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pbp1A

Victor ID 3093
Gene Name pbp1A
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4442813
NCBI Protein GI 116516330
Locus Tag SPD_0336
Protein Accession YP_815850.1
Other Database IDs UniProtKB-ID: Q04M98_STRP2
UniRef100: UniRef100_Q04M98
UniRef90: UniRef90_Q8DR59
UniRef50: UniRef50_Q8DR59
UniParc: UPI0000E53281
EMBL: CP000410
EMBL-CDS: ABJ54626.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000019296.
EnsemblGenome_TRS: EBSTRT00000019296
EnsemblGenome_PRO: EBSTRP00000018536
GenomeReviews: CP000410_GR
KEGG: spd:SPD_0336
eggNOG: COG0744
HOGENOM: HBG672432
OMA: NVERATN
ProtClustDB: CLSK877241
Taxonomy ID 373153
Gene Starting Position 340391
Gene Ending Position 342550
Gene Strand (Orientation) -
Protein Name penicillin-binding protein 1A
DNA Sequence 
>gi|116515308:340391-342550 Streptococcus pneumoniae D39, complete genome
GTTATGGTTGTGCTGGTTGAGGATTCTGATTTTGTTGATCAGGGGTTGTATTTGATTGTTGCGTATTATT
GTTAGGATTGGTAGTCGTACTATTATTTGTGCTTGGAGTGGTTGAGCTAGACTGTGAAGTTGAACTATCT
GATGATGAGCTTGAACTTTCAGTTGATGGGGGTTGTTGTGGAGCAGGTGAGCTCCACGTAGAACGAGCAC
CATTTTTAAATACGAATTCTCCATTTCTGTAGAGCCCCTCTGGTATATTCCAATCCTCTGGATTGCTTCC
TTCAGACAGGTAGGTCATCATAGAGCGGTAAACTTTGGCAGCGACCGTAAGGCCATTGCCTACAAGTGGT
GTCAGACGGTTAGAATAGCCTGTCCATACAGCCATTGAATATTTACGCGTATAGCCAGCAAATAGTTCAT
CAGGTGCTACAAATTGAGAGGTCTTGATGTGGTTTTCAATTTCCTCGTCTGTATAGTTAGAGGTTCCTGT
TTTACCAGCCTGAGGGAGCCAAGCAAGATAGGCATTTCGTCCAGTTCCATAACTCAAGACTGTTTTCATC
ATGTCGGTCATCATATAGGCTGTCGTTTCTTTCATGGCACGAGTTCCGACATTAGAGAACTCTTTTTCAC
TCCCATCACTAAAGACGACTTTATGGATATACATTGGTTTATAGTAAGTTCCACCATTTGCAAAGGCAGC
GTAAGCAGCAGCCATCTTTTCACTACTTGCTCCATATTTTTTGTCTGATTCGGTTGTGTTACTTGAAATG
GCATTTGAGTAGTGAATACTTGGGTAGTCGATTCCGAGACCATTTAGGAAAGTCTTGGCGCGGTTGAGTC
CGACCTTGTTTAGAGTTTCCACGGCTGGGACGTTTCGCGATTGTTGCAGGGCGTATTGCAAGGTGATGTT
GCCAAAGTAGCCCCTATCCCAGTTATAAACAGGGGTATTTGTCCCAGGGTAGTTATAGGGCTCATCGTGA
ACGATAGTGGCAGTTGAATCGTAGACACCGTACTCCAAGGCAGGAGCATAGTCTGTGATCGGTTTCATAG
TTGATCCCCAGTCGCGGTTTGTTTCTACTGCTTGGTTAATTCCGAAGGAAACATTACTTGACTGATGGCG
TGCTCCTAGCTGGGCAATGACTTTACCGTTAGAAACATCAACAATGGTAGAAGCGACTTGCAATTCATCG
TCTGGATAGGCAACGTATTCGTCTGTATTGTAAATATCCCACAGATGTTTTTGAGCTTCTTGGTCTACAT
