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SP_0071

Victor ID 3140
Gene Name SP_0071
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 929838
NCBI Protein GI 15900016
Locus Tag SP_0071
Protein Accession NP_344620.1
Other Database IDs UniProtKB-ID: ZMPC_STRPN
UniRef100: UniRef100_Q97T80
UniRef90: UniRef90_Q97T80
UniRef50: UniRef50_Q97T80
UniParc: UPI0000051BE0
EMBL: AE005672
EMBL-CDS: AAK74260.1
RefSeq_NT: NC_003028.3
MEROPS: M26.003
EnsemblGenome: EBSTRG00000026328
EnsemblGenome_TRS: EBSTRT00000026328
EnsemblGenome_PRO: EBSTRP00000025420
GenomeReviews: AE005672_GR
KEGG: spn:SP_0071
TIGR: SP_0071
HOGENOM: HBG703220
OMA: QEPGHEG
ProtClustDB: CLSK883904
BioCyc: SPNE170187-1:SP_0071-MONOMER
Taxonomy ID 170187
Gene Starting Position 73760
Gene Ending Position 79330
Gene Strand (Orientation) +
Protein Name immunoglobulin A1 protease
DNA Sequence 
>gi|194172857:73760-79330 Streptococcus pneumoniae TIGR4 chromosome, complete genome
TATGAGCCGAAAAAGCATTGGTGAGAAACGCCATAGTTTCTCGATGAGAAAGTTGTCAGTGGGATTGGTA
TCAGTTACTGTATCTAGTTTCTTTTTGATGAGTCAAGGGATTCAATCGGTATCGGCCGATAATATGGAAA
GTCCAATTCATTATAAGTATATGACCGAGGGTAAATTGACAGACGAGGAAAAATCCTTGCTGGTAGAGGC
CCTTCCACAACTGGCTGAAGAATCAGATGATACTTATTACTTGGTTTATAGATCTCAACAGTTTTTACCG
AATACAGGTTTTAACCCAACTGTTGGTACTTTCCTTTTTACTGCAGGATTGAGCTTGTTAGTTTTATTGG
TTTCTAAAAGGGAAAATGGAAAGAAACGACTTGTTCATTTTCTGCTGTTGACTAGCATGGGAGTTCAATT
GTTGCCGGCCAGTGCTTTTGGGTTGACCAGCCAGATTTTATCTGCCTATAATAGTCAGCTTTCTATCGGA
GTCGGGGAACATTTACCAGAGCCTCTGAAAATCGAAGGTTATCAATATATTGGTTATATCAAAACTAAGA
AACAGGATAATACAGAGCTTTCAAGGACAGTTGATGGGAAATACTCTGCTCAAAGAGATAGTCAACCAAA
CTCTACAAAAACATCAGATGTAGTTCATTCAGCTGATTTAGAATGGAACCAAGGACAGGGGAAGGTTAGT
TTACAAGGTGAAGCATCAGGGGATGATGGACTTTCAGAAAAATCTTCTATAGCAGCAGACAATCTATCTT
CTAATGATTCATTCGCAAGTCAAGTTGAGCAGAATCCGGATCACAAAGGAGAATCTGTAGTTCGACCAAC
AGTGCCAGAACAAGGAAATCCTGTGTCTGCTACAACGGTGCAGAGTGCGGAAGAGGAAGTATTGGCGACG
ACAAATGATCGACCAGAGTATAAACTTCCATTGGAAACCAAAGGCACGCAAGAACCCGGTCATGAGGGTG
AAGCCGCAGTCCGTGAAGACTTACCAGTCTACACTAAGCCACTAGAAACCAAAGGTACACAAGGACCCGG
ACATGAAGGTGAAGCTGCAGTTCGCGAGGAAGAACCAGCTTACACAGAACCGTTAGCAACGAAAGGCACG
CAAGAGCCAGGTCATGAGGGCAAAGCTACAGTCCGCGAAGAGACTCTAGAGTACACGGAACCGGTAGCGA
