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nanA from Streptococcus pneumoniae R6

Victor ID 3112
Gene Name nanA from Streptococcus pneumoniae R6
Sequence Strain (Species/Organism) Streptococcus pneumoniae R6
NCBI Gene ID 933902
NCBI Protein GI 15903579
Locus Tag spr1536
Protein Accession NP_359129.1
Other Database IDs UniProtKB-ID: NANA_STRR6
UniRef100: UniRef100_P62576
UniRef90: UniRef90_P62576
UniRef50: UniRef50_P62576
UniParc: UPI000012FD46
EMBL: AE007317
EMBL-CDS: AAL00340.1
RefSeq_NT: NC_003098.1
PDB: 2W20
PDB: 3H71
PDB: 3H72
PDB: 3H73
EnsemblGenome: EBSTRG00000015609
EnsemblGenome_TRS: EBSTRT00000015609
EnsemblGenome_PRO: EBSTRP00000015005
GenomeReviews: AE007317_GR
KEGG: spr:spr1536
eggNOG: COG4409
HOGENOM: HBG702052
OMA: DWMKFLG
ProtClustDB: CLSK560471
BioCyc: SPNE171101:SPR1536-MONOMER
Taxonomy ID 171101
Gene Starting Position 1514943
Gene Ending Position 1518050
Gene Strand (Orientation) -
Protein Name Sialidase A precursor (neuraminidase A)
DNA Sequence 
>gi|15902044:1514943-1518050 Streptococcus pneumoniae R6, complete genome
CTTATTGTTCTCTCTTTTTCCCTAGCGTAAACAGACCAAGGAAGAAAGCTGTTAGTCCTAGTGAAGCTAG
GAGGTCACTCTCCTTGTTTCCTGTTTCAGGAAGTGCCTGCTGAGCAAGAGGAGCTTTGTAAGTATAATCT
TCTTTTGTAGTAAGAGTTACAAGCGAATCAGATCCCTTATACTCTGCGATTTCATGAACAGCTGGCTCTG
TACCATTAACTCCCCCTGTAAATTCTGGCTTCTCGACTGTTGGAGCTGCTTCTTCACCAGCTGTCCCTAG
TGGGCCTGTGTATTCTGGCTTCTCGACTGTCGGGGCTGGCTCTTCGCCGGATGTCCCTAGTGGGCCTGTG
TATTCTGGCTTCTCGACTGTTGGAGCTGGCTCTTCGCCGGATGTCCCTAATGGGCCTGTGTATTCTGGCA
CTTCATGAACAGCAGCTTCACTTCCGTTCATTCCATTCGAAAGCTTAGTGCCCGCCACAGAGACTGGTAA
ATTATGCATACTTTCAATTGCACCTTCTGCCAAACCTGTAACTTTTTGACCCATATCCTCTGAATCCACT
GTAAATAGGAGGGTTTTTGTATCATACTGGGTCATGAAGCGTGCTGTTTTACCATTTGCCAATTGAAGGG
TTGGAGCCTTGTTGACCAATACTTCTGAGTCGAACTCCAAGCCAATAACTCCTTTGCCCATCTCTCTAGT
TCGCTTCACTTTCGCTTCGGTAGGAGAAATCAGATCTTTGCTCAAAAAGTCCCAATTAAATTTTCTAAAT
GATAGGGTATAGGCATTTTGTCCTTTTTCAGTATGTTCATACAAGATGCCATACTCCCCATTTCCTAATT
