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zmpB from Streptococcus pneumoniae Hungary19A-6

Victor ID 3058
Gene Name zmpB from Streptococcus pneumoniae Hungary19A-6
Sequence Strain (Species/Organism) Streptococcus pneumoniae Hungary19A-6
NCBI Gene ID 6028839
NCBI Protein GI 169833025
Locus Tag SPH_0759
Protein Accession YP_001694137.1
Other Database IDs UniProtKB-ID: B1IAK2_STRPI
UniRef100: UniRef100_B1IAK2
UniRef90: UniRef90_B1IAK2
UniRef50: UniRef50_Q8DQN5
UniParc: UPI00016DB81C
EMBL: CP000936
EMBL-CDS: ACA36139.1
RefSeq_NT: NC_010380.1
MEROPS: M26.002
EnsemblGenome: EBSTRG00000024964.
EnsemblGenome_TRS: EBSTRT00000024964
EnsemblGenome_PRO: EBSTRP00000024130
GenomeReviews: CP000936_GR
KEGG: spv:SPH_0759
HOGENOM: HBG697431
OMA: SVNGEPE
ProtClustDB: CLSK883904
BioCyc: SPNE487214:SPH_0759-MONOMER
Taxonomy ID 487214
Gene Starting Position 709543
Gene Ending Position 715245
Gene Strand (Orientation) +
Protein Name zinc metalloprotease ZmpB
DNA Sequence 
>gi|169832377:709543-715245 Streptococcus pneumoniae Hungary19A-6, complete genome
AGTGTTTAAAAAAGACCGTTTTTCAATTCGTAAGATTAAGGGAGTTGTAGGCTCTGTATTTCTTGGAAGC
CTTTTGATGGCTCCTTCTGTAGTGGACGCAGCTACCTATCACTATGTAAATAAAGAGATTATTTCACAAG
AAGCTAAAGATTTAATTCAGACAGGAAAGCCTGACAGGAATGAAGTTGTATATGGTTTGGTGTATCAAAA
AGATCAGTTGCCTCAAACAGGGACAGAAGCATCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGC
TTGCTTTTAATCTACAAGAGAAAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTC
TTCCTAGTGCAGGGGCTGTAGACCCAGTTGCGACCCTAGCGCTGGCTAGTCGAGAGGGTGTTGTTGAAAT
GGATGGCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGACACTGTTTTA
GAAGAAACCTCAGCAAAACCTGGAGAGGTGACTGTAGTCGAAGTTGAGACTCCTCAATCAACAACAAATC
AGGAGCAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAGGAAGCTCCAAAAGAAGAAGCACCTAGAAC
AGAAGAAAGTCCAAAGGAAGAACCAAAATCGGAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAA
GAGGGGAAAGAAGATTCAGCAGAACCAGCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAG
AGGAAAAAGTAGCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACC
ACCAGTAGAACAAGCAAAAGTCCCAGAACAACCCGTGCAACCTACACAAGCTGAGCAACCAAGTACACCA
AAAGAATCATCACAACAAGAAAATCCTAAAGAAGATAGGGGAGCGGAAGAGACACCGAAACAAGAAGATG
AACAGCCAGCAGAAGCCCCAGAAATCAAGGTTGAAGAACCAGTAGAATCAAAAGAGGAGACTAAAACAGC
TAAGGGGACGCAAGAAGAAGGCAAAGAAGGTCAAGCACCAGTACAAGAAGTAAACCCAGAATATAAAGTA
ACAACAGGTACAGTTGAGAAGTCTACCGAAAGTGAATTAGATTTCACAACAGAAGTAGTTCCGGATGACA
