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zmpC

Victor ID 3447
Gene Name zmpC
Sequence Strain (Species/Organism) Streptococcus pneumoniae G54
NCBI Gene ID 6479482
NCBI Protein GI 194396933
Locus Tag SPG_0074
Protein Accession YP_002036789.1
Other Database IDs UniProtKB-ID: B5E5L7_STRP4
UniRef100: UniRef100_B5E5L7
UniRef90: UniRef90_Q97T80
UniRef50: UniRef50_Q97T80
UniParc: UPI000152DFC1
EMBL: CP001015
EMBL-CDS: ACF55048.1
RefSeq_NT: NC_011072.1
EnsemblGenome: EBSTRG00000021749.
EnsemblGenome_TRS: EBSTRT00000021749
EnsemblGenome_PRO: EBSTRP00000020915
GenomeReviews: CP001015_GR
KEGG: spx:SPG_0074
HOGENOM: HBG703220
OMA: THEMVHN
ProtClustDB: CLSK883904
Taxonomy ID 512566
Gene Starting Position 72226
Gene Ending Position 77796
Gene Strand (Orientation) +
Protein Name zinc metalloprotease ZmpC
DNA Sequence 
>gi|194396645:72226-77796 Streptococcus pneumoniae G54 chromosome, complete genome
TATGAGCCGAAAAAGCATTGGTGAGAAACGCCATAGTTTCTCGATGAGAAAGTTGTCAGTGGGATTGGTA
TCAGTTACTGTATCTAGTTTCTTTTTGATGAGTCAAGGGATTCAATCGGTATCGGCCGATAATATGGAAA
GTCCAATTCATTATAAGTATATGACCGAGGGTAAATTGACAGACGAGGAAAAATCCTTGCTGGTAGAGGC
CCTTCCACAACTGGCTGAAGAATCAGATGATACTTATTACTTGGTTTATAGATCTCAACAGTTTTTACCG
AATACAGGTTTTAACCCAACTGTTGGTACTTTCCTTTTTACTGCAGGATTGAGCTTGTTAGTTTTATTGG
TTTCTAAAAGGGAAAATGGAAAGAAACGACTTGTTCATTTTCTGCTGTTGACTAGCATGGGAGTTCAATT
GTTGCCGGCCAGTGCTTTTGGGTTGACCAGCCAGATTTTATCTGCCTATAATAGTCAGCTTTCTATCGGA
GTCGGGGAACATTTACCAGAGCCTCTGAAAATCGAAGGTTATCAATATATTGGTTATATCAAAACTAAGA
AACAGGATAATACAGAGCTTTCAAGGACAGTTGATGGGAAATACTCTGCTCAAAGAGATAGTCAACCAAA
CTCTACAAAAACATCAGATGTAGTTCATTCAGCTGATTTAGAATGGAACCAAGGACAGGGGAAGGTTAGT
TTACAAGGTGAAGCATCAGGGGATGATGGACTTTCAGAAAAATCTTCTATAGCAGCAGACAATCTATCTT
CTAATGATTCATTCGCAAGTCAAGTTGAGCAGAATCCGGATCACAAAGGAGAATCTGTAGTTCGACCAAC
AGTGCCAGAACAAGGAAATCCTGTGTCTGCTACAACGGTGCAGAGTGCGGAAGAGGAAGTATTGGCGACG
ACAAATGATCGACCAGAGTATAAACTTCCATTGGAAACCAAAGGCACGCAAGAACCCGGTCATGAGGGTG
AAGCCGCAGTCCGTGAAGACTTACCAGTCTACACTAAGCCACTAGAAACCAAAGGTACACAAGGACCCGG
ACATGAAGGTGAAGCTGCAGTTCGCGAGGAAGAACCAGCTTACACAGAACCGTTAGCAACGAAAGGCACG
CAAGAGCCAGGTCATGAGGGCAAAGCTACAGTCCGCGAAGAGACTCTAGAGTACACGGAACCGGTAGCGA
CAAAAGGCACACAAGAACCCGAACATGAGGGCGAAGCGGCAGTAGAAGAAGAACTTCCGGCTTTAGAGGT
CACTACACGAAATAGAACGGAAATCCAGAATATTCCTTATACAACAGAAGAAATTCAGGATCCAACACTT
