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spxB from Streptococcus pneumoniae G54

Victor ID 3444
Gene Name spxB from Streptococcus pneumoniae G54
Sequence Strain (Species/Organism) Streptococcus pneumoniae G54
NCBI Gene ID 6479320
NCBI Protein GI 194397524
Locus Tag SPG_0663
Protein Accession YP_002037378.1
Other Database IDs UniProtKB-ID: B5E333_STRP4
UniRef100: UniRef100_E0SXI7
UniRef90: UniRef90_Q54970
UniRef50: UniRef50_Q54970
UniParc: UPI00004A7D4F
EMBL: CP001015
EMBL-CDS: ACF55639.1
RefSeq_NT: NC_011072.1
EnsemblGenome: EBSTRG00000022706.
EnsemblGenome_TRS: EBSTRT00000022706
EnsemblGenome_PRO: EBSTRP00000021872
GenomeReviews: CP001015_GR
KEGG: spx:SPG_0663
HOGENOM: HBG323037
OMA: KHRERSL
ProtClustDB: CLSK883986
Taxonomy ID 512566
Gene Starting Position 649534
Gene Ending Position 651309
Gene Strand (Orientation) +
Protein Name pyruvate oxidase
DNA Sequence 
>gi|194396645:649534-651309 Streptococcus pneumoniae G54 chromosome, complete genome
TATGACTCAAGGGAAAATTACTGCATCTGCAGCAATGCTTAACGTATTGAAAACATGGGGCGTAGATACA
ATCTACGGTATCCCATCAGGAACACTCAGCTCATTGATGGACGCTTTGGCTGAAGACAAAGATATCCGCT
TCTTACAAGTTCGCCACGAAGAGACAGGTGCTCTTGCAGCGGTTATGCAAGCTAAATTCGGCGGCTCAAT
CGGGGTTGCAGTTGGTTCAGGTGGTCCAGGTGCGACTCACTTGATTAACGGTGTTTACGATGCAGCTATG
GATAACACTCCATTCCTAGCGATCCTTGGATCACGTCCAGTTAACGAATTGAACATGGATGCTTTCCAAG
AGCTTAACCAAAACCCAATGTACAACGGTATCGCTGTTTACAACAAACGTGTAGCTTACGCTGAGCAATT
GCCAAAAGTAATTGACGAAGCCTGCCGTGCTGCAATTTCTAAAAAAGGTCCAGCTGTTGTTGAAATTCCA
GTAAACTTCGGTTTCCAAGAAATCGACGAAAACTCATACTACGGTTCAGGTTCATACGAACGCTCATTCA
TCGCTCCTGCTTTGAACGAAGTTGAAATCGACAAAGCTGTTGAAATCTTGAACAATGCTGAACGCCCAGT
TATCTATGCTGGATTTGGTGGTGTTAAAGCTGGTGAAGTGATTACTGAATTGTCACGTAAAATCAAAGCA
CCAATCATCACAACTGGTAAAAACTTTGAAGCTTTCGAATGGAACTATGAAGGTTTGACAGGTTCTGCTT
ACCGTGTTGGTTGGAAACCAGCCAACGAAGTGGTCTTTGAAGCAGACACAGTTCTTTTCCTTGGTTCAAA
CTTCCCATTTGCTGAAGTTTACGAAGCATTCAAGAACACTGAAAAATTCATCCAAGTCGATATCGACCCT
TACAAACTTGGTAAACGTCATGCCCTTGACGCTTCAATCCTTGGTGATGCTGGTCAAGCAGCTAAAGCTA
TCCTTGACAAAGTAAACCCAGTTGAATCAACTCCATGGTGGCGTGCAAACGTTAAGAACAACCAAAACTG
GCGTGATTACATGAACAAACTCGAAGGTAAAACTGAGGGTGAATTGCAATTGTATCAAGTTTACAATGCA
ATCAACAAACATGCTGATCAAGACGCTATCTACTCAATCGACGTAGGTAACACTACTCAAACATCTACTC
GTCACCTTCACATGACACCTAAGAACATGTGGCGTACATCTCCACTCTTTGCGACAATGGGTATTGCCCT
TCCTGGTGGTATCGCTGCTAAGAAAGACAATCCAGATCGCCAAGTATGGAACATCATGGGTGATGGAGCA
TTCAACATGTGCTACCCAGACGTTATCACAAACGTTCAATACGACCTTCCAGTTATCAACCTTGTCTTCT
CAAATGCTGAGTACGGCTTCATCAAGAACAAATACGAAGATACAAACAAACACTTGTTTGGTGTAGACTT
CACAAACGCTGACTACGCTAAAATTGCGGAAGCTCAAGGAGCTGTTGGATTCACAGTTGACCGTATCGAA
GACATCGATGCAGTTGTTGCAGAAGCTGTTAAATTGAACAAAGAAGGTAAAACTGTTGTCATCGATGCTC
GCATCACTCAACACCGTCCACTTCCAGTAGAAGTACTTGAATTGGATCCAAAACTTCACTCAGAAGAAGC
TATCAAAGCCTTCAAGGAAAAATACGAAGCAGAAGAACTCGTACCATTCCGTCTCTTCTTGGAAGAAGAA
GGATTGCAATCACGCGCAATTAAATA
Protein Sequence 
>gi|194397524|ref|YP_002037378.1| pyruvate oxidase [Streptococcus pneumoniae G54] MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits (Spellerberg et al., 1996).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Spellerberg et al., 1996: Spellerberg B, Cundell DR, Sandros J, Pearce BJ, Idanpaan-Heikkila I, Rosenow C, Masure HR. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular microbiology. 1996; 19(4); 803-813. [PubMed: 8820650].