CAAAATATGTAGATGAAGAAGTTGTTGAACGTCAAGGGTCTAAAGGAGTTCAAGTTACGAAAACAACTTA
CGAAACAGTGGAAGTTGTAGAGACAGACAAAGTCCTTTCTACAACTACAGAAGTGAAAACTCCTGTTGTT
CCTAAAGTCGTTAAAAAAGGAACAAAACCAGTTGAAGGAACAGCAGTTGAAACAAGAGAAGAAGTCATTC
CTTTTGCTACAAAAGAACAAGAAGATGGCACTTTAAAACGCGGAACAAGACAAGTAGCTCAAGAAGGTGT
AAACGGTAAGAAACAAATTACTGAAACCTATAAAACAATTCGCGGAGAAAAAACAAACGAAGCTCCAACA
GTAGAAGAAACAGTTCTCCAAGCACCTCAAGATGAGATTATCAAAAAAGGCACAAAAGGTTTAGAAAAAC
CAACCTTAGAATGGGTTAAAACAGATAAAGATGTCTTGAAGAAGAGTGCGACAGCCAGTTATACATTGAA
TAAACCAGATGGGGTAGAAATCAAATCCATCAAAGTAGCTCTAAAAGATAATACTGGAACAGTTATTAAA
GAAGTAACGGTAGAAGAAAATAACTTAAACGTTACTTTAGACAACTTGAAATATTATCAAGGTTATACAC
TATCCACAACCATGGTCTATAATCGAGGCGAAGGCGAAGAAACTGAAACGTTAGAAGATAAAGAAGTTCA
GTTAGACCTTAAAAAAGTTGAAATCAAAAACATCAAAGAAACTAGCTTGATGAGTGTGGATGATGCTGGT
GTTGAAACAGATAAGAGCTTACTTACTGAAAAACCGACAGACGTTGCTCCACTTTACCTACGAGTGACAA
CTCATGATAACAAAGTAACAAGACTTGCTGTTGATAAGATTGAAGAAGTAGAAGAAGACGGAAAAACTTT
ATACAAAGTTACTGCCAAAGCACCAGACTTAGTTCAACGTAATGCTGATAACACACTTAGCGAAGAGTAT
GTTCATTACTTTGAAAAACAACTTCCAAAAATTGGAAATGTGTATTACAACTTCAACGAGTTGATTACAG
ATATGCAAAAAACACCGAATGGCGAGTTTAAACTTGGTGCAGACTTGAATGCTGTCAATGTTCCAACACC
AAATAAATCTTATGTGACTGCTAAATTTACTGGTAAGTTGTATAGTGAAGGTGATAAACACTATACTATT
CACAACTTAGCACGTCCATTGTTTGCGCAAGCTGAAAACGCTCATATTCATGACATCAACCTCGGTAATG
TAAATATTAATATGCCGTGGGCGAACAAAACAGCACCTCTTGGTGAAATGTTCAAGAAGTCAACTATTGA
AAACGTCAAAGTAACAGGTAATGTTGTCGGTAACAATGACGTTACAGGTATGGTCAACAAACTGGACGAA
TCTGATATGCGTAACGTAGCTTTCATTGGAAATATTACAAGTGTAGGTAGCGCTGGATGGTGGTCTGGTG
GACTTGTCAGTGAAAGCTGGAGAAGTAACACAGATAATTCTTATATTGATACCACCATCAAAGGTAATAA
AGCTAAGGTAGGTGGATTAATTGCTAAGTTAAATCACGGTGCTGACCCACGAGATGTTGGTGCGAGAGGT
CGTTTGAAGAACTCTGTCGCAAAAGGTACTATTGATGTGAGAGACCCACAAGAAACTGGTGGATTGCTGC
ATTCTAACTGGTCATGGGGTCTTGCAGAAAACAATATTACCATGATGAAAGTGAAGAATGGAGGAGAAAT
TTTATATGGTTCTCGTGATGCAGAAGATGATGATTACTTCGGAGCGAATTGGGTGCGTAATAATAATGCG
TTCGTCAATGGAATCAGTGAAGGGAAACAATCCTATTCTCGTTCTAGTCGCTGGAAAGGGATTTCTGAAG
ATGAAGCTAAAACTCGTATTGCCAAAATGGGAATTACAGCTCATGAATACGAAATTACACAACATTTGAC
TGATAAATTGAACCGTGCAGCATTTAAAGAAGACACATATAAAACAACTCAAGATTACAAAACTGAAAGA
GAATTAGCGTATCGTAATATTGAAAAGCTTCAACCATTCTACAATAAAGAATGGATTATCAACCAAGGTA
ACAAATTAACAGACGGTTCAAACTTAATGATTAAAGAGGTATTGTCCGTTATAGGTATGAAGAACGGTCA
GTTCGTGACCGATTTGTCTGATATTGATAAGATTATGATTCACTACGCTGATGGTACGAAAGAAGAAAAA
ACTGTCACACGTAAAGCTGACTCAAAAGTGCAACAAATTCGTGAATATAGTGTTGAAGGTCTTGGTGATG