CTGAAAAATCGTCGTAAGATTGAACGACAAGGGCAAGCAGGGACACGTACAATTCAATATGAAGACTACA
TCGTAAATGGTAATGTCGTAGAAACTAAAGAAGTGTCACGAACTGAAGTAGCTCCGGTCAACGAAGTCGT
TAAAGTAGGAACACTTGTGAAAGTTAAACCTACAGTAGAAATTACAAACTTAACAAAAGTTGAGAACAAA
AAATCTATAACTGTAAGTTATAACTTAATAGACACTACCTCAGCATATGTTTCTGCAAAAACGCAAGTTT
TCCATGGAGACAAGCTAGTTAAAGAGGTGGATATAGAAAATCCTGCCAAAGAGCAAGTAATATCAGGTTT
AGATTACTACACACCGTATACAGTTAAAACACACCTAACTTATAATTTGGGTGAAAATAATGAGGAAAAT
ACTGAAACATCAACTCAAGATTTCCAATTAGAGTATAAGAAAATAGAGATTAAAGATATTGATTCAGTAG
AATTATACGGTAAAGAAAATGATCGTTATCGTAGATATTTAAGTCTAAGTGAAGCGCCGACTGATACGGC
TAAATACTTTGTAAAAGTGAAATCAGATCGCTTCAAAGAAATGTACCTACCTGTAAAATCTATTACAGAA
AATACGGATGGAACGTATAAAGTGACGGTAGCCGTTGATCAACTTGTCGAAGAAGGTACAGACGGTTACA
AAGATGATTACACATTTACTGTAGCTAAATCTAAAGCAGAGCAACCAGGAGTTTACACATCCTTTAAACA
GCTGGTAACAGCCATGCAAAGCAATCTGTCTGGTGTCTATACATTGGCTTCAGATATGACCGCAGATGAG
GTGAGCTTAGGCGATAAGCAGACAAGTTATCTCACAGGTGCATTTACAGGGAGCTTGATCGGTTCTGATG
GAACAAAATCGTATGCCATTTATGATTTGAAAAAACCATTATTTGATACATTAAATGGTGCTACAGTTAG
AGATTTGGATATTAAAACTGTTTCTGCTGATAGTAAAGAAAATGTCGCAGCGCTGGCGAAGGCAGCGAAT
AGCGCGAATATTAATAATGTTGCAGTAGAAGGAAAAATCTCAGGTGCGAAATCTGTTGCGGGATTAGTAG
CGAGCGCAACAAATACAGTGATAGAAAACAGCTCGTTTACAGGGAAACTTATCGCAAATCACCAGGACAG
TAATAAAAATGATACTGGAGGAATAGTAGGTAATATAACAGGAAATAGTTCGAGAGTTAATAAAGTTAGG
GTAGATGCCTTAATCTCTACTAATGCACGCAATAATAACCAAACAGCTGGAGGGATAGTAGGTAGATTAG
AAAATGGTGCATTGATATCTAATTCGGTTGCTACTGGAGAAATACGAAATGGTCAAGGATATTCTAGAGT
CGGAGGAATAGTAGGATCTACGTGGCAAAACGGTCGAGTAAATAATGTTGTGAGTAACGTAGATGTTGGA
GATGGTTATGTTATCACCGGTGATCAATACGCAGCAGCAGATGTGAAAAATGCAAGTACATCAGTTGATA
ATAGAAAAGCAGACAGATTCGCTACAAAATTATCAAAAGACCAAATAGACGCGAAAGTTGCTGATTATGG
AATCACAGTAACTCTTGATGATACTGGGCAAGATTTAAAACGTAATCTAAGAGAAGTTGATTATACAAGA
CTAAATAAAGCAGAAGCTGAAAGAAAAGTAGCTTATAGCAACATAGAAAAACTGATGCCATTCTACAATA
AAGACCTAGTAGTTCACTATGGTAACAAAGTAGCGACAACAGATAAACTTTACACTACAGAATTGTTAGA
TGTTGTGCCGATGAAAGATGATGAAGTAGTAACGGATATTAATAATAAGAAAAATTCAATAAATAAAGTT
ATGTTACATTTCAAAGATAATACAGTAGAATACCTAGATGTAACATTCAAAGAAAACTTCATAAACAGTC
AAGTAATCGAATACAATGTTACAGGAAAAGAATATATATTCACACCAGAAGCATTTGTTTCAGACTATAC
AGCGATAACGAATAACGTACTAAGCGACTTGCAAAATGTAACACTTAACTCAGAAGCTACTAAAAAAGTA
CTAGGAGCAGCGAATGATGCAGCCTTAGATAACCTATACTTAGATAGACAATTTGAAGAAGTTAAAGCTA
