Victors

igA
Victor ID	3435
Gene Name	igA
Sequence Strain (Species/Organism)	Streptococcus pneumoniae G54
NCBI Gene ID	6478876
NCBI Protein GI	194398492
Locus Tag	SPG_1053
Protein Accession	YP_002037763.1
Other Database IDs	UniProtKB-ID: B5E4P7_STRP4 UniRef100: UniRef100_B5E4P7 UniRef90: UniRef90_B5E4P7 UniRef50: UniRef50_Q59947 UniParc: UPI00017C171A EMBL: CP001015 EMBL-CDS: ACF56607.1 RefSeq_NT: NC_011072.1 MEROPS: M26.001 EnsemblGenome: EBSTRG00000021715. EnsemblGenome_TRS: EBSTRT00000021715 EnsemblGenome_PRO: EBSTRP00000020881 GenomeReviews: CP001015_GR KEGG: spx:SPG_1053 HOGENOM: HBG703220 OMA: IVEPEKV ProtClustDB: CLSK883904
Taxonomy ID	512566
Gene Starting Position	1018652
Gene Ending Position	1024489
Gene Strand (Orientation)	+
Protein Name	immunoglobulin A1 protease
DNA Sequence	>gi\|194396645:1018652-1024489 Streptococcus pneumoniae G54 chromosome, complete genome AATGGAAAAGTATTTTGGTGAAAAACAAGAGCGTTTTTCATTTAGAAAATTATCAGTAGGACTTGTATCT GCAACGATTTCAAGTTTATTTTTTATGTCTGTATTAGCTAGTTCATCTGTGGATGCTCAAGAAACTGCGG GAGTTCACTATAAATATGTGGCAGATTCAGAGCTATCATCAGAAGAAAAGAAGCAGCTTGTCTATGATAT TCCGACATACGTGGAGAATGATGATGAAACTTATTATCTTGTTTATAAGTTAAATTCTCAAAATCAACTG GCGGAATTACCAAATACTGGAAGCAAGAATGAGAGGCAAGCCCTAGTTGCTGGTGCTAGCTTAGCTGCTC TGGGAATTTTAATTTTTGCTGTTTCCAAGAAAAAGGTTAAGAATAAAACGGTATTACATTTAGTATTGGT TGCGGGAATAGGAAATGGTGTCTTAGTTTCAGTCCATGCTTTAGAAAATCATCTTTTGCTAAATTACAAT ACGGACTATGAATTGACCTCTGGAGAAAAATTACCTCTTCCTAAAGAGATTTCAGGTTACACTTATATTG GATATATCAAAGAGGGAAAAACGACTTCTGATTTTGAAGTAAGTAATCAAGAAAAATCAGCAGCCACTCC TACAAAACAACAAAAGGTGGATTATAATGTTACACCAAATTTTGTAGACCATCCATCAACAGTACAAGCT ATTCAGGAACAAACACCTGTTTCTTCAACTAAGCCGACAGAAGTTCAAGTAGTTGAAAAACCTTTCTCTA CTGAATTAATCAATCCAAGAAAAGAAGAGAAACAATCTTCAGATTCTCAAGAACAATTAGCCGAACATAA GAATCTAGAAACGAAGAAAGAGGAGAAGATTTCTCCAAAAGAAAAGACTGGGGTAAATACATTAAATCCA CAGGATGAAGTTTTATCAGGTCAATTGAACAAACCTGAACTCTTATATCGTGAGGAAACTATAGAGACAA AAATAGATTTTCAAGAAGAAATTCAAGAAAATCCTGATTTAGCTGAAGGAACTGTAAGAGTAAAACAAGA AGGTAAATTAGGTAAGAAAGTTGAAATCGTCAGAATATTCTCTGTAAACAAGGAAGAAGTTTCGCGAGAA ATTGTTTCGACTTCAACGACTGCGCCTATTCCAAGAATAGTCGAAAAAGGTACTAAAAAAACTCAAGTTA TAAAGGAACAACCTGAGACTGGTGTAGAACATAAGGACGTACAGTCTGGAGCTATTGTTGAACCCGCAAT TCAGCCTGAGTTGCCAGAAGCTGTAGTAAGTGATAAAGGCGTACCAGAAGTTCAACCAGCGTTACCGGAA GCAGTCGTAACCGACAAAGGTGAGCCCGCTGTCCAACCTGAATTACCCGAAGCTGTTGTAACTGACAAAG