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spxB from Streptococcus pneumoniae ATCC 700669

Victor ID 3615
Gene Name spxB from Streptococcus pneumoniae ATCC 700669
Sequence Strain (Species/Organism) Streptococcus pneumoniae ATCC 700669
NCBI Gene ID 7328274
NCBI Protein GI 221231532
Locus Tag SPN23F_06550
Protein Accession YP_002510684.1
Other Database IDs UniProtKB-ID: B8ZN27_STRPJ
UniRef100: UniRef100_E0SXI7
UniRef90: UniRef90_Q54970
UniRef50: UniRef50_Q54970
UniParc: UPI00004A7D4F
EMBL: FM211187
EMBL-CDS: CAR68502.1
RefSeq_NT: NC_011900.1
EnsemblGenome: EBSTRG00000070722.
EnsemblGenome_TRS: EBSTRT00000072779
EnsemblGenome_PRO: EBSTRP00000067598
GenomeReviews: FM211187_GR
HOGENOM: HBG323037
ProtClustDB: CLSK883986
Taxonomy ID 561276
Gene Starting Position 645569
Gene Ending Position 647344
Gene Strand (Orientation) +
Protein Name pyruvate oxidase
DNA Sequence 
>gi|221230948:645569-647344 Streptococcus pneumoniae ATCC 700669, complete genome
TATGACTCAAGGGAAAATTACTGCATCTGCAGCAATGCTTAACGTATTGAAAACATGGGGCGTAGATACA
ATCTACGGTATCCCATCAGGAACACTCAGCTCATTGATGGACGCTTTGGCTGAAGACAAAGATATCCGCT
TCTTACAAGTTCGCCACGAAGAGACAGGTGCTCTTGCAGCGGTTATGCAAGCTAAATTCGGCGGCTCAAT
CGGGGTTGCAGTTGGTTCAGGTGGTCCAGGTGCGACTCACTTGATTAACGGTGTTTACGATGCAGCTATG
GATAACACTCCATTCCTAGCGATCCTTGGATCACGTCCAGTTAACGAATTGAACATGGATGCTTTCCAAG
AGCTTAACCAAAACCCAATGTACAACGGTATCGCTGTTTACAACAAACGTGTAGCTTACGCTGAGCAATT
GCCAAAAGTAATTGACGAAGCCTGCCGTGCTGCAATTTCTAAAAAAGGTCCAGCTGTTGTTGAAATTCCA
GTAAACTTCGGTTTCCAAGAAATCGACGAAAACTCATACTACGGTTCAGGTTCATACGAACGCTCATTCA
TCGCTCCTGCTTTGAACGAAGTTGAAATCGACAAAGCTGTTGAAATCTTGAACAATGCTGAACGCCCAGT
TATCTATGCTGGATTTGGTGGTGTTAAAGCTGGTGAAGTGATTACTGAATTGTCACGTAAAATCAAAGCA
CCAATCATCACAACTGGTAAAAACTTTGAAGCTTTCGAATGGAACTATGAAGGTTTGACAGGTTCTGCTT
ATCGTGTTGGTTGGAAACCAGCCAACGAAGTGGTCTTTGAAGCAGACACAGTTCTTTTCCTTGGTTCAAA
CTTCCCATTTGCTGAAGTTTACGAAGCATTCAAGAACACTGAAAAATTCATCCAAGTTGATATCGACCCT
TACAAACTTGGTAAACGTCATGCCCTTGACGCTTCAATCCTTGGTGATGCTGGTCAAGCAGCTAAAGCTA
TCCTTGACAAAGTAAACCCAGTTGAATCAACTCCATGGTGGCGTGCAAACGTTAAGAACAACCAAAACTG
GCGTGATTACATGAACAAACTCGAAGGTAAAACTGAGGGTGAATTGCAATTGTATCAAGTTTACAATGCA
ATCAACAAACATGCTGATCAAGACGCTATCTACTCAATCGACGTAGGTAACACTACTCAAACATCTACTC
GTCACCTTCACATGACACCTAAGAACATGTGGCGTACATCTCCACTCTTTGCGACAATGGGTATTGCCCT
TCCTGGTGGTATCGCTGCTAAGAAAGACAATCCAGATCGCCAAGTATGGAACATCATGGGTGACGGAGCA
TTCAACATGTGCTACCCAGACGTTATCACAAACGTTCAATACGACCTTCCAGTTATCAACCTTGTCTTCT
CAAATGCTGAGTACGGCTTCATCAAGAACAAATACGAAGATACAAACAAACACTTGTTTGGTGTAGACTT
CACAAACGCTGACTACGCTAAAATTGCGGAAGCTCAAGGAGCTGTTGGATTCACAGTTGACCGTATCGAA
GACATCGATGCAGTTGTTGCAGAAGCTGTTAAATTGAACAAAGAAGGTAAAACTGTTGTCATCGATGCTC
GCATCACTCAACACCGTCCACTTCCAGTAGAAGTACTTGAATTGGATCCAAAACTTCACTCAGAAGAAGC
TATCAAAGCCTTCAAGGAAAAATACGAAGCAGAAGAACTCGTACCATTCCGTCTCTTCTTGGAAGAAGAA
GGATTGCAATCACGCGCAATTAAATA
Protein Sequence 
>gi|221231532|ref|YP_002510684.1| pyruvate oxidase [Streptococcus pneumoniae ATCC 700669] MTQGKITASAAMLNVLKTWGVDTIYGIPSGTLSSLMDALAEDKDIRFLQVRHEETGALAAVMQAKFGGSIGVAVGSGGPGATHLINGVYDAAMDNTPFLAILGSRPVNELNMDAFQELNQNPMYNGIAVYNKRVAYAEQLPKVIDEACRAAISKKGPAVVEIPVNFGFQEIDENSYYGSGSYERSFIAPALNEVEIDKAVEILNNAERPVIYAGFGGVKAGEVITELSRKIKAPIITTGKNFEAFEWNYEGLTGSAYRVGWKPANEVVFEADTVLFLGSNFPFAEVYEAFKNTEKFIQVDIDPYKLGKRHALDASILGDAGQAAKAILDKVNPVESTPWWRANVKNNQNWRDYMNKLEGKTEGELQLYQVYNAINKHADQDAIYSIDVGNTTQTSTRHLHMTPKNMWRTSPLFATMGIALPGGIAAKKDNPDRQVWNIMGDGAFNMCYPDVITNVQYDLPVINLVFSNAEYGFIKNKYEDTNKHLFGVDFTNADYAKIAEAQGAVGFTVDRIEDIDAVVAEAVKLNKEGKTVVIDARITQHRPLPVEVLELDPKLHSEEAIKAFKEKYEAEELVPFRLFLEEEGLQSRAIK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: spxB mutant has a loss in the ability to attach eukayrotic cells and is attenuated in rabbits (Spellerberg et al., 1996).
COG COG0028EH, under E: Amino acid transport and metabolism; H: Coenzyme transport and metabolism
References
Spellerberg et al., 1996: Spellerberg B, Cundell DR, Sandros J, Pearce BJ, Idanpaan-Heikkila I, Rosenow C, Masure HR. Pyruvate oxidase, as a determinant of virulence in Streptococcus pneumoniae. Molecular microbiology. 1996; 19(4); 803-813. [PubMed: 8820650].