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SP_0664

Victor ID 3222
Gene Name SP_0664
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930613
NCBI Protein GI 15900565
Locus Tag SP_0664
Protein Accession NP_345169.1
Other Database IDs UniProtKB-ID: ZMPB_STRPN
UniRef100: UniRef100_Q9L7Q2
UniRef90: UniRef90_Q9L7Q2
UniRef50: UniRef50_Q9L7Q2
UniParc: UPI00004C2D11
EMBL: AF221126
EMBL: AE005672
EMBL-CDS: AAF31454.1
EMBL-CDS: AAK74809.1
RefSeq_NT: NC_003028.3
MEROPS: M26.002
EnsemblGenome: EBSTRG00000025237
EnsemblGenome_TRS: EBSTRT00000025237
EnsemblGenome_PRO: EBSTRP00000024329
GenomeReviews: AE005672_GR
KEGG: spn:SP_0664
TIGR: SP_0664
HOGENOM: HBG697431
OMA: FTHELTH
ProtClustDB: CLSK883904
BioCyc: SPNE170187-1:SP_0664-MONOMER
Taxonomy ID 170187
Gene Starting Position 634855
Gene Ending Position 640500
Gene Strand (Orientation) +
Protein Name zinc metalloprotease ZmpB, putative
DNA Sequence 
>gi|194172857:634855-640500 Streptococcus pneumoniae TIGR4 chromosome, complete genome
GATGGCTCCTTCTGTAGTGGACGCAGCCACCTATCACTATGTAAATAAAGAGATTATTTCACAAGAAGCT
AAAGATTTAATTCAGACAGGAAAGCCTGACAGGAATGAAGTTGTATATGGTTTGGTGTATCAAAAAGATC
AGTTGCCTCAAACAGGGACAGAAGCATCTGTTTTGACAGCTTTTGGTTTGCTGACTGTTGGGAGCTTGCT
TTTAATCTACAAGAGAAAGAAAATTGCTAGCGTCTTTCTAGTTGGAGCTATGGGATTGGTAGTTCTTCCT
AGTGCAGGGGCTGTAGACCCAGTTGCGACCCTAGCGCTGGCTAGTCGAGAGGGTGTTGTTGAAATGGAGG
GCTATCGCTATGTTGGTTATCTATCAGGTGACATCCTCAAAACGCTTGGCTTGGACACTGTTTTAGAAGA
AACCTCAGCAAAACCTGGAGAGGTGACTGTGGTCGAAGTTGAGACTCCTCAATCAATAACAAATCAGGAG
CAAGCTAGGACAGAAAACCAAGTAGTAGAGACAGAGGAAGCTCCAAAAGAAGAAGCACCTAAAACAGAAG
AAAGTCCAAAGGAAGAACCAAAATCGGAGGTAAAACCTACTGACGACACCCTTCCTAAAGTAGAAGAGGG
GAAAGAAGATTCAGCAGAACCAGCTCCAGTTGAAGAAGTAGGTGGAGAAGTTGAGTCAAAACCAGAGGAA
AAAGTAGCAGTTAAGCCAGAAAGTCAACCATCAGACAAACCAGCTGAGGAATCAAAAGTTGAACAAGCAG
GTGAACCAGTCGCGCCAAGAGAAGACGAAAAGGCACCAGTCGAGCCAGAAAAGCAACCAGAAGCTCCTGA
AGAAGAGAAGGCTGTAGAGGAAACACCGAAACAAGAAGAGTCAACTCCAGATACCAAGGCTGAAGAAACT
GTAGAACCAAAAGAGGAGACTGTTAATCAATCTATTGAACAACCAAAAGTTGAAACGCCTGCTGTAGAAA
AACAAACAGAACCAACAGAGGAACCAAAAGTTGAACAAGCAGGTGAACCAGTCGCGCCAAGAGAAGACGA
ACAGGCACCAACGGCACCAGTTGAGCCAGAAAAGCAACCAGAAGTTCCTGAAGAAGAGAAGGCTGTAGAG
GAAACACCGAAACCAGAAGATAAAATAAAGGGTATTGGTACTAAAGAACCAGTTGATAAAAGTGAGTTAA