GCGAGCCTGAAGTTCAACCTGAATTACCCGAAGCTGTTGTAACTGACAAAGGCGAGCCTGAAGTTCAACC AGCGTTACCCGAAGCGGTTGTAAGTGATAAAGGTGAACCAGAGCAGGTAGCCCCATTGCCAGAATATACA AGACCACAAGCAGGTGCAGTAGTTGAACCTGCAATCCAACCAGAGTTACCAGAAGCTGTTGTAACTGACA AAGGAGAACCAGCAGTCCAACCAGAGCTACCGGAAGCGGTTGTAACTGACAAAGGTGAGACTGAGGTTCA ACCAGAGTCGCCAGATACTGTGGTAAGTGATAAAGGTGAACCTAAACAGGTAGCACCGCTTCCAGAATAT ACAGGACCACAAGCCAGCGCTATTGTTGAACCAGAGCAAGTAGCACCACTACCAGAATACACAGGGGTAC AAGCCGGATCGATAGTCGAGCCAGAGAAAGTAGAAGCACCGAAAGAATATACTGGTAAAATCGAACAACC TAGTGCAGAAGATACTAAACCTGAAAATGAGGCAAGCTCTACAAATGGGGAATCGGAACGTCCTAAAGAT AAAATTAAAGAAGAAAAACAAGTCGACAAGAAACTAGAACTTAGAAATGTTTCAAACGTGGAATTATATA CGGTAGAAAATAATAAATATCGACATATTACGGCTGTAGATGGTGCTTTAGATAGTTCATTGAAGTATTT CATGAAGGTAAAATCAGAAAATTTTAAAGATATAATGTTGCCTGTTACTAAAATTGAAAGTACAACAAAA AACAATAAAGAAGTATACAAAATTGTGGCTCATGCAGAAAATCTAATTCAACACGAAAACAATGTTATTT CGAATGACTATACATATTATTTACCAAAAACTCAGCAAAGTGAAACTGGCGTCTATACATCATTTAAAAA TTTAGTTGATGCAATGAATAGTGACCCTAATGGAACATTCCATTTAGGTGCAACTATGGATGCTCGTGAA GTTGAACTTCCGGATGATCAAGAAAGTTATGTAAAAAATGAATTTTACGGAAAATTAATAGGTGAAAATA ATGGTAAGTATTATGCTATTTATAACTTGAAAAAACCTTTATTTAAAACTCTAAACACCGCTACTATTCA NAATCTTTCAATAAAAGAAGCGAATGTTTCTTCTAAAGAAGATGCTGCTACNATATCGAAAGAAGCAAAA TACAATACTCTTATAGATANTGTTCATTCTGATGGTATTATAGCTGGTGAACGTGGAATTGGTGGATTGG TTTCAAAAGTAGATAACTCGAGAATTTCTAATAGTAGTTTTACAGGCAGAATAACTAACACATATGATAC AACTGTAGGGTATGAAATTGGTGGTTTAGTAGGTAAACTTTCTGGTTCGCTTGCTTCTATAGAGAAATCA ATAGCATCGATTGACATAGCCTCTAATGCAAAATCAGGAGATCAAATTGTTGGTGGTATAGCCGGAGTTG TTGAGAAAAGTGCGACAATTAAGTATAGCTATGTTGAAGGAAATGTTAACAATGTGCGACACTTTGGTAA AGTTGGGGGAGTTGCAGGTAATCTTTGGGATAGAGATTCACAAGATGTAAGTAAATCAGGTAAACTATCA TATGTTTTAAGTGATGTTAATGTAACAAATGGTAATGCTATATCGGGTGATAATTTTGATAATATGAAAG AAGATCATGCTTATAGTAGTAAAGGCAATAAAGTAGTAAATGTAGTCCAAGTAGATGATGAACTTGTGAC TAAAGATTCAGATGTACAAAGAGGTACGGTATTAGATGCTGATAAAGTAAAAGAGAAAAAGGCAGAATTG GTTTCCAAACACAGCACTAAAGTAGAAGATTTTGATTTCACTTCAAGATACACTACTATTTACAATGAAG TAACAGGTTATCAAAAGTCGAGAGAACAAGTATATAAAAATATTGAAAAACTATTACCGTTCTATAATCG AGAGACAATTGTTAAATATGGTAATTTAGTAGATGAAAGCAGCGAGCTATTTACTAAAGAACTTCTATCA GTTGTTCCTATGAAGAATAATGAAGTAATAACTGATATTAATAAAAATAAACAAGAAATAAACAAATTGT TATTACATTTTGAAGGTAATAAATCACAAGTATTAAATATTGCATATAAGAATGATTTCTCTAAAGTTGC TGAGTATAGTATAGAGTATCAAGGATTATTATATACTCCCAATACTCTATTGCATGACTACAGTAATATT GTAGATAATGTTTTAACTGACTTGAATTCTGTACAATATGATTCAAATGCAATTAAGAAAATATTAGATA