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polC

Victor ID 3173
Gene Name polC
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930082
NCBI Protein GI 15900208
Locus Tag SP_0274
Protein Accession NP_344812.1
Other Database IDs UniProtKB-ID: DPO3_STRPN
UniRef100: UniRef100_Q97SQ2
UniRef90: UniRef90_Q04MH6
UniRef50: UniRef50_Q1J4M0
UniParc: UPI000005138A
EMBL: AE005672
EMBL-CDS: AAK74452.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026725
EnsemblGenome_TRS: EBSTRT00000026725
EnsemblGenome_PRO: EBSTRP00000025817
GenomeReviews: AE005672_GR
KEGG: spn:SP_0274
TIGR: SP_0274
HOGENOM: HBG617116
OMA: WKTTHFD
ProtClustDB: PRK00448
BioCyc: SPNE170187-1:SP_0274-MONOMER
Taxonomy ID 170187
Gene Starting Position 250617
Gene Ending Position 255008
Gene Strand (Orientation) +
Protein Name DNA polymerase III PolC
DNA Sequence 
>gi|194172857:250617-255008 Streptococcus pneumoniae TIGR4 chromosome, complete genome
AATGTCAAATAGTTTTGAAATTTTGATGAATCAATTGGGGATGCCTGCTGAAATGAGACAGGCTCCTGCT
TTAGCACAGGCCAATATTGAGCGAGTTGTGGTTCATAAAATTAGTAAGGTATGGGAGTTTCATTTCGTAT
TTTCTAATATTTTACCGATTGAAATCTTTTTAGAATTAAAGAAAGGTTTGAGCGAAGAATTTTCTAAGAC
AGGCAATAAAGCTGTTTTTGAAATTAAGGCTCGGTCTCAAGAATTTTCAAATCAGCTCTTGCAGTCCTAC
TATAGGGAGGCTTTCTCTGAAGGTCCATGTGCTAGTCAAGGTTTTAAGTCCCTTTATCAAAATTTGCAAG
TTCGTGCTGAGGGTAATCAGCTATTTATTGAAGGATCTGAAGCGATTGATAAGGAACATTTTAAGAAGAA
TCATCTTCCTAATTTAGCCAAACAACTTGAAAAGTTTGGTTTTCCAACTTTTAACTGTCAAGTCGAGAAG
AATGATGTCCTGACCCAAGAGCAGGAAGAGGCCTTTCATGCTGAAAATGAGCAGATTGTTCAAGCTGCCA
ATGAGGAAGCGCTCCGTGCTATGGAACAACTGGAGCAGATGGCACCTCCTCCAGCGGAAGAGAAACCAGC
CTTTGATTTTCAAGCGAAAAAAGCTGCAGCTAAACCCAAGCTGGATAAGGCGGAGATTACTCCTATGATC
GAAGTGACGACAGAGGAAAATCGTCTGGTATTTGAAGGGGTTGTTTTTGATGTGGAGCAAAAAGTGACTA
GAACAGGTCGTGTTTTAATCAACTTTAAAATGACGGACTATACTTCAAGTTTTTCTATGCAAAAGTGGGT
TAAAAACGAGGAAGAGGCCCAGAAGTTTGACCTCATCAAGAAGAATTCTTGGCTCCGAGTTCGAGGGAAT
GTGGAGATGAATAACTTCACACGCGATTTGACTATGAACGTACAGGATCTGCAGGAAGTTGTTCACTATG
AGCGGAAGGATTTGATGCCAGAAGGTGAGCGTCGGGTTGAGTTTCATGCTCATACTAACATGTCGACTAT
GGATGCTTTGCCAGAGGTCGAAGAGATTGTTGCAACAGCTGCTAAGTGGGGACACAAGGCGGTTGCTATC
ACGGACCATGGGAATGTCCAGTCCTTTCCACATGGCTATAAGGCGGCTAAGAAAGCGGGAATCCAGCTGA
TCTATGGGATGGAAGCCAATATCGTGGAGGACCGTGTCCCTATCGTCTATAACGAAGTGGAGATGGACTT
GTCAGAAGCAACCTACGTGGTCTTTGACGTGGAAACGACGGGACTTTCAGCTATCTATAATGACTTGATT
CAGGTTGCGGCTTCTAAGATGTACAAGGGGAATGTTATTGCTGAATTTGATGAATTTATCAATCCTGGGC
ATCCCTTGTCAGCCTTTACTACAGAGTTAACTGGAATTACAGATGATCATGTCAAAAATGCCAAACCACT