TTGTGTACACACCAAATATGGTCGAAAAAGATAGAGCGCAATTAATTACTGATATTAAGGCGAAATTGGA
TAGCGTCCAATTGATTTCACCAGAAGTGCGCAATTTGATGGATAAACGTGGCAAAGCGCATGAAAACACG
GATGAACGTCGTAATGGCTACATTCGAAACCTATTCCTTGAAGAAAGTTTGGATGAAGTGAAAGGAAACC
TTGATAAGCTTGTGAAAGCTCTTGTTGAAAATGAAGACCATCAATTGAATGGTGATGAAGCGGCAATGAA
AGCTCTTGTCAAGAAAGTTGAAGACAACAAAGCGAAAATCATGTTAGGTCTTGCTTATCTCAATCGCTAC
TATGGATTCAAATATGACGAAAAGTCTATGAAGGATATTATGATGTTCAAACCGGACTTCTATGGTAAGA
ATGTTAGTGTCTTGGACTTCTTGATTAGAGTTGGTTCAAGAGAACACAATATTAAAGGTAACAGAACGTT
AGAAGCTTATCGTGAAGTAATTGGTGGAACGATTGGTATCGGTGAGTTAAACGGTTTCTTAAACTATAAT
ATGCGTTTATTCACAGAAGAAACTGACATCAATACTTGGTACAAAAAAGCTGTATCGCATACCAACTATA
TTGTTGAAAAACAATCCTCAAACCCTGCGTTTGCCAACAAGAAATATCGCCTTTATGAAAACTTGAACAA
TGGTGAACATGGTAAATATATTTTACCACTTCTCACTACGAAGAAAGCTCATATGTTCTTGATTTCAACC
TATAATACATTAGCGTTTAGTGCGTTTGAGAAATATGGTAAGAATACAGAAGCTGAACGTGAAGCGTTTA
AGAAAGAAATCGATTTACGTGCTCAAGAGCAAATTAATTACTTAGACTTCTGGTCAAGACTTGCAGCTGA
TAATGTACGTGACAGATTGTTAAAATCTGAAAATATGGTTCCGTCTGCAATTTGGGATAACCAAGAAGTT
CCAGGTCATGGATGGGCTGATAGAATGGGTCATAATAAGAATGGTGACTATGCTCCGGTTCGTGAGTTCT
ATGGACCTACAGGTAAATGGCATGGATACAATGGTACGGGTGCATATGCTTATATCTTTACTAATCCACA
AAACTCAGAAGCTGTATATTATATCATATCTAGTATGATCAGTGATTTCGGTACTTCTGCATTCACTCAT
GAAACTACACACATTAATGACCGTATGGCGTATCTAGGTGGATGGCGTCACCGTGAAGGTACTGACGTAG
AAGCATTTGCCCAAGGTATGTTACAATCACCGGCTGTCTCAAGTCCGAACGGCGACTACGGTGCTTTAGG
TCTTAACATGGCTTACAAACGTGAAAACGATGGTAACCAATGGTACAACTATGATTCAAATAAATTAGAT
AGTCGTGCGAAGATTGACCATTACATGAAGAATTACAACGAAGCGCTCATGATGCTTGACCACTTAGAAG
CTGATGCCGTTATCGCGAAGAATAACGGAGATAACAACAAGTGGTTCAAGAAGATGGATAAGAAATGGCG
TGAGAACGCTAATCGAAATGGATTAGTGGGACAACCACACCAATGGGATTTACTTCGTGACCTAAATGAA
GAAGAGAATAAGAAGAAATTGACAAGCATTGATGACCTTGTAGATGGAAATTATGTAACGAAGCATAATA
TGCCGGGTAATAAACACTATCGTGCTGAAGGGTTTGATACAGCGTATCAAACTGTAAACATGATGGCTGG
TATTTACGGTGGTAATACTAGTAAGAGTGCTGTTGGTTCTATCTCGTTCAAACATAACACCTTCCGTATG
TGGGGTTACTTCGGTTATCTTGATGGATTTGTAGGTTATGCATCTAACAAATATAAAGACGCGGCTAACA
AAGAAAATAAAGGCTTACTTGGCGACGACTTTATTATCAAGAAAGTGTCTGACGGTAAATTTGACAGCCT
AGAAGCTTGGAAGAAAGAATGGTTTAAAGAAGTTAAAGCTAAAGGTGAAAAAGGATTTGTTGCTATTGAA
ATTGATGGTAAAACAATCACTAACTATGCTGAACTTCGTGAATTGTTCGACAAAGCTGTTGAAGCTGACC
TGAAAGCTGGTAACTCTAACCAAACAGTTGCCCTTAAAGAAAAGGTTTATAAACAACTCTTGCAGAAATC
AGATGGATTTGTAGGAAATCTTTTTAAAGCATA
Protein Sequence 
