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SP_0641

Victor ID 3216
Gene Name SP_0641
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930590
NCBI Protein GI 15900547
Locus Tag SP_0641
Protein Accession NP_345151.1
Other Database IDs UniProtKB-ID: Q97RY6_STRPN
UniRef100: UniRef100_Q97RY6
UniRef90: UniRef90_B2IMV5
UniRef50: UniRef50_C1C607
UniParc: UPI000005150F
EMBL: AE005672
EMBL-CDS: AAK74791.1
RefSeq_NT: NC_003028.3
HSSP: P00782
MEROPS: S08.064
EnsemblGenome: EBSTRG00000027192.
EnsemblGenome_TRS: EBSTRT00000027192
EnsemblGenome_PRO: EBSTRP00000026284
GenomeReviews: AE005672_GR
KEGG: spn:SP_0641
TIGR: SP_0641
HOGENOM: HBG702201
OMA: HRIKFAN
ProtClustDB: CLSK559872
BioCyc: SPNE170187-1:SP_0641-MONOMER
Taxonomy ID 170187
Gene Starting Position 603894
Gene Ending Position 610316
Gene Strand (Orientation) +
Protein Name serine protease, subtilase family
DNA Sequence 
>gi|194172857:603894-610316 Streptococcus pneumoniae TIGR4 chromosome, complete genome
AATGAAAAAAAGTACAGTATTGTCATTAACCACAGCTGCAGTTATTTTAGCAGCCTATGCCCCTAATGAG
GTAGTCTTAGCAGACACATCTAGCTCTGAAGATGCTTTAAACATCTCTGATAAAGAAAAAGTAGCAGAAA
ATAAAGAGAAACATGAAAATATCCATAGTGCTATGGAAACTTCACAGGATTTTAAAGAGAAGAAAACAGC
AGTCATTAAGGAAAAAGAAGTTGTTAGTAAAAATCCTGTGATAGACAATAACACTAGCAATGAAGAAGCA
AAAATCAAAGAAGAAAATTCCAATAAATCCCAAGGAGATTATACGGACTCATTTGTGAATAAAAACACAG
AAAATCCCAAAAAAGAAGATAAAGTTGTCTATATTGCTGAATTTAAAGATAAAGAATCTGGAGAAAAAGC
AATCAAGGAACTATCCAGTCTTAAGAATACAAAAGTTTTATATACTTATGATAGAATTTTTAACGGTAGT
GCCATAGAAACAACTCCAGATAACTTGGACAAAATTAAACAAATAGAAGGTATTTCATCGGTTGAAAGGG
CACAAAAAGTCCAACCCATGATGAATCATGCCAGAAAGGAAATTGGAGTTGAGGAAGCTATTGATTACCT
AAAGTCTATCAATGCTCCGTTTGGGAAAAATTTTGATGGTAGAGGTATGGTCATTTCAAATATCGATACT
GGAACAGATTATAGACATAAGGCTATGAGAATCGATGATGATGCCAAAGCCTCAATGAGATTTAAAAAAG
AAGACTTAAAAGGCACTGATAAAAATTATTGGTTGAGTGATAAAATCCCTCATGCGTTCAATTATTATAA
TGGTGGCAAAATCACTGTAGAAAAATATGATGATGGAAGGGATTATTTTGACCCACATGGGATGCATATT
GCAGGGATTCTTGCTGGAAATGATACTGAACAAGACATCAAAAACTTTAACGGCATAGATGGAATTGCAC