ATATAGCAGAACACCTAAGAAAAGTATTAGCGATGGATAAATCAATCAATACTACAGGAGACGGTGTAGT
TGAATACGTAAGTGAGAAAATCAAAAATAACAAAGAAGCATTTATGCTAGGTCTTACTTATATGAACCGT
TGGTACGATATTAATTATGGTAAAATGAATACAAAAGATTTATCTACGTACAAGTTTGACTTTAACGGAA
ATAATGAGACTTCAACGTTGGATACTATTGTCGCATTAGGAAATAGTGGACTAGATAACCTGAGAGCTTC
AAATACTGTAGGTTTATATGCGAATAAACTTGCATCGGTAAAAGGAGAAGATTCAGTCTTTGACTTCGTA
GAAGCGTATAGAAAACTGTTCTTACCAAACAAAACAAATAACGAGTGGTTTAAAGAAAATACAAAGGCAT
ATATAGTCGAAATGAAGTCTGATATTGCAGAAGTACGAGAAAAACAAGAATCACCAACAGCCGATAGAAA
ATATTCATTAGGAGTTTACGATAGAATATCAGCACCAAGTTGGGGGCATAAGAGTATGTTATTACCACTA
CTAACTTTACCTGAAGAATCTGTGTATATTTCATCGAATATGTCTACACTTGCATTCGGTTCGTATGAAA
GATATCGTGATAGTGTGGATGGAGTTATTCTTTCAGGAGATGCTTTACGAACTTATGTAAGAAATAGAGT
TGATATAGCAGCGAAAAGGCATAGAGACCATTATGATATTTGGTACAATCTTCTTGACAGTGCTTCAAAA
GAAAAACTTTTCCGTTCTGTGATAGTTTATGATGGATTCAATGTAAAAGATGAGACAGGAAGAACTTATT
GGGCAAGGTTAACGGATAAAAACATCGGCTCTATTAAAGAATTCTTCGGACCTGTTGGGAAATGGTATGA
GTATAATAGTAGTGCAGGAGCGTATGCGAATGGAAGTTTAACGCACTTTGTGTTAGATAGATTATTAGAT
GCTTATGGAACGTCGGTTTATACTCATGAAATGGTTCATAATTCTGATTCTGCAATCTACTTTGAAGGAA
ATGGTAGACGTGAAGGATTGGGAGCGGAGTTATACGCACTTGGTTTACTGCAATCTGTAGATAGTGTAAA
TTCTCATATTTTAGCTTTAAATACGTTATATAAAGCAGAAAAAGATGATTTGAATAGATTGCATACATAT
AATCCGGTGGAACGTTTCGATTCGGATGAGGCGCTTCAAAGTTATATGCATGGATCATATGATGTAATGT
ATACACTTGATGCGATGGAAGCAAAAGCGATATTAGCTCAAAATAATGATGTTAAGAAAAAATGGTTTAG
AAAAATAGAAAATTATTACGTTCGTGATACTAGACATAATAAAGATACACATGCAGGAAATAAAGTCCGT
CCATTAACAGATGAAGAAGTAGCTAACTTAACATCGTTAAACTCATTAATCGACAACGACATCATAAATA
GACGTAGCTATGATGATAATAGAGAATATAAACGAAATGGCTACTATACTATAAGTATGTTCTCTCCTGT
ATACGCAGCGCTAAGCAATTCGAAAGGTGCTCCTGGAGATATTATGTTTAGAAAAATAGCTTATGAATTA
CTTGCGGAAAAAGGTTATCACAAAGGATTCCTACCTTATGTTTCTAATCAGTACGGAGCAGAAGCATTTG
CCAGCGGAAGCAAAACATTCTCATCATGGCATGGAAGAGATGTTGCTTTAGTGACAGATGATTTAGTATT
TAAGAAAGTATTCAATGGTGAGTACTCATCATGGGCTGATTTCAAAAAAGCAATGTTTAAACAACGTATA
GATAAACAAGATAATCTGAAACCAATAACAATTCAATACGAATTAGGTAATCCTAATAGTACAAAAGAAG
TAACTATAACAACGGCTGCACAAATGCAACAATTAATTAATGAAGCGGCTGCGAAAGATATTACTAATAT
AGATCGTGCAACGAGTCATACCCCAGCAAGTTGGGTGCATTTATTAAAACAAAAAATCTATAATGCATAT
CTTCGCACTACAGATGACTTTAGAAATTCTATATATAAATA
Protein Sequence 
