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SP_2095

Victor ID 3191
Gene Name SP_2095
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930248
NCBI Protein GI 15901910
Locus Tag SP_2095
Protein Accession NP_346514.1
Other Database IDs UniProtKB-ID: Q97NE8_STRPN
UniRef100: UniRef100_Q97NE8
UniRef90: UniRef90_B2IN13
UniRef50: UniRef50_B2IN13
UniParc: UPI0000051AFE
EMBL: AE005672
EMBL-CDS: AAK76154.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000026351.
EnsemblGenome_TRS: EBSTRT00000026351
EnsemblGenome_PRO: EBSTRP00000025443
GenomeReviews: AE005672_GR
KEGG: spn:SP_2095
TIGR: SP_2095
HOGENOM: HBG325345
OMA: VEAHDIA
ProtClustDB: CLSK884195
BioCyc: SPNE170187-1:SP_2095-MONOMER
Taxonomy ID 170187
Gene Starting Position 2003047
Gene Ending Position 2003586
Gene Strand (Orientation) -
Protein Name 5-formyltetrahydrofolate cyclo-ligase family protein
DNA Sequence 
>gi|194172857:2003047-2003586 Streptococcus pneumoniae TIGR4 chromosome, complete genome
ATCAAAGATTTCCTTCATCAATTAATACCTCCTGAACAGGAATATCATGGTTTTCAGGTATAAAGTCCTG
AATTTGACAAGGATATATCGTACTCAAAGTACGACCAGAAAAATGTTCCAGATAGCGGTCATAATAGCCT
CCACCGTATCCTATCCGATATCCTTTCGTCGTAAAAGCCAGACCAGGAACATGAATCAAATCAATCTGAG
ATGCATCCACCACTTCCAAATCTCCCTGTAGCTCCAGTAAGGCAAAGAAAGTTTTTACCAACTGTTGCGG
ATCATAGACCACAAAGTCCATGCGCCCCTTGGGATAAGTTTTGGGTATTAAAACCTTCTTGCCGTCCTTC
AGCGCCTGCTCAATCAGTTCCTGCGTTTGAAACTCATGAGAAAAAGAGAGGTAGGTTGCGATGACCTTGG
CTTCTTGATAAAAGGGGTGTTGTAAAAGCCGCTCGGTTAAAGCTTGGTCTATAGCCTGTTTTTGCTCTTG
AGATATAGCCTTCATTTCATGCAAGACTTGCTTGCGTAATTCCGATTTCA
Protein Sequence 
>gi|15901910|ref|NP_346514.1| 5-formyltetrahydrofolate cyclo-ligase [Streptococcus pneumoniae TIGR4] MKSELRKQVLHEMKAISQEQKQAIDQALTERLLQHPFYQEAKVIATYLSFSHEFQTQELIEQALKDGKKVLIPKTYPKGRMDFVVYDPQQLVKTFFALLELQGDLEVVDASQIDLIHVPGLAFTTKGYRIGYGGGYYDRYLEHFSGRTLSTIYPCQIQDFIPENHDIPVQEVLIDEGNL
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_2095 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0212H, under H: Coenzyme transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].