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nanA from Streptococcus pneumoniae D39

Victor ID 3082
Gene Name nanA from Streptococcus pneumoniae D39
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4442379
NCBI Protein GI 116517141
Locus Tag SPD_1504
Protein Accession YP_816960.1
Other Database IDs UniProtKB-ID: Q04J78_STRP2
UniRef100: UniRef100_Q04J78
UniRef90: UniRef90_Q04J78
UniRef50: UniRef50_D3H7K8
UniParc: UPI0000E5332B
EMBL: CP000410
EMBL-CDS: ABJ55437.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000020686.
EnsemblGenome_TRS: EBSTRT00000020686
EnsemblGenome_PRO: EBSTRP00000019926
GenomeReviews: CP000410_GR
KEGG: spd:SPD_1504
eggNOG: COG4409
HOGENOM: HBG702052
OMA: DWMKFLG
ProtClustDB: CLSK560471
Taxonomy ID 373153
Gene Starting Position 1522474
Gene Ending Position 1525467
Gene Strand (Orientation) -
Protein Name sialidase A precursor
DNA Sequence 
>gi|116515308:1522474-1525467 Streptococcus pneumoniae D39, complete genome
CTTATTGTTCTCTCTTTTTCCCTAGCGTAAACAGACCAAGGAAGAAAGCTGTTAGTCCTAGTGAAGCTAG
GAGGTCACTCTCCTTGTTTCCTGTTTCAGGAAGTGCCTGCTGAGCAAGAGGAGCTTTGTAAGTATAATCT
TCTTTTGTAGTAAGAGTTACAAGCGAATCAGATCCCTTATACTCTGCGATTTCATGAACAGCTGGCTCTG
TACCATTAACTCCCCCTGTAAATTCTGGCTTCTCGACTGTTGGAGCTGCTTCTTCACCAGCTGTCCCTAG
TGGGCCTGTGTATTCTGGCTTCTCGACTGTCGGGGCTGGCTCTTCGCCGGATGTCCCTAGTGGGCCTGTG
TATTCTGGCTTCTCGACTGTTGGAGCTGGCTCTTCGCCGGATGTCCCTAATGGGCCTGTGTATTCTGGCA
CTTCATGAACAGCAGCTTCACTTCCGTTCATTCCATTCGAAAGCTTAGTGCCCGCCACAGAGACTGGTAA
ATTATGCATACTTTCAATTGCACCTTCTGCCAAACCTGTAACTTTTTGACCCATATCCTCTGAATCCACT
GTAAATAGGAGGGTTTTTGTATCATACTGGGTCATGAAGCGTGCTGTTTTACCATTTGCCAATTGAAGGG
TTGGAGCCTTGTTGACCAATACTTCTGAGTCGAACTCCAAGCCAATAACTCCTTTGCCCATCTCTCTAGT
TCGCTTCACTTTCGCTTCGGTAGGAGAAATCAGATCTTTGCTCAAAAAGTCCCAATTAAATTTTCTAAAT
GATAGGGTATAGGCATTTTGTCCTTTTTCAGTATGTTCATACAAGATGCCATACTCCCCATTTCCTAATT
CTTGGAGCGAATTATAGGCAAACTCTCCTTTTTGAATTGGATTGTGTTTGAGCCAAGTCAACTCACCATT
TTCTTCGACACGTGCCAAGTGGACCATCCCATTTTCACGTTTCGGTCCACCTGCATTACTGAGGATGATG
TATTCTTTTCCTTCGTGCATCGTATGGATAGCAGACATTTGAACATAGACATCTTTAACCTGTGGATAAC
GTTTGATATCCTTCTCCCAAGTCACTCCTCCGTCTTTACTTGTAGCAACCTGAAGATCTCCAGTCAAACC
ACGCATAAAGAGTTTAACATCTCCATTGTTTAGTTGTACCACCGTTGATTCTGTATTTTGCGCACGTCTA
TTGTTCATCGTAGAAGAGTGGATCTTTTGACCGTCTACCTGACGGTTATCGTTGACCGCTTCTCCAGCAT
