Search: for Help
About
Introduction
Statistics
Your PHIDIAS
Register or Login
Philert
Submission
Curated Data
Victors
BBP (Brucella)
Phinfo
Phinet
HazARD
Data Analysis
Phigen
Pacodom
BLAST
Help & Documents
Documents
FAQs
Links
Acknowledgements
Disclaimer
Contact Us
UMMS Logo

leuS

Victor ID 3169
Gene Name leuS
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930056
NCBI Protein GI 15900189
Locus Tag SP_0254
Protein Accession NP_344793.1
Other Database IDs UniProtKB-ID: SYL_STRPN
UniRef100: UniRef100_Q97SS0
UniRef90: UniRef90_A4W4F3
UniRef50: UniRef50_A4W4F3
UniParc: UPI0000051375
EMBL: AE005672
EMBL-CDS: AAK74433.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026876
EnsemblGenome_TRS: EBSTRT00000026876
EnsemblGenome_PRO: EBSTRP00000025968
GenomeReviews: AE005672_GR
KEGG: spn:SP_0254
TIGR: SP_0254
HOGENOM: HBG693845
OMA: ERGNFPV
ProtClustDB: PRK00390
BioCyc: SPNE170187-1:SP_0254-MONOMER
Taxonomy ID 170187
Gene Starting Position 224751
Gene Ending Position 227252
Gene Strand (Orientation) +
Protein Name leucyl-tRNA synthetase
DNA Sequence 
>gi|194172857:224751-227252 Streptococcus pneumoniae TIGR4 chromosome, complete genome
CATGAGTTTTTACAATCATAAAGAAATTGAGCCTAAGTGGCAGGGCTACTGGGCAGAACATCATACATTT
AAGACAGGAACAGATACATCAAAACCTAAGTTTTATGCGCTTGATATGTTCCCTTATCCGTCTGGAGCTG
GTCTGCACGTAGGACACCCAGAAGGTTATACTGCAACCGATATCCTCAGTCGTTACAAACGTGCGCAAGG
CTACAATGTCCTTCACCCAATGGGTTGGGATGCTTTTGGTTTGCCTGCAGAGCAATACGCTATGGATACT
GGTAATGACCCAGCAGAATTTACAGCGGAAAACATTGCCAACTTCAAACGTCAAATTAATGCGCTTGGAT
TTTCTTATGACTGGGATCGTGAAGTCAACACAACAGATCCAAACTACTACAAGTGGACTCAATGGATTTT
CACCAAGCTTTACGAAAAAGGCTTGGCCTATGAAGCTGAAGTGCCAGTAAACTGGGTTGAGGAATTGGGA
ACTGCCATTGCCAATGAAGAAGTGCTTCCTGACGGAACTTCTGAGCGTGGAGGCTATCCAGTTGTCCGCA
AACCAATGCGCCAATGGATGCTCAAAATCACGGCTTACGCAGAGCGCTTGCTCAATGACTTAGATGAACT
AGATTGGTCAGAGTCTATCAAGGATATGCAACGCAACTGGATTGGTAAATCAACTGGTGCCAATGTAACT
TTCAAAGTAAAAGGAACAGACAAGGAATTTACAGTCTTTACTACTCGTCCGGACACACTTTTCGGTGCGA
CTTTCACTGTCTTGGCTCCTGAACATGAATTAGTAGACGCTATCACAAGTTCAGAGCAAGCAGAAGCTGT
AGCAGACTATAAACACCAAGCCAGCCTTAAGTCTGACTTGGCTCGTACAGACCTTGCTAAAGAAAAAACA
GGGGTTTGGACTGGTGCTTATGCCATCAACCCTGTCAATGGTAAGGAAATGCCAATCTGGATTGCAGACT
ATGTCCTTGCTAGTTATGGAACAGGTGCGGTTATGGCTGTGCCTGCCCACGACCAACGTGACTGGGAATT
TGCCAAACAATTTGACCTTCCAATCGTCGAAGTACTTGAAGGTGGAAATGTCGAAGAAGCTGCCTACACA
GAGGATGGCCTGCATGTCAATTCAGACTTCCTAGATGGATTGAACAAAGAAGACGCTATTGCCAAGATTG
TGGCTTGGTTGGAAGAAAAAGGCTGTGGTCAGGAGAAGGTTACCTACCGTCTCCGCGACTGGCTCTTTAG
