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ply from Streptococcus pneumoniae ATCC 700669

Victor ID 3617
Gene Name ply from Streptococcus pneumoniae ATCC 700669
Sequence Strain (Species/Organism) Streptococcus pneumoniae ATCC 700669
NCBI Gene ID 7328330
NCBI Protein GI 221232655
Locus Tag SPN23F_19470
Protein Accession YP_002511809.1
Other Database IDs UniProtKB-ID: B8ZNM4_STRPJ
UniRef100: UniRef100_Q04IN8
UniRef90: UniRef90_Q04IN8
UniRef50: UniRef50_Q04IN8
UniParc: UPI000000E963
EMBL: FM211187
EMBL-CDS: CAR69699.1
RefSeq_NT: NC_011900.1
EnsemblGenome: EBSTRG00000070674.
EnsemblGenome_TRS: EBSTRT00000072818
EnsemblGenome_PRO: EBSTRP00000067195
GenomeReviews: FM211187_GR
HOGENOM: HBG337470
ProtClustDB: CLSK877006
Taxonomy ID 561276
Gene Starting Position 1889502
Gene Ending Position 1890917
Gene Strand (Orientation) -
Protein Name pneumolysin (thiol-activated cytolysin)
DNA Sequence 
>gi|221230948:1889502-1890917 Streptococcus pneumoniae ATCC 700669, complete genome
CCTAGTCATTTTCTACCTTATCTTCTACCTGAGGATAGAGAGTTGTTCCCCAAATAGAAATCGTCCGCTT
ACGCACTAGTGGCAAATCGGTTTTTTCATAAACCGTACGCCACCATTCCCAGGCAAGCCCGGTACACTCT
CTAATTTTGACAGAGAGATTACGAACATTCCCTTTTAAAGGAATACTAGTGGTAAAGTGAGCCGTCAAAT
CCTGCCCATTTCTGTCCCAAGCCTTAGGAGTCAAGACTTCCTTACCTTGATGATCATAGGATAATTCATC
CCAAGTAATATAATATTGGGCAACATAGGCACCACTATGATCCAGCAGTAAATCTCCGTTTCTGTAAGCT
GTAACCTTAGTCTCAACATAGTCTGTACTATTTTGAAAGGTCGCAACTACATTGTCACGTAAAAAAGAAG
TTGTATAGGAAATCGGCAAGCCTGGATGATCTGCTGTAAAGCGACTGCCTTCTTGAATCAAGTCCTCTAC
CATGTCCACCTTGCCTGTTACAACTCGGGCACCCGAACTTGGGTCGCCCCCTAAAATAACCGCCTTCACT
TCTGTATTGTCCAAAATCTGCTTCCACTCTGTCTGAGGAGCTACCTTGACTCCTTTTATCAAAGCTTCAA
AAGCAGCCTCTACTTCATCACTCTTACTCGTGGTTTCCAACTTGAGATAGACTTGGCGCCCATAAGCAAC
ACTCGAAATATAGACCAAAGGACGCTCTGCAGAAATTCCTCTCTGTTTTAAATCCTCTACCGTTACAGTA
TCTTGAAACACATCTCCTGGATTTTTAACAGCATCTACGCTGACTGTATAATAAATCTGCTTAAAATTAA
CAATCTGAATCTGCTTTTCGCCTGAATGGACAGAGTTAAAATCAATATCAAGAGAATTCCCTGTCTTTTC
AAAGTCAGAACCAAACTTGACCTTGAGTTGTTCCATGCTGTGAGCCGTGATTTTTTCATACTGCATTCTA
GCTGGGACATTATTGACCTGACCATAATCTTGATGCCACTTAGCCAACAAATCGTTTACCGCTCCGCGAA
CACTTGAATTGCTGGGGTCTTCCACTTGGAGAAAGCTATCGCTACTTGCCAAACCAGGCAAATCAATACT
ATAAGTCATCGGAGCACGATCGACCGCAAGAAGAGTGGGATTATTCTCTAACAAGGTCTCATCCACTACG
AGAAGTGCTCCAGGATAGAGGCGACTGTCGTTGGTAGCTGTTACAGAAATATCACTTGTATTTGTCGACA
AGCTCCGCTTCTTTCTTTCGATAACAACAAACTCATCGGGTAGCTGATTACCCTCTTTGATGAAACGATT
TTCAATACTTTCTCCCTGATGGGTCAAGAGTTTCTTTTTATCGTAATTCATAGCTAGTATAAAGTCATTT
ACTGCTTTATTTGCCA
Protein Sequence 
>gi|221232655|ref|YP_002511809.1| pneumolysin (thiol-activated cytolysin) [Streptococcus pneumoniae ATCC 700669] MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWDELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ply mutant is attenuated in mice (Berry and Paton, 2000).
References
Berry and Paton, 2000: Berry AM, Paton JC. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins. Infection and immunity. 2000; 68(1); 133-140. [PubMed: 10603379].