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SP_0268

Victor ID 3172
Gene Name SP_0268
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930075
NCBI Protein GI 15900202
Locus Tag SP_0268
Protein Accession NP_344806.1
Other Database IDs UniProtKB-ID: Q97SQ7_STRPN
UniRef100: UniRef100_Q97SQ7
UniRef90: UniRef90_D3HB38
UniRef50: UniRef50_D3HB38
UniParc: UPI0000051385
EMBL: AE005672
EMBL-CDS: AAK74446.1
RefSeq_NT: NC_003028.3
PDB: 2J44
EnsemblGenome: EBSTRG00000025252.
EnsemblGenome_TRS: EBSTRT00000025252
EnsemblGenome_PRO: EBSTRP00000024344
GenomeReviews: AE005672_GR
KEGG: spn:SP_0268
TIGR: SP_0268
HOGENOM: HBG575037
OMA: SNFEADA
ProtClustDB: CLSK803694
BioCyc: SPNE170187-1:SP_0268-MONOMER
Taxonomy ID 170187
Gene Starting Position 242845
Gene Ending Position 246687
Gene Strand (Orientation) -
Protein Name alkaline amylopullulanase, putative
DNA Sequence 
>gi|194172857:242845-246687 Streptococcus pneumoniae TIGR4 chromosome, complete genome
TTTAGTTCTCTTTTTTATTTTTTAGTAAGAAACCGAGACCAAGGAGCGCAAGGAGGCTGATTCCTGCAAA
TAGGAGTTTGTTTTCGTTTTTGATTCCTGTATTTGGAAGTTCAGCTTGTTTATCTGGGGTTGCAGGTATA
TTTTCCTTGCTAGAGTTTTCTACCGATTCGTTTCGAACCGCTTCTTTTACAGATGATGCTTGTGCTTCTT
GTGCTGGTTGTTCAGCTTGTGAATCAGCTGTAGCTTGGCTAGGTTTATTTTCCGCATCAGCTACTTTGGC
ATCTGGTTTAGTAGAATCAGGTCTAGCTTCTGGAGCTGGGTCTTGATGTGCAGGGTGAGAAGCTTCATTT
TGATGTTCAGGCTTGGAAGGGGTTGAGTCTGGTTTCTCTTCTGCAGTTGACTCATGGCTAGTTCCATTTT
GAGAGACTCGAAGAACAGTAGCTGTAAGGGCATTCAATTTCAAGCCTTTTTCAGTCCATTCAAGTCCTTT
CGGGTTGGCAATTCCGACTGGTCCTGCTTGGTTTTCATCTGCCAAAACTTCCGCATTTCTTAGATGTGCA
AAGGCAGTTCCCAAATTAAATTCGCGAGCTTTTTCATCCGCATTGACAAAGACTGCGTAGATATCGCCGT
TTGGAGCAGTGATTTGGTAGCCAATCACTACATCCTCTTTTTCCACACCATTTTGGCCTGGGACAGTGAT
GAGGTGGACACGGTCTTTGATATCTTGAAGACTCTTAAGTCGGAAGGCATCTGTAGATTGACGAAGGGCA
ATCAAACCTTTCATATAGTCACGGCTCTTGACATTTTCAGGATAAGCTTTACCATCTGTAGCCTTAGTCC
AGTCAAACTTGTTGACTGCATCACTAGAATCGTAAGAGTCATGGATGAAGTAAGGATAGTCAAATGGGTT
GCCGTCCTTATCACGCAACAAGTGAGATTTGTTTGGAACCTTATCCTCTGCTACTGGAGTCTTGTAGGCT
GGGTCACGGAATTGTTTAGTACGTCCATATTCCTGACCGGAGTGGATAAATGGAGTTCCTTGAGCTGTCA
AGACCATGAGATTTCCAAGTCGTAAACGACGGTGGATTTCAGCATAGTTCTCAGCCTTGCTTGGGTCTTT
TTTGATAGACTGGGCAATGATGTCAAAGAGGGTCAAGTTATCATGGGCTGCGATGTATTGGATGACATCT