GCCAAGTTTTTCCATGATCATCTGAATAGATGATACGAGAAGATTGCGAGCCATTTAAGTGAGATACATT
ATTAGTCGTATAAACCGGTATCAAAATCCGTCCCTTGTGAGGCCCATTCCGAAGTACAATTCCTGTTCCA
GGACCTACACCCAAGAATTTCATCCAATCGGCTTTGACCATCGGAGTAATATCTTGAGGCGCTGACCATG
TCTTCCCGTCGTCATCACTGTAGGACATCCATAGATAGCTATCCTTGGCAATTCTAAATGGAGAAGTTTT
GTTTGTTGTGAAGTAGATATTGCCTAGTAATTGGTTACCCTTGTATAGATCCCCCTTGTCGCTATAGGCT
GGTTTAACAGGATCTACAACAACGCGATAGTCTGTCGCCTTACCATCTGGTGTATAGACAGTACCATTTT
CTCGAATGGTATAAGCTCCCTTTTCTCCTTCACGATAGAGGATTTGATAGGTTTTTCCATCGATTTTTTT
GTAGGCTTCTTCTTTTTGTGAAGACATTCCAAAGATTCCCTTCCCTTCTGGGAACATGTCATAGATAGAA
AAGATTCGTTTGGTTTCAGGATCTTGAACCAACACCATATCGATATTCACTGGTGAACCGATCGATGGGT
CAGAAGCTTTTGGATTGTCACGTAAGTTGGTAATGGTTACTCGGTCACCCCAAGTTTTACCATTATCTTC
ACTACGTCTGATGACCATACCGATATCACCCCAGTCACTCGAATGGAGACGGCGTTCATCTGCACCTGCG
ATCAAAGTTCCTTTATCTGTCTTGAGAAGTGCTGGAATACGATAACTCTTGATTCCATCTTTATTTGGTT
TACCGTTACGCCCGCTTTCGAATATGTCCGTTTTCTCTGTTAAAGCCGCTCCTTCAGGTAGTTTTTTTTC
TAAATCTGAGCGTTTAAAAAGTTGACTACGTTTTTGTACCTCTTCTGGTGTTAAAGCACGATTATACACA
GTGAGATTCCGAATCTGTAGATTTGACCCCCAAACCGTATTGTTGGCACGCTTGGTTGCTCCGATTTGCA
CATGCGTTACATCTGGCATATCTTTAATGAAATTGCCAGATCTCAGACTTGTTCGAGATAATACCCCGTT
TACGTAGAGGCGCACTCGGCCTTTAGGTAGTTCTGCTGTCGGTTTTTCAACTGTGAAAGTCACAGAATTC
CACTGACCTGGTTTAACTTTTAAGGGTGCATCGTTGTAATTATTGTAAAACTGTTTCCCATCCGAACCAC
GCCCCTCTAGAGTAGCAGTATTATTGTAAACTGCCATAGTGAAGTACTCATCTTTTTTAGTAGCACTTGA
CACAGAAAAGAGATTATAGAATGCTGGGGCCTTGGCATCTGGCTTAAACTCCATGTGAACTGTTGCGTTT
TCAAGTTTCTTTAGTTTATCTAGTTCACTTGATAAATCAACTCTCTGACCATTTGAAGCATTGGTTTCAA
CATCTTCTTTTTCTATCACTGTTTCGACATTTTCCAAATCTCGTGCATAGTAATCTCTTGGAATTTTTTC
TTCTTGCTTATCTTTCCTTTCTTGTTCTTGCTTATTGCCAGAAAGTTCAGTCTCTGAAGAAGGCTGGCTC
TTTTCTGTATCAGTTAGGGTTGAGCTCTCCCCCGAAAGTTGAGTTTCATTTGCCAGAGGTTGCTCACTTG
CCCCTTCTTGAGCTAAAACAGGAGACGTTCCAAATACCACTGCTCCTACAATCA
Protein Sequence 
>gi|116517141|ref|YP_816960.1| sialidase A [Streptococcus pneumoniae D39] MIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nanA mutant is attenuated in mice (Polissi et al., 1998).
COG COG4409G, under G: Carbohydrate transport and metabolism
References
Polissi et al., 1998: Polissi A, Pontiggia A, Feger G, Altieri M, Mottl H, Ferrari L, Simon D. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infection and immunity. 1998; 66(12); 5620-5629. [PubMed: 9826334].