>gi|169833025|ref|YP_001694137.1| zinc metalloprotease ZmpB [Streptococcus pneumoniae Hungary19A-6] MFKKDRFSIRKIKGVVGSVFLGSLLMAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMDGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSTTNQEQARTENQVVETEEAPKEEAPRTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEPPVEQAKVPEQPVQPTQAEQPSTPKESSQQENPKEDRGAEETPKQEDEQPAEAPEIKVEEPVESKEETKTAKGTQEEGKEGQAPVQEVNPEYKVTTGTVEKSTESELDFTTEVVPDDTKYVDEEVVERQGSKGVQVTKTTYETVEVVETDKVLSTTTEVKTPVVPKVVKKGTKPVEGTAVETREEVIPFATKEQEDGTLKRGTRQVAQEGVNGKKQITETYKTIRGEKTNEAPTVEETVLQAPQDEIIKKGTKGLEKPTLEWVKTDKDVLKKSATASYTLNKPDGVEIKSIKVALKDNTGTVIKEVTVEENNLNVTLDNLKYYQGYTLSTTMVYNRGEGEETETLEDKEVQLDLKKVEIKNIKETSLMSVDDAGVETDKSLLTEKPTDVAPLYLRVTTHDNKVTRLAVDKIEEVEEDGKTLYKVTAKAPDLVQRNADNTLSEEYVHYFEKQLPKIGNVYYNFNELITDMQKTPNGEFKLGADLNAVNVPTPNKSYVTAKFTGKLYSEGDKHYTIHNLARPLFAQAENAHIHDINLGNVNINMPWANKTAPLGEMFKKSTIENVKVTGNVVGNNDVTGMVNKLDESDMRNVAFIGNITSVGSAGWWSGGLVSESWRSNTDNSYIDTTIKGNKAKVGGLIAKLNHGADPRDVGARGRLKNSVAKGTIDVRDPQETGGLLHSNWSWGLAENNITMMKVKNGGEILYGSRDAEDDDYFGANWVRNNNAFVNGISEGKQSYSRSSRWKGISEDEAKTRIAKMGITAHEYEITQHLTDKLNRAAFKEDTYKTTQDYKTERELAYRNIEKLQPFYNKEWIINQGNKLTDGSNLMIKEVLSVIGMKNGQFVTDLSDIDKIMIHYADGTKEEKTVTRKADSKVQQIREYSVEGLGDVVYTPNMVEKDRAQLITDIKAKLDSVQLISPEVRNLMDKRGKAHENTDERRNGYIRNLFLEESLDEVKGNLDKLVKALVENEDHQLNGDEAAMKALVKKVEDNKAKIMLGLAYLNRYYGFKYDEKSMKDIMMFKPDFYGKNVSVLDFLIRVGSREHNIKGNRTLEAYREVIGGTIGIGELNGFLNYNMRLFTEETDINTWYKKAVSHTNYIVEKQSSNPAFANKKYRLYENLNNGEHGKYILPLLTTKKAHMFLISTYNTLAFSAFEKYGKNTEAEREAFKKEIDLRAQEQINYLDFWSRLAADNVRDRLLKSENMVPSAIWDNQEVPGHGWADRMGHNKNGDYAPVREFYGPTGKWHGYNGTGAYAYIFTNPQNSEAVYYIISSMISDFGTSAFTHETTHINDRMAYLGGWRHREGTDVEAFAQGMLQSPAVSSPNGDYGALGLNMAYKRENDGNQWYNYDSNKLDSRAKIDHYMKNYNEALMMLDHLEADAVIAKNNGDNNKWFKKMDKKWRENANRNGLVGQPHQWDLLRDLNEEENKKKLTSIDDLVDGNYVTKHNMPGNKHYRAEGFDTAYQTVNMMAGIYGGNTSKSAVGSISFKHNTFRMWGYFGYLDGFVGYASNKYKDAANKENKGLLGDDFIIKKVSDGKFDSLEAWKKEWFKEVKAKGEKGFVAIEIDGKTITNYAELRELFDKAVEADLKAGNSNQTVALKEKVYKQLLQKSDGFVGNLFKA
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: zmpB mutant is attenuated in mice (Chiavolini et al., 2003).
COG COG3583S, under S: Function unknown
References
Chiavolini et al., 2003: Chiavolini D, Memmi G, Maggi T, Iannelli F, Pozzi G, Oggioni MR. The three extra-cellular zinc metalloproteinases of Streptococcus pneumoniae have a different impact on virulence in mice. BMC microbiology. 2003; 3; 14. [PubMed: 12841855].