CCAGGGCTGTCAGCTTCAAAGTTAGTTGGTTGAGCAATGAGATTTTTAAAGATGGTGTTGACATCACGCT
TGCCACCTGTGATAAAGGCAGGTTGACCTTCGTTTGGATAACCAGATTTGAGGTTGTTACGGATGTCATC
TGAAAAGACAGCGACAGTATCGGTATGTTTCATCCAATCTTGGTCAGCAGCTTTAGTAGGCATGTTTTCA
TCACCGGCATAGGTTCTCCAACCTTCACCAAGCATGATGAGGTTTGGATTGAGGGCGCGTGCAGCCTTGT
AAGCTTCTTCGATAGAAGCGGCGTCATGGTCTCCCATCATATCGAAACGGAAGCCATCCACTTTGTAGGT
ATCAACTAGGTATTTGATAGAGTCAATTAGGAGCCGTTTGGTCATATGGTGGGTTGTCCCCAAGCGTCCA
CCACCAAAGCTAGTTCGAGGTGTGCCATCGGCATCCATAAAGTGGTAGTAGTTTGGTTCCAAATCTTCAA
AGAGATCGACTTTGGCTGTGTGGTTATAAACGACATCTAGGATAGCTCCCATACCACGTTTGTGGATTTC
GTTGATGAGGTTTTTAAATTCTGCGATTCGTTTTTCTGGATTCTTAGGATCGCTTGAGTACATACCAGTC
AAGGAGAAGTAGTTTTGAGGGTCATATCCCCAGTTGTAGTTGCTGTTGCTTGAAGCGTAGTCAGACAAGC
GTTCATGGTTTTTCAATTCATTGACAAAGTAGTAAGACAAGACTGGAAGGAGCTGGATATGGGTTACACC
CAAGTCTTTGAGATAGTCTAGTTTTTCAATGAAGGCTTCAAAAGTCCCAAATGGTTTGGTCAAGTCTTTT
GCAATGGCAGGATCTGAAGTGAAATCACGCACATGAGCTTCGTAGATAACGGCGTCTTCACGAGTCTTGA
AATTGTGAATCTTACCATAAGTCAAGTCTTGAGGTCCGAGTTTAGCTGGATCTACAAAGGCGGCTTTAGC
CACTTTATGGGCATCGTCAATCTTGGAATCGTCGCTATTCCAAGCAGCAAGAGATTTAGCGTAAGGATCG
AGTGCAAGAACAGTTTTACCTTGACGCTCGATTTGGTATTGATAATAGTAGCCAGTGAAATCTGTGATTC
CGAGTTTGTTTGTGCTGTCTAGAGTTTGTTTCCAAGTTCCTCTTTCCCCTTTTTCAAGAGCGACAGTTCC
AACTACTTTGTCAGGGTCATTCTTGTCGTAGACAACAACAGAAACCTTATCAGCACTTGGTGACCAAAGG
GTCAAATCAACTTGTTTTCCTTCTTCTTTTAGGTCAGCTCCCAGTTTGCCATCATAGCTGTATGTCTCAT
CTTTCAGGCGCCAGCTTGTTTTGGTAGTGAATTGGTCGGAATTGTAGCTAACAGTATAAGGATGTTTTGT
GTCAGAGAAATCTCCGCTGTAGGTCACTTTCTTACCAGCTTCATCGATTGCAACATCGGTAATAGTTACC
TTGTTTCCTAGGTGATTAGTGATGTTGGAGTGTTTGAGGATATCTTCTTTTTTAGCACCGACAAGTGTTG
AAAAGCTACTTTCAATGCTAGAAGTGCCTACGTGTTGGGCTCCTGTCATACGGATATCATGGACATAGTA
TGGATTTGTGTAAATCGATTCATCATCGTCTTTTAGGAAAATTTGGCTATGATTTTTCAAATCTGTGAAC
TTATAATTTTCTTTACGGATTTTCACGTCGTCTCCTTGTTTGCTCTCATCTAGTAATAAAAATCCAAATT
CTCTTGCGGCTTCATTAAGAGGAATGTCGATATAGCGGCCATATTTGCCTGTAGCCGTAAAGTCTGTTCC
GTCAGGCCATTGAGCGCTACTTGGATTTTTCACATCTCCCCAGTACCAGAGAGATTTCTTGTCATAGTTG
CCATCTGTGCGGTAGTAGTTGACGCGAACAGTTCCTGCAGGCTGTGGCTCGTAAGAGAAAACCTTGTAAT
CTTGGTCTAACCAAGCTTCGTTCATTTTTGGAACTAGTTTTTCTACAGATTTATCGCCGGTTAGATTTTT
TCCAGCTGTATTGTTGATGAGGAAGCTAATTTTCTTGGCTTGTTCTCCCTTTAATTTGACATCTAGGTAA
