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purB

Victor ID 3083
Gene Name purB
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4442401
NCBI Protein GI 116516623
Locus Tag SPD_0062
Protein Accession YP_815510.1
Other Database IDs UniProtKB-ID: Q04N14_STRP2
UniRef100: UniRef100_Q04N14
UniRef90: UniRef90_P72478
UniRef50: UniRef50_Q2G2S0
UniParc: UPI00000E3397
EMBL: CP000410
EMBL-CDS: ABJ54919.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000019522.
EnsemblGenome_TRS: EBSTRT00000019522
EnsemblGenome_PRO: EBSTRP00000018762
GenomeReviews: CP000410_GR
KEGG: spd:SPD_0062
eggNOG: COG0015
HOGENOM: HBG499008
OMA: KVWEQGK
ProtClustDB: PRK08937
Taxonomy ID 373153
Gene Starting Position 59174
Gene Ending Position 60472
Gene Strand (Orientation) +
Protein Name adenylosuccinate lyase
DNA Sequence 
>gi|116515308:59174-60472 Streptococcus pneumoniae D39, complete genome
CATGATCAACCGTTACTCTCGCCCTGAGATGGCGAATATTTGGAGTGAAGAAAATAAATACCGTGCTTGG
CTTGAGGTGGAAATCCTCTCTGACGAGGCATGGGCTGAGTTGGGGGAAATCCCTAAGGAAGATGTGGCTT
TGATTCGCAAGAAGGCGGACTTTGACATCGACCGTATTTTGGAAATTGAGCAGGAGACGCGCCACGATGT
GGTGGCTTTCACGCGTGCGGTTTCTGAGACTCTTGGTGAAGAGCGCAAGTGGGTTCACTATGGGTTAACT
TCTACCGACGTGGTGGATACTGCTTATGGTTACCTCTACAAGCAGGCCAACGACATCATCCGTCGTGACC
TTGAAAACTTCACTAATATCATCGCTGACAAGGCCAAGGAGCACAAGTTCACCATCATGATGGGGCGTAC
TCATGGTGTGCACGCTGAGCCGACAACTTTTGGTCTTAAATTGGCAACTTGGTATAGCGAAATGAAACGC
AATATCGAGCGTTTCGAGCATGCGGCTGCTGGTGTAGAAGCTGGTAAGATTTCTGGTGCGGTTGGGAACT
TTGCCAATATCCCACCATTTGTAGAGGAGTATGTCTGCAACAAGCTTGGTATCCGTGCTCAAGAAATCTC
TACACAAGTCCTTCCTCGTGACCTTCACGCTGAGTACTTTGCAGTTCTTGCCAGCATTGCGACTTCAATC
GAACGTATGGCGACTGAGATTCGTGGTCTACAAAAATCTGAGCAACGCGAAGTAGAAGAGTTCTTTGCTA
AAGGGCAAAAAGGGTCTTCAGCAATGCCTCACAAACGCAACCCAATCGGTTCTGAAAATATGACTGGTCT
GGCGCGTGTCATTCGTGGTCACATGATTACGGCTTATGAAAACGTCGCTCTCTGGCACGAACGCGATATT
TCCCACTCATCAGCTGAGCGTATCATCACACCAGATACGACCATTTTGATTGACTACATGCTCAACCGTT
TTGGAAATATCGTCAAGAACTTGACAGTCTTCCCAGAAAATATGATCCGAAACATGAACTCGACTTTTGG
TCTTATCTTTAGCCAACGGGCTATGTTGACATTGATTGAAAAAGGCATGACCCGTGAGCAAGCCTATGAC
TTGGTGCAACCAAAAACAGCCTACTCTTGGGACAACCAAGTAGACTTTAAACCACTTCTTGAGGCAGATT
CAGAAGTAACATCACGTCTCACTCAAGAAGAAATCGATGAAATCTTCAACCCAGTTTATTACACCAAACG
AGTGGATGATATCTTTGAACGTCTTGGACTAGGTGATTA
Protein Sequence 
>gi|116516623|ref|YP_815510.1| adenylosuccinate lyase [Streptococcus pneumoniae D39] MINRYSRPEMANIWSEENKYRAWLEVEILSDEAWAELGEIPKEDVALIRKKADFDIDRILEIEQETRHDVVAFTRAVSETLGEERKWVHYGLTSTDVVDTAYGYLYKQANDIIRRDLENFTNIIADKAKEHKFTIMMGRTHGVHAEPTTFGLKLATWYSEMKRNIERFEHAAAGVEAGKISGAVGNFANIPPFVEEYVCNKLGIRAQEISTQVLPRDLHAEYFAVLASIATSIERMATEIRGLQKSEQREVEEFFAKGQKGSSAMPHKRNPIGSENMTGLARVIRGHMITAYENVALWHERDISHSSAERIITPDTTILIDYMLNRFGNIVKNLTVFPENMIRNMNSTFGLIFSQRAMLTLIEKGMTREQAYDLVQPKTAYSWDNQVDFKPLLEADSEVTSRLTQEEIDEIFNPVYYTKRVDDIFERLGLGD
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a purB mutant was attenuated in a murine model (Lau et al., 2001)
COG COG0015F, under F: Nucleotide transport and metabolism
References
Lau et al., 2001: Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, Bryant AP, McDevitt D, Morrison DA, Holden DW. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Molecular microbiology. 2001; 40(3); 555-571. [PubMed: 11359563].