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SP_0445

Victor ID 3197
Gene Name SP_0445
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930383
NCBI Protein GI 15900362
Locus Tag SP_0445
Protein Accession NP_344966.1
Other Database IDs UniProtKB-ID: Q97SD9_STRPN
UniRef100: UniRef100_E0TSA5
UniRef90: UniRef90_C1C5H8
UniRef50: UniRef50_B7GH16
UniParc: UPI0000051439
EMBL: AE005672
EMBL-CDS: AAK74606.1
RefSeq_NT: NC_003028.3
HSSP: P07342
EnsemblGenome: EBSTRG00000027088.
EnsemblGenome_TRS: EBSTRT00000027088
EnsemblGenome_PRO: EBSTRP00000026180
GenomeReviews: AE005672_GR
KEGG: spn:SP_0445
TIGR: SP_0445
HOGENOM: HBG323037
OMA: SESIKPQ
ProtClustDB: PRK07282
BioCyc: SPNE170187-1:SP_0445-MONOMER
Taxonomy ID 170187
Gene Starting Position 417448
Gene Ending Position 419148
Gene Strand (Orientation) +
Protein Name acetolactate synthase catalytic subunit
DNA Sequence 
>gi|194172857:417448-419148 Streptococcus pneumoniae TIGR4 chromosome, complete genome
AATGGAGAAAATCAGTTTAGAATCTCCTAAGACGGGGTCGGACCTAGTTTTGGAAACACTTCGTGATTTA
GGAGTTGATACCATCTTTGGTTATCCTGGTGGTGCGGTTTTGCCTTTTTATGATGCGATATATAATTTTA
AAGGCATTCGCCACATTCTAGGGCGCCATGAGCAAGGTTGTTTGCATGAAGCTGAAGGTTATGCCAAATC
AACTGGAAAGTTGGGTGTTGCCGTCGTCACTAGTGGACCAGGAGCAACAAATGCCATTACAGGGATTGCG
GATGCCATGAGCGATAGCGTTCCCCTTTTGGTCTTTACAGGTCAGGTGGCGCGAGCAGGGATTGGGAAGG
ATGCCTTTCAGGAGGCAGACATCGTGGGAATTACCATGCCAATCACTAAGTACAATTACCAAGTTCGTGA
GACAGCTGATATTCCGCGTATCATTACGGAAGCTGTCCATATCGCAACTACAGGCCGTCCAGGGCCAGTT
GTAATTGACCTACCAAAAGACATATCTGCTTTAGAAACAGACTTCATTTATTCACCAGAAGTGAATTTAC
CAAGTTATCAGCCGACTCTTGAGCCGAATGATATGCAAATCAAGAAAATCTTGAAGCAATTGTCCAAGGC
TAAAAAGCCAGTCTTGTTAGCTGGTGGTGGAATTAGTTATGCTGAGGCTGCTACGGAACTAAATGAATTT
GCAGAACGCTATCAAATTCCAGTGGTAACCAGTCTTTTGGGACAAGGAACGATTGCAACGAGTCACCCAC
TCTTTCTTGGAATGGGAGGCATGCACGGGTCATTCGCAGCAAATATTGCTATGACGGAAGCGGACTTTAT
GATTAGTATTGGTTCTCGTTTCGATGACCGTTTGACGGGGAATCCTAAGACTTTCGCTAAGAATGCTAAG
GTTGCCCACATTGATATTGACCCAGCTGAGATTGGCAAGATTATCAGTGCAGACATTCCTGTAGTTGGAG
ATGCTAAGAAGGCCTTGCAAATGTTGCTAGCAGAACCAACAGTTCACAACAACACTGAAAAGTGGATTGA
GAAAGTCACTAAAGACAAGAATCGTGTTCGTTCTTATGATAAGAAAGAGCGTGTGGTTCAACCGCAAGCA
GTTATTGAACGAATTGGTGAATTGACGAATGGAGATGCCATTGTGGTAACAGACGTTGGTCAACACCAAA
TGTGGACAGCTCAGTATTATCCCTACCAAAATGAACGTCAGTTAGTGACTTCAGGTGGTTTGGGAACAAT
GGGCTTTGGAATTCCAGCAGCAATCGGTGCTAAAATTGCTAACCCAGATAAGGAAGTAGTCTTGTTTGTT
GGGGATGGTGGTTTCCAAATGACCAACCAGGAGTTGGCTATTTTGAATATTTACAAGGTGCCAATCAAGG
TGGTTATGCTGAACAATCATTCACTTGGAATGGTTCGCCAGTGGCAGGAATCCTTCTATGAAGGCAGAAC
ATCAGAGTCGGTCTTTGATACCCTTCCTGATTTCCAATTGATGGCGCAGGCTTATGGTATTAAAAACTAT
AAGTTTGACAATCCTGAGACCTTGGCTCAAGACCTTGAAGTCATCACTGAGGATGTTCCTATGCTAATTG
AGGTAGATATTTCTCGTAAGGAACAGGTGTTACCAATGGTACCGGCTGGTAAGAGTAATCATGAGATGTT
GGGGGTGCAGTTCCATGCGTA
Protein Sequence 
>gi|15900362|ref|NP_344966.1| acetolactate synthase catalytic subunit [Streptococcus pneumoniae TIGR4] MEKISLESPKTGSDLVLETLRDLGVDTIFGYPGGAVLPFYDAIYNFKGIRHILGRHEQGCLHEAEGYAKSTGKLGVAVVTSGPGATNAITGIADAMSDSVPLLVFTGQVARAGIGKDAFQEADIVGITMPITKYNYQVRETADIPRIITEAVHIATTGRPGPVVIDLPKDISALETDFIYSPEVNLPSYQPTLEPNDMQIKKILKQLSKAKKPVLLAGGGISYAEAATELNEFAERYQIPVVTSLLGQGTIATSHPLFLGMGGMHGSFAANIAMTEADFMISIGSRFDDRLTGNPKTFAKNAKVAHIDIDPAEIGKIISADIPVVGDAKKALQMLLAEPTVHNNTEKWIEKVTKDKNRVRSYDKKERVVQPQAVIERIGELTNGDAIVVTDVGQHQMWTAQYYPYQNERQLVTSGGLGTMGFGIPAAIGAKIANPDKEVVLFVGDGGFQMTNQELAILNIYKVPIKVVMLNNHSLGMVRQWQESFYEGRTSESVFDTLPDFQLMAQAYGIKNYKFDNPETLAQDLEVITEDVPMLIEVDISRKEQVLPMVPAGKSNHEMLGVQFHA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0445 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].