TCTCAGATAAAGTTAAAAATACGGAATTATACTTAGATGAGCAATTTGTTAAAACAAAAGCAAATATAAA AGATACTTTATCAAAACTTCTGTCAGCGGATGCAGCAATCGCTGAGAATAGTAATTCGATAATTGATAAT TATGTTATTCAGAAAATCAAACAGAATAAAGAAGCTTTATTGTTAGGATTAACATACTTAGAGCGTTGGT ACAATTTTAAATATGGTGAAACGAAAGCAAAAGATTTAGTTATGTATCACTTGGATTTCTTCGGTAAATC TAATAGTTCTGCATTAGATAATGTTATTCAATTAGGTAAATCTGGATTTAACAATTTACTAGCAAAAAAT AATGTAATTACTTACAATGTATTATTATCTAAAAATTATGGAACTGAAAGTTTATTTAAAGCATTAGAAG GATATAGAAAAGTATTCTTACCAACAACTTCTAACAATGAGTGGTTTAAAGCTCAAACTAAAGCATATAT TGTTGAAGAAAAATCTTCTATTCCAGAAGTAAGTAAAAAACAATCAGAACAAGGAACTAAGTATTCTATA GGAATTTATGATAGATTAACTAGTCCGTCATGGAAATATCAAAGTATGGTCTTACCACTATTAACTTTAC CTGAAGAAAAAACAGTATTTATGATAGCGAATATTTCAACAATAGGATTTGGTGCTTATGATAGATATAG AAGTAAAGTCCATCCTAAAGGAGATAACTTAAATAAATTTGTAGAAGACAATGTAAGAGAAGCTGCAAAA AGATTTAGAGATCATTATGATTATTGGTATAAAATATTAGAGCCTGAGAATAGAGAGAAACTTTATAGAA GTTTATTAGTATACGATGCATTTAAATTTGGTCGAGATAATACTGAAGATAAAGTAACTTATCAAGCTGA TTTTGAAACTGATCATCCAGCTATAAAATACTTCTTTGGACCTGCGGGGAATAATGTTGTTCATAATGGA CACGGAGCATATGCTACCGGAGATGCATTCTATTATATGGCATATCGTATGTTGGATAAAGATGGAGCTG TAACATATACTCATGAAATGACACATAACTCTGATAGAGAAATTTATCTTGGAGGATATGGAAGAAGAAG CGGATTAGGGCCTGAGTTTTATGCTAAGGGCTTATTACAAGCACCTGACCACCCATATGATCCAACAATA ACAATTAACTCTGTGTTGAAATATGATGATTCAGAAAATTCAACAAGACTTCAAGTAGCTGATCCAACTC AACGATTTAATAGTGCAGAAGACCTACATAATTATATGCATAATATGTTTGATTTAATATATACTCTTGA AATATTAGAAGGTCGTGCTGTAGCTAAATTAGATTATAATGCGAAAAATGATTTATTAAGAAAAATTGAG AATAAATATAAGCAAGATCCAGATGGTAATTCTGTTTATGCGACAAATGTTGTTCGCAGATTAACGATGG ATGAAGTTAATAAATTAAATTCTTTTGATAGTTTAATTGAAAATGATATTATTACTAGCAGAGGGTACAA AGACCAAGAATATAAGAGAAATGGTTATTATACAATTGATTTATTTTCACCGATTTATTCAGCTCTTAGT GGAGAGAAAGGGACTCCTGGTGATTTAATGGGACGTCGTATAGCATTCGAATTATTAGCTGCAAAAGGAT ATAAAGAGGGCATGGTACCTTATATCTCAAATCAATATGAAAAAGATGCAAAAGCTGCGGGAAGTAAGAT TAAATCTTATGGTAAAGAAGTAGGTTTAGTTACAGATAAATTAGTACTTGAAAAGGTATTTAATAATCGT TACTCATCTTGGGTAGAATTTAAAAAAGCAATGTATAATGAGCGAATAGCTAAATTTAATAATCTAATAA GTGTTAGCTTTAATAATCCAAATGTAAGTTGGGGAAGAACTAATAGAATAACAATAACTAGCATAGCCAA CCTTCAAAATATGATAAATACGGCTGTCAATGAAGATGCTGAAGATTTTAGAGCACAATTATACCCTGAT ACAAATAGTAGAGTTCTTAAACTGAAAAAAGCAATATATAAAGCCTATCTTGACCAAACAAATGATTTTA GAAGATCAATTTTTGAGAATAAAAAATA