TAGCCGTAGTCATCTTTCTTGGCATCCTTGAAGGACAAAGCTCCGTTTGGCCAGTTTTCAGATGGTTTTT
CAACATCGTCCCAAGTCCATAGTCCTTGAGCATCCTTGTTTTCTTCAGGAAGTTTTTTGACATGGATACG
GAAGTAGTTATCTTCGATGGGCTCTTCTGCCTTAGTTTCAGTTGTTACTGGACTAGTAGAAGTAGTTGGC
TCACTTGAACGATCTTGTCCAGTTTGTGGTGCTGGATCGGCTGGGCTTGCAGCAGGTTTTTCTTCTGTTT
TCTCTAGGGAAGCGTTTGCATTTCCAGGTGAAGAAATATCACTTTCGTTCTTACCAGAGCCAGCTGCTGT
ATCAGTAAGAGGTTGGGCAAGGGTGGTTGTATTTCTGTTGTTGGGTTCGTTAGTGGTTGGTGTACTTTCG
TCGGATGAGATAGTTGGTGTAGCCATGGCAAGCAAGACAAGGCTTGCGCCGATAAGGACAGAACCAGTTC
CATTTTTGAGGGAACGGATGCTGTAGACCATTTTTTTCTCAGTGTGAGATGGTGTTTTTCTCA
Protein Sequence 
>gi|15900202|ref|NP_344806.1| alkaline amylopullulanase [Streptococcus pneumoniae TIGR4] MRKTPSHTEKKMVYSIRSLKNGTGSVLIGASLVLLAMATPTISSDESTPTTNEPNNRNTTTLAQPLTDTAAGSGKNESDISSPGNANASLEKTEEKPAASPADPAPQTGQDRSSEPTTSTSPVTTETKAEEPIEDNYFRIHVKKLPEENKDAQGLWTWDDVEKPSENWPNGALSFKDAKKDDYGYYLDVKLKGEQAKKISFLINNTAGKNLTGDKSVEKLVPKMNEAWLDQDYKVFSYEPQPAGTVRVNYYRTDGNYDKKSLWYWGDVKNPSSAQWPDGTDFTATGKYGRYIDIPLNEAAREFGFLLLDESKQGDDVKIRKENYKFTDLKNHSQIFLKDDDESIYTNPYYVHDIRMTGAQHVGTSSIESSFSTLVGAKKEDILKHSNITNHLGNKVTITDVAIDEAGKKVTYSGDFSDTKHPYTVSYNSDQFTTKTSWRLKDETYSYDGKLGADLKEEGKQVDLTLWSPSADKVSVVVYDKNDPDKVVGTVALEKGERGTWKQTLDSTNKLGITDFTGYYYQYQIERQGKTVLALDPYAKSLAAWNSDDSKIDDAHKVAKAAFVDPAKLGPQDLTYGKIHNFKTREDAVIYEAHVRDFTSDPAIAKDLTKPFGTFEAFIEKLDYLKDLGVTHIQLLPVLSYYFVNELKNHERLSDYASSNSNYNWGYDPQNYFSLTGMYSSDPKNPEKRIAEFKNLINEIHKRGMGAILDVVYNHTAKVDLFEDLEPNYYHFMDADGTPRTSFGGGRLGTTHHMTKRLLIDSIKYLVDTYKVDGFRFDMMGDHDAASIEEAYKAARALNPNLIMLGEGWRTYAGDENMPTKAADQDWMKHTDTVAVFSDDIRNNLKSGYPNEGQPAFITGGKRDVNTIFKNLIAQPTNFEADSPGDVIQYIAAHDNLTLFDIIAQSIKKDPSKAENYAEIHRRLRLGNLMVLTAQGTPFIHSGQEYGRTKQFRDPAYKTPVAEDKVPNKSHLLRDKDGNPFDYPYFIHDSYDSSDAVNKFDWTKATDGKAYPENVKSRDYMKGLIALRQSTDAFRLKSLQDIKDRVHLITVPGQNGVEKEDVVIGYQITAPNGDIYAVFVNADEKAREFNLGTAFAHLRNAEVLADENQAGPVGIANPKGLEWTEKGLKLNALTATVLRVSQNGTSHESTAEEKPDSTPSKPEHQNEASHPAHQDPAPEARPDSTKPDAKVADAENKPSQATADSQAEQPAQEAQASSVKEAVRNESVENSSKENIPATPDKQAELPNTGIKNENKLLFAGISLLALLGLGFLLKNKKEN
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0268 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG1523G, under G: Carbohydrate transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].