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glnA from Streptococcus pneumoniae R6

Victor ID 3129
Gene Name glnA from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 934783
Uniprot ID Q8DQX6
NCBI Protein GI 15902488
Locus Tag spr0444
Protein Accession NP_358038.1
Other Database IDs UniProtKB-ID: Q8DQX6_STRR6
UniRef100: UniRef100_E0TSP1
UniRef90: UniRef90_E0TSP1
UniRef50: UniRef50_D5T5L0
UniParc: UPI0000051475
EMBL: AE007317
EMBL-CDS: AAK99248.1
RefSeq_NT: NC_003098.1
HSSP: P06201
EnsemblGenome: EBSTRG00000015334.
EnsemblGenome_TRS: EBSTRT00000015334
EnsemblGenome_PRO: EBSTRP00000014730
GenomeReviews: AE007317_GR
KEGG: spr:spr0444
eggNOG: COG0174
HOGENOM: HBG553755
OMA: RVPLYKP
ProtClustDB: CLSK876973
BioCyc: SPNE171101:SPR0444-MONOMER
Taxonomy ID 171101
Gene Starting Position 448510
Gene Ending Position 449856
Gene Strand (Orientation) +
Protein Name Glutamine synthetase type 1
DNA Sequence 
>gi|15902044:448510-449856 Streptococcus pneumoniae R6, complete genome
TATGCCAATCACAGCTGCAGATATTCGTCGTGAAGTCAAGGAAAAAAATGTTACCTTTATTCGTCTTATG
TTCTCAGATATTTTGGGAACCATGAAAAACGTCGAAATTCCTGCTACAGATGAACAGTTAGATAAGGTCT
TGTCGAACAAGGTTATGTTTGATGGATCTTCTATTGAAGGTTTTGTACGTATCAATGAGTCGGATATGTA
CTTGTACCCGGACTTGGATACATGGACAGTCTTCCCTTGGGGAGATGAAAATGGAAGTGTTGCAGGTCTG
ATCTGTGATGTCTATACAACAGAAGGTGAACCATTTGCGGGTGACCCTCGTGGTAATTTGAAACGAGCTC
TTCGTCACATGGAAGAAGTTGGATTCAAATCCTTCAACCTTGGTCCAGAGCCAGAATTCTTCCTATTTAA
GTTGGATGAAAATGGGGACCCAACACTTGAAGTGAATGACAAGGGTGGCTACTTTGATTTGGCACCTACT
GACCTTGCGGACAACACACGTCGTGAGATTGTGAATGTCTTGACCAAAATGGGATTTGAAGTAGAAGCGA
GTCACCACGAGGTTGCGGTTGGACAGCATGAGATTGACTTTAAGTACGATGAAGTTCTCCGTGCTTGTGA
TAAGATTCAAATCTTTAAGCTTGTTGTTAAAACCATTGCTCGCAAACACGGACTTTACGCAACATTTATG
GCGAAGCCAAAATTTGGTATTGCTGGATCAGGTATGCACTGTAATATGTCCTTGTTTGATGCAGAAGGAA
ATAACGCCTTCTTTGATCCAAATGATCCAAAAGGAATGCAGTTGTCAGAAACAGCTTACCATTTCCTAGG
CGGTTTGATCAAGCATGCTTACAACTATACTGCCATCATGAACCCAACAGTTAACTCATACAAACGTTTG
GTTCCAGGTTATGAAGCGCCTGTTTACATTGCTTGGGCTGGTCGTAACCGTTCGCCACTTGTGCGCGTAC
CTGCTTCACGTGGTATGGGAACTCGTCTTGAGTTGCGTTCAGTGGATCCAATGGCGAACCCTTACGTTGC
TATGGCTGTTCTTTTGGAAGTTGGTTTGTATGGTATTGAAAATAAAATCGAAGCACCAGCTCCTATCGAA
GAAAATATCTACATCATGACAGCAGAAGAGCGCAAGGAAGCTGGTATTACAGACCTTCCATCAACTCTTC
ACAACGCTTTGAAAGCTTTGACAGAAGATGAAGTGGTTAAAGCTGCTCTCGGAGATCACATCTACACTAG
CTTCCTTGAAGCCAAACGAATCGAATGGGCAAGTTATGCAACCTTCGTTTCACAATGGGAAATTGATAAT
TATTTAGACCTTTACTA
Protein Sequence 
>gi|15902488|ref|NP_358038.1| glutamine synthetase, type I [Streptococcus pneumoniae R6] MPITAADIRREVKEKNVTFIRLMFSDILGTMKNVEIPATDEQLDKVLSNKVMFDGSSIEGFVRINESDMYLYPDLDTWTVFPWGDENGSVAGLICDVYTTEGEPFAGDPRGNLKRALRHMEEVGFKSFNLGPEPEFFLFKLDENGDPTLEVNDKGGYFDLAPTDLADNTRREIVNVLTKMGFEVEASHHEVAVGQHEIDFKYDEVLRACDKIQIFKLVVKTIARKHGLYATFMAKPKFGIAGSGMHCNMSLFDAEGNNAFFDPNDPKGMQLSETAYHFLGGLIKHAYNYTAIMNPTVNSYKRLVPGYEAPVYIAWAGRNRSPLVRVPASRGMGTRLELRSVDPMANPYVAMAVLLEVGLYGIENKIEAPAPIEENIYIMTAEERKEAGITDLPSTLHNALKALTEDEVVKAALGDHIYTSFLEAKRIEWASYATFVSQWEIDNYLDLY
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: glnA mutant had significantly reduced adhesion to Detroit 562 human pharyngeal epithelial cells (Kloosterman et al., 2006).
Predicted Interacting Host Protein P15104; Q5TDP6
COG COG0174E, under E: Amino acid transport and metabolism
References
Kloosterman et al., 2006: Kloosterman TG, Hendriksen WT, Bijlsma JJ, Bootsma HJ, van Hijum SA, Kok J, Hermans PW, Kuipers OP. Regulation of glutamine and glutamate metabolism by GlnR and GlnA in Streptococcus pneumoniae. The Journal of biological chemistry. 2006; 281(35); 25097-25109. [PubMed: 16787930].