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glnA from Streptococcus pneumoniae CGSP14

Victor ID 3052
Gene Name glnA from Streptococcus pneumoniae CGSP14
Sequence Strain (Species/Organism) Streptococcus pneumoniae CGSP14
NCBI Gene ID 6218347
NCBI Protein GI 182683450
Locus Tag SPCG_0480
Protein Accession YP_001835197.1
Other Database IDs UniProtKB-ID: B2IMA5_STRPS
UniRef100: UniRef100_E0TSP1
UniRef90: UniRef90_E0TSP1
UniRef50: UniRef50_D5T5L0
UniParc: UPI0000051475
EMBL: CP001033
EMBL-CDS: ACB89732.1
RefSeq_NT: NC_010582.1
EnsemblGenome: EBSTRG00000016924.
EnsemblGenome_TRS: EBSTRT00000016924
EnsemblGenome_PRO: EBSTRP00000016238
GenomeReviews: CP001033_GR
KEGG: spw:SPCG_0480
HOGENOM: HBG553755
OMA: RVPLYKP
ProtClustDB: CLSK876973
Taxonomy ID 516950
Gene Starting Position 476082
Gene Ending Position 477428
Gene Strand (Orientation) +
Protein Name glutamine synthetase, type I
DNA Sequence 
>gi|182682970:476082-477428 Streptococcus pneumoniae CGSP14, complete genome
TATGCCAATCACAGCTGCAGATATTCGTCGTGAAGTCAAGGAAAAAAATGTTACCTTTATTCGTCTTATG
TTCTCAGATATTTTGGGAACCATGAAAAACGTCGAAATTCCTGCTACAGATGAACAGTTAGATAAGGTCT
TGTCGAACAAGGTTATGTTTGATGGATCTTCTATTGAAGGTTTTGTACGTATCAATGAGTCGGATATGTA
CTTGTACCCGGACTTGGATACATGGACAGTCTTCCCTTGGGGAGATGAAAATGGAAGTGTTGCAGGTCTG
ATCTGTGATGTTTATACAACAGAAGGTGAACCATTTGCGGGTGACCCTCGTGGTAATTTGAAACGAGCTC
TTCGTCACATGGAAGAAGTTGGATTCAAATCCTTCAACCTTGGTCCAGAGCCAGAATTCTTCCTATTTAA
GTTGGATGAAAATGGGGACCCAACACTTGAAGTGAATGACAAGGGTGGCTACTTTGATTTGGCACCTACT
GACCTTGCGGACAACACACGTCGTGAGATTGTGAATGTCTTGACCAAAATGGGATTTGAAGTAGAAGCGA
GTCACCACGAGGTTGCGGTTGGACAGCATGAGATTGACTTTAAGTACGATGAAGTTCTCCGTGCTTGTGA
TAAGATTCAAATCTTTAAACTTGTTGTTAAAACCATTGCTCGCAAACACGGACTTTACGCAACATTTATG
GCGAAGCCAAAATTTGGTATTGCTGGCTCAGGTATGCACTGTAATATGTCCTTGTTTGATGCAGAAGGAA
ATAACGCCTTCTTTGATCCAAATGATCCAAAAGGAATGCAGTTGTCAGAAACAGCTTACCATTTCCTAGG
CGGTTTGATCAAGCATGCTTACAACTATACTGCCATCATGAACCCAACAGTTAACTCATACAAACGTTTG
GTTCCAGGTTATGAAGCGCCTGTTTACATTGCTTGGGCTGGTCGTAACCGTTCGCCACTTGTGCGCGTAC
CTGCTTCACGTGGTATGGGAACTCGTCTTGAGTTGCGTTCAGTGGATCCAATGGCGAACCCTTACGTTGC
TATGGCTGTTCTTTTGGAAGTTGGTTTGTATGGTATTGAAAATAAAATCGAAGCACCAGCTCCTATCGAA
GAAAATATCTACATCATGACAGCAGAAGAGCGCAAGGAAGCTGGTATTACAGACCTTCCATCAACTCTTC
ACAACGCTTTGAAAGCTTTGACAGAAGATGAAGTGGTTAAAGCTGCTCTCGGAGATCACATCTATACTAG
CTTCCTTGAAGCCAAACGAATCGAATGGGCAAGTTATGCAACCTTCGTTTCACAATGGGAAATTGATAAT
TATTTAGACCTTTACTA
Protein Sequence 
>gi|182683450|ref|YP_001835197.1| glutamine synthetase, type I [Streptococcus pneumoniae CGSP14] MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLDKVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEGEPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDLAPTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLVVKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAYHFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGTRLELRSVDPMANPYVAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDLPSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells (Kloosterman et al., 2006).
COG COG0174E, under E: Amino acid transport and metabolism
References
Kloosterman et al., 2006: Kloosterman TG, Hendriksen WT, Bijlsma JJ, Bootsma HJ, van Hijum SA, Kok J, Hermans PW, Kuipers OP. Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae. The Journal of biological chemistry. 2006; 281(35); 25097-25109. [PubMed: 16787930].