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SP_0474

Victor ID 3201
Gene Name SP_0474
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930412
NCBI Protein GI 15900389
Locus Tag SP_0474
Protein Accession NP_344993.1
Other Database IDs UniProtKB-ID: Q97SB2_STRPN
UniRef100: UniRef100_B1RZB9
UniRef90: UniRef90_Q8DQZ3
UniRef50: UniRef50_A4VSU1
UniParc: UPI00000C9C95
EMBL: AE005672
EMBL-CDS: AAK74633.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026793.
EnsemblGenome_TRS: EBSTRT00000026793
EnsemblGenome_PRO: EBSTRP00000025885
GenomeReviews: AE005672_GR
KEGG: spn:SP_0474
TIGR: SP_0474
HOGENOM: HBG532931
OMA: GLFGENW
ProtClustDB: CLSK803712
BioCyc: SPNE170187-1:SP_0474-MONOMER
Taxonomy ID 170187
Gene Starting Position 452129
Gene Ending Position 453451
Gene Strand (Orientation) +
Protein Name PTS system, cellobiose-specific IIC component
DNA Sequence 
>gi|194172857:452129-453451 Streptococcus pneumoniae TIGR4 chromosome, complete genome
GATGAACAATATTTTAGCGTTTTTAGAAACAAAAGTCGCTCCGTTTGGTGAAAAAGTTGGCAACCAACGG
CATTTGAAAGCTATTCGTGAAGGATTTATGATGGCAATGCCTTTGATTTTAGTCGGCTCTTTATTTCTTA
TTCTAATCAGTTGGCCTCAAGAGGCTTTTACAAATTGGCTGAATAGTGTTGGATTGCTAAGTATCTTGAC
AACTATGAATCAGTCAACAGTAGCGATTATCTCCTTGGTCGCTTGTTTCGGTATTGCCTACAGGTTGTCG
GAAGGATATGGTACAGATGGTCCGTCGGCAGGGATCATAGCCTTATCCAGTTTTGTATTGATGGCACCTC
GTTTTTCGAGTATGGTTTATGATAAAAATGGGGAGCAGGTCAAGCAGTTATTTGGCGGCGCAATACCATT
TTCTAGCCTGAATGCATCTTCTTTGTTTATGGCGATTACTATTGGATTGGTTACAGCAGAGATTTATCGT
ATGTTTATCCAGCGCGGAATTACGATAAAAATGCCAAGTGGTGTCCCAGATGTAGTAAGTAAATCATTTT
CAGCTCTTTTATCTGGTTTTACTACTTTTGTTTTGTGGGCTTTGGTCTTAAAAGGTCTTGAAGCGGCAGG
AGTTGCAGGAGGTCTCAACGGACTCCTAGGTGCAATTGTTGGAACACCGCTTAAGTTAATTGCAGGAACG
CTTCCAGGTATGATTCTATGTGTTATTGTAAACTCATTCTTTTGGTTCTGTGGAGTTAATGGGGGACAAG
TTTTAAATGCTTTTGTAGACCCAGTTTGGTTACAATTTACTACAGAAAACCAAGAAGCTGTGGCTGCAGG
ACAAACACTCCAACACATTATTACATTACCGTTTAAAGATTTATTTGTATTTATTGGTGGCGGTGGAGCG
ACTATTGGTCTTGCGATTTGTCTCTTCCTATTTAGTAAGAGTCGTGCGAATAAAACATTAGGTAAGCTAG
CTATTATACCGTCTATTTTTAATATCAATACAGCTATTCTATTTACGTTTCCAACAGTTTTAAATCCGAT
TATGCTGATTCCGTTTATTGCTACTCCTACAATCAATGCCTTGATTACCTATGTATCAATGGCTGTAGGA
TTAGTACCCTATACAACAGGTGTAATCCTTCCGTGGACAATGCCACCGATTATAGGAGGCTTCCTTGCAA
CAGGGGCTAGTTGGCGAGGAGCTCTATTACAAGTTGTTTTGATTTTGGTTTCTGTAGCAATTTATTATCC
ATTCTTCAAAATTGCAGATAAACGCAATCTTGAAAAAGAAAAAGCTACTGTTGGAGGGAAATA
Protein Sequence 
>gi|15900389|ref|NP_344993.1| PTS system cellobiose-specific transporter subunit IIC [Streptococcus pneumoniae TIGR4] MNNILAFLETKVAPFGEKVGNQRHLKAIREGFMMAMPLILVGSLFLILISWPQEAFTNWLNSVGLLSILTTMNQSTVAIISLVACFGIAYRLSEGYGTDGPSAGIIALSSFVLMAPRFSSMVYDKNGEQVKQLFGGAIPFSSLNASSLFMAITIGLVTAEIYRMFIQRGITIKMPSGVPDVVSKSFSALLSGFTTFVLWALVLKGLEAAGVAGGLNGLLGAIVGTPLKLIAGTLPGMILCVIVNSFFWFCGVNGGQVLNAFVDPVWLQFTTENQEAVAAGQTLQHIITLPFKDLFVFIGGGGATIGLAICLFLFSKSRANKTLGKLAIIPSIFNINTAILFTFPTVLNPIMLIPFIATPTINALITYVSMAVGLVPYTTGVILPWTMPPIIGGFLATGASWRGALLQVVLILVSVAIYYPFFKIADKRNLEKEKATVGGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0474 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG1455G, under G: Carbohydrate transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].