CAAAAGGCACACAAGAACCCGAACATGAGGGCGAAGCGGCAGTAGAAGAAGAACTTCCGGCTTTAGAGGT
CACTACACGAAATAGAACGGAAATCCAGAATATTCCTTATACAACAGAAGAAATTCAGGATCCAACACTT
CTGAAAAATCGTCGTAAGATTGAACGACAAGGGCAAGCAGGGACACGTACAATTCAATATGAAGACTACA
TCGTAAATGGTAATGTCGTAGAAACTAAAGAAGTGTCACGAACTGAAGTAGCTCCGGTCAACGAAGTCGT
TAAAGTAGGAACACTTGTGAAAGTTAAACCTACAGTAGAAATTACAAACTTAACAAAAGTTGAGAACAAA
AAATCTATAACTGTAAGTTATAACTTAATAGACACTACCTCAGCATATGTTTCTGCAAAAACGCAAGTTT
TCCATGGAGACAAGCTAGTTAAAGAGGTGGATATAGAAAATCCTGCCAAAGAGCAAGTAATATCAGGTTT
AGATTACTACACACCGTATACAGTTAAAACACACCTAACTTATAATTTGGGTGAAAATAATGAGGAAAAT
ACTGAAACATCAACTCAAGATTTCCAATTAGAGTATAAGAAAATAGAGATTAAAGATATTGATTCAGTAG
AATTATACGGTAAAGAAAATGATCGTTATCGTAGATATTTAAGTCTAAGTGAAGCGCCGACTGATACGGC
TAAATACTTTGTAAAAGTGAAATCAGATCGCTTCAAAGAAATGTACCTACCTGTAAAATCTATTACAGAA
AATACGGATGGAACGTATAAAGTGACGGTAGCCGTTGATCAACTTGTCGAAGAAGGTACAGACGGTTACA
AAGATGATTACACATTTACTGTAGCTAAATCTAAAGCAGAGCAACCAGGAGTTTACACATCCTTTAAACA
GCTGGTAACAGCCATGCAAAGCAATCTGTCTGGTGTCTATACATTGGCTTCAGATATGACCGCAGATGAG
GTGAGCTTAGGCGATAAGCAGACAAGTTATCTCACAGGTGCATTTACAGGGAGCTTGATCGGTTCTGATG
GAACAAAATCGTATGCCATTTATGATTTGAAGAAACCATTATTTGATACATTAAATGGTGCTACAGTTAG
AGATTTGGATATTAAAACTGTTTCTGCTGATAGTAAAGAAAATGTCGCAGCGCTGGCGAAGGCAGCGAAT
AGCGCGAATATTAATAATGTTGCAGTAGAAGGAAAAATCTCAGGTGCGAAATCTGTTGCGGGATTAGTAG
CGAGCGCAACAAATACAGTGATAGAAAACAGCTCGTTTACAGGGAAACTTATCGCAAATCACCAGGACAG
TAATAAAAATGATACTGGAGGAATAGTAGGTAATATAACAGGAAATAGTTCGAGAGTTAATAAAGTTAGG
GTAGATGCCTTAATCTCTACTAATGCACGCAATAATAACCAAACAGCTGGAGGGATAGTAGGTAGATTAG
AAAATGGTGCATTGATATCTAATTCGGTTGCTACTGGAGAAATACGAAATGGTCAAGGATATTCTAGAGT
CGGAGGAATAGTAGGATCTACGTGGCAAAACGGTCGAGTAAATAATGTTGTGAGTAACGTAGATGTTGGA
GATGGTTATGTTATCACCGGTGATCAATACGCAGCAGCAGATGTGAAAAATGCAAGTACATCAGTTGATA
ATAGAAAAGCAGACAGATTCGCTACAAAATTATCAAAAGACCAAATAGACGCGAAAGTTGCTGATTATGG
AATCACAGTAACTCTTGATGATACTGGGCAAGATTTAAAACGTAATCTAAGAGAAGTTGATTATACAAGA
CTAAATAAAGCAGAAGCTGAAAGAAAAGTAGCTTATAGCAACATAGAAAAACTGATGCCATTCTACAATA
AAGACCTAGTAGTTCACTATGGTAACAAAGTAGCGACAACAGATAAACTTTACACTACAGAATTGTTAGA
TGTTGTGCCGATGAAAGATGATGAAGTAGTAACGGATATTAATAATAAGAAAAATTCAATAAATAAAGTT
ATGTTACATTTCAAAGATAATACAGTAGAATACCTAGATGTAACATTCAAAGAAAACTTCATAAACAGTC
AAGTAATCGAATACAATGTTACAGGAAAAGAATATATATTCACACCAGAAGCATTTGTTTCAGACTATAC
