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htrA

Victor ID 3620
Gene Name htrA
Sequence Strain (Species/Organism) Streptococcus pneumoniae ATCC 700669
NCBI Gene ID 7328624
NCBI Protein GI 221232937
Locus Tag SPN23F_22720
Protein Accession YP_002512091.1
Other Database IDs UniProtKB-ID: B8ZQD0_STRPJ
UniRef100: UniRef100_B2IP00
UniRef90: UniRef90_E0SZH3
UniRef50: UniRef50_Q9LA06
UniParc: UPI000152F355
EMBL: FM211187
EMBL-CDS: CAR70001.1
RefSeq_NT: NC_011900.1
MEROPS: S01.447
EnsemblGenome: EBSTRG00000071821.
EnsemblGenome_TRS: EBSTRT00000071234
EnsemblGenome_PRO: EBSTRP00000066170
GenomeReviews: FM211187_GR
HOGENOM: HBG585708
ProtClustDB: CLSK2460826
Taxonomy ID 561276
Gene Starting Position 2219290
Gene Ending Position 2220471
Gene Strand (Orientation) +
Protein Name serine protease
DNA Sequence 
>gi|221230948:2219290-2220471 Streptococcus pneumoniae ATCC 700669, complete genome
TATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTT
AGTGGAGCCTTGGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAATA
ATAGTACTATTACACAAACTGCCTATAAGAACGAAAATTCAACAACACAGGCTGTTAACAAAGTAAAAGA
TGCTGTTGTTTCTGTTATTACTTATTCGGCAAACAGACAAAATAGCGTATTTGGCAATGATGATACTGAC
ACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTATTTATAAAAAGAATGATAAAGAAGCTTACA
TCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGATTGTCAGATGGGACTAAAGT
ACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTAAAAATCTCTTCAGAAAAAGTG
ACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCC
CGTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTT
AAAATCGGAAGATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAAC
TCTGGCGGCCCACTGATCAATATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATG
GAGGAACATCTGTAGAAGGTCTTGGTTTCGCAATTCCTGCAAATGATGCTATCAATATTATTGAACAGTT
AGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCCAGATGGTTAATTTATCTAATGTGAGTACA
AGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAGTTGTTCGTTCGGTACAAAGTA
ATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGAGATTGCTTC
ATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGT
AACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTA
Protein Sequence 
>gi|221232937|ref|YP_002512091.1| serine protease [Streptococcus pneumoniae ATCC 700669] MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSANRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISSEKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLINIQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVVVRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: htrA mutant is attenuated in mice (Ibrahim et al., 2004).
COG COG0265O, under O: Posttranslational modification, protein turnover, chaperones
References
Ibrahim et al., 2004: Ibrahim YM, Kerr AR, McCluskey J, Mitchell TJ. Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. Journal of bacteriology. 2004; 186(16); 5258-5266. [PubMed: 15292127].