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codY from Streptococcus pneumoniae JJA

Victor ID 3933
Gene Name codY from Streptococcus pneumoniae JJA
Sequence Strain (Species/Organism) Streptococcus pneumoniae JJA
NCBI Gene ID 7679394
NCBI Protein GI 225855025
Locus Tag SPJ_1490
Protein Accession YP_002736537.1
Other Database IDs UniProtKB-ID: CODY_STRZJ
UniRef100: UniRef100_C1C8H3
UniRef90: UniRef90_Q04JG7
UniRef50: UniRef50_A2RCV3
UniParc: UPI000152B52E
EMBL: CP000919
EMBL-CDS: ACO18042.1
RefSeq_NT: NC_012466.1
EnsemblGenome: EBSTRG00000076360
EnsemblGenome_TRS: EBSTRT00000076362
EnsemblGenome_PRO: EBSTRP00000072098
GenomeReviews: CP000919_GR
KEGG: sjj:SPJ_1490
OMA: HIFEELD
ProtClustDB: PRK04158
BioCyc: SPNE1313:SPJ_1490-MONOMER
Taxonomy ID 488222
Gene Starting Position 1415635
Gene Ending Position 1416423
Gene Strand (Orientation) -
Protein Name GTP-sensing transcriptional pleiotropic repressor CodY
DNA Sequence 
>gi|225853611:1415635-1416423 Streptococcus pneumoniae JJA, complete genome
ATTAGTAATCTCTTTTCTTCACTTCTTCAAAAATATCTGAAATCAAGACCTTAAGATAGGTTCCCTTCAT
TCCAAGTGAGCGACTTTCAATAATCCCCGCAGACTCAAGTTTACGAAGAGCATTGACAATCACAGAGCGA
GTGATTCCGATACGATCTGCAATCACTGACGCAGTCAACTTCCCTTCATTTCCATTTAATTCCCCTAAAA
TTGCTGAAACAGCACGGAGTTCGGAGTAAGAAAGGGTATTGACCGCCATGGTGACAGCAGTACGACGACG
AATATTTTTCTCATCTTCTTCACGTTGGAAGTTAAGAAGCTGAATCCCAACAACGGTACTGGCAATCTCA
ACAAGAACCAAGTCCTCATCTTCGAATTTTTTATCATTACGCCAAATAATCAAAGAACCAAGGCGAATCC
CCGATACATGAATCGGTGCAATAGTCGTCAAGCCATCTGGAAAATCATCTCTACTCTCAACAGGGAAAAT
ACTCATATCATGCTCAACAGGCAAGTTTGCTTCTGTTTCGTAAATCATATTAGCCCCTTGAACGTAGTCA
TCTGGGAAAATCTTAGTTTGGAAGAATTGCTCTACGCGATCTGTATTTGTTTTATAACGCATAAAATAGC
CAAGCAGACGTCCCTTACTATTGATAATGCAGGCATTGCAATGAATAATATCCGCTAACTGACGCGTAAT
AGCGTTGTAAGGGAGCTCATCCTGCAACTGCTCCTCTGAGCGTTTCAAAATTGATGTAATTTTTCTAGTT
TTTTCTAATAAATGTGCCA
Protein Sequence 
>gi|225855025|ref|YP_002736537.1| transcriptional repressor CodY [Streptococcus pneumoniae JJA] MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGKLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro (Hendriksen et al., 2008).
COG COG4465K, under K: Transcription
References
Hendriksen et al., 2008: Hendriksen WT, Bootsma HJ, Estevão S, Hoogenboezem T, de Jong A, de Groot R, Kuipers OP, Hermans PW. CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. Journal of bacteriology. 2008; 190(2); 590-601. [PubMed: 18024519].