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purL

Victor ID 3443
Gene Name purL
Sequence Strain (Species/Organism) Streptococcus pneumoniae G54
NCBI Gene ID 6479310
NCBI Protein GI 194397931
Locus Tag SPG_0051
Protein Accession YP_002036766.1
Other Database IDs UniProtKB-ID: B5E5J4_STRP4
UniRef100: UniRef100_B5E5J4
UniRef90: UniRef90_Q5M205
UniRef50: UniRef50_B5XJ16
UniParc: UPI00017C1749
EMBL: CP001015
EMBL-CDS: ACF56046.1
RefSeq_NT: NC_011072.1
EnsemblGenome: EBSTRG00000022465.
EnsemblGenome_TRS: EBSTRT00000022465
EnsemblGenome_PRO: EBSTRP00000021631
GenomeReviews: CP001015_GR
KEGG: spx:SPG_0051
HOGENOM: HBG305972
OMA: ERGIAYY
ProtClustDB: CLSK876991
Taxonomy ID 512566
Gene Starting Position 44071
Gene Ending Position 47796
Gene Strand (Orientation) +
Protein Name phosphoribosylformylglycinamide synthetase
DNA Sequence 
>gi|194396645:44071-47796 Streptococcus pneumoniae G54 chromosome, complete genome
GATGGATAAACGTATTTTTGTTGAAAAAAAGGCTGATTTTCAGGTCAAGTCAGAGAGTTTGGTTAGAGAG
CTCCAGCACAACGTGGGACTGTCAAGCTTGAAAAGTATTCGTATTGTGCAAGTATATGATGTATTTGACT
TGGCTGAGGACTTGTTTGCACCTGCAGAGAAGCACATTTTCTCTGAGCAGGGAACCGACCATGTTTTAGA
TGAAGTATCTGTGCAGGCGGATCTTGCTAACTATGCTTTCTTTGCCATTGAAAGTCTGCCAGGGCAGTTT
GACCAGCGTGCAGCTTCGTCACAGGAAGCCTTGCTTTTGTTGGGAAGTTCGAGTGACGTGACAGTCAACA
CAGCCCAACTTTACTTGGTGAATAAAGATATTGATGCGACTGAGTTGGAAGCTGTCAAAAACTACCTGCT
CAATCCAGTTGATTCTCGTTTCAAGGATATCACGACAGGGATTGCCAAGCAGGAGTTTTCAGAGTCAGAC
AAGACCATTCCAAAATTGACTTTCTTTGAAAGCTATACAGCAGAAGACTTTGCTCGCTACAAGGCCGAGC
AAGGGATGGCCATGGAAGTGGATGATTTGCTCTTTATCCAAGACTACTTTAAGTCAATCGGGCGCGTGCC
AACTGAGACTGAACTCAAGGTTTTGGACACTTACTGGTCTGACCACTGCCGTCATACGACTTTTGAGACA
GAGTTGAAACACATCGACTTTTCAGCTTCTAAATTTCAAAAGCAATTGCAGTCAACCTATGACAAGTATA
TTGCCATGCGCGAGGAGTTAGGTCGGTCTGAAAAACCACAAACCTTGATGGATATGGCGACTATTTTCGG
TCGTTATGAGCGTGCTAACGGACGATTGGATGATATGGAAGTCTCTGACGAAATCAATGCCTGCTCAGTT
GAAATTGAAGTGGATGTTGATGGTGTCAAGGAACCTTGGCTCCTCATGTTTAAAAATGAAACCCACAACC
ATCCAACAGAAATTGAGCCATTTGGTGGAGCGGCTACCTGTATCGGTGGAGCTATTCGTGATCCGTTGTC
AGGCCGTTCCTATGTTTACCAAGCCATGCGTATTTCAGGTGCTGGTGATATTACAGCACCGATTTCGGAA
ACTCGTGCTGGGAAATTGCCACAACAAGTCATTTCTAAAACAGCAGCTCATGGTTATTCTTCATATGGTA
ACCAGATTGGGCTTGCCACAACCTACGTTCGTGAATACTTCCACCCAGGCTTTGTAGCTAAACGTATGGA