CCGTCAACGTTACTGGGGTGAGCCAATTCCAATCATTCATTGGGAAGATGGAACTTCAACAGCTGTTCCT
GAAACTGAATTGCCGCTTGTCTTGCCTGTAACCAAGGATATCCGTCCTTCAGGTACTGGTGAAAGTCCAC
TAGCTAACTTGACAGATTGGCTTGAAGTGACTCGTGAAGATGGTGTCAAAGGTCGTCGTGAAACCAACAC
TATGCCACAATGGGCTGGTTCAAGCTGGTACTACCTCCGCTATATTGACCCGCACAATACTGAGAAATTG
GCTGATGAGGACCTCCTCAAACAATGGTTGCCAGTAGATATCTACGTGGGTGGTGCGGAACATGCTGTAC
TTCACTTGCTTTATGCTCGTTTCTGGCATAAATTCCTCTATGACCTCGGTGTTGTTCCGACTAAGGAACC
ATTCCAAAAACTCTTTAACCAAGGGATGATTTTGGGAACAAGCTACCGTGACCACCGTGGTGCTCTTGTG
GCAACCGACAAGGTTGAAAAACGTGATGGTTCCTTCTTCCATGTAGAAACAGGGGAAGAGTTGGAGCAAG
CGCCAGCCAAGATGTCTAAATCGCTCAAGAACGTTGTTAACCCAGACGATGTGGTGGAACAATACGGTGC
CGATACCCTTCGTGTTTATGAAATGTTTATGGGACCACTCGATGCTTCGATTGCTTGGTCAGAAGAAGGT
TTGGAAGGAAGCCGTAAGTTCCTTGACCGAGTTTACCGTTTGATTACAAGTAAAGAAATCCTTGCGGAAA
ACAATGGTGCTCTTGACAAGGTTTACAACGAAACAGTCAAAGCTGTTACTGAGCAAATTGAGTCTCTCAA
ATTCAACACAGCTATTGCCCAACTTATGGTCTTTGTCAATGCTGCTAACAAGGAAGATAAGCTTTATGTT
GACTATGCCAAAGGCTTTATTCAATTGATTGCACCATTTGCACCTCACTTGGCAGAAGAACTCTGGCAAA
CAGTCGCAGAAACAGGTGAGTCAATCTCTTATGTAGCTTGGCCAACTTGGGACGAAAGCAAATTGGTTGA
AGATGAAATTGAAATTGTCGTCCAAATCAAAGGAAAAGTTCGTGCCAAACTCATGGTTGCTAAAGATCTA
TCACGTGAAGAATTACAAGAAATCGCTTTAGCTGATGAAAAAGTCAAAGCAGAAATTGACGGTAAGGAAA
TCGTGAAAGTAATTGCGGTACCGAATAAACTCGTTAATATCGTCGTTAAATA
Protein Sequence 
>gi|15900189|ref|NP_344793.1| leucyl-tRNA synthetase [Streptococcus pneumoniae TIGR4] MSFYNHKEIEPKWQGYWAEHHTFKTGTDTSKPKFYALDMFPYPSGAGLHVGHPEGYTATDILSRYKRAQGYNVLHPMGWDAFGLPAEQYAMDTGNDPAEFTAENIANFKRQINALGFSYDWDREVNTTDPNYYKWTQWIFTKLYEKGLAYEAEVPVNWVEELGTAIANEEVLPDGTSERGGYPVVRKPMRQWMLKITAYAERLLNDLDELDWSESIKDMQRNWIGKSTGANVTFKVKGTDKEFTVFTTRPDTLFGATFTVLAPEHELVDAITSSEQAEAVADYKHQASLKSDLARTDLAKEKTGVWTGAYAINPVNGKEMPIWIADYVLASYGTGAVMAVPAHDQRDWEFAKQFDLPIVEVLEGGNVEEAAYTEDGLHVNSDFLDGLNKEDAIAKIVAWLEEKGCGQEKVTYRLRDWLFSRQRYWGEPIPIIHWEDGTSTAVPETELPLVLPVTKDIRPSGTGESPLANLTDWLEVTREDGVKGRRETNTMPQWAGSSWYYLRYIDPHNTEKLADEDLLKQWLPVDIYVGGAEHAVLHLLYARFWHKFLYDLGVVPTKEPFQKLFNQGMILGTSYRDHRGALVATDKVEKRDGSFFHVETGEELEQAPAKMSKSLKNVVNPDDVVEQYGADTLRVYEMFMGPLDASIAWSEEGLEGSRKFLDRVYRLITSKEILAENNGALDKVYNETVKAVTEQIESLKFNTAIAQLMVFVNAANKEDKLYVDYAKGFIQLIAPFAPHLAEELWQTVAETGESISYVAWPTWDESKLVEDEIEIVVQIKGKVRAKLMVAKDLSREELQEIALADEKVKAEIDGKEIVKVIAVPNKLVNIVVK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: leuS mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0495J, under J: Translation, ribosomal structure and biogenesis
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].