTGGTGATGCTGGTCAAGCAGCTAAAGCTA
TCCTTGACAAAGTAAACCCAGTTGAATCAACTCCATGGTGGCGTGCAAACGTTAAGAACAACCAAAACTG
GCGTGATTACATGAACAAACTCGAAGGTAAAACTGAGGGTGAATTGCAATTGTATCAAGTTTACAATGCA
ATCAACAAACATGCTGATCAAGACGCTATCTACTCAATCGACGTAGGTAACACTACTCAAACATCTACTC
GTCACCTTCACATGACACCTAAGAACATGTGGCGTACATCTCCACTCTTTGCGACAATGGGTATTGCCCT
TCCTGGTGGTATCGCTGCTAAGAAAGACAATCCAGATCGCCAAGTATGGAACATCATGGGTGACGGAGCA
TTCAACATGTGCTACCCAGACGTTATCACAAACGTTCAATACGACCTTCCAGTTATCAACCTTGTCTTCT
CAAATGCTGAGTACGGCTTCATCAAGAACAAATACGAAGATACAAACAAACACTTGTTTGGTGTAGATTT
CACAAACGCTGACTACGCTAAAATTGCGGAAGCTCAAGGAGCTGTTGGATTCACAGTTGACCGTATCGAA
GACATCGATGCAGTTGTTGCAGAAGCTGTTAAATTGAACAAAGAAGGTAAAACTGTTGTCATCGATGCTC
GCATCACTCAACACCGTCCACTTCCAGTAGAAGTACTTGAATTGGATCCAAAACTTCACTCAGAAGAAGC
TATCAAAGCCTTCAAGGAAAAATACGAAGCAGAAGAACTCGTACCATTCCGTCTCTTCTTGGAAGAAGAA
GGATTGCAATCACGCGCAATTAAATA
Protein Sequence 
>gi|169832534|ref|YP_001694187.1| pyruvate oxidase [Streptococcus pneumoniae Hungary19A-6] MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAVSKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits (Spellerberg et al., 1996).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Spellerberg et al., 1996: Spellerberg B, Cundell DR, Sandros J, Pearce BJ, Idanpaan-Heikkila I, Rosenow C, Masure HR. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular microbiology. 1996; 19(4); 803-813. [PubMed: 8820650].