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purH

Victor ID 3136
Gene Name purH
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 929804
NCBI Protein GI 15899995
Locus Tag SP_0050
Protein Accession NP_344599.1
Other Database IDs UniProtKB-ID: PUR9_STRPN
UniRef100: UniRef100_C1CNS9
UniRef90: UniRef90_C1CNS9
UniRef50: UniRef50_Q833Z3
UniParc: UPI0000051BC9
EMBL: AE005672
EMBL-CDS: AAK74239.1
RefSeq_NT: NC_003028.3
EnsemblGenome: EBSTRG00000027015
EnsemblGenome_TRS: EBSTRT00000027015
EnsemblGenome_PRO: EBSTRP00000026107
GenomeReviews: AE005672_GR
KEGG: spn:SP_0050
TIGR: SP_0050
HOGENOM: HBG498048
OMA: ASDGFFP
ProtClustDB: PRK00881
BioCyc: SPNE170187-1:SP_0050-MONOMER
Taxonomy ID 170187
Gene Starting Position 53070
Gene Ending Position 54617
Gene Strand (Orientation) +
Protein Name bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase
DNA Sequence 
>gi|194172857:53070-54617 Streptococcus pneumoniae TIGR4 chromosome, complete genome
AATGACTAAACGCGTCTTAATCAGCGTCTCAGACAAAGCGGGCATTGTTGAATTTGCCCAAGAACTCAAA
AAACTTGGTTGGGAGATTATCTCAACAGGTGGAACTAAGGTTGCCCTTGATAATGCTGGGGTGGATACCA
TTGCTATCGATGATGTGACTGGTTTCCCAGAAATGATGGACGGTCGTGTGAAGACCCTCCACCCAAATAT
CCACGGAGGGCTTCTCGCTCGTCGTGACTTGGATAGCCACTTGGAAGCGGCTAAGGACAACAAGATTGAG
CTCATTGACCTTGTGGTGGTCAACCTTTACCCATTTAAGGAAACTATCCTTAAACCAGATGTGACTTATG
CTGATGCAGTTGAAAATATCGATATTGGTGGGCCATCTATGCTTCGTTCAGCAGCGAAAAATCATGCCAG
TGTTACAGTTGTGGTAGATCCTGCTGACTACGCTGTGGTTTTGGATGAATTGGCAGCAAACGGCGAAACC
TCTTATGAAACTCGCCAACGTTTAGCAGCCAAAGTATTTCGTCACACAGCGGCTTATGACGCCTTGATTG
CAGAATACTTCACAGCTCAAGTGGGTGAAAGCAAGCCTGAAAAACTCACTTTGACTTATGACCTCAAGCA
ACCAATGCGTTACGGTGAGAATCCTCAACAAGACGCGGACTTTTACCAGAAAGCTTTGCCTACAGACTAC
TCCATTGCTTCAGCCAAACAGCTCAACGGGAAAGAATTGTCATTTAATAATATCCGTGATGCAGATGCTG
CTATCCGTATCATCCGTGACTTCAAAGATAGTCCAACCGTTGTGGCTCTCAAACACATGAATCCATGTGG
AATTGGTCAAGCTGATGACATCGAGACTGCTTGGGACTACGCTTATGAGTCTGACCCAGTGTCTATCTTT
GGTGGGATTGTCGTCCTCAACCGTGAGGTGGATGCTGCGACAGCTGAGAAGATGCACGGCGTTTTCCTCG
AAATCATCATTGCACCAAGCTATACGGATGAAGCGCTAGCCATTTTGATCAATAAAAAGAAAAACTTGCG
TATCCTTGCCTTGCCATTTAATGCTCAAGAGGCTAGCGAAGTGGAAGCAGAATACACAGGTGTAGTCGGT
GGACTTCTCGTGCAAAATCAAGACGTGGTCAAGGAAAGCCCAGCTGACTGGCAAGTGGTGACTAAACGTC
AGCCAACTGAGACAGAAGCGACTGCTCTTGAGTTCGCTTGGAAGGCTATCAAGTACGTCAAATCAAATGG
TATTATCGTGACCAACGACCACATGACACTTGGTGTTGGTCCAGGTCAAACCAACCGTGTGGCTTCTGTT
CGCCTTGCCATTGACCAAGCCAAAGATCGTCTGGACGGGGCGGTCCTTGCTTCAGATGCCTTCTTCCCAT
TTGCGGATAACGTGGAAGAAATCGCCAAAGCAGGAATTAAGGCCATCATCCAGCCCGGTGGCTCTGTCCG
TGACCAAGAATCCATCGAAGCAGCGGATAAATACGGCTTGACTATGGTCTTTACAGGTGTGAGACATTTT
AGACATTA
Protein Sequence 
>gi|15899995|ref|NP_344599.1| bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase [Streptococcus pneumoniae TIGR4] MTKRVLISVSDKAGIVEFAQELKKLGWEIISTGGTKVALDNAGVDTIAIDDVTGFPEMMDGRVKTLHPNIHGGLLARRDLDSHLEAAKDNKIELIDLVVVNLYPFKETILKPDVTYADAVENIDIGGPSMLRSAAKNHASVTVVVDPADYAVVLDELAANGETSYETRQRLAAKVFRHTAAYDALIAEYFTAQVGESKPEKLTLTYDLKQPMRYGENPQQDADFYQKALPTDYSIASAKQLNGKELSFNNIRDADAAIRIIRDFKDSPTVVALKHMNPCGIGQADDIETAWDYAYESDPVSIFGGIVVLNREVDAATAEKMHGVFLEIIIAPSYTDEALAILINKKKNLRILALPFNAQEASEVEAEYTGVVGGLLVQNQDVVKESPADWQVVTKRQPTETEATALEFAWKAIKYVKSNGIIVTNDHMTLGVGPGQTNRVASVRLAIDQAKDRLDGAVLASDAFFPFADNVEEIAKAGIKAIIQPGGSVRDQESIEAADKYGLTMVFTGVRHFRH
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: purH mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0138F, under F: Nucleotide transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].