AGCGATAACGAATAACGTACTAAGCGACTTGCAAAATGTAACACTTAACTCAGAAGCTACTAAAAAAGTA
CTAGGAGCAGCGAATGATGCAGCCTTAGATAACCTATACTTAGATAGACAATTTGAAGAAGTTAAAGCTA
ATATAGCAGAACACCTAAGAAAAGTATTAGCGATGGATAAATCAATCAATACTACAGGAGACGGTGTAGT
TGAATACGTAAGTGAGAAAATCAAAAATAACAAAGAAGCATTTATGCTAGGTCTTACTTATATGAACCGT
TGGTACGATATTAATTATGGTAAAATGAATACAAAAGATTTATCTACGTACAAGTTTGACTTTAACGGAA
ATAATGAGACTTCAACGTTGGATACTATTGTCGCATTAGGAAATAGTGGACTAGATAACCTGAGAGCTTC
AAATACTGTAGGTTTATATGCGAATAAACTTGCATCGGTAAAAGGAGAAGATTCAGTCTTTGACTTCGTA
GAAGCGTATAGAAAACTGTTCTTACCAAACAAAACAAATAACGAGTGGTTTAAAGAAAATACAAAGGCAT
ATATAGTCGAAATGAAGTCTGATATTGCAGAAGTACGAGAAAAACAAGAATCACCAACAGCCGATAGAAA
ATATTCATTAGGAGTTTACGATAGAATATCAGCACCAAGTTGGGGGCATAAGAGTATGTTATTACCACTA
CTAACTTTACCTGAAGAATCTGTGTATATTTCATCGAATATGTCTACACTTGCATTCGGTTCGTATGAAA
GATATCGTGATAGTGTGGATGGAGTTATTCTTTCAGGAGATGCTTTACGAACTTATGTAAGAAATAGAGT
TGATATAGCAGCGAAAAGGCATAGAGACCATTATGATATTTGGTACAATCTTCTTGACAGTGCTTCAAAA
GAAAAACTTTTCCGTTCTGTGATAGTTTATGATGGATTCAATGTAAAAGATGAGACAGGAAGAACTTATT
GGGCAAGGTTAACGGATAAAAACATCGGCTCTATTAAAGAATTCTTCGGACCTGTTGGGAAATGGTATGA
GTATAATAGTAGTGCAGGAGCGTATGCGAATGGAAGTTTAACGCACTTTGTGTTAGATAGATTATTAGAT
GCTTATGGAACGTCGGTTTATACTCATGAAATGGTTCATAATTCTGATTCTGCAATCTACTTTGAAGGAA
ATGGTAGACGTGAAGGATTGGGAGCGGAGTTATACGCACTTGGTTTACTGCAATCTGTAGATAGTGTAAA
TTCTCATATTTTAGCTTTAAATACGTTATATAAAGCAGAAAAAGATGATTTGAATAGATTGCATACATAT
AATCCGGTGGAACGTTTCGATTCGGATGAGGCGCTTCAAAGTTATATGCATGGATCATATGATGTAATGT
ATACACTTGATGCGATGGAAGCAAAAGCGATATTAGCTCAAAATAATGATGTTAAGAAAAAATGGTTTAG
AAAAATAGAAAATTATTACGTTCGTGATACTAGACATAATAAAGATACACATGCAGGAAATAAAGTCCGT
CCATTAACAGATGAAGAAGTAGCTAACTTAACATCGTTAAACTCATTAATCGACAACGACATCATAAATA
GACGTAGCTATGATGATAGTAGAGAATATAAACGAAATGGCTACTATACTATAAGTATGTTCTCTCCTGT
ATACGCAGCGCTAAGCAATTCGAAAGGTGCTCCTGGAGATATTATGTTTAGAAAAATAGCTTATGAATTA
CTTGCGGAAAAAGGTTATCACAAAGGATTCCTACCTTATGTTTCTAATCAGTACGGAGCAGAAGCATTTG
CCAGCGGAAGCAAAACATTCTCATCATGGCATGGAAGAGATGTTGCTTTAGTGACAGATGATTTAGTATT
TAAGAAAGTATTCAATGGTGAGTACTCATCATGGGCTGATTTCAAAAAAGCAATGTTTAAACAACGTATA
GATAAACAAGATAATCTGAAACCAATAACAATTCAATACGAATTAGGTAATCCTAATAGTACAAAAGAAG
TAACTATAACAACGGCTGCACAAATGCAACAATTAATTAATGAAGCGGCTGCGAAAGATATTACTAATAT
AGATCGTGCAACGAGTCATACCCCAGCAAGTTGGGTGCATTTATTAAAACAAAAAATCTATAATGCATAT