ATAATCAAATTGATAAAGCTAGTTCAGTTTCTCCTACTGATTATTCTACAGCAAGTTACAATGCTCTTGG
ACCTGTTTTAGAAACTGCAAAAGGTGTCTATGCTTCAGAGCCTGTAAAACAGCCTGAGGTAAATAGCGAG
ACAAATAAACTTAAAACGGCTATTGACGCTCTAAACGTTGATAAAACTGAATTAAACAATACGATTGCAG
ATGCAAAAACAAAGGTAAAAGAACATTACAGTGATAGAAGTTGGCAAAACCTCCAAACTGAAGTTACAAA
GGCTGAAAAAGTTGCAGCTAATACAGATGCTAAACAAAGTGAAGTTAACGAAGCTGTTGAAAAATTAACT
GCAACTATTGAAAAATTGGTTGAATTATCTGAAAAGCCAATATTAACATTGACTAGTACCGATAAGAAAA
TATTGGAACGTGAAGCTGTTGCTAAGTATACTCTAGAAAATCAAAACAAAACAAAAATCAAATCAATCAC
AGCTGAATTGAAAAAAGGAGAAGAAGTTATTAATACTGTAGTCCTTACAGATGACAAGGTAACAACAGAA
ACTATAAGCGCTGCATTTAAGAACCTAGAGTACTACAAAGAATACACCCTATCTACAACTATGATTTACG
ACAGAGGTAACGGTGAAGAAACTGAAACTCTAGAAAATCAAAATATTCAATTAGATCTTAAAAAAGTTGA
GCTTAAAAATATTAAACGTACAGATTTAATCAAATACGAAAATGGAAAAGAAACTAATGAATCACTGATA
ACAACTATTCCTGATGATAAGAGCAATTATTATTTAAAAATAACTTCAAATAATCAGAAAACTACATTAC
TAGCTGTTAAAAATATAGAAGAAACTACGGTTAACGGAACACCTGTATATAAAGTTACAGCAATCGCAGA
CAATTTAGTCTCTAGAACTGCTGATAATAAATTTGAAGAAGAATACGTTCACTATATTGAAAAACCTAAA
GTCCACGAAGATAATGTATATTATAATTTCAAAGAATTAGTGGAAGCTATTCAAAACGATCCTTCAAAAG
AATATCGTCTGGGACAATCAATGAGCGCTAGAAATGTTGTTCCTAATGGAAAATCATATATCACTAAAGA
ATTCACAGGAAAACTTTTAAGTTCTGAAGGAAAACAATTTGCTATTACTGAATTGGAACATCCATTATTT
AATGTGATAACAAACGCAACGATAAATAATGTGAATTTTGAAAATGTAGAGATAGAACGTTCTGGTCAAG
ATAATATTGCATCATTAGCCAATACTATGAAAGGTTCTTCAGTTATTACAAATGTCAAAATTACAGGCAC
ACTTTCAGGTCGTAATAATGTTGCTGGATTTGTAAATAATATGAATGATGGAACTCGTATTGAAAATGTT
GCTTTCTTTGGCAAACTACACTCTACAAGTGGAAATGGCTCTCATACAGGGGGAATTGCAGGTACAAACT
ATAGAGGAATTGTTAGAAAAGCATATGTTGATGCTACTATTACAGGAAACAAAACACGCGCCAGCTTGTT
AGTTCCTAAAGTAGATTATGGATTAACTCTAGACCATCTTATTGGTACAAAAGCTCTCCTAACTGAGTCG
GTTGTAAAAGGTAAAATAGATGTTTCAAATCCAGTAGAAGTTGGAGCAATAGCAAGTAAGACTTGGCCTG
TAGGTACGGTAAGTAATTCTGTCAGCTATGCTAAGATTATCCGTGGAGAGGAGTTATTCGGCTCTAACGA
CGTTGATGATTCTGATTATGCTAGTGCTCATATAAAAGATTTATATGCGGTAGAGGGATATTCGTCAGGT
AATAGATCATTTAGGAAATCTAAAACATTTACTAAATTAACTAAAGAACAAGCTGATGCTAAAGTTACTA
CTTTCAATATTACTGCTGATAAATTAGAAAGTGATCTATCTCCTCTTGCAAAACTTAATGAAGAAAAAGC
CTATTCTAGTATTCAAGATTATAACGCTGAATATAACCAAGCCTATAAAAATCTTGAAAAATTAATACCA
TTCTACAATAAAGATTATATTGTATATCAAGGTAATAAATTAAATAAAGAACACCATCTAAATACTAAAG
AAGTTCTTTCTGTTACCGCGATGAACAACAATGAGTTTATCACAAACCTAGATGAAGCTAATAAAATTAT
