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potD from Streptococcus pneumoniae R6

Victor ID 3123
Gene Name potD from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 934459
NCBI Protein GI 15903286
Locus Tag spr1243
Protein Accession NP_358836.1
Other Database IDs UniProtKB-ID: Q8DPC5_STRR6
UniRef100: UniRef100_Q04JW3
UniRef90: UniRef90_C1CEX4
UniRef50: UniRef50_Q2YX72
UniParc: UPI00000E3610
EMBL: AE007317
EMBL-CDS: AAL00047.1
RefSeq_NT: NC_003098.1
HSSP: P23861
EnsemblGenome: EBSTRG00000014549.
EnsemblGenome_TRS: EBSTRT00000014549
EnsemblGenome_PRO: EBSTRP00000013945
GenomeReviews: AE007317_GR
KEGG: spr:spr1243
eggNOG: COG0687
HOGENOM: HBG638705
OMA: WADYVAP
ProtClustDB: CLSK884080
BioCyc: SPNE171101:SPR1243-MONOMER
Taxonomy ID 171101
Gene Starting Position 1242786
Gene Ending Position 1243856
Gene Strand (Orientation) -
Protein Name ABC transporter substrate-binding protein - spermidine/putrescine transport
DNA Sequence 
>gi|15902044:1242786-1243856 Streptococcus pneumoniae R6, complete genome
CCTACTTCCGATACATTTTAAACTGTAGGAAGAGGTCGCTATATTTCCCTGTCCATTTATGGTCAAATTT
CTCATAAACTTCTAGGTGTTTCATGGTTTCAACATCGGGATAGAAGGCCTTATCTTCCTTTGTTTCCTCT
GGGAGCAATTCCTTCGCTGGTAGGTTTGGTGTTGAATAGCCGACATACTCCGCATTTTGGAGAGCATTTT
CAGGTTTCAACATAAAGTTGATAAAGGCATAGGCTGAGTCTTGATTTTTAACTGTTTTGGGAATGACCAT
ATTGTCAAACCAAAGATTGCTGGCCTCTGTCGGTACCACATAACGTAGATTTTCATTTTTTTCTAACATT
TGGCTGGCTTCACCAGAGAAGGTCACGCCGATTGCAACATTATTCTGAATCATGTAGCCCTTCATCTCGT
CCGCAACGATAGCCTTGATATTTGGAGTCAGTTTGTAGAGCTTATCCACTGTCTCTTCCAACTGCTGCGG
ATCCTTGGAGTTGAGGCTGTAGCCGAGGGAATTGAGTCCTAGTCCCAGCACCTCACGCGCCCCATCAAAA
AGCATGATAGAATTCTTATACTCCAGCTTCCAAAGGTCATCCCAATGCTCAGGCGCTTCATCTACCATGG
TTTCGTTGTAGACAATTCCTAAGGTTCCCCAGAAGTAAGGGATGGAGAATTTATTACCTGGGTCAAAGGA
CTGGTTGAGAAACTCTGGTCCGATATTTTCGATTCCTTCAATTTTTGAATAATCAAGCGGAACCAAGAGG
TCTTCGTCCTTCATCTTGTTAATCATGTATTCACTTGGAATGGCAATATCGTAGGTCGTTCCACCCTGCT
TTATCTTAGTGTACATGGCTTCGTTGGAGTCAAAAGCCTCGTACTGAACTTGAATTCCTGTTTCTTCTGT
AAACTGAGTCAAGAGTTCAGGATCGATATAGTCTCCCCAGTTATAGATAACCAATTTTTGACTATCTCGA
CTATTGATTTTACTATCTAAATGAGTCGCAATTCCCCACAAGACAAGGATAATCGCTGCAATTCCTGCTA
AAAATGAATAGATTTTTTTCA
Protein Sequence 
>gi|15903286|ref|NP_358836.1| spermidine/putrescine ABC transporter substrate-binding protein [Streptococcus pneumoniae R6] MKKIYSFLAGIAAIILVLWGIATHLDSKINSRDSQKLVIYNWGDYIDPELLTQFTEETGIQVQYEAFDSNEAMYTKIKQGGTTYDIAIPSEYMINKMKDEDLLVPLDYSKIEGIENIGPEFLNQSFDPGNKFSIPYFWGTLGIVYNETMVDEAPEHWDDLWKLEYKNSIMLFDGAREVLGLGLNSLGYSLNSKDPQQLEETVDKLYKLTPNIKAIVADEMKGYMIQNNVAIGVTFSGEASQMLEKNENLRYVVPTEASNLWFDNMVIPKTVKNQDSAYAFINFMLKPENALQNAEYVGYSTPNLPAKELLPEETKEDKAFYPDVETMKHLEVYEKFDHKWTGKYSDLFLQFKMYRK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: potD mutant is attenuated in pulmonary and systemic models of infection in mice (Ware et al., 2006).
COG COG0687E, under E: Amino acid transport and metabolism
References
Ware et al., 2006: Ware D, Jiang Y, Lin W, Swiatlo E. Involvement of potD in Streptococcus pneumoniae polyamine transport and pathogenesis. Infection and immunity. 2006; 74(1); 352-361. [PubMed: 16368990].