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SP_1923

Victor ID 3343
Gene Name SP_1923
Sequence Strain (Species/Organism) Streptococcus pneumoniae TIGR4
NCBI Gene ID 931915
NCBI Protein GI 15901747
Locus Tag SP_1923
Protein Accession NP_346351.1
Other Database IDs UniProtKB-ID: TACY_STRPN
UniRef100: UniRef100_P0C2J9
UniRef90: UniRef90_Q04IN8
UniRef50: UniRef50_Q04IN8
UniParc: UPI0000051A46
EMBL: AE005672
EMBL-CDS: AAK75991.1
RefSeq_NT: NC_003028.3
TCDB: 1.C.12.1.5
EnsemblGenome: EBSTRG00000025395
EnsemblGenome_TRS: EBSTRT00000025395
EnsemblGenome_PRO: EBSTRP00000024487
GenomeReviews: AE005672_GR
KEGG: spn:SP_1923
TIGR: SP_1923
HOGENOM: HBG337470
OMA: GAYVAQF
ProtClustDB: CLSK877006
Taxonomy ID 170187
Gene Starting Position 1831895
Gene Ending Position 1833310
Gene Strand (Orientation) -
Protein Name pneumolysin
DNA Sequence 
>gi|194172857:1831895-1833310 Streptococcus pneumoniae TIGR4 chromosome, complete genome
CCTAGTCATTTTCTACCTTATCTTCTACCTGAGGATAGAGAGTTGTTCCCCAAATAGAAATCGTCCGCTT
ACGCACTAGTGGCAAATCGGTTTTTTCATAAACCGTACGCCACCATTCCCAGGCAAGCCCGGTACACTCT
CTAATTTTGACAGAGAGATTACGAACATTCCCTTTTAAAGGAATACTAGTGGTAAAGTGAGCCGTTAAAT
CCTGCCCATTTCTGTCCCAAGCCTTAGGAGTCAAGACTTCCTTACCTTGATGATCATAGGATAATTCATT
CCAAGTAATATAATATTGGGCAACATAGGCACCACTATGATCCAGCAGTAAATCTCCGTTTCTGTAAGCT
GTAACCTTAGTCTCAACATAGTCTGTACTATTTTGAAAGGTCGCAACTACATTGTCACGTAAAAAAGAAG
TTGTATAGGAAATCGGCAAGCCTGGATGATCTGCTGTAAAGCGACTGCCTTCTTGAATCAAGTCCTCTAC
CATATCCACCTTGCCTGTTACAACTCGGGCACCCGAACTTGGGTCGCCCCCTAAAATAACCGCCTTCACT
TCTGTATTGTCCAAAATCTGTTTCCACTCTGTCTGAGGAGCTACCTTGACTCCTTTTATCAAAGCTTCAA
AAGCAGCCTCTACTTCATCACTCTTACTCGTGGTTTCCAACTTGAGATAGACTTGGCGCCCATAAGCAAC
ACTCGAAATATAGACCAAAGGACGCTCTGCAGAAATTCCTCTCTGTTTTAAATCCTCTACCGTTACAGTA
TCTTGAAACACATCTCCTGGATTTTTAACAGCATCTACGCTGACTGTATAATAAATCTGCTTAAAATTAA
CAATCTGAATCTGCTTTTCGCCTGAATGGACAGAGTTAAAATCAATATCAAGAGAATTCCCTGTCTTTTC
AAAGTCAGAACCAAACTTGACCTTGAGTTGTTCCATGCTGTGAGCCGTGATTTTTTCATACTGCATTCTA
GCTGGGACATTATTGACCTGACCATAATCTTGATGCCACTTAGCCAACAAATCGTTTACCGCTCCGCGAA
CACTTGAATTGCTGGGGTCTTCCACTTGGAGAAAGCTATCGCTACTTGCCAAACCAGGCAAATCAATACT
ATAAGTCATCGGAGCACGATCGACCGCAAGAAGAGTGGGATTATTCTCTAACAAGGTCTCATCCACTACG
AGAAGTGCTCCAGGATAGAGGCGACTGTCGTTGGTAGCTGTTACAGAAATATCACTTGTATTTGTCGACA
AGCTCCGCTTCTTTCTTTCGATAACAACAAACTCATCGGGTAGCTGATTACCCTCTTTGATGAAACGATT
TTCAATACTTTCTCCCTGATGGGTCAAGAGTTTCTTTTTATCGTAATTCATAGCTAGTATAAAGTCATTT
ACTGCTTTATTTGCCA
Protein Sequence 
>gi|15901747|ref|NP_346351.1| pneumolysin [Streptococcus pneumoniae TIGR4] MANKAVNDFILAMNYDKKKLLTHQGESIENRFIKEGNQLPDEFVVIERKKRSLSTNTSDISVTATNDSRLYPGALLVVDETLLENNPTLLAVDRAPMTYSIDLPGLASSDSFLQVEDPSNSSVRGAVNDLLAKWHQDYGQVNNVPARMQYEKITAHSMEQLKVKFGSDFEKTGNSLDIDFNSVHSGEKQIQIVNFKQIYYTVSVDAVKNPGDVFQDTVTVEDLKQRGISAERPLVYISSVAYGRQVYLKLETTSKSDEVEAAFEALIKGVKVAPQTEWKQILDNTEVKAVILGGDPSSGARVVTGKVDMVEDLIQEGSRFTADHPGLPISYTTSFLRDNVVATFQNSTDYVETKVTAYRNGDLLLDHSGAYVAQYYITWNELSYDHQGKEVLTPKAWDRNGQDLTAHFTTSIPLKGNVRNLSVKIRECTGLAWEWWRTVYEKTDLPLVRKRTISIWGTTLYPQVEDKVEND
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: pneumolysin mutant is attenuated in mice (Hava and Camilli, 2002).
References
Hava and Camilli, 2002: Hava DL, Camilli A. Large-scale identification of serotype 4 Streptococcus pneumoniae virulence factors. Molecular microbiology. 2002; 45(5); 1389-1406. [PubMed: 12207705].