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SP_0586

Victor ID 3210
Gene Name SP_0586
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 930532
NCBI Protein GI 15900495
Locus Tag SP_0586
Protein Accession NP_345099.1
Other Database IDs UniProtKB-ID: Q97S30_STRPN
UniRef100: UniRef100_A5LAE1
UniRef90: UniRef90_E0SWR3
UniRef50: UniRef50_Q5M088
UniParc: UPI00000514D4
EMBL: AE005672
EMBL-CDS: AAK74739.1
RefSeq_NT: NC_003028.3
HSSP: P00394
EnsemblGenome: EBSTRG00000027266.
EnsemblGenome_TRS: EBSTRT00000027266
EnsemblGenome_PRO: EBSTRP00000026358
GenomeReviews: AE005672_GR
KEGG: spn:SP_0586
TIGR: SP_0586
HOGENOM: HBG649727
OMA: FFPPKTP
ProtClustDB: CLSK876860
BioCyc: SPNE170187-1:SP_0586-MONOMER
Taxonomy ID 170187
Gene Starting Position 556411
Gene Ending Position 557277
Gene Strand (Orientation) +
Protein Name 5,10-methylenetetrahydrofolate reductase, putative
DNA Sequence 
>gi|194172857:556411-557277 Streptococcus pneumoniae TIGR4 chromosome, complete genome
TATGTCACGCCAAACACCGTCACTCTCATTTGAAGTGTTCCCTCCAAACCCAGCCGTGGGTAATGATAAC
ATTATTTCAGCCTTGCAGGATATGCAGGAGTTGGCTCCCCATTTTATCAGTGTAACTGCCAGCAATAATA
AATTTAATATCAAGGAAACGACGGTTCGTTTGGCTGACTTTATCCAAAATGATTTGGCGATTCCGACCAT
TGCCCACTTGCCAGCTATTTATCTAACTAAGGACAAGGTTGCTGAAACTATTGCTGACTTGGACAAAGTT
GGGGTGCAGAAAATCTTGGCTCTTCGTGGGGATATTATTCCAGACGTGGAACCACAAAAGGATTTCCGCT
ATGCAACCGACTTGATTGAGTTTATCAAGGAACAAACCCCTCACTTTGATATTATTGGAGCTTGCTATCC
AGAAGGGCATCCAGATTCGCCAAATCAGATTTCAGATATTCAAAATCTTAAGAAGAAAGTGGATGCAGGC
TGTTCGAGCCTCGTAACTCAGCTCTTCTTTGACAATGAGCGCTTCTATGATTTTCAGGACAAGTGTATCT
TGGCTGGGATTGATGTTCCCATTCATGCAGGAATTATGCCAATTCTGAATCGAAATCAGGCTCTCCGACT
CTTGAAGACTTGTGAGAATATCCATCTTCCACGCAAATTTAAAGCCATCTTAGACAAGTATGAGCATGAC
CCTGAGTCGCTCAGAGCAGCAGGACTTGCCTATGCAGTGGACCAAATCGTGGACTTGGTAACTCAGGATG
TTGCCGGTGTGCATCTCTATACGATGAATAATGCTGATACAGCAAAATACATCCATCAAGCAACCCATGC
CTTGTTTAATCACCAGTCTCTAGGATA
Protein Sequence 
>gi|15900495|ref|NP_345099.1| 5,10-methylenetetrahydrofolate reductase [Streptococcus pneumoniae TIGR4] MSRQTPSLSFEVFPPNPAVGNDNIISALQDMQELAPHFISVTASNNKFNIKETTVRLADFIQNDLAIPTIAHLPAIYLTKDKVAETIADLDKVGVQKILALRGDIIPDVEPQKDFRYATDLIEFIKEQTPHFDIIGACYPEGHPDSPNQISDIQNLKKKVDAGCSSLVTQLFFDNERFYDFQDKCILAGIDVPIHAGIMPILNRNQALRLLKTCENIHLPRKFKAILDKYEHDPESLRAAGLAYAVDQIVDLVTQDVAGVHLYTMNNADTAKYIHQATHALFNHQSLG
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: SP_0586 mutant is attenuated in mice (Hava and Camilli, 2002).
COG COG0685E, under E: Amino acid transport and metabolism
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].