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codY from Streptococcus pneumoniae R6

Victor ID 3114
Gene Name codY from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 933916
NCBI Protein GI 15903482
Locus Tag spr1439
Protein Accession NP_359032.1
Other Database IDs UniProtKB-ID: CODY_STRR6
UniRef100: UniRef100_Q04JG7
UniRef90: UniRef90_Q04JG7
UniRef50: UniRef50_A2RCV3
UniParc: UPI00000E365D
EMBL: AE007317
EMBL-CDS: AAL00243.1
RefSeq_NT: NC_003098.1
EnsemblGenome: EBSTRG00000014522
EnsemblGenome_TRS: EBSTRT00000014522
EnsemblGenome_PRO: EBSTRP00000013918
GenomeReviews: AE007317_GR
KEGG: spr:spr1439
eggNOG: COG4465
HOGENOM: HBG304760
OMA: HIFEELD
ProtClustDB: PRK04158
BioCyc: SPNE171101:SPR1439-MONOMER
Taxonomy ID 171101
Gene Starting Position 1422735
Gene Ending Position 1423523
Gene Strand (Orientation) -
Protein Name transcriptional repressor CodY
DNA Sequence 
>gi|15902044:1422735-1423523 Streptococcus pneumoniae R6, complete genome
ATTAGTAATCTCTTTTCTTCACTTCTTCAAAAATATCTGAAATCAAGACCTTAAGATAGGTTCCCTTCAT
TCCAAGTGAGCGACTTTCAATAATCCCCGCAGACTCAAGTTTACGAAGAGCATTGACAATCACAGAGCGA
GTGATTCCGATACGATCTGCAATCACTGACGCAGTCAACTGCCCTTCATTTCCATTTAATTCCCCTAAAA
TTGCTGAAACAGCACGGAGTTCGGAGTAAGAAAGGGTATTGACCGCCATGGTGACAGCAGTACGACGACG
AATATTTTTCTCATCTTCTTCACGTTGGAAGTTAAGAAGCTGAATCCCAACAACGGTACTGGCAATCTCA
ACAAGAACCAAGTCCTCATCTTCGAATTTTTTATCATTACGCCAAATAATCAAAGAACCAAGGCGAATCC
CCGATACATGAATCGGTGCAATAGTCGTCAAGCCATCTGGAAAATCATCTCTACTCTCAACAGGGAAAAT
ACTCATATCATGCTCAACAGGCAAGTTTGCTTCTGTTTCGTAAATCATATTAGCCCCTTGAACGTAGTCA
TCTGGGAAAATCTTAGTTTGGAAGAATTGCTCTACGCGATCTGTATTTGTTTTATAACGCATAAAATAGC
CAAGCAGACGTCCCTTACTATTGATAATGCAGGCATTGCAATGAATAATATCCGCTAACTGACGCGTAAT
AGCGTTGTAAGGGAGCTCATCCTGCAACTGCTCCTCTGAGCGTTTCAAAATTGATGTAATTTTTCTAGTT
TTTTCTAATAAATGTGCCA
Protein Sequence 
>gi|15903482|ref|NP_359032.1| transcriptional repressor CodY [Streptococcus pneumoniae R6] MAHLLEKTRKITSILKRSEEQLQDELPYNAITRQLADIIHCNACIINSKGRLLGYFMRYKTNTDRVEQFFQTKIFPDDYVQGANMIYETEANLPVEHDMSIFPVESRDDFPDGLTTIAPIHVSGIRLGSLIIWRNDKKFEDEDLVLVEIASTVVGIQLLNFQREEDEKNIRRRTAVTMAVNTLSYSELRAVSAILGELNGNEGQLTASVIADRIGITRSVIVNALRKLESAGIIESRSLGMKGTYLKVLISDIFEEVKKRDY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: codY mutant has lower bacterial loads during infection in mice compared to the wild type and have a diminished ability to adhere to nasopharangeal cells in vitro (Hendriksen et al., 2008).
COG COG4465K, under K: Transcription
References
Hendriksen et al., 2008: Hendriksen WT, Bootsma HJ, Estevão S, Hoogenboezem T, de Jong A, de Groot R, Kuipers OP, Hermans PW. CodY of Streptococcus pneumoniae: link between nutritional gene regulation and colonization. Journal of bacteriology. 2008; 190(2); 590-601. [PubMed: 18024519].