CTTGGAGCGAATTATAGGCAAACTCTCCTTTTTGAATTGGATTGTGTTTGAGCCAAGTCAACTCACCATT
TTCTTCGACACGTGCCAAGTGGACCATCCCATTTTCACGTTTCGGTCCACCTGCATTACTGAGGATGATG
TATTCTTTTCCTTCGTGCATCGTATGGATAGCAGACATTTGAACATAGACATCTTTAACCTGTGGATAAC
GTTTGATATCCTTCTCCCAAGTCACTCCTCCGTCTTTACTTGTAGCAACCTGAAGATCTCCAGTCAAACC
ACGCATAAAGAGTTTAACATCTCCATTGTTTAGTTGTACCACCGTTGATTCTGTATTTTGCGCACGTCTA
TTGTTCATCGTAGAAGAGTGGATCTTTTGACCGTCTACCTGACGGTTATCGTTGACCGCTTCTCCAGCAT
GCCAAGTTTTTCCATGATCATCTGAATAGATGATACGAGAAGATTGCGAGCCATTTAAGTGAGATACATT
ATTAGTCGTATAAACCGGTATCAAAATCCGTCCCTTGTGAGGCCCATTCCGAAGTACAATTCCTGTTCCA
GGACCTACACCCAAGAATTTCATCCAATCGGCTTTGACCATCGGAGTAATATCTTGAGGCGCTGACCATG
TCTTCCCGTCGTCATCACTGTAGGACATCCATAGATAGCTATCCTTGGCAATTCTAAATGGAGAAGTTTT
GTTTGTTGTGAAGTAGATATTGCCTAGTAATTGGTTACCCTTGTATAGATCCCCCTTGTCGCTATAGGCT
GGTTTAACAGGATCTACAACAACGCGATAGTCTGTCGCCTTACCATCTGGTGTATAGACAGTACCATTTT
CTCGAATGGTATAAGCTCCCTTTTCTCCTTCACGATAGAGGATTTGATAGGTTTTTCCATCGATTTTTTT
GTAGGCTTCTTCTTTTTGTGAAGACATTCCAAAGATTCCCTTCCCTTCTGGGAACATGTCATAGATAGAA
AAGATTCGTTTGGTTTCAGGATCTTGAACCAACACCATATCGATATTCACTGGTGAACCGATCGATGGGT
CAGAAGCTTTTGGATTGTCACGTAAGTTGGTAATGGTTACTCGGTCACCCCAAGTTTTACCATTATCTTC
ACTACGTCTGATGACCATACCGATATCACCCCAGTCACTCGAATGGAGACGGCGTTCATCTGCACCTGCG
ATCAAAGTTCCTTTATCTGTCTTGAGAAGTGCTGGAATACGATAACTCTTGATTCCATCTTTATTTGGTT
TACCGTTACGCCCGCTTTCGAATATGTCCGTTTTCTCTGTTAAAGCCGCTCCTTCAGGTAGTTTTTTTTC
TAAATCTGAGCGTTTAAAAAGTTGACTACGTTTTTGTACCTCTTCTGGTGTTAAAGCACGATTATACACA
GTGAGATTCCGAATCTGTAGATTTGACCCCCAAACCGTATTGTTGGCACGCTTGGTTGCTCCGATTTGCA
CATGCGTTACATCTGGCATATCTTTAATGAAATTGCCAGATCTCAGACTTGTTCGAGATAATACCCCGTT
TACGTAGAGGCGCACTCGGCCTTTAGGTAGTTCTGCTGTCGGTTTTTCAACTGTGAAAGTCACAGAATTC
CACTGACCTGGTTTAACTTTTAAGGGTGCATCGTTGTAATTATTGTAAAACTGTTTCCCATCCGAACCAC
GCCCCTCTAGAGTAGCAGTATTATTGTAAACTGCCATAGTGAAGTACTCATCTTTTTTAGTAGCACTTGA
CACAGAAAAGAGATTATAGAATGCTGGGGCCTTGGCATCTGGCTTAAACTCCATGTGAACTGTTGCGTTT
TCAAGTTTCTTTAGTTTATCTAGTTCACTTGATAAATCAACTCTCTGACCATTTGAAGCATTGGTTTCAA
