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nanA from Streptococcus pneumoniae ATCC 700669

Victor ID 3630
Gene Name nanA from Streptococcus pneumoniae ATCC 700669
Sequence Strain (Species/Organism) Streptococcus pneumoniae ATCC 700669
NCBI Gene ID 7329489
NCBI Protein GI 221232428
Locus Tag SPN23F_16920
Protein Accession YP_002511581.1
Other Database IDs UniProtKB-ID: B8ZMF7_STRPJ
UniRef100: UniRef100_D6ZMP9
UniRef90: UniRef90_D6ZMP9
UniRef50: UniRef50_P62576
UniParc: UPI00019234E7
EMBL: FM211187
EMBL-CDS: CAR69464.1
RefSeq_NT: NC_011900.1
EnsemblGenome: EBSTRG00000072557.
EnsemblGenome_TRS: EBSTRT00000072483
EnsemblGenome_PRO: EBSTRP00000066646
GenomeReviews: FM211187_GR
HOGENOM: HBG702052
ProtClustDB: CLSK560471
Taxonomy ID 561276
Gene Starting Position 1633309
Gene Ending Position 1636206
Gene Strand (Orientation) -
Protein Name sialidase A (neuraminidase A)
DNA Sequence 
>gi|221230948:1633309-1636206 Streptococcus pneumoniae ATCC 700669, complete genome
CTTATTGTTCTCTCTTTTTCCCTAGCGTAAACAGACCAAGGAAGAAAGCTGTTAGTCCTAGTGAAGCTAG
GAGGTCACTCTCCTTGTTTCCTGTTTCAGGAAGTGCCTGCTGAGCAAGAGGAGCTTTGTAAGTATAATCT
TCTTTTGTAGTAAGAGTTACAAGCGAATCAGATCCCTTATACTCTGCGATTTCATGAACAGCTGGCTCTG
TACCATTAACTCCCCCTGTAAATTCTGGAACTTCATGCACCGCTGCTTTGCTACCATTTACTCCGCCAGG
AACTCTGGCACCTGCTAGATTTACAGGAAGATTATGCATACTTTCGATGCTTCCTTTAGCTATACCAATA
ATTTCCTGTCCGATATCTTCCTTATCTACTGCAAACAACAAGGTCTTGCTATCATACTGGGTTAGGAAAG
TCGCTGTTTTACCATTTGCCAATTGAAGGGTTGGAGCCTTGTTGACCAATACTTCTGAGTCAAACTCCAA
GCCAATAACTCCTTTGCCCATCTCTCCTTTGCCCATCTCTCTAGTTCGCTTCACTTTCGCTTCGGTAGGA
GAAATCAGATCTTTGCTCAAAAATTCCCAATTAAATTTTCTAAATGATAGGGTATAGGCATTTTGTCCTT
TTTCAGTATGTTCATACAAGATGCCATACTCCCCATTTCCTAATTCTTGGAGCGAATTATAGGCAAACTC
TCCTTTTTGAATTGGATTGTGTTTGAGCCAAGTCAACTCACCATTTTCTTCGACACGTGCCAAGTGGACC
ATCCCATTTTCACGATTCGGTCCACCTGCATTGCTGAGGATAATGTATTCTTTTCCATTATGCATCGTAT
GGATAGCAGACATTTGAACATAGACATCTTTAACCTGTGGATAACGTTTGATATCCTTCTCCCAAGTCAC
TCCTCCGTCTTTACTTGTAGCAACCTGAAGATCTCCAGTCAAACCACGCATAAAGAGTTTAACATCTCCA
TTGTTTAGTTGTACCACCGTTGATTCTGTATTTTGCGCACGTTTATTGTTCATCGTAGAAGAGTGGATCT
TTTGACCGTCTACCTGACGGTTATCGTTGACCGCTTCTCCAGCATGCCAAGTTTTTCCATGATCATCTGA
ATAGATGACACGAGAAGATTGCGAGCCATTTAAGTGAGATACATTATTAGTCGTATAAACCGGTATCAAA
ATCCGTCCCTTGTGAGGCCCATTCCGAAGTACAATTCCTGTTCCAGGACCTACACCCAAGAATTTCATCC
AATCGGCTTTGACCATCGGAGTAATATCTTGAGGCGCTGACCATGTCTTCCCGTCGTCATCACTGTAGGA
CATCCATAGATAGCTATCCTTGGCAATTCTAAATGGAGAAGTTTTGTTTGTTGTGAAGTAGATATTGCCT
AGTAATTGGTTACCCTTGTATAGATCACCCTTGTCGCTATAGGCTGGTTTAACAGGATCTACAACAACGC