CTAATGCACAAATTTTCTCTTACAAAATGTATTCTGACGCAGGATCTGGGTTTGCGGGTGATGAAACAAT
GTTTCATGCTATTGAAGATTCTATCAAACACAACGTTGATGTTGTTTCGGTATCATCTGGTTTTACAGGA
ACAGGTCTTGTAGGTGAGAAATATTGGCAAGCTATTCGGGCATTAAGAAAAGCAGGCATTCCAATGGTTG
TCGCTACGGGTAACTATGCGACTTCTGCTTCAAGTTCTTCATGGGATTTAGTAGCAAATAATCATCTGAA
AATGACCGACACTGGAAATGTAACACGAACTGCAGCACATGAAGATGCGATAGCGGTCGCTTCTGCTAAA
AATCAAACAGTTGAGTTTGATAAAGTTAACATAGGTGGAGAAAGTTTTAAATACAGAAATATAGGGGCCT
TTTTCGATAAGAGTAAAATCACAACAAATGAAGATGGAACAAAAGCTCCTAGTAAATTAAAATTTGTATA
TATAGGCAAGGGGCAAGACCAAGATTTGATAGGTTTGGATCTTAGGGGCAAAATTGCAGTAATGGATAGA
ATTTATACAAAGGATTTAAAAAATGCTTTTAAAAAAGCTATGGATAAGGGTGCACGCGCCATTATGGTTG
TAAATACTGTAAATTACTACAATAGAGATAATTGGACAGAGCTTCCAGCTATGGGATATGAAGCGGATGA
AGGTACTAAAAGTCAAGTGTTTTCAATTTCAGGAGATGATGGTGTAAAGCTATGGAACATGATTAATCCT
GATAAAAAAACTGAAGTCAAAAGAAATAATAAAGAAGATTTTAAAGATAAATTGGAGCAATACTATCCAA
TTGATATGGAAAGTTTTAATTCCAACAAACCGAATGTAGGTGACGAAAAAGAGATTGACTTTAAGTTTGC
ACCTGACACAGACAAAGAACTCTATAAAGAAGATATCATCGTTCCAGCAGGATCTACATCTTGGGGGCCA
AGAATAGATTTACTTTTAAAACCCGATGTTTCAGCACCTGGTAAAAATATTAAATCCACGCTTAATGTTA
TTAATGGCAAATCAACTTATGGCTATATGTCAGGAACTAGTATGGCGACTCCAATCGTGGCAGCTTCTAC
TGTTTTGATTAGACCGAAATTAAAGGAAATGCTTGAAAGACCTGTATTGAAAAATCTTAAGGGAGATGAC
AAAATAGATCTTACAAGTCTTACAAAAATTGCCCTACAAAATACTGCGCGACCTATGATGGATGCAACTT
CTTGGAAAGAAAAAAGTCAATACTTTGCATCACCTAGACAACAGGGAGCAGGCCTAATTAATGTGGCCAA
TGCTTTGAGAAATGAAGTTGTAGCAACTTTCAAAAACACTGATTCTAAAGGTTTGGTAAACTCATATGGT
TCCATTTCTCTTAAAGAAATAAAAGGTGATAAAAAATACTTTACAATCAAGCTTCACAATACATCAAACA
GACCTTTGACTTTTAAAGTTTCAGCATCAGCGATAACTACAGATTCTCTAACTGACAGATTAAAACTTGA
TGAAACATATAAAGATGAAAAATCTCCAGATGGTAAGCAAATTGTTCCAGAAATTCACCCAGAAAAAGTC
AAAGGAGCAAATATCACATTTGAGCATGATACTTTCACTATAGGCGCAAATTCTAGCTTTGATTTGAATG
CGGTTATAAATGTTGGAGAGGCCAAAAACAAAAATAAATTTGTAGAATCATTTATTCATTTTGAGTCAGT
GGAAGAAATGGAAGCTCTAAACTCCAACGGGAAGAAAATAAACTTCCAACCTTCTTTGTCGATGCCTCTA
ATGGGATTTGCTGGGAATTGGAACCACGAACCAATCCTTGATAAATGGGCTTGGGAAGAAGGGTCAAGAT
CAAAAACACTGGGAGGTTATGATGATGATGGTAAACCGAAAATTCCAGGAACCTTAAATAAGGGAATTGG