CATCTTCTTTTTCTATCACTGTTTCGACATTTTCCAAATCTCGTGCATAGTAATCTCTTGGAATTTTTTC
TTCTTGCTTATCTTTCCTTTCTTGTTCTTGCTTATTGCCAGAAAGTTCAGTCTCTGAAGAAGGCTGGCTC
TTTTCTGTATCAGTTAGGGTTGAGCTCTCCCCCGAAAGTTGAGTTTCATTTGCCAGAGGTTGCTCACTTG
CCCCTTCTTGAGCTAAAACAGGAGACGTTCCAAATACCACTGCTCCTACAATCATAGAAACCGCTCCTAC
CGATAGTTTCCTAATGCTATAACGACACTTACGTTCTTGAACACTCCGATTCATACTGTTCCTCTCTATA
TCTATATCCCGATTTCTGAAATAAGACA
Protein Sequence 
>gi|15903579|ref|NP_359129.1| neuraminidase A [Streptococcus pneumoniae R6] MSYFRNRDIDIERNSMNRSVQERKCRYSIRKLSVGAVSMIVGAVVFGTSPVLAQEGASEQPLANETQLSGESSTLTDTEKSQPSSETELSGNKQEQERKDKQEEKIPRDYYARDLENVETVIEKEDVETNASNGQRVDLSSELDKLKKLENATVHMEFKPDAKAPAFYNLFSVSSATKKDEYFTMAVYNNTATLEGRGSDGKQFYNNYNDAPLKVKPGQWNSVTFTVEKPTAELPKGRVRLYVNGVLSRTSLRSGNFIKDMPDVTHVQIGATKRANNTVWGSNLQIRNLTVYNRALTPEEVQKRSQLFKRSDLEKKLPEGAALTEKTDIFESGRNGKPNKDGIKSYRIPALLKTDKGTLIAGADERRLHSSDWGDIGMVIRRSEDNGKTWGDRVTITNLRDNPKASDPSIGSPVNIDMVLVQDPETKRIFSIYDMFPEGKGIFGMSSQKEEAYKKIDGKTYQILYREGEKGAYTIRENGTVYTPDGKATDYRVVVDPVKPAYSDKGDLYKGNQLLGNIYFTTNKTSPFRIAKDSYLWMSYSDDDGKTWSAPQDITPMVKADWMKFLGVGPGTGIVLRNGPHKGRILIPVYTTNNVSHLNGSQSSRIIYSDDHGKTWHAGEAVNDNRQVDGQKIHSSTMNNRRAQNTESTVVQLNNGDVKLFMRGLTGDLQVATSKDGGVTWEKDIKRYPQVKDVYVQMSAIHTMHEGKEYIILSNAGGPKRENGMVHLARVEENGELTWLKHNPIQKGEFAYNSLQELGNGEYGILYEHTEKGQNAYTLSFRKFNWDFLSKDLISPTEAKVKRTREMGKGVIGLEFDSEVLVNKAPTLQLANGKTARFMTQYDTKTLLFTVDSEDMGQKVTGLAEGAIESMHNLPVSVAGTKLSNGMNGSEAAVHEVPEYTGPLGTSGEEPAPTVEKPEYTGPLGTSGEEPAPTVEKPEYTGPLGTAGEEAAPTVEKPEFTGGVNGTEPAVHEIAEYKGSDSLVTLTTKEDYTYKAPLAQQALPETGNKESDLLASLGLTAFFLGLFTLGKKREQ
Molecule Role Virulence factor
Molecule Role Annotation MUTATION: nanA mutant is attenuated in mice (Polissi et al., 1998).
COG COG4409G, under G: Carbohydrate transport and metabolism
References
Polissi et al., 1998: Polissi A, Pontiggia A, Feger G, Altieri M, Mottl H, Ferrari L, Simon D. Large-scale identification of virulence genes from Streptococcus pneumoniae. Infection and immunity. 1998; 66(12); 5620-5629. [PubMed: 9826334].