ACTTGGTGCCGTTGTTGGTGCGGCTCCCAAGGGCAATGTTGTCCGTGAAAAACCTGAAGCAGGTGATGTG
ATCATCCTTCTCGGAGGCAAAACAGGTCGTGATGGTGTCGGTGGTGCGACGGGCTCTTCTAAGGTTCAAA
CAGTTGAGTCTGTAGAGACTGCTGGTGCTGAGGTTCAAAAAGGAAATGCCATCGAAGAACGCAAGATTCA
GCGCCTCTTCCGTAATGGCAATGTCACTCGTCTGATCAAGAAGTCCAATGACTTTGGGGCAGGCGGCGTC
TGTGTGGCTATCGGTGAATTGGCAGACGGTCTTGAAATCGACCTCAACAAGGTGCCTCTTAAATACCAGG
GCTTGAATGGTACAGAAATTGCCATCTCTGAATCACAAGAACGGATGGCGGTCGTGGTTCGTCCTGAAGA
TGTGGATGCCTTCGTTGCCGAATGTAACAAAGAAAATATTGATGCTGTTGTGGTGGCGATAGTAACTGAA
AAACCAAATCTTGTCATGCACTGGAATGGTGAGACAATCGTTGACTTGGAGCGTCGTTTCCTTGACACCA
ATGGTGTGCGCGTGGTTGTCGATGCCAAAGTTGTGGACAAGGATGTCAAACTCCCAGAAGAGCGTCAAAC
ATCTGCTGAAACACTGGAATCAGATACCCTTACGGTTCTATCTGACCTCAACCATGCAAGTCAAAAAGGA
TTACAGACTATCTTTGACTGCTCTGTTGGACGCTCAACGGTTAATCACCCACTTGGTGGTCGTTACCAAC
TCACACCAACTGAGGCATCTGTGCAGAAATTGCCAGTTCAACACGGTGTGACTCATACTGCGTCGGTCAT
TGCTCAAGGTTTCAACCCATATGTAGCTGAATGGTCTCCATACCACGGTGCTGCTTATGCGGTTATCGAA
GCAACTGCTCGTTTGGTGGCTGCTGGTGCCAACTGGTCCAAGGCTCGTTTCTCTTACCAAGAGTATTTCG
AGCGTATGGATAAACAAGCAGAGCGTTTCGGTCAGCCAGTAGCTGCTCTTCTAGGTTCTATTGAAGCACA
AATTCAGCTTGGCTTGCCATCTATCGGTGGTAAGGACTCCATGTCTGGTACCTTTGAAGAATTGACCGTT
CCGCCAACCTTGGTTGCCTTTGGGGTGACGACGGCAGATAGCCGTAAGGTGCTCTCTCCAGAATTTAAAG
CTGTTGGGGAAAATATCTACTACATCCCAGGTCAAGCCCTCTCTGCAGAGATTGATTTTGACTTGATTAA
GAAAAATTTTGCTCAGTTTGAAGCCATCCAAGCTGACCATAAAGTGACATCTGCATCAGCTGTCAAATAC
GGTGGTGTAGTTGAAAGTTTGGCTCTTGCTACCTTTGGAAACTATATTGGTGCAGAGGTGACCTTGCCTG
AACTTGAAACAGCTTTGACAGCTCAATTAGGCGGCTTTGTCTTCACATCTCCTGAAGAAATTGCTGGAGT
AGAGAAGGTTGGACAAACGAAAGCAGACTTTACACTGACTGTCAACGGTGTGAAGCTAGATGGACACAAG
CTTGACAGTGCATTTCAAGGGACATTGGAAGAAGTTTACCCAACAGAATTTACCCAAGCGAAAGAACTAG
AAGAAGTACCAGCTGTGGCATCAGATGTTGTGATTAAAGCCAAAGAAAAGGTTGAAAAACCTGTGGTTTA
CATCCCAGTCTTTCCAGGAACCAACTCAGAATATGATTCAGCTAAGGCCTTCGAAAAAGAAGGTGCAGAG
GTCAATTTGGTGCCATTCGTGACCTTGAATGAAGAAGCTATTGTCAAGTCAGTTGAAACTATGGTTGACA
ATATCGACAAGACTAATATTCTCTTCTTTGCTGGTGGATTCTCGGCTGCGGATGAACCAGATGGTTCAGC
TAAGTTTATCGTCAATATCCTGCTTAATGAAAAAGTGCGTGTGGCTATTGATAGCTTTATCGCCCGTGGT
GGTTTGATTATCGGTATTTGTAATGGATTCCAAGCCTTAGTCAAATCGGGTCTCCTACCCTACGGAAACT
TTGAAGTTGCTAACAGTACTAGCCCAACCCTCTTCTACAATGATGCCAACCAACACGTGGCCAAGATGGT