TGGAGAACATGGTATAGATAAATTTAATCCAGCAGGAGTTATACAAAATAGAAAAGATAAAAATACAACA
TCCCTGGATCAAAATCCAGAATTATTTGCTTTCAATAACGAAGGGATCAACGCTCCATCATCAAGTGGTT
CTAAGATTGCTAACATTTATCCTTTAGATTCAAATGGAAATCCTCAAGATGCTCAACTTGAAAGAGGATT
AACACCTTCTCCACTTGTATTAAGAAGTGCAGAAGAAGGATTGATTTCAATAGTAAATACAAATAAAGAG
GGAGAAAATCAAAGAGACTTAAAAGTCATTTCGAGAGAACACTTTATTAGAGGAATTTTAAATTCTAAAA
GCAATGATGCAAAGGGAATCAAATCATCTAAACTAAAAGTTTGGGGTGACTTGAAGTGGGATGGACTCAT
CTATAATCCTAGAGGTAGAGAAGAAAATGCACCAGAAAGTAAGGATAATCAAGATCCTGCTACTAAGATA
AGAGGTCAATTTGAACCGATTGCGGAAGGTCAATATTTCTATAAATTTAAATATAGATTAACTAAAGATT
ACCCATGGCAGGTTTCCTATATTCCTGTAAAAATTGATAACACCGCCCCTAAGATTGTTTCGGTTGATTT
TTCAAATCCTGAAAAAATTAAGTTGATTACAAAGGATACTTATCATAAGGTAAAAGATCAGTATAAGAAT
GAAACGCTATTTGCGAGAGATCAAAAAGAACATCCTGAAAAATTTGACGAGATTGCGAACGAAGTTTGGT
ATGCTGGCGCCGCTCTTGTTAATGAAGATGGAGAGGTTGAAAAAAATCTTGAAGTAACTTACGCAGGTGA
GGGTCAAGGAAGAAATAGAAAACTTGATAAAGACGGAAATACCATTTATGAAATTAAAGGTGCGGGAGAT
TTAAGGGGAAAAATCATTGAAGTCATTGCATTAGATGGTTCTAGCAATTTCACAAAGATTCATAGAATTA
AATTTGCTAATCAGGCTGATGAAAAGGGGATGATTTCCTATTATCTAGTAGATCCTGATCAAGATTCATC
TAAATATCAAAAGCTTGGCGAGATTGCAGAATCTAAATTTAAAAATTTAGGAAATGGAAAAGAGGGTAGT
CTAAAAAAAGATACAACTGGGGTAGAACATCATCATCAAGAAAATGAAGAGTCTATTAAAGAAAAATCTA
GTTTTACTATTGATAGAAATATTTCAACAATTAGAGACTTTGAAAATAAAGACTTAAAGAAACTCATTAA
AAAGAAATTTAGAGAAGTTGATGATTTTACAAGTGAAACTGGTAAGAGAATGGAGGAATACGATTATAAA
TACGATGATAAAGGAAATATAATAGCCTACGATGATGGGACTGATCTAGAATATGAAACTGAGAAACTTG
ACGAAATCAAATCAAAAATTTATGGTGTTCTAAGTCCGTCTAAAGATGGACACTTTGAAATTCTTGGAAA
GATAAGTAATGTTTCTAAAAATGCCAAGGTATATTATGGGAATAACTATAAATCTATAGAAATCAAAGCG
ACCAAGTATGATTTCCACTCAAAAACGATGACATTTGATCTATACGCTAATATTAATGATATTGTGGATG
GATTAGCTTTTGCAGGAGATATGAGATTATTTGTTAAAGATAATGATCAGAAAAAAGCTGAAATTAAAAT
TAGAATGCCTGAAAAAATTAAGGAAACTAAATCAGAATATCCCTATGTATCAAGTTATGGGAATGTCATA
GAATTAGGGGAAGGAGATCTTTCAAAAAACAAACCAGACAATTTAACTAAAATGGAATCTGGTAAAATCT
ATTCTGATTCAGAAAAACAACAATATCTGTTAAAGGATAATATCATTCTAAGAAAAGGCTATGCACTAAA
AGTGACTACCTATAATCCTGGAAAAACGGATATGTTAGAAGGAAATGGAGTCTATAGCAAGGAAGATATA
GCAAAAATACAAAAGGCCAATCCTAATCTAAGAGCCCTTTCAGAAACAACAATTTATGCTGATAGTAGAA