AGAACAAGTTTTGCAAGAATTCCAAGAATTTTGCAAGGATACGGTCCTAGTTGCCCACAATGCTACCTTT
GACGTTGGCTTTATGAATGCTAATTATGAGCGGCATGATCTTCCAAAGATTAGTCAGCCAGTTATTGATA
CGCTGGAGTTTGCTAGAAACCTCTATCCTGAGTATAAACGCCATGGTTTGGGGCCTTTGACCAAGCGTTT
TGGTGTGGCCTTGGAACATCACCACATGGCCAACTACGATGCGGAAGCGACTGGTCGTCTGCTTTTCATC
TTTATCAAAGAGGTAGCAGAAAAACATGGTGTGACCGATTTAGCTAGACTCAACATTGATCTAATCAGTC
CAGATTCTTACAAAAAAGCTCGGATCAAGCATGCGACCATCTATGTCAAGAATCAGGTAGGTCTAAAAAA
TATCTTTAAGCTGGTTTCCTTGTCTAATACCAAGTATTTTGAAGGAGTGCCACGGATTCCGAGAACGGTT
CTAGATGCCCATCGAGAGGGCTTGATTTTAGGTTCAGCCTGTTCAGAGGGTGAAGTTTTTGACGTGGTCG
TTTCTCAAGGTGTGGATGCGGCGGTTGAGGTGGCCAAGTATTATGATTTTATCGAGGTCATGCCACCGGC
TATCTATGCACCCTTGATTGCCAAAGAGCAGGTCAAGGATATGGAGGAACTCCAGACCATTATCAAGAGT
TTGATAGAGGTTGGAGACCGCCTTGGCAAGCCTGTTCTGGCTACGGGAAATGTTCACTATATCGAACCGG
AAGAAGAGATTTATCGTGAAATTATCGTCCGTAGTTTGGGACAGGGTGCGATGATTAATCGAACTATCGG
TCATGGTGAACATGCCCAACCAGCACCACTTCCAAAGGCTCATTTTCGAACGACTAATGAGATGTTGGAT
GAATTTGCCTTTTTGGGAGAGGAACTGGCTCGTAAACTGGTTATTGAAAACACCAATGCCTTGGCAGAAA
TATTTGAATCCGTTGAAGTCGTTAAGGGTGACTTGTATACGCCTTTCATCGACAAGGCTGAAGAAACAGT
TGCTGAGTTGACCTATAAGAAAGCTTTTGAGATTTATGGAAATCCGCTGCCAGATATTGTTGATTTGCGG
ATTGAAAAAGAATTAACATCCATACTGGGGAATGGATTTGCTGTGATTTATCTGGCATCGCAGATGCTGG
TGCAACGTTCTAATGAACGGGGTTATTTGGTTGGTTCTCGTGGGTCTGTCGGATCTAGTTTCGTTGCGAC
CATGATTGGGATTACGGAGGTCAATCCTCTCTCTCCTCACTATGTCTGTGGTCAGTGTCAGTACAGTGAG
TTTATCACAGATGGTTCGTACGGTTCAGGATTTGATATGCCCCATAAGGACTGTCCAAACTGTGGTCACA
AACTCAGTAAAAACGGACAGGATATTCCGTTTGAGACCTTCCTTGGTTTTGATGGGGATAAGGTTCCTGA
TATTGACTTGAACTTCTCGGGAGAAGATCAGCCTAGCGCCCACTTGGATGTGCGTGATATCTTTGGTGAA
GAATATGCCTTCCGTGCGGGAACGGTTGGTACGGTAGCTGCCAAGACTGCCTATGGATTTGTCAAAGGTT
ACGAGCGAGATTATGGCAAGTTTTATCGTGATGCAGAAGTAGAACGCCTCGCTCAAGGAGCGGCGGGTGT
CAAGCGGACAACAGGCCAACACCCGGGGGGAATCGTTGTTATTCCGAACTACATGGATGTCTACGATTTT
ACGCCTGTCCAGTATCCAGCAGATGATGTCACGGCTGAATGGCAGACCACTCACTTTAACTTCCACGATA
TCGATGAGAACGTCCTCAAACTCGATGTACTGGGACATGATGATCCGACTATGATTCGAAAACTTCAGGA
TTTGTCTGGTATTGACCCTAATAAAATTCCTATGGATGACGAAGGCGTGATGGCACTCTTTTCTGGGACT
GATGTGCTAGGGGTAACACCTGAACAAATTGGAACGCCTACGGGTATGTTGGGGATTCCAGAGTTTGGAA
CAAATTTCGTACGTGGAATGGTAGACGAAACCCATCCGACAACCTTTGCGGAATTGCTTCAGCTGTCTGG
TCTGTCCCACGGTACTGATGTTTGGTTGGGGAATGCTCAGGATCTGATTAAGCAAGGAATAGCGGACCTA
TCGACTGTTATCGGTTGTCGGGACGACATCATGGTTTACCTCATGCATGCGGGTCTGGAACCTAAGATGG
CCTTTACCATTATGGAACGGGTACGTAAGGGTTTGTGGCTAAAGATTTCAGAAGAGGAGAGAAATGGCTA
