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luxS from Streptococcus pneumoniae R6

Victor ID 3128
Gene Name luxS from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 934756
NCBI Protein GI 15902352
Locus Tag spr0308
Protein Accession NP_357902.1
Other Database IDs UniProtKB-ID: LUXS_STRR6
UniRef100: UniRef100_Q04MC2
UniRef90: UniRef90_Q04MC2
UniRef50: UniRef50_Q1JAI5
UniParc: UPI00000513CE
EMBL: AE007317
EMBL-CDS: AAK99112.1
RefSeq_NT: NC_003098.1
EnsemblGenome: EBSTRG00000015181
EnsemblGenome_TRS: EBSTRT00000015181
EnsemblGenome_PRO: EBSTRP00000014577
GenomeReviews: AE007317_GR
KEGG: spr:spr0308
eggNOG: COG1854
HOGENOM: HBG347473
OMA: VRIAKTM
ProtClustDB: PRK02260
BioCyc: SPNE171101:SPR0308-MONOMER
Taxonomy ID 171101
Gene Starting Position 308452
Gene Ending Position 308934
Gene Strand (Orientation) -
Protein Name S-ribosylhomocysteinase
DNA Sequence 
>gi|15902044:308452-308934 Streptococcus pneumoniae R6, complete genome
TTTAAATCACATGACGTTCAAAGGCATCATCTGAAATCCCTTGTTCCAAGATGAGTTTTGCCCATTCTTT
AGCAGAGAAGAGGCTGTGGTCCTTGTAGTTTCCGCAAGATTCGATGGTTGTCCCTGGGACATCTTCCCAA
GTAGTAGTTTCAGCGATTTCCTTGAGCGAATCCTTGATAACAGCTGCGATTTTAGCACTGGTGTGACGTC
CCCACATAATCATGTGGAAGCCTGTGCGGCAACCAAATGGTGAACAGTCAATCATGCCGTCAATGCGGGT
ACGGATGAGTTTGGCTAAGAGGTGCTCGATAGTGTGAAGGCCGGCAGTAGGGATAGAGTCTTCGTTTGGC
TGCACCAAGCGAATATCATAATTGGAGATGATGTCTCCTTTTGGTCCTGTTTCTTCCCCAATCAAGCGAA
CATAGGGTGCTTTGACAATGGTGTGGTCAAGTTCAAAACTTTCGACAATAACTTCTTTTGACA
Protein Sequence 
>gi|15902352|ref|NP_357902.1| S-ribosylhomocysteinase [Streptococcus pneumoniae R6] MSKEVIVESFELDHTIVKAPYVRLIGEETGPKGDIISNYDIRLVQPNEDSIPTAGLHTIEHLLAKLIRTRIDGMIDCSPFGCRTGFHMIMWGRHTSAKIAAVIKDSLKEIAETTTWEDVPGTTIESCGNYKDHSLFSAKEWAKLILEQGISDDAFERHVI
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: luxS mutant has defective ability to persist in the nasopharyngeal tissues of mice (Joyce et al., 2004).
COG COG1854T, under T: Signal transduction mechanisms
References
Joyce et al., 2004: Joyce EA, Kawale A, Censini S, Kim CC, Covacci A, Falkow S. LuxS is required for persistent pneumococcal carriage and expression of virulence and biosynthesis genes. Infection and immunity. 2004; 72(5); 2964-2975. [PubMed: 15102809].