ATGTTGAAGATGGAAGAAGTACCCAATCTGTATTAATGTCGGCTTTGGACGGCTTTAACATTATAAGGTA
TCAAGTGTTTACATTTAAAATGAACGATAAAGGGGAAGCTATCGATAAAGACGGAAATCTTGTGACAGAT
TCTTCTAAACTTGTATTATTTGGTAAGGATGATAAAGAATACACTGGAGAGGATAAGTTCAATGTAGAAG
CTATAAAAGAAGATGGCTCCATGTTATTTATTGATACCAAACCAGTAAACCTTTCAATGGATAAGAACTA
CTTTAATCCATCTAAATCTAATAAAATTTATGTACGAAATCCAGAATTTTATTTAAGAGGTAAGATTTCT
GATAAGGGTGGTTTTAACTGGGAATTGAGAGTTAATGAATCGGTTGTAGATAATTATTTAATCTACGGAG
ATTTACACATTGATAACACTAGAGATTTTAATATTAAGCTGAATGTTAAAGACGGTGACATCATGGACTG
GGGAATGAAAGACTATAAAGCAAACGGATTTCCAGATAAGGTAACAGATATGGATGGAAATGTTTATCTT
CAAACTGGCTATAGCGATTTGAATGCTAAAGCAGTTGGAGTCCACTATCAGTTTTTATATGATAATGTTA
AACCCGAAGTAAACATTGATCCTAAGGGAAATACTAGTATCGAATATGCTGATGGAAAATCTGTAGTCTT
TAACATCAATGATAAAAGAAATAATGGATTCGATGGTGAGATTCAAGAACAACATATTTATATAAATGGA
AAAGAATATACATCATTTAATGATATTAAACAAATAATAGACAAGACACTAAACATTAAGATTGTTGTAA
AAGATTTTGCAAGAAATACAACCGTAAAAGAATTCATTTTAAATAAAGATACGGGAGAGGTAAGTGAATT
AAAACCTCATAGGGTAACTGTGACCATTCAAAATGGAAAAGAAATGAGTTCAACGATAGTGTCGGAAGAA
GATTTTATTTTACCTGTTTATAAGGGTGAATTAGAAAAAGGATACCAATTTGATGGTTGGGAAATTTCTG
GTTTCGAAGGTAAAAAAGACGCTGGCTATGTTATTAATCTATCAAAAGATACCTTTATAAAACCTGTATT
CAAGAAAATAGAGGAGAAAAAGGAGGAAGAAAATAAACCTACTTTTGATGTATCGAAAAAGAAAGATAAC
CCACAAGTAAACCATAGTCAATTAAATGAAAGTCACAGAAAAGAGGATTTACAAAGAGAAGAGCATTCAC
AAAAATCTGATTCAACTAAGGATGTTACAGCTACAGTTCTTGATAAAAACAATATCAGTAGTAAATCAAC
TACTAACAATCCTAATAAGTTGCCAAAAACTGGAACAGCAAGCGGAGCCCAGACACTATTAGCTGCCGGA
ATAATGTTTATAGTAGGAATTTTTCTTGGATTGAAGAAAAAAAATCAAGATTA
Protein Sequence 
>gi|15900547|ref|NP_345151.1| serine protease [Streptococcus pneumoniae TIGR4] MKKSTVLSLTTAAVILAAYAPNEVVLADTSSSEDALNISDKEKVAENKEKHENIHSAMETSQDFKEKKTAVIKEKEVVSKNPVIDNNTSNEEAKIKEENSNKSQGDYTDSFVNKNTENPKKEDKVVYIAEFKDKESGEKAIKELSSLKNTKVLYTYDRIFNGSAIETTPDNLDKIKQIEGISSVERAQKVQPMMNHARKEIGVEEAIDYLKSINAPFGKNFDGRGMVISNIDTGTDYRHKAMRIDDDAKASMRFKKEDLKGTDKNYWLSDKIPHAFNYYNGGKITVEKYDDGRDYFDPHGMHIAGILAGNDTEQDIKNFNGIDGIAPNAQIFSYKMYSDAGSGFAGDETMFHAIEDSIKHNVDVVSVSSGFTGTGLVGEKYWQAIRALRKAGIPMVVATGNYATSASSSSWDLVANNHLKMTDTGNVTRTAAHEDAIAVASAKNQTVEFDKVNIGGESFKYRNIGAFFDKSKITTNEDGTKAPSKLKFVYIGKGQDQDLIGLDLRGKIAVMDRIYTKDLKNAFKKAMDKGARAIMVVNTVNYYNRDNWTELPAMGYEADEGTKSQVFSISGDDGVKLWNMINPDKKTEVKRNNKEDFKDKLEQYYPIDMESFNSNKPNVGDEKEIDFKFAPDTDKELYKEDIIVPAGSTSWGPRIDLLLKPDVSAPGKNIKSTLNVINGKSTYGYMSGTSMATPIVAASTVLIRPKLKEMLERPVLKNLKGDDKIDLTSLTKIALQNTARPMMDATSWKEKSQYFASPRQQGAGLINVANALRNEVVATFKNTDSKGLVNSYGSISLKEIKGDKKYFTIKLHNTSNRPLTFKVSASAITTDSLTDRLKLDETYKDEKSPDGKQIVPEIHPEKVKGANITFEHDTFTIGANSSFDLNAVINVGEAKNKNKFVESFIHFESVEEMEALNSNGKKINFQPSLSMPLMGFAGNWNHEPILDKWAWEEGSRSKTLGGYDDDGKPKIPGTLNKGIGGEHGIDKFNPAGVIQNRKDKNTTSLDQNPELFAFNNEGINAPSSSGSKIANIYPLDSNGNPQDAQLERGLTPSPLVLRSAEEGLISIVNTNKEGENQRDLKVISREHFIRGILNSKSNDAKGIKSSKLKVWGDLKWDGLIYNPRGREENAPESKDNQDPATKIRGQFEPIAEGQYFYKFKYRLTKDYPWQVSYIPVKIDNTAPKIVSVDFSNPEKIKLITKDTYHKVKDQYKNETLFARDQKEHPEKFDEIANEVWYAGAALVNEDGEVEKNLEVTYAGEGQGRNRKLDKDGNTIYEIKGAGDLRGKIIEVIALDGSSNFTKIHRIKFANQADEKGMISYYLVDPDQDSSKYQKLGEIAESKFKNLGNGKEGSLKKDTTGVEHHHQENEESIKEKSSFTIDRNISTIRDFENKDLKKLIKKKFREVDDFTSETGKRMEEYDYKYDDKGNIIAYDDGTDLEYETEKLDEIKSKIYGVLSPSKDGHFEILGKISNVSKNAKVYYGNNYKSIEIKATKYDFHSKTMTFDLYANINDIVDGLAFAGDMRLFVKDNDQKKAEIKIRMPEKIKETKSEYPYVSSYGNVIELGEGDLSKNKPDNLTKMESGKIYSDSEKQQYLLKDNIILRKGYALKVTTYNPGKTDMLEGNGVYSKEDIAKIQKANPNLRALSETTIYADSRNVEDGRSTQSVLMSALDGFNIIRYQVFTFKMNDKGEAIDKDGNLVTDSSKLVLFGKDDKEYTGEDKFNVEAIKEDGSMLFIDTKPVNLSMDKNYFNPSKSNKIYVRNPEFYLRGKISDKGGFNWELRVNESVVDNYLIYGDLHIDNTRDFNIKLNVKDGDIMDWGMKDYKANGFPDKVTDMDGNVYLQTGYSDLNAKAVGVHYQFLYDNVKPEVNIDPKGNTSIEYADGKSVVFNINDKRNNGFDGEIQEQHIYINGKEYTSFNDIKQIIDKTLNIKIVVKDFARNTTVKEFILNKDTGEVSELKPHRVTVTIQNGKEMSSTIVSEEDFILPVYKGELEKGYQFDGWEISGFEGKKDAGYVINLSKDTFIKPVFKKIEEKKEEENKPTFDVSKKKDNPQVNHSQLNESHRKEDLQREEHSQKSDSTKDVTATVLDKNNISSKSTTNNPNKLPKTGTASGAQTLLAAGIMFIVGIFLGLKKKNQD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0641 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG1404O, under O: Posttranslational modification, protein turnover, chaperones
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].