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ply from Streptococcus pneumoniae CGSP14

Victor ID 3040
Gene Name ply from Streptococcus pneumoniae CGSP14
Sequence Strain (Species/Organism) Streptococcus pneumoniae CGSP14
NCBI Gene ID 6217360
NCBI Protein GI 182684868
Locus Tag SPCG_1898
Protein Accession YP_001836615.1
Other Database IDs UniProtKB-ID: B2IM12_STRPS
UniRef100: UniRef100_P0C2J9
UniRef90: UniRef90_Q04IN8
UniRef50: UniRef50_Q04IN8
UniParc: UPI0000051A46
EMBL: CP001033
EMBL-CDS: ACB91150.1
RefSeq_NT: NC_010582.1
EnsemblGenome: EBSTRG00000017777.
EnsemblGenome_TRS: EBSTRT00000017777
EnsemblGenome_PRO: EBSTRP00000017091
GenomeReviews: CP001033_GR
KEGG: spw:SPCG_1898
HOGENOM: HBG337470
OMA: GAYVAQF
ProtClustDB: CLSK877006
Taxonomy ID 516950
Gene Starting Position 1883621
Gene Ending Position 1885036
Gene Strand (Orientation) -
Protein Name pneumolysin
DNA Sequence 
>gi|182682970:1883621-1885036 Streptococcus pneumoniae CGSP14, complete genome
CCTAGTCATTTTCTACCTTATCTTCTACCTGAGGATAGAGAGTTGTTCCCCAAATAGAAATCGTCCGCTT
ACGCACTAGTGGCAAATCGGTTTTTTCATAAACCGTACGCCACCATTCCCAGGCAAGCCCGGTACACTCT
CTAATTTTGACAGAGAGATTACGAACATTCCCTTTTAAAGGAATACTAGTGGTAAAGTGAGCCGTTAAAT
CCTGCCCATTTCTGTCCCAAGCCTTAGGAGTCAAGACTTCCTTACCTTGATGATCATAGGATAATTCATT
CCAAGTAATATAATATTGGGCAACATAGGCACCACTATGATCCAGCAGTAAATCTCCGTTTCTGTAAGCT
GTAACCTTAGTCTCAACATAGTCTGTACTATTTTGAAAGGTCGCAACTACATTGTCACGTAAAAAAGAAG
TTGTATAGGAAATCGGCAAGCCTGGATGATCTGCTGTAAAGCGACTGCCTTCTTGAATCAAGTCCTCTAC
CATATCCACCTTGCCTGTTACAACTCGGGCACCCGAACTTGGGTCGCCCCCTAAAATAACCGCCTTCACT
TCTGTATTGTCCAAAATCTGCTTCCACTCTGTCTGAGGAGCTACCTTGACTCCTTTTATCAAAGCTTCAA
AAGCAGCCTCTACTTCATCACTCTTACTCGTGGTTTCCAACTTGAGATAGACTTGGCGCCCATAAGCAAC
ACTCGAAATATAGACCAAAGGACGCTCTGCAGAAATTCCTCTCTGTTTTAAATCCTCTACCGTTACAGTA
TCTTGAAACACATCTCCTGGATTTTTAACAGCGTCTACGCTGACTGTATAATAAATCTGCTTAAAATTAA
CAATCTGAATCTGCTTTTCGCCTGAATGGACAGAGTTAAAATCAATATCAAGAGAATTCCCTGTCTTTTC
AAAGTCAGAACCAAACTTGACCTTGAGTTGTTCCATGCTGTGAGCCGTGATTTTTTCATACTGCATTCTA
GCTGGGACATTATTGACCTGACCATAATCTTGATGCCACTTAGCCAACAAATCGTTTACCGCTCCGCGAA
CACTTGAATTGCTGGGGTCTTCCACTTGGAGAAAGCTATCGCTACTTGCCAAACCAGGCAAATCAATACT
ATAAGTCATCGGAGCACGATCGACCGCAAGAAGAGTGGGATTATTCTCTAACAAGGTCTCATCCACTACG
AGAAGTGCTCCAGGATAGAGGCGACTGTCGTTGGTAGCTGTTACAGAAATATCACTTGTATTTGTCGACA
AGCTCCGCTTCTTTCTTTCGATAACAACAAACTCATCGGGTAGCTGATTACCCTCTTTGATGAAACGATT
TTCAATACTTTCTCCCTGATGGGTCAAGAGTTTCTTTTTATCGTAATTCATAGCTAGTATAAAGTCATTT
ACTGCTTTATTTGCCA
Protein Sequence 
>gi|182684868|ref|YP_001836615.1| pneumolysin [Streptococcus pneumoniae CGSP14] MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ply mutant is attenuated in mice (Berry and Paton, 2000).
References
Berry and Paton, 2000: Berry AM, Paton JC. Additive attenuation of virulence of Streptococcus pneumoniae by mutation of the genes encoding pneumolysin and other putative pneumococcal virulence proteins. Infection and immunity. 2000; 68(1); 133-140. [PubMed: 10603379].