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lytA from Streptococcus pneumoniae R6

Victor ID 3108
Gene Name lytA from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 933669
NCBI Protein GI 15903796
Locus Tag spr1754
Protein Accession NP_359346.1
Other Database IDs UniProtKB-ID: Q7ZAK4_STRR6
UniRef100: UniRef100_Q04IM8
UniRef90: UniRef90_C1CGE1
UniRef50: UniRef50_P32762
UniParc: UPI000000E964
EMBL: AE007317
EMBL-CDS: AAL00557.1
RefSeq_NT: NC_003098.1
HSSP: P06653
EnsemblGenome: EBSTRG00000016274.
EnsemblGenome_TRS: EBSTRT00000016274
EnsemblGenome_PRO: EBSTRP00000015670
GenomeReviews: AE007317_GR
KEGG: spr:spr1754
eggNOG: COG5263
HOGENOM: HBG702446
OMA: YDIENGL
ProtClustDB: CLSK560258
BioCyc: SPNE171101:SPR1754-MONOMER
Taxonomy ID 171101
Gene Starting Position 1722068
Gene Ending Position 1723024
Gene Strand (Orientation) -
Protein Name Autolysin (N-acetylmuramoyl-L-alanine amidase)
DNA Sequence 
>gi|15902044:1722068-1723024 Streptococcus pneumoniae R6, complete genome
ATTATTTTACTGTAATCAAGCCATCTGGCTCTACTGTGAATTCTGGCCTGTCTGCCAGTGTTCCGTCTGG
TTTGAGGTAGTACCAGCCTGTTCCGTCCGCTGACTGGATAAAGGCATTTGATACCATGGCGCCTTCTTTA
GCGTCTAAGTAGTACCAAGTGTCCTTGTACTTGACCCAGCCTGTCTTCATGGCACCTTCTTCGTTGAAAT
AGTACCACTTATCAGCGATTTTCTTCCAGCCTGTAGCCATTTCGCCTGAGTTGTCGAACCAGTACCAGTT
GCCGTCTGTGTGCTTCCTCCAGCGGTCTGCAAGCATATAGCCTGAACTGTCAAAGTAGTACCAAGTGCCA
TTGATTTTCTCAAACTTGTCTTTTGGATAAGAGCCGTCTGAATGTACGTACCAGTAGCCAGTGTCATTCT
TCTGCCAGCCTGTTTCAATCGTCAAGCCGTTCTCAATATCATGCTTAAACTGCTCACGGCTAATGCCCCA
TTTAGCAAGATATGGATAAGGGTCAACGTGGTCTGAGTGGTTGTTTGGTTGGTTATTCGTGCAATACTCG
TGCGTTTTAATTCCAGCTAAACTCCCTGTATCAAGCGTTTTCGGCAAACCTGCTTCATCTGCTAGATTGC
GTAAGAGTTCGATATAAAGGCGGTAGTCCGTCATGAACTCTTCTTTGGTTGAATGGCTTTCAATCAGTTC
AACCGCTGCATAGGTCTCAGCATTCCAACCGCCCCCAACGTCCCAGGCACCATTATCAACAGGTCCTACC
TGCATGATGCAACCGTTCCCAACAATGTGCGAGAAAAAACCTAATTCTGGGTCTTTCCGCCAGTGATAAT
CCGCTTCATTCTGTACGGTTGAATGCGGATTCCCAGTTGAGTGTGCGTGTACTTGCCTATATGGTTGCAC
GCCGACTTGAGGCAAATCTGTTCTTAATTTACTCACATTAATTTCCA
Protein Sequence 
>gi|15903796|ref|NP_359346.1| N-acetylmuramoyl-L-alanine amidase [Streptococcus pneumoniae R6] MEINVSKLRTDLPQVGVQPYRQVHAHSTGNPHSTVQNEADYHWRKDPELGFFSHIVGNGCIMQVGPVDNGAWDVGGGWNAETYAAVELIESHSTKEEFMTDYRLYIELLRNLADEAGLPKTLDTGSLAGIKTHEYCTNNQPNNHSDHVDPYPYLAKWGISREQFKHDIENGLTIETGWQKNDTGYWYVHSDGSYPKDKFEKINGTWYYFDSSGYMLADRWRKHTDGNWYWFDNSGEMATGWKKIADKWYYFNEEGAMKTGWVKYKDTWYYLDAKEGAMVSNAFIQSADGTGWYYLKPDGTLADRPEFTVEPDGLITVK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: lytA mutant is attenuated in mice (Berry and Paton, 2000).
COG COG5263R, under R: General function prediction only
References
Berry and Paton, 2000: Berry AM, Paton JC. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins. Infection and immunity. 2000; 68(1); 133-140. [PubMed: 10603379].