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nanA from Streptococcus pneumoniae CGSP14

Victor ID 3045
Gene Name nanA from Streptococcus pneumoniae CGSP14
Sequence Strain (Species/Organism) Streptococcus pneumoniae CGSP14
NCBI Gene ID 6217600
NCBI Protein GI 182684635
Locus Tag SPCG_1665
Protein Accession YP_001836382.1
Other Database IDs UniProtKB-ID: B2IRU8_STRPS
UniRef100: UniRef100_B2IRU8
UniRef90: UniRef90_B2IRU8
UniRef50: UniRef50_P62576
UniParc: UPI000172B951
EMBL: CP001033
EMBL-CDS: ACB90917.1
RefSeq_NT: NC_010582.1
EnsemblGenome: EBSTRG00000017171.
EnsemblGenome_TRS: EBSTRT00000017171
EnsemblGenome_PRO: EBSTRP00000016485
GenomeReviews: CP001033_GR
KEGG: spw:SPCG_1665
HOGENOM: HBG702052
OMA: DWMKFLG
ProtClustDB: CLSK560471
Taxonomy ID 516950
Gene Starting Position 1637746
Gene Ending Position 1640688
Gene Strand (Orientation) -
Protein Name sialidase A precursor (neuraminidase A)
DNA Sequence 
>gi|182682970:1637746-1640688 Streptococcus pneumoniae CGSP14, complete genome
CTTATTGTTCTCTCTTTTTCCCTAGCGTAAACAGACCAAGGAAGAAAGCTGTTAGTCCTAGTGAAGCTAG
GAGGTCACTCTCCTTGTTTCCTGTTTCAGGAAGTGCCTGCTGAGCAAGAGGAGCTTTGTAAGTATAATCT
TCTTTTGTAGTAAGAGTTACAAGCGAATCAGATCCCTTATACTCTGCGATTTCATGAACAGCTGGCTCTG
TACCATTAACTCCCCCTGTAAATTCTGGAACTTCATGCACCGCTGCTTTGCTACCATTTACTCCGCCAGG
AACTCTGGCACCTGCTAGATTTACAGGAAGATTATGCATACTTTCGATGCTTCCTTTAGCTATACCAATA
ATTTCCTGTCCGATATCTTCCTTATCTACTGCAAACAACAAGGTCTTGCTATCATACTGGGTTAGGAAAG
TCGCTGTTTTACCATTTGCCAATTGAAGGGTTGGAGCCTTGTTGACCAATACTTCTGAGTCGAACTCCAA
GCCAATAACTCCTTTGCCCATCTCTCCTTTGCCCATCTCTCTAGTTCGCTTCACTTTCGCTTCGGTAGGA
GAAATCAGATCTTTGCTCAAAAAGTCCCAATTAAATTTTCTAAATGATAGGGTATAGGCATTTTGTCCTT
TTTCAGTATGTTCATACAAGATACCATACTCCCCATTTCCTAATTCTTGGAGCGAATTATAGGCAAACTC
TCCTTTTTGAATTGGATTGTGTTTGAGCCAAGTCAACTCACCATTTTCTTCGACACGTGCCAAGTGGACC
ATCCCATTTTCACGTTTCGGTCCACCTGCATTACTGAGGATGATGTATTCTTTTCCTTCGTGCATCGTAT
GGATAGCAGACATTTGAACATAGACATCTTTAACCTGTGGATAACGTTTGATATCCTTCTCCCAAGTCAC
TCCTCCGTCTTTACTTGTAGCAACCTGAAGATCTCCAGTCAAACCACGCATAAAGAGTTTAACATCTCCA
TTGTTTAGTTGTACCACCGTTGATTCTGTATTTTGCGCACGTTCATTGTTCATCGTAGAAGAGTGGATCT
TTTGACCGTCTACCTGACGGTTATCGTTGACCGCTTCTCCAGCATGCCAAGTTTTTCCATGATCATCTGA
ATAGATGACACGAGAAGATTGCGAGCCATTTAAGTGAGATACATTATTAGTCGTATAAACCGGTATCAAA
ATCCGTCCCTTGTGAGGCCCATTCCGAAGTACAATTCCTGTTCCAGGACCTGTTCCTAGGAACTTCATCC
AATCCTTGCGAAGACCTGGAGTAATGTCTCTCGGTGCAGACCAAGTTTTACCATCATCGTCACTATATGA
CATCCATAGATAGCTCGTATTGGCTACTCTAAATGGATTTTTTGTACTGTGTGCAAAATAGATATTTCCA
ATCAATTCCTGACCTTTGTAAAGATTTCCTTTATCTCTATAGCCAGGTTCTGTTGGATTCACTACAACAC