GATAGTCTGTCGCCTTACCATCTGGTGTATAGACAGTACCATTTTCTCGAATGGTATAAGCTCCCTTTTC
TCCTTCACGATAGAGGATTTGATAGGTTTTTCCATCGATTTTTTTGTAGGCTTCTTCTTTTTGTGAAGAC
ATTCCAAAGATTCCCTTCCCTTCTGGGAACATGTCATAGATAGAAAAGATTCGTTTGGTTTCAGGATCTT
GAACCAACACCATATCGATATTCACTGGTGAACCGATCGATGGGTCAAAAGCTTTTGGATTGTCACGTAA
GTTGGTAATGGTTACTCGGTCACCCCAAGTTTTACCATTATCTTCACTACGTCTGATGACCATACCGATA
TCACCCCAGTCACTCGAATGGAGACGGCGTTCATCTGCACCTGCGATCAAAGTTCCTTTATCTGTCTTGA
GAAGTGCTGGAATACGATAACTCTTGATTCCATCTTTATTTGGTTTACCGTTACGCCCGCTTTCGAATAT
GTCCGTTTTCTCTGTTAAAACCGCTCCTTCAGGTAGTTTTTTTTCTAAATCTGAGCGTTTAAAAAGTTGA
CTACGTTTTTGTACCTCTTCTGGTGTTAAAGCACGATTATACACAGTGAGATTCCGAATCTGTAGATTTG
ACCCCCAAACCGTATTGTTGGCACGCTTGGTTGCTCCGATTTGTACATGCGTTACATCTGGCATATCTTT
AATGAAATTGCCAGATTTCAGACTTGTTCGAGATAATACCCCGTTTACGTAGAGGCGCACTCGGCCTTTA
GGTAGTTCTGGTGTCGGTTTTTCAACTGTGAAAGTCACAGAATTCCACTGACCTGGTTTAACTTTTAAGG
GTGCATCGTTGTAATTACCGTAAAACTGTTTCCCATCCGAACCACGCCCCTCTAGAGTAGCAGTATTATT
GTAAACTGCCATAGTGAAGTACTCATCTTTTTTAGTAGCACTTGACACAGAAAAGAGATTATAGAATGCT
GGAGCCTTGGCATCTGGCTTAAACTCCATGTGAACTGTTGCGTTTTCAAGTTTCTTTAGTTTATCTAGTT
CACTTGATAAATCAACTCTCTGACCATTTGAAGCATTGGTTTCAACATCTTCTTTTTCTATCACTGTTTC
GACATTTTCCAAATCTCGTGCATAGTAATCTCTTGGAATTTTTTCTTCTTGCTTATCTTTCCTTTCTTGT
TCTTGCTTATTGCCAGAAAGTTCAGTCTCTGAAGAAGGCTGGCTCTTTTCTGTATCAGTTAGGGTTGAGC
TCTCCCCCGAAAGTTGAGTTTCATTTGCCAGAGGTTGCTCACTTGCCCCTTCTTGAGCTAAAACAGGAGA
CGTTCCAAATACCACTGCTCCTACAATCATAGAAACCGCTCCTACCGATAGTTTCCTAATGCTATAACGA
CACTTACGTTCTTGAACACTCCGATTCA
Protein Sequence 
>gi|221232428|ref|YP_002511581.1| sialidase A (neuraminidase A) [Streptococcus pneumoniae ATCC 700669] MNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYGNYNDAPLKVKPGQWNSVTFTVEKPTPELPKGRVRLYVNGVLSRTSLKSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAVLTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKAFDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRVIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNKRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHNGKEYIILSNAGGPNRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWEFLSKDLISPTEAKVKRTREMGKGEMGKGVIGLEFDSEVLVNKAPTLQLANGKTATFLTQYDSKTLLFAVDKEDIGQEIIGIAKGSIESMHNLPVNLAGARVPGGVNGSKAAVHEVPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nanA mutant is attenuated in mice (Polissi et al., 1998).
COG COG4409G, under G: Carbohydrate transport and metabolism
References
Polissi et al., 1998: Polissi A, Pontiggia A, Feger G, Altieri M, Mottl H, Ferrari L, Simon D. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infection and immunity. 1998; 66(12); 5620-5629. [PubMed: 9826334].