TTGTGTAGACATCCATCCCAGTTGTGAGTAGGTTATAGCCTGTTTCTTCTTCAACTTGATTGATGACTTC
CTTGAGGTAATTATCCATGTAAGCAGGGTAATTACTTGCTGATTTGAGACTTTGTAGCCCATCAGTAATT
GGTGTATTGACTGCTTTCTCATACTGTTCAGCAGAGATGTAGCCTTGATTTTTCATTTCAGATAAGACCA
AGTTTCGGCGGTCTTGGGCTGCTTCTGGATGTGAATAGGGGTCATATTGGTTTGGTGCCTGAGGCATTCC
AGCCAGCAAGGCTAACTGAGGTAAACTTAAATTATTGAGGTCTTTACCATAGTAGTTTTGAGCTGCTGTC
TGCATTCCATAGTTCCCATTAGACATGTAGACCTTATTTATATAGTAGGTCAAGATTTCTTGCTTGGTTG
CTTTTTGTTCTAACTGAATCGCTAACCAAGCTTCCTGAGCCTTACGAGAAATAGTCTGGTCGGAAGTCGA
AGTTGAAAAGTAAGTCAACTTAATCAACTGTTGAGTGAGAGTTGATCCACCTTGGAGGGAATTGCTTTGC
AGATTGCGCAAGAAAGCTCCCAGGATACGGATGGTATCAATCCCCCTGTGGTCGAAGAAGCGATGGTCTT
CGATAGAAACGATTGCCTTAACCAAATCTGTGGGAATATCATTAGCTTGGGCATTGACGCGGCGTTCAGA
ACCCAAGTCAGCAATGAGTTGATTTTTATTGTCGTAGATTTTACTAGAAGTTGTTGCAACTAGTTTACTC
TCGGATAGGCTAGGAGCCTTGCTAACGTAGTAGAAAAAAACTCCTCCGCCTAAGACAATGGCTGCGATAA
CCAAGCTTAAGAAGCTAATGCTCAGATACTTGATTAGGCGCAGAATCGTTGGTTTGTTCA
Protein Sequence 
>gi|116516330|ref|YP_815850.1| penicillin-binding protein 1A [Streptococcus pneumoniae D39] MNKPTILRLIKYLSISFLSLVIAAIVLGGGVFFYYVSKAPSLSESKLVATTSSKIYDNKNQLIADLGSERRVNAQANDIPTDLVKAIVSIEDHRFFDHRGIDTIRILGAFLRNLQSNSLQGGSTLTQQLIKLTYFSTSTSDQTISRKAQEAWLAIQLEQKATKQEILTYYINKVYMSNGNYGMQTAAQNYYGKDLNNLSLPQLALLAGMPQAPNQYDPYSHPEAAQDRRNLVLSEMKNQGYISAEQYEKAVNTPITDGLQSLKSASNYPAYMDNYLKEVINQVEEETGYNLLTTGMDVYTNVDQEAQKHLWDIYNTDEYVAYPDDELQVASTIVDVSNGKVIAQLGARHQSSNVSFGINQAVETNRDWGSTMKPITDYAPALEYGVYDSTATIVHDEPYNYPGTNTPVYNWDRGYFGNITLQYALQQSRNVPAVETLNKVGLNRAKTFLNGLGIDYPSIHYSNAISSNTTESDKKYGASSEKMAAAYAAFANGGTYYKPMYIHKVVFSDGSEKEFSNVGTRAMKETTAYMMTDMMKTVLSYGTGRNAYLAWLPQAGKTGTSNYTDEEIENHIKTSQFVAPDELFAGYTRKYSMAVWTGYSNRLTPLVGNGLTVAAKVYRSMMTYLSEGSNPEDWNIPEGLYRNGEFVFKNGARSTWSSPAPQQPPSTESSSSSSDSSTSQSSSTTPSTNNSTTTNPNNNTQQSNTTPDQQNQNPQPAQP
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a pbp1A mutant was attenuated in a murine model (Lau et al., 2001)
COG COG0744M, under M: Cell wall/membrane/envelope biogenesis
References
Lau et al., 2001: Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, Bryant AP, McDevitt D, Morrison DA, Holden DW. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Molecular microbiology. 2001; 40(3); 555-571. [PubMed: 11359563].