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SP_0199

Victor ID 3162
Gene Name SP_0199
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 929994
NCBI Protein GI 15900135
Locus Tag SP_0199
Protein Accession NP_344739.1
Other Database IDs UniProtKB-ID: Q97SW5_STRPN
UniRef100: UniRef100_E0SUY4
UniRef90: UniRef90_E0SUY4
UniRef50: UniRef50_D3HBA1
UniParc: UPI00000C9C86
EMBL: AE005672
EMBL-CDS: AAK74379.1
RefSeq_NT: NC_003028.3
HSSP: Q9NG96
EnsemblGenome: EBSTRG00000026355.
EnsemblGenome_TRS: EBSTRT00000026355
EnsemblGenome_PRO: EBSTRP00000025447
GenomeReviews: AE005672_GR
KEGG: spn:SP_0199
TIGR: SP_0199
HOGENOM: HBG694312
OMA: GHRYYPR
ProtClustDB: CLSK2301232
BioCyc: SPNE170187-1:SP_0199-MONOMER
Taxonomy ID 170187
Gene Starting Position 185328
Gene Ending Position 186752
Gene Strand (Orientation) +
Protein Name cardiolipin synthetase
DNA Sequence 
>gi|194172857:185328-186752 Streptococcus pneumoniae TIGR4 chromosome, complete genome
CATGGCTCCCATTTTATGGATTACTGTCCTCATTCTACTGAGTATCATCACAATCATTTCGATAGTCAAC
CGTAATACGACTCCTGAGAATAAGGTAACCTGGTTGTTAGTAGCCTTTGTGCCAGTATTTGGTCCCTTGC
TCTATCTGATGTTTGGTGAAAGGCGATTGTCCAAAAAAGAAATCAAACAACTGAAGAAGCTAGGCTCTAT
GCATTTCCAAGAAGCAAATAGCCAGCTACTAAAAGAGAAATTAAAAGAAAGTGACAAGGCAGCTTATGGA
GTCATCAAGTCCTTATTGAGTATGGATACCAATGCTGACATCTATGATCAAACTGCCTCTACATTTTTTC
CTAACGGAGAAGCTATGTGGAAAAAGATGGTAGAAGATCTTAAAAAGGCTGAGAAATTTATTTTCTTGGA
ATATTACATTATAGAAGAAGGTTTGATGTGGAATCGCATACTAGATATACTAGAGCAAAAGGTAGCTCAG
GGTGTAGAGGTTAAGATGCTCTATGATGATATCGGCTGTATGGCTACTTTAACAGGAGATTATGCACATC
GACTTCGTCAGCTGGGCATCGAGGCCCATAAATTCAATAAAGTTATTCCTCGTTTGACAGTGGCTTATAA
TAACAGAGATCATAGAAAAATATTGATTGTTGATGGTCAGATAGCCTATACTGGTGGGGTCAATCTGGCA
GATGAGTACATTAACCACGTCGAGAGATTTGGTTATTGGAAGGATAGTGGAATTCGCTTAGACGGACTAG
CAGTAAAAGCTCTGACACGCTTATTTTTGACCACTTGGTACATTAATCGAGGAGAAATTAGTGATTTTGA
TCAATATCATTTAGAAAATCATTCTATCCCGAGTGACGGTTTAACCATTCCATACGGAAGTGGACCCAAG
CCAATTTTTCGAGCGCAGGTAGGGAAAAAAGTTTATCAGAGTTTAATCAATCAAGCAACAGAATCGGTCT
ATATTACGACACCTTATTTGATTATAGATTATGATTTAACAGAGACAATCAAAAATGCAGCTATGAGAGG
GGTCGATGTTCGAATTATCACCCCTTACATACCAGATAAGAAGTTCATTCAGTTAGTCACGAGAGGAGCT
TATCCCGACCTTCTTTCTGCTGGTGTTCGGATTTATGAGTATAGTCCAGGTTTTATTCATAGTAAGCAGA
TGTTGGTAGACGAAGATTTTGCGGTGGTGGGGACAATCAATCTCGACTACCGGAGCTTGGTACACCATTA
TGAAAATGCAGTCTTACTCTATAAAACTCCTTCTATAAGGGAAATCGCCCGAGATTTTCGAAATATATTT
GCAGATTCTCAGGAAGTCTATCCTCATTCTATCAAAACGAGCTGGTATCAAAAGCTTGTAAAAGAAATCG
CCCAGCTATTCGCCCCTATCTTATA
Protein Sequence 
>gi|15900135|ref|NP_344739.1| cardiolipin synthetase [Streptococcus pneumoniae TIGR4] MAPILWITVLILLSIITIISIVNRNTTPENKVTWLLVAFVPVFGPLLYLMFGERRLSKKEIKQLKKLGSMHFQEANSQLLKEKLKESDKAAYGVIKSLLSMDTNADIYDQTASTFFPNGEAMWKKMVEDLKKAEKFIFLEYYIIEEGLMWNRILDILEQKVAQGVEVKMLYDDIGCMATLTGDYAHRLRQLGIEAHKFNKVIPRLTVAYNNRDHRKILIVDGQIAYTGGVNLADEYINHVERFGYWKDSGIRLDGLAVKALTRLFLTTWYINRGEISDFDQYHLENHSIPSDGLTIPYGSGPKPIFRAQVGKKVYQSLINQATESVYITTPYLIIDYDLTETIKNAAMRGVDVRIITPYIPDKKFIQLVTRGAYPDLLSAGVRIYEYSPGFIHSKQMLVDEDFAVVGTINLDYRSLVHHYENAVLLYKTPSIREIARDFRNIFADSQEVYPHSIKTSWYQKLVKEIAQLFAPIL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0199 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG1502I, under I: Lipid transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].