TGTTCACTATGCGGACGGTACAAAAGATTACTTTAACTTGTCTTCTAGCAGTGAAGGTTTAAGTAATGTA
AAAGAATATACTATAACTGACTTAGGAATTAAATATACACCTAATATCGTTCAAAAAGATAACACTACTC
TTGTTAATGATATAAAATCTATTTTAGAATCAGTAGAGCTTCAGTCTCAAACGATGTATCAGCATCTAAA
TCGATTAGGTGACTATAGAGTTAATGCAATCAAAGATTTATATTTAGAAGAAAGCTTCACAGATGTTAAA
GAAAACTTAACAAACCTAATCACAAAATTAGTTCAAAACGAAGAACATCAACTAAATGATTCTCCAGCTG
CTCGTCAAATGATTCGTGATAAAGTCGAGAAAAACAAAGCAGCTTTATTACTAGGTTTAACTTACCTAAA
TCGTTACTATGGAGTTAAATTTGGTGATGTTAATATTAAAGAATTAATGCTATTCAAACCAGATTTCTAT
GGTGAAAAAGTTAGCGTATTAGACAGATTAATTGAAATCGGTTCTAAAGAGAACAACATTAAAGGTTCAC
GTACATTCGACGCATTCGGTCAAGTATTGGCTAAATATACTAAATCAGGTAATTTAGATGCATTTTTAAA
TTATAATAGACAATTGTTCACAAATATAGACAATATGAACGATTGGTTTATTGATGCTACAGAAGACCAT
GTCTACATCGCAGAACGCGCTTCTGAGGTCGAAGAAATTAAAAATTCTAAACATCGTGCATTCGATAATT
TAAAACGAAGTCACCTTAGAAATACTATACTCCCACTACTGAATATTGATAAAGCACATCTTTATTTAAT
TTCAAATTATAATGCAATTGCCTTTGGTAGTGCAGAGCGATTAGGTAAAAAATCATTAGAAGATATTAAA
GATATCGTTAACAAAGCTGCAGATGGTTATAGAAACTATTATGATTTCTGGTATCGTCTAGCGTCTGATA
ACGTTAAACAACGACTACTAAGAGATGCTGTTATTCCTATTTGGGAAGGTTATAACGCTCCTGGTGGATG
GGTTGAAAAATATGGCCGCTATAATACCGACAAAGTATATACTCCTCTTAGAGAATTCTTTGGTCCTATG
GATAAGTATTATAATTATAATGGAACAGGAGCTTATGCTGCTATATATCCTAACTCTGATGATATTAGAA
CTGATGTAAAATATGTTCATTTAGAAATGGTTGGTGAATACGGTATTTCAGTTTACACACATGAAACAAC
ACACGTCAACGACCGTGCGATTTACTTAGGTGGCTTTGGACACCGTGAAGGTACTGATGCTGAAGCATAT
GCTCAGGGTATGCTACAAACTCCTGTTACTGGTAGTGGATTTGATGAGTTTGGTTCTTTAGGTATTAATA
TGGTATTTAAACGCAAAAATGATGGGAATCAGTGGTATATTACAGATCCAAAAACTCTAAAAACACGAGA
AGATATTAATAGATATATGAAGGGTTATAATGACACTTTAACTCTTCTTGATGAAATTGAGGCTGAATCT
GTGATTTCTCAACAAAATAAAGATTTAAATAGTGCATGGTTCAAAAAAATAGATAGAGAATACCGTGATA
ACAATAAATTAAATCAATGGGATAAAATTCGAAATCTAAGTCAAGAAGAGAAAAATGAATTAAATATTCA
ATCTGTTAATGATTTAGTTGATCAACAATTAATGACTAATCGCAATCCAGGTAATGGTATCTATAAACCC
GAAGCAATTAGCTATAACGATCAATCACCTTATGTAGGTGTTAGAATGATGACCGGTATCTACGGAGGTA
ATACTAGTAAAGGTGCTCCTGGAGCTGTTTCATTCAAACATAATGCTTTTAGATTATGGGGTTACTACGG
ATACGAAAATGGGTTCTTAGGTTATGCTTCAAATAAATATAAACAACAATCTAAAACAGATGGTGAGTCT
GTTCTAAGTGATGAATATATTATCAAGAAAATATCTAACAATACATTTAATACTATTGAAGAATTTAAAA
AAGCTTACTTCAAAGAAGTTAAAGATAAAGCAACGAAAGGATTAACAACATTCGAAGTAAATGGTTCTTC
CGTTTCATCATACGATGATTTACTGACATTGTTTAAAGAAGCTGTTAAAAAAGATGCCGAAACTCTTAAA
CAAGAAGCAAACGGTAATAAAACAGTATCTATGAATAATACAGTTAAATTAAAAGAAGCTGTTTATAAGA