GGAAACTCGCATTGCCAATACCAACTCACCATGGTTGGCTGGTGTGCAAGTGGGCGATATCCACGCTATT
CCTGTTTCGCACGGTGAAGGGAAGTTTGTCGTGACGGCTGAGGAATTTGCAGAGCTCCGTGACAATGGAC
AAATTTTCAGCCAATACGTTGACTTTAACGGTAAACCAAGTATGGATTCTAAGTACAATCCGAATGGTTC
TGTCCATGCCATCGAAGGAATTACCAGCAAGAATGGTCAAATCATCGGTAAGATGGGCCACTCAGAACGT
TATGAGGACGGTCTTTTCCAAAATATCCCAGGCAATAAAGACCAGCACCTGTTCGCGTCAGCGGTTAAAC
ATTTCACTGGAAAATA
Protein Sequence 
>gi|194397931|ref|YP_002036766.1| phosphoribosylformylglycinamide synthetase [Streptococcus pneumoniae G54] MDKRIFVEKKADFQVKSESLVRELQHNVGLSSLKSIRIVQVYDVFDLAEDLFAPAEKHIFSEQGTDHVLDEVSVQADLANYAFFAIESLPGQFDQRAASSQEALLLLGSSSDVTVNTAQLYLVNKDIDATELEAVKNYLLNPVDSRFKDITTGIAKQEFSESDKTIPKLTFFESYTAEDFARYKAEQGMAMEVDDLLFIQDYFKSIGRVPTETELKVLDTYWSDHCRHTTFETELKHIDFSASKFQKQLQSTYDKYIAMREELGRSEKPQTLMDMATIFGRYERANGRLDDMEVSDEINACSVEIEVDVDGVKEPWLLMFKNETHNHPTEIEPFGGAATCIGGAIRDPLSGRSYVYQAMRISGAGDITAPISETRAGKLPQQVISKTAAHGYSSYGNQIGLATTYVREYFHPGFVAKRMELGAVVGAAPKGNVVREKPEAGDVIILLGGKTGRDGVGGATGSSKVQTVESVETAGAEVQKGNAIEERKIQRLFRNGNVTRLIKKSNDFGAGGVCVAIGELADGLEIDLNKVPLKYQGLNGTEIAISESQERMAVVVRPEDVDAFVAECNKENIDAVVVAIVTEKPNLVMHWNGETIVDLERRFLDTNGVRVVVDAKVVDKDVKLPEERQTSAETLESDTLTVLSDLNHASQKGLQTIFDCSVGRSTVNHPLGGRYQLTPTEASVQKLPVQHGVTHTASVIAQGFNPYVAEWSPYHGAAYAVIEATARLVAAGANWSKARFSYQEYFERMDKQAERFGQPVAALLGSIEAQIQLGLPSIGGKDSMSGTFEELTVPPTLVAFGVTTADSRKVLSPEFKAVGENIYYIPGQALSAEIDFDLIKKNFAQFEAIQADHKVTSASAVKYGGVVESLALATFGNYIGAEVTLPELETALTAQLGGFVFTSPEEIAGVEKVGQTKADFTLTVNGVKLDGHKLDSAFQGTLEEVYPTEFTQAKELEEVPAVASDVVIKAKEKVEKPVVYIPVFPGTNSEYDSAKAFEKEGAEVNLVPFVTLNEEAIVKSVETMVDNIDKTNILFFAGGFSAADEPDGSAKFIVNILLNEKVRVAIDSFIARGGLIIGICNGFQALVKSGLLPYGNFEVANSTSPTLFYNDANQHVAKMVETRIANTNSPWLAGVQVGDIHAIPVSHGEGKFVVTAEEFAELRDNGQIFSQYVDFNGKPSMDSKYNPNGSVHAIEGITSKNGQIIGKMGHSERYEDGLFQNIPGNKDQHLFASAVKHFTGK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: a purL mutant was attenuated in a murine model (Lau et al., 2001)
COG COG0046F, under F: Nucleotide transport and metabolism
References
Lau et al., 2001: Lau GW, Haataja S, Lonetto M, Kensit SE, Marra A, Bryant AP, McDevitt D, Morrison DA, Holden DW. A functional genomic analysis of type 3 Streptococcus pneumoniae virulence. Molecular microbiology. 2001; 40(3); 555-571. [PubMed: 11359563].