>gi|194396933|ref|YP_002036789.1| zinc metalloprotease ZmpC [Streptococcus pneumoniae G54] MSRKSIGEKRHSFSMRKLSVGLVSVTVSSFFLMSQGIQSVSADNMESPIHYKYMTEGKLTDEEKSLLVEALPQLAEESDDTYYLVYRSQQFLPNTGFNPTVGTFLFTAGLSLLVLLVSKRENGKKRLVHFLLLTSMGVQLLPASAFGLTSQILSAYNSQLSIGVGEHLPEPLKIEGYQYIGYIKTKKQDNTELSRTVDGKYSAQRDSQPNSTKTSDVVHSADLEWNQGQGKVSLQGEASGDDGLSEKSSIAADNLSSNDSFASQVEQNPDHKGESVVRPTVPEQGNPVSATTVQSAEEEVLATTNDRPEYKLPLETKGTQEPGHEGEAAVREDLPVYTKPLETKGTQGPGHEGEAAVREEEPAYTEPLATKGTQEPGHEGKATVREETLEYTEPVATKGTQEPEHEGEAAVEEELPALEVTTRNRTEIQNIPYTTEEIQDPTLLKNRRKIERQGQAGTRTIQYEDYIVNGNVVETKEVSRTEVAPVNEVVKVGTLVKVKPTVEITNLTKVENKKSITVSYNLIDTTSAYVSAKTQVFHGDKLVKEVDIENPAKEQVISGLDYYTPYTVKTHLTYNLGENNEENTETSTQDFQLEYKKIEIKDIDSVELYGKENDRYRRYLSLSEAPTDTAKYFVKVKSDRFKEMYLPVKSITENTDGTYKVTVAVDQLVEEGTDGYKDDYTFTVAKSKAEQPGVYTSFKQLVTAMQSNLSGVYTLASDMTADEVSLGDKQTSYLTGAFTGSLIGSDGTKSYAIYDLKKPLFDTLNGATVRDLDIKTVSADSKENVAALAKAANSANINNVAVEGKISGAKSVAGLVASATNTVIENSSFTGKLIANHQDSNKNDTGGIVGNITGNSSRVNKVRVDALISTNARNNNQTAGGIVGRLENGALISNSVATGEIRNGQGYSRVGGIVGSTWQNGRVNNVVSNVDVGDGYVITGDQYAAADVKNASTSVDNRKADRFATKLSKDQIDAKVADYGITVTLDDTGQDLKRNLREVDYTRLNKAEAERKVAYSNIEKLMPFYNKDLVVHYGNKVATTDKLYTTELLDVVPMKDDEVVTDINNKKNSINKVMLHFKDNTVEYLDVTFKENFINSQVIEYNVTGKEYIFTPEAFVSDYTAITNNVLSDLQNVTLNSEATKKVLGAANDAALDNLYLDRQFEEVKANIAEHLRKVLAMDKSINTTGDGVVEYVSEKIKNNKEAFMLGLTYMNRWYDINYGKMNTKDLSTYKFDFNGNNETSTLDTIVALGNSGLDNLRASNTVGLYANKLASVKGEDSVFDFVEAYRKLFLPNKTNNEWFKENTKAYIVEMKSDIAEVREKQESPTADRKYSLGVYDRISAPSWGHKSMLLPLLTLPEESVYISSNMSTLAFGSYERYRDSVDGVILSGDALRTYVRNRVDIAAKRHRDHYDIWYNLLDSASKEKLFRSVIVYDGFNVKDETGRTYWARLTDKNIGSIKEFFGPVGKWYEYNSSAGAYANGSLTHFVLDRLLDAYGTSVYTHEMVHNSDSAIYFEGNGRREGLGAELYALGLLQSVDSVNSHILALNTLYKAEKDDLNRLHTYNPVERFDSDEALQSYMHGSYDVMYTLDAMEAKAILAQNNDVKKKWFRKIENYYVRDTRHNKDTHAGNKVRPLTDEEVANLTSLNSLIDNDIINRRSYDDNREYKRNGYYTISMFSPVYAALSNSKGAPGDIMFRKIAYELLAEKGYHKGFLPYVSNQYGAEAFASGSKTFSSWHGRDVALVTDDLVFKKVFNGEYSSWADFKKAMFKQRIDKQDNLKPITIQYELGNPNSTKEVTITTAAQMQQLINEAAAKDITNIDRATSHTPASWVHLLKQKIYNAYLRTTDDFRNSIYK
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: zmpC mutant is attenuated in mice (Oggioni et al., 2003).
COG COG3583S, under S: Function unknown
References
Oggioni et al., 2003: Oggioni MR, Memmi G, Maggi T, Chiavolini D, Iannelli F, Pozzi G. Pneumococcal zinc metalloproteinase ZmpC cleaves human matrix metalloproteinase 9 and is a virulence factor in experimental pneumonia. Molecular microbiology. 2003; 49(3); 795-805. [PubMed: 12864860].