TATCGAAGCAATGAAGGCTAATAAGGTGCCAGAGTGGTATATCGAATCCTGTGGGAAAATTAAGTACATG
TTCCCTAAGGCCCATGCGGCAGCCTACGTTATGATGGCCTTGCGTGTAGCTTACTTCAAGGTTCACCATC
CTATTTATTACTACTGTGCTTACTTCTCCATTCGTGCTAAGGCTTTTGATATCAAGACCATGGGTGCGGG
CTTGGAGGTCATCAAGCGCAGAATGGAAGAAATCTCTGAAAAACGGAAGAACAATGAAGCCTCTAATGTG
GAAATCGATCTCTATACAACTCTTGAGATTGTCAATGAGATGTGGGAACGAGGTTTCAAGTTTGGTAAAT
TAGATCTCTACTGTAGTCAGGCGACAGAGTTCCTCATCGACGGGGATACCCTTATCCCACCATTTGTAGC
AATGGATGGTCTGGGAGAGAACGTTGCCAAGCAACTGGTGCGGGCGCGTGAAGAGGGAGAATTCCTCTCT
AAAACAGAACTACGCAAGCGTGGTGGACTCTCATCAACCTTGGTTGAAAAGATGGATGAGATGGGTATTC
TTGGAAATATGCCAGAGGATAACCAGTTGAGTTTGTTTGATGAGTTGTTTTA
Protein Sequence 
>gi|15900208|ref|NP_344812.1| DNA polymerase III PolC [Streptococcus pneumoniae TIGR4] MSNSFEILMNQLGMPAEMRQAPALAQANIERVVVHKISKVWEFHFVFSNILPIEIFLELKKGLSEEFSKTGNKAVFEIKARSQEFSNQLLQSYYREAFSEGPCASQGFKSLYQNLQVRAEGNQLFIEGSEAIDKEHFKKNHLPNLAKQLEKFGFPTFNCQVEKNDVLTQEQEEAFHAENEQIVQAANEEALRAMEQLEQMAPPPAEEKPAFDFQAKKAAAKPKLDKAEITPMIEVTTEENRLVFEGVVFDVEQKVTRTGRVLINFKMTDYTSSFSMQKWVKNEEEAQKFDLIKKNSWLRVRGNVEMNNFTRDLTMNVQDLQEVVHYERKDLMPEGERRVEFHAHTNMSTMDALPEVEEIVATAAKWGHKAVAITDHGNVQSFPHGYKAAKKAGIQLIYGMEANIVEDRVPIVYNEVEMDLSEATYVVFDVETTGLSAIYNDLIQVAASKMYKGNVIAEFDEFINPGHPLSAFTTELTGITDDHVKNAKPLEQVLQEFQEFCKDTVLVAHNATFDVGFMNANYERHDLPKISQPVIDTLEFARNLYPEYKRHGLGPLTKRFGVALEHHHMANYDAEATGRLLFIFIKEVAEKHGVTDLARLNIDLISPDSYKKARIKHATIYVKNQVGLKNIFKLVSLSNTKYFEGVPRIPRTVLDAHREGLILGSACSEGEVFDVVVSQGVDAAVEVAKYYDFIEVMPPAIYAPLIAKEQVKDMEELQTIIKSLIEVGDRLGKPVLATGNVHYIEPEEEIYREIIVRSLGQGAMINRTIGHGEHAQPAPLPKAHFRTTNEMLDEFAFLGEELARKLVIENTNALAEIFESVEVVKGDLYTPFIDKAEETVAELTYKKAFEIYGNPLPDIVDLRIEKELTSILGNGFAVIYLASQMLVQRSNERGYLVGSRGSVGSSFVATMIGITEVNPLSPHYVCGQCQYSEFITDGSYGSGFDMPHKDCPNCGHKLSKNGQDIPFETFLGFDGDKVPDIDLNFSGEDQPSAHLDVRDIFGEEYAFRAGTVGTVAAKTAYGFVKGYERDYGKFYRDAEVERLAQGAAGVKRTTGQHPGGIVVIPNYMDVYDFTPVQYPADDVTAEWQTTHFNFHDIDENVLKLDVLGHDDPTMIRKLQDLSGIDPNKIPMDDEGVMALFSGTDVLGVTPEQIGTPTGMLGIPEFGTNFVRGMVDETHPTTFAELLQLSGLSHGTDVWLGNAQDLIKQGIADLSTVIGCRDDIMVYLMHAGLEPKMAFTIMERVRKGLWLKISEEERNGYIEAMKANKVPEWYIESCGKIKYMFPKAHAAAYVMMALRVAYFKVHHPIYYYCAYFSIRAKAFDIKTMGAGLEVIKRRMEEISEKRKNNEASNVEIDLYTTLEIVNEMWERGFKFGKLDLYCSQATEFLIDGDTLIPPFVAMDGLGENVAKQLVRAREEGEFLSKTELRKRGGLSSTLVEKMDEMGILGNMPEDNQLSLFDELF
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: polC mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG2176L, under L: Replication, recombination and repair
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].