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ciaR from Streptococcus pneumoniae D39

Victor ID 3063
Gene Name ciaR from Streptococcus pneumoniae D39
Sequence Strain (Species/Organism) Streptococcus pneumoniae D39
NCBI Gene ID 4441190
NCBI Protein GI 116515465
Locus Tag SPD_0701
Protein Accession YP_816195.1
Other Database IDs UniProtKB-ID: Q04LA3_STRP2
UniRef100: UniRef100_P0A4H8
UniRef90: UniRef90_P0A4H8
UniRef50: UniRef50_P0A4H8
UniParc: UPI00000515B6
EMBL: CP000410
EMBL-CDS: ABJ53761.1
RefSeq_NT: NC_008533.1
EnsemblGenome: EBSTRG00000019398.
EnsemblGenome_TRS: EBSTRT00000019398
EnsemblGenome_PRO: EBSTRP00000018638
GenomeReviews: CP000410_GR
KEGG: spd:SPD_0701
eggNOG: COG0745
HOGENOM: HBG753323
OMA: VILPKEQ
ProtClustDB: CLSK876907
Taxonomy ID 373153
Gene Starting Position 714756
Gene Ending Position 715496
Gene Strand (Orientation) +
Protein Name DNA-binding response regulator CiaR
DNA Sequence 
>gi|116515308:714756-715496 Streptococcus pneumoniae D39, complete genome
AATGCAGAGAGTTGAGTTTTTTTTAAGGCAAATTTGGTATAATAGTTTTAATAAGGAGGAGTTTCTCATG
ATAAAAATCTTATTGGTTGAGGATGACCTAGGTCTGTCAAATTCAGTATTTGACTTTTTAGACGATTTTG
CGGATGTTATGCAGGTATTTGATGGAGAAGAAGGTCTCTACGAAGCTGAGAGTGGTGTCTATGACTTGAT
TTTGCTGGATTTGATGTTGCCAGAAAAAAATGGTTTCCAAGTCTTAAAAGAATTGCGTGAAAAGGGAATT
ACGACACCAGTTCTGATTATGACTGCCAAGGAAAGTTTGGATGACAAGGGACATGGATTTGAACTGGGAG
CGGATGATTATCTGACCAAACCTTTCTACCTAGAAGAACTTAAAATGCGGATTCAGGCCCTTCTCAAACG
TTCAGGGAAGTTTAATGAAAACACCTTGACTTATGGGAATATCGTGGTTAATTTATCAACCAATACCGTT
AAAGTTGAAGATACTCCTGTCGAATTGCTGGGGAAAGAGTTCGATTTACTAGTTTATTTCCTTCAAAATC
AAAATGTGATTTTGCCTAAGACGCAGATTTTTGACCGTCTATGGGGATTTGATAGTGATACAACGATTTC
GGTTGTCGAAGTCTATGTTTCAAAAGTCCGTAAGAAATTAAAGGGAACCACTTTTGCAGAGAATTTGCAA
ACCTTGCGTAGTGTTGGGTATCTTTTAAAAGATGTTCAGTA
Protein Sequence 
>gi|116515465|ref|YP_816195.1| DNA-binding response regulator CiaR [Streptococcus pneumoniae D39] MQRVEFFLRQIWYNSFNKEEFLMIKILLVEDDLGLSNSVFDFLDDFADVMQVFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTAKESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFNENTLTYGNIVVNLSTNTVKVEDTPVELLGKEFDLLVYFLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYVSKVRKKLKGTTFAENLQTLRSVGYLLKDVQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: ciaR mutant is attenuated in mice (Ibrahim et al., 2004).
COG COG0745TK, under T: Signal transduction mechanisms; K: Transcription
References
Ibrahim et al., 2004: Ibrahim YM, Kerr AR, McCluskey J, Mitchell TJ. Control of virulence by the two-component system CiaR/H is mediated via HtrA, a major virulence factor of Streptococcus pneumoniae. Journal of bacteriology. 2004; 186(16); 5258-5266. [PubMed: 15292127].