GATAATCCGTCTTTTGATTTTGTGCATTATACACTTCTCCATTCTCACGAACAGTATAATGACCAGACTC
TCCTTGTTTATACAAGATTTGATAAGTTTTATCCCCTATCTTTTCATAAGCTTTTTCAGGTGTTTTTGGC
ATTCCAAAAACTGCTCGACCTTCTGGGAACATATCATAAATTGAGAAGATTCTCTTTGTTGTCGGGTCTT
GAACCAAAACCATATCAATATTTAGAGGCGATGGCGCAGCAGGATCTTTAGCTTCAGGATTATCTCGAAG
ATTGGAGATAACCACCTTATCTCCCCATGTCTTTCCATTATCTTCACTACGTCTGATGACCATACCGATA
TCACCCCAGTCACTCGAATGGAGACGGCGTTCATCTGCACCTGCGATCAAAGTTCCTTTATCTGTCTTGA
GAAGTGCTGGAATACGATAACTCTTGATTCCATCTTTATTTGGTTTACCGTTACGCCCGCTTTCGAATAT
GTCCGTTTTCTCTGTTAAAACCGCTCCTTCAGGTAGTTTTTTTTCTAAATCTGAGCGTTTAAAAAGTTGA
CTACGTTTTTGTACCTCTTCTGGTGTTAAAGCACGATTATACACAGTGAGATTCTGAATCTGTAGATTTG
ACCCCCAAACCGTATTGTTGGCACGCTTGGTTGCTCCGATTTGCACATGCGTTACATCTGGCATATCTTT
AATGAAATTGCCAGATTTCAGACTTGTTCGAGATAATACCCCGTTTACGTAGAGGCGCACTCGGCCTTTA
GGTAGTTCTGCTGTCGGTTTTTCAACTGTGAAAGTCACAGAATTCCACTGACCTGGTTTAACTTTTAAGG
GTGCATCGTTGTAATTACCGTAAAACTGTTGCCCATCCGAACCACGCCCCTCTAGAGTAGCAGTATTATT
GTAAACTGCCATAGTGAAGTACTCATCTTTTTTAGTAGCACTTGACACAGAAAAGAGATTATAGAATGCT
GGGGCCTTGGCATCTGGCTTAAACTCCATGTGAACTGTTGCGTTTTCAAGTTTCTTTAGTTTATCTAGTT
CACTTGATAAATCAACTCTCTGACCATTTGAAGCATTGGTTTCAACATCTTCTTTTTCTATCACTGTTTC
GACATTTTCCAAATCTCGTGCATAGTAATCTCTTGGAATTTTTTCTTCTTGCTTATCTTTCCTTTCTTGT
TCTTGCTTATTGCCAGAAAGTTCAGTCTCTGAAGAAGGCTGGCTCTTTTCTGTATCAGTTAGGGTTGAGC
TCTCCCCCGAAAGTTGAGTTTCATTTGCCAGAGGTTGCTCACTTGCCCCTTCTTGAGCTAAAACAGGAGA
CGTTCCAAATACCACTGCTCCTACAATCATAGAAACCGCTCCTACCGATAGTTTCCTAATGCTATAACGA
CACTTACGTTCTTGAACACTCCGATTCATACTGATCCTCTCTATATCTATATCCCGATTTCTGAAATAAG
ACA
Protein Sequence 
>gi|182684635|ref|YP_001836382.1| sialidase A (neuraminidase A) [Streptococcus pneumoniae CGSP14] MSYFRNRDIDIERISMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGQQFYGNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIQNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAVLTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDKVVISNLRDNPEAKDPAAPSPLNIDMVLVQDPTTKRIFSIYDMFPEGRAVFGMPKTPEKAYEKIGDKTYQILYKQGESGHYTVRENGEVYNAQNQKTDYRVVVNPTEPGYRDKGNLYKGQELIGNIYFAHSTKNPFRVANTSYLWMSYSDDDGKTWSAPRDITPGLRKDWMKFLGTGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNERAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKGSIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nanA mutant is attenuated in mice (Polissi et al., 1998).
COG COG4409G, under G: Carbohydrate transport and metabolism
References
Polissi et al., 1998: Polissi A, Pontiggia A, Feger G, Altieri M, Mottl H, Ferrari L, Simon D. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infection and immunity. 1998; 66(12); 5620-5629. [PubMed: 9826334].