CTTCGCACTACAGATGACTTTAGAAATTCTATATATAAATA
Protein Sequence 
>gi|15900016|ref|NP_344620.1| immunoglobulin A1 protease [Streptococcus pneumoniae TIGR4] MSRKSIGEKRHSFSMRKLSVGLVSVTVSSFFLMSQGIQSVSADNMESPIHYKYMTEGKLTDEEKSLLVEALPQLAEESDDTYYLVYRSQQFLPNTGFNPTVGTFLFTAGLSLLVLLVSKRENGKKRLVHFLLLTSMGVQLLPASAFGLTSQILSAYNSQLSIGVGEHLPEPLKIEGYQYIGYIKTKKQDNTELSRTVDGKYSAQRDSQPNSTKTSDVVHSADLEWNQGQGKVSLQGEASGDDGLSEKSSIAADNLSSNDSFASQVEQNPDHKGESVVRPTVPEQGNPVSATTVQSAEEEVLATTNDRPEYKLPLETKGTQEPGHEGEAAVREDLPVYTKPLETKGTQGPGHEGEAAVREEEPAYTEPLATKGTQEPGHEGKATVREETLEYTEPVATKGTQEPEHEGEAAVEEELPALEVTTRNRTEIQNIPYTTEEIQDPTLLKNRRKIERQGQAGTRTIQYEDYIVNGNVVETKEVSRTEVAPVNEVVKVGTLVKVKPTVEITNLTKVENKKSITVSYNLIDTTSAYVSAKTQVFHGDKLVKEVDIENPAKEQVISGLDYYTPYTVKTHLTYNLGENNEENTETSTQDFQLEYKKIEIKDIDSVELYGKENDRYRRYLSLSEAPTDTAKYFVKVKSDRFKEMYLPVKSITENTDGTYKVTVAVDQLVEEGTDGYKDDYTFTVAKSKAEQPGVYTSFKQLVTAMQSNLSGVYTLASDMTADEVSLGDKQTSYLTGAFTGSLIGSDGTKSYAIYDLKKPLFDTLNGATVRDLDIKTVSADSKENVAALAKAANSANINNVAVEGKISGAKSVAGLVASATNTVIENSSFTGKLIANHQDSNKNDTGGIVGNITGNSSRVNKVRVDALISTNARNNNQTAGGIVGRLENGALISNSVATGEIRNGQGYSRVGGIVGSTWQNGRVNNVVSNVDVGDGYVITGDQYAAADVKNASTSVDNRKADRFATKLSKDQIDAKVADYGITVTLDDTGQDLKRNLREVDYTRLNKAEAERKVAYSNIEKLMPFYNKDLVVHYGNKVATTDKLYTTELLDVVPMKDDEVVTDINNKKNSINKVMLHFKDNTVEYLDVTFKENFINSQVIEYNVTGKEYIFTPEAFVSDYTAITNNVLSDLQNVTLNSEATKKVLGAANDAALDNLYLDRQFEEVKANIAEHLRKVLAMDKSINTTGDGVVEYVSEKIKNNKEAFMLGLTYMNRWYDINYGKMNTKDLSTYKFDFNGNNETSTLDTIVALGNSGLDNLRASNTVGLYANKLASVKGEDSVFDFVEAYRKLFLPNKTNNEWFKENTKAYIVEMKSDIAEVREKQESPTADRKYSLGVYDRISAPSWGHKSMLLPLLTLPEESVYISSNMSTLAFGSYERYRDSVDGVILSGDALRTYVRNRVDIAAKRHRDHYDIWYNLLDSASKEKLFRSVIVYDGFNVKDETGRTYWARLTDKNIGSIKEFFGPVGKWYEYNSSAGAYANGSLTHFVLDRLLDAYGTSVYTHEMVHNSDSAIYFEGNGRREGLGAELYALGLLQSVDSVNSHILALNTLYKAEKDDLNRLHTYNPVERFDSDEALQSYMHGSYDVMYTLDAMEAKAILAQNNDVKKKWFRKIENYYVRDTRHNKDTHAGNKVRPLTDEEVANLTSLNSLIDNDIINRRSYDDSREYKRNGYYTISMFSPVYAALSNSKGAPGDIMFRKIAYELLAEKGYHKGFLPYVSNQYGAEAFASGSKTFSSWHGRDVALVTDDLVFKKVFNGEYSSWADFKKAMFKQRIDKQDNLKPITIQYELGNPNSTKEVTITTAAQMQQLINEAAAKDITNIDRATSHTPASWVHLLKQKIYNAYLRTTDDFRNSIYK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0071 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG3583S, under S: Function unknown
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].