Protein Sequence	>gi\|194398492\|ref\|YP_002037763.1\| immunoglobulin A1 protease [Streptococcus pneumoniae G54] MEKYFGEKQERFSFRKLSVGLVSATISSLFFMSVLASSSVDAQETAGVHYKYVADSELSSEEKKQLVYDIPTYVENDDETYYLVYKLNSQNQLAELPNTGSKNERQALVAGASLAALGILIFAVSKKKVKNKTVLHLVLVAGIGNGVLVSVHALENHLLLNYNTDYELTSGEKLPLPKEISGYTYIGYIKEGKTTSDFEVSNQEKSAATPTKQQKVDYNVTPNFVDHPSTVQAIQEQTPVSSTKPTEVQVVEKPFSTELINPRKEEKQSSDSQEQLAEHKNLETKKEEKISPKEKTGVNTLNPQDEVLSGQLNKPELLYREETIETKIDFQEEIQENPDLAEGTVRVKQEGKLGKKVEIVRIFSVNKEEVSREIVSTSTTAPIPRIVEKGTKKTQVIKEQPETGVEHKDVQSGAIVEPAIQPELPEAVVSDKGVPEVQPALPEAVVTDKGEPAVQPELPEAVVTDKGEPEVQPELPEAVVTDKGEPEVQPALPEAVVSDKGEPEQVAPLPEYTRPQAGAVVEPAIQPELPEAVVTDKGEPAVQPELPEAVVTDKGETEVQPESPDTVVSDKGEPKQVAPLPEYTGPQASAIVEPEQVAPLPEYTGVQAGSIVEPEKVEAPKEYTGKIEQPSAEDTKPENEASSTNGESERPKDKIKEEKQVDKKLELRNVSNVELYTVENNKYRHITAVDGALDSSLKYFMKVKSENFKDIMLPVTKIESTTKNNKEVYKIVAHAENLIQHENNVISNDYTYYLPKTQQSETGVYTSFKNLVDAMNSDPNGTFHLGATMDAREVELPDDQESYVKNEFYGKLIGENNGKYYAIYNLKKPLFKTLNTATIXNLSIKEANVSSKEDAATISKEAKYNTLIDXVHSDGIIAGERGIGGLVSKVDNSRISNSSFTGRITNTYDTTVGYEIGGLVGKLSGSLASIEKSIASIDIASNAKSGDQIVGGIAGVVEKSATIKYSYVEGNVNNVRHFGKVGGVAGNLWDRDSQDVSKSGKLSYVLSDVNVTNGNAISGDNFDNMKEDHAYSSKGNKVVNVVQVDDELVTKDSDVQRGTVLDADKVKEKKAELVSKHSTKVEDFDFTSRYTTIYNEVTGYQKSREQVYKNIEKLLPFYNRETIVKYGNLVDESSELFTKELLSVVPMKNNEVITDINKNKQEINKLLLHFEGNKSQVLNIAYKNDFSKVAEYSIEYQGLLYTPNTLLHDYSNIVDNVLTDLNSVQYDSNAIKKILDISDKVKNTELYLDEQFVKTKANIKDTLSKLLSADAAIAENSNSIIDNYVIQKIKQNKEALLLGLTYLERWYNFKYGETKAKDLVMYHLDFFGKSNSSALDNVIQLGKSGFNNLLAKNNVITYNVLLSKNYGTESLFKALEGYRKVFLPTTSNNEWFKAQTKAYIVEEKSSIPEVSKKQSEQGTKYSIGIYDRLTSPSWKYQSMVLPLLTLPEEKTVFMIANISTIGFGAYDRYRSKVHPKGDNLNKFVEDNVREAAKRFRDHYDYWYKILEPENREKLYRSLLVYDAFKFGRDNTEDKVTYQADFETDHPAIKYFFGPAGNNVVHNGHGAYATGDAFYYMAYRMLDKDGAVTYTHEMTHNSDREIYLGGYGRRSGLGPEFYAKGLLQAPDHPYDPTITINSVLKYDDSENSTRLQVADPTQRFNSAEDLHNYMHNMFDLIYTLEILEGRAVAKLDYNAKNDLLRKIENKYKQDPDGNSVYATNVVRRLTMDEVNKLNSFDSLIENDIITSRGYKDQEYKRNGYYTIDLFSPIYSALSGEKGTPGDLMGRRIAFELLAAKGYKEGMVPYISNQYEKDAKAAGSKIKSYGKEVGLVTDKLVLEKVFNNRYSSWVEFKKAMYNERIAKFNNLISVSFNNPNVSWGRTNRITITSIANLQNMINTAVNEDAEDFRAQLYPDTNSRVLKLKKAIYKAYLDQTNDFRRSIFENKK
Molecule Role	Virulence factor
Molecule Role Annotation	MUTATION: iga mutant is attenuated in mice (Chiavolini et al., 2003).
COG	COG3583S, under S: Function unknown
References	*Chiavolini et al., 2003:* Chiavolini D, Memmi G, Maggi T, Iannelli F, Pozzi G, Oggioni MR. The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice. BMC microbiology. 2003; 3; 14. [PubMed: 12841855].


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igA