AACTTCTTCAACAAACAAATAGCTTTAAAACTTCAATCTTTAAATA
Protein Sequence 
>gi|15900565|ref|NP_345169.1| zinc metalloprotease ZmpB [Streptococcus pneumoniae TIGR4] MAPSVVDAATYHYVNKEIISQEAKDLIQTGKPDRNEVVYGLVYQKDQLPQTGTEASVLTAFGLLTVGSLLLIYKRKKIASVFLVGAMGLVVLPSAGAVDPVATLALASREGVVEMEGYRYVGYLSGDILKTLGLDTVLEETSAKPGEVTVVEVETPQSITNQEQARTENQVVETEEAPKEEAPKTEESPKEEPKSEVKPTDDTLPKVEEGKEDSAEPAPVEEVGGEVESKPEEKVAVKPESQPSDKPAEESKVEQAGEPVAPREDEKAPVEPEKQPEAPEEEKAVEETPKQEESTPDTKAEETVEPKEETVNQSIEQPKVETPAVEKQTEPTEEPKVEQAGEPVAPREDEQAPTAPVEPEKQPEVPEEEKAVEETPKPEDKIKGIGTKEPVDKSELNNQIDKASSVSPTDYSTASYNALGPVLETAKGVYASEPVKQPEVNSETNKLKTAIDALNVDKTELNNTIADAKTKVKEHYSDRSWQNLQTEVTKAEKVAANTDAKQSEVNEAVEKLTATIEKLVELSEKPILTLTSTDKKILEREAVAKYTLENQNKTKIKSITAELKKGEEVINTVVLTDDKVTTETISAAFKNLEYYKEYTLSTTMIYDRGNGEETETLENQNIQLDLKKVELKNIKRTDLIKYENGKETNESLITTIPDDKSNYYLKITSNNQKTTLLAVKNIEETTVNGTPVYKVTAIADNLVSRTADNKFEEEYVHYIEKPKVHEDNVYYNFKELVEAIQNDPSKEYRLGQSMSARNVVPNGKSYITKEFTGKLLSSEGKQFAITELEHPLFNVITNATINNVNFENVEIERSGQDNIASLANTMKGSSVITNVKITGTLSGRNNVAGFVNNMNDGTRIENVAFFGKLHSTSGNGSHTGGIAGTNYRGIVRKAYVDATITGNKTRASLLVPKVDYGLTLDHLIGTKALLTESVVKGKIDVSNPVEVGAIASKTWPVGTVSNSVSYAKIIRGEELFGSNDVDDSDYASAHIKDLYAVEGYSSGNRSFRKSKTFTKLTKEQADAKVTTFNITADKLESDLSPLAKLNEEKAYSSIQDYNAEYNQAYKNLEKLIPFYNKDYIVYQGNKLNKEHHLNTKEVLSVTAMNNNEFITNLDEANKIIVHYADGTKDYFNLSSSSEGLSNVKEYTITDLGIKYTPNIVQKDNTTLVNDIKSILESVELQSQTMYQHLNRLGDYRVNAIKDLYLEESFTDVKENLTNLITKLVQNEEHQLNDSPAARQMIRDKVEKNKAALLLGLTYLNRYYGVKFGDVNIKELMLFKPDFYGEKVSVLDRLIEIGSKENNIKGSRTFDAFGQVLAKYTKSGNLDAFLNYNRQLFTNIDNMNDWFIDATEDHVYIAERASEVEEIKNSKHRAFDNLKRSHLRNTILPLLNIDKAHLYLISNYNAIAFGSAERLGKKSLEDIKDIVNKAADGYRNYYDFWYRLASDNVKQRLLRDAVIPIWEGYNAPGGWVEKYGRYNTDKVYTPLREFFGPMDKYYNYNGTGAYAAIYPNSDDIRTDVKYVHLEMVGEYGISVYTHETTHVNDRAIYLGGFGHREGTDAEAYAQGMLQTPVTGSGFDEFGSLGINMVFKRKNDGNQWYITDPKTLKTREDINRYMKGYNDTLTLLDEIEAESVISQQNKDLNSAWFKKIDREYRDNNKLNQWDKIRNLSQEEKNELNIQSVNDLVDQQLMTNRNPGNGIYKPEAISYNDQSPYVGVRMMTGIYGGNTSKGAPGAVSFKHNAFRLWGYYGYENGFLGYASNKYKQQSKTDGESVLSDEYIIKKISNNTFNTIEEFKKAYFKEVKDKATKGLTTFEVNGSSVSSYDDLLTLFKEAVKKDAETLKQEANGNKTVSMNNTVKLKEAVYKKLLQQTNSFKTSIFK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0664 mutant is attenuated in mice (Hava and Camilli, 2002).
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].