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lytA from Streptococcus pneumoniae D39

Victor ID 3080
Gene Name lytA from Streptococcus pneumoniae D39
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4442230
NCBI Protein GI 116516777
Locus Tag SPD_1737
Protein Accession YP_817160.1
Other Database IDs UniProtKB-ID: Q04IM8_STRP2
UniRef100: UniRef100_Q04IM8
UniRef90: UniRef90_C1CGE1
UniRef50: UniRef50_P32762
UniParc: UPI000000E964
EMBL: CP000410
EMBL-CDS: ABJ55073.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000020431.
EnsemblGenome_TRS: EBSTRT00000020431
EnsemblGenome_PRO: EBSTRP00000019671
GenomeReviews: CP000410_GR
KEGG: spd:SPD_1737
eggNOG: COG5263
HOGENOM: HBG702446
OMA: YDIENGL
ProtClustDB: CLSK560258
Taxonomy ID 373153
Gene Starting Position 1729600
Gene Ending Position 1730556
Gene Strand (Orientation) -
Protein Name autolysin/N-acetylmuramoyl-L-alanine amidase
DNA Sequence 
>gi|116515308:1729600-1730556 Streptococcus pneumoniae D39, complete genome
ATTATTTTACTGTAATCAAGCCATCTGGCTCTACTGTGAATTCTGGCCTGTCTGCCAGTGTTCCGTCTGG
TTTGAGGTAGTACCAGCCTGTTCCGTCCGCTGACTGGATAAAGGCATTTGATACCATGGCGCCTTCTTTA
GCGTCTAAGTAGTACCAAGTGTCCTTGTACTTGACCCAGCCTGTCTTCATGGCACCTTCTTCGTTGAAAT
AGTACCACTTATCAGCGATTTTCTTCCAGCCTGTAGCCATTTCGCCTGAGTTGTCGAACCAGTACCAGTT
GCCGTCTGTGTGCTTCCTCCAGCGGTCTGCAAGCATATAGCCTGAACTGTCAAAGTAGTACCAAGTGCCA
TTGATTTTCTCAAACTTGTCTTTTGGATAAGAGCCGTCTGAATGTACGTACCAGTAGCCAGTGTCATTCT
TCTGCCAGCCTGTTTCAATCGTCAAGCCGTTCTCAATATCATGCTTAAACTGCTCACGGCTAATGCCCCA
TTTAGCAAGATATGGATAAGGGTCAACGTGGTCTGAGTGGTTGTTTGGTTGGTTATTCGTGCAATACTCG
TGCGTTTTAATTCCAGCTAAACTCCCTGTATCAAGCGTTTTCGGCAAACCTGCTTCATCTGCTAGATTGC
GTAAGAGTTCGATATAAAGGCGGTAGTCCGTCATGAACTCTTCTTTGGTTGAATGGCTTTCAATCAGTTC
AACCGCTGCATAGGTCTCAGCATTCCAACCGCCCCCAACGTCCCAGGCACCATTATCAACAGGTCCTACC
TGCATGATGCAACCGTTCCCAACAATGTGCGAGAAAAAACCTAATTCTGGGTCTTTCCGCCAGTGATAAT
CCGCTTCATTCTGTACGGTTGAATGCGGATTCCCAGTTGAGTGTGCGTGTACTTGCCTATATGGTTGCAC
GCCGACTTGAGGCAAATCTGTTCTTAATTTACTCACATTAATTTCCA
Protein Sequence 
>gi|116516777|ref|YP_817160.1| autolysin/N-acetylmuramoyl-L-alanine amidase [Streptococcus pneumoniae D39] MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGISREQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADRPEFTVEPDGLITVK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lytA mutant is attenuated in mice (Berry and Paton, 2000).
COG COG5263R, under R: General function prediction only
References
Berry and Paton, 2000: Berry AM, Paton JC. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins. Infection and immunity. 2000; 68(1